Devon Ryan
@dpryan79.bsky.social
An American in Germany, an ion channel guy in bioinformatics, a proponent of scientific skepticism in an irrational world.
@devon@genomic.social, @dpryan79 on twitter and github
@devon@genomic.social, @dpryan79 on twitter and github
Reposted by Devon Ryan
End qualified immunity.
"According to his running club, the man, who is a U.S. citizen, was returning from a team run when agents pulled him out of his vehicle, tackled him to the ground and kneeled on top of him, allegedly breaking six ribs and causing internal bleeding"
US citizen, 67, ‘has six ribs broken’ by Border Patrol agents, his running club says
The incident unfolded Saturday in Chicago’s Old Irving Park neighborhood, where residents say federal agents disrupted a children’s Halloween parade
www.independent.co.uk
October 29, 2025 at 1:54 AM
End qualified immunity.
Reposted by Devon Ryan
PubMed is running on autopilot during shutdown, but key independent committee has been abolished www.bmj.com/content/391/... 🧪
October 22, 2025 at 5:55 PM
PubMed is running on autopilot during shutdown, but key independent committee has been abolished www.bmj.com/content/391/... 🧪
Reposted by Devon Ryan
Graduate seminar did a deep dive on Thomas Paine’s Common Sense yesterday. At the line, “in America the law is king,” they (14 students from 6 countries) burst out laughing. I've been doing this for 35 years and this is the first time that was a laugh line.
October 22, 2025 at 10:21 AM
Graduate seminar did a deep dive on Thomas Paine’s Common Sense yesterday. At the line, “in America the law is king,” they (14 students from 6 countries) burst out laughing. I've been doing this for 35 years and this is the first time that was a laugh line.
You know you work for a software company when the description of meeting room names in your new office comes with regex that they will all follow.
October 21, 2025 at 6:38 AM
You know you work for a software company when the description of meeting room names in your new office comes with regex that they will all follow.
Reposted by Devon Ryan
Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11
Read the thread below for a summary of our findings 🧵1/11
September 17, 2025 at 2:55 PM
Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11
Read the thread below for a summary of our findings 🧵1/11
Reposted by Devon Ryan
New blog post – A quick look at Roche's SBX
lh3.github.io/2025/09/11/a...
lh3.github.io/2025/09/11/a...
September 12, 2025 at 3:26 AM
New blog post – A quick look at Roche's SBX
lh3.github.io/2025/09/11/a...
lh3.github.io/2025/09/11/a...
Reposted by Devon Ryan
Now published in GigaScience with minor improvements: academic.oup.com/gigascience/...
* Download: zenodo.org/records/1490...
* More info: github.com/lh3/panmask
* Download: zenodo.org/records/1490...
* More info: github.com/lh3/panmask
Preprint on "Finding easy regions for short-read variant calling from pangenome data": arxiv.org/abs/2507.03718
September 4, 2025 at 4:44 PM
Now published in GigaScience with minor improvements: academic.oup.com/gigascience/...
* Download: zenodo.org/records/1490...
* More info: github.com/lh3/panmask
* Download: zenodo.org/records/1490...
* More info: github.com/lh3/panmask
Reposted by Devon Ryan
August 27, 2025 at 7:34 AM
Reposted by Devon Ryan
My 6th grader is doing a survey for ethics class on the concepts of happiness and luck (or Glück for the German speakers). If you have a few minutes to submit your thoughts she’d appreciate it. docs.google.com/forms/d/1y2b...
May 27, 2025 at 6:03 AM
My 6th grader is doing a survey for ethics class on the concepts of happiness and luck (or Glück for the German speakers). If you have a few minutes to submit your thoughts she’d appreciate it. docs.google.com/forms/d/1y2b...
Reposted by Devon Ryan
These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
May 26, 2025 at 4:32 AM
These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.
Reposted by Devon Ryan
I’m overwhelmed by the expressions of sympathy and support.
And still this pales in comparison to what they are doing to immigrants and to undermine the Bill of Rights.
If you could do one thing for me, call your representatives and demand accountability for their white supremacist terrorism.
And still this pales in comparison to what they are doing to immigrants and to undermine the Bill of Rights.
If you could do one thing for me, call your representatives and demand accountability for their white supremacist terrorism.
Just got mine.
Totally expected, but it still sucks.
Probably the most for all the work that so many of us put in on behalf of US taxpayers that is now wasted and will never come to fruition.
Totally expected, but it still sucks.
Probably the most for all the work that so many of us put in on behalf of US taxpayers that is now wasted and will never come to fruition.
April 30, 2025 at 6:12 AM
I’m overwhelmed by the expressions of sympathy and support.
And still this pales in comparison to what they are doing to immigrants and to undermine the Bill of Rights.
If you could do one thing for me, call your representatives and demand accountability for their white supremacist terrorism.
And still this pales in comparison to what they are doing to immigrants and to undermine the Bill of Rights.
If you could do one thing for me, call your representatives and demand accountability for their white supremacist terrorism.
This seems like a good thing. Are we aloud to have good things? I feel like this is going to turn into a Charlie Brown and Lucy with the football sort of situation.
NEW: ICE says it is restoring the legal status of thousands of international students in the SEVIS database (used jointly by the govt and universities) after continuing court losses. (h/t @johnhawkinson.bsky.social) storage.courtlistener.com/recap/gov.us...
April 25, 2025 at 4:32 PM
This seems like a good thing. Are we aloud to have good things? I feel like this is going to turn into a Charlie Brown and Lucy with the football sort of situation.
Anyone want to go in on an industry collab to fund this?
what kind of doge disaster is this one?
the nnsa kind - where they oops!ed then tried to hire people back
the ebola kind - where they oops!ed then failed to hire people back
the lead poisoning kind - where they oopsed! then didn't even try to hire people back
www.theregister.com/2025/04/16/h...
the nnsa kind - where they oops!ed then tried to hire people back
the ebola kind - where they oops!ed then failed to hire people back
the lead poisoning kind - where they oopsed! then didn't even try to hire people back
www.theregister.com/2025/04/16/h...
Homeland Security funding for CVE program expires
: Because vulnerability management has nothing to do with national security, right?
www.theregister.com
April 16, 2025 at 4:09 PM
Anyone want to go in on an industry collab to fund this?
Reposted by Devon Ryan
I've seen enough. Donald Trump is not abiding by a lawful Supreme Court ruling. As a member of Congress, I fully support impeaching him. NOW.
April 16, 2025 at 2:45 PM
I've seen enough. Donald Trump is not abiding by a lawful Supreme Court ruling. As a member of Congress, I fully support impeaching him. NOW.
Reposted by Devon Ryan
How is this Python package real pypi.org/project/tari...
April 15, 2025 at 2:26 PM
How is this Python package real pypi.org/project/tari...
Reposted by Devon Ryan
Cruel Fate, 1525: Our cow died during the night. We will surely perish.
Cruel Fate, 2025: Our Keurig stopped working during the night. We will surely perish.
Cruel Fate, 2025: Our Keurig stopped working during the night. We will surely perish.
April 13, 2025 at 5:27 PM
Cruel Fate, 1525: Our cow died during the night. We will surely perish.
Cruel Fate, 2025: Our Keurig stopped working during the night. We will surely perish.
Cruel Fate, 2025: Our Keurig stopped working during the night. We will surely perish.
Reposted by Devon Ryan
That’s a wild backdoor…
1. LLM-generated code tries to run code from online software packages. Which is normal but
2. The packages don’t exist. Which would normally cause an error but
3. Nefarious people have made malware under the package names that LLMs make up most often. So
4. Now the LLM code points to malware.
2. The packages don’t exist. Which would normally cause an error but
3. Nefarious people have made malware under the package names that LLMs make up most often. So
4. Now the LLM code points to malware.
LLMs hallucinating nonexistent software packages with plausible names leads to a new malware vulnerability: "slopsquatting."
April 13, 2025 at 6:54 AM
That’s a wild backdoor…
Burn
The problem with most machine-based random number generators is that they’re not TRULY random, so if you need genuine randomness it is sometimes necessary to link your code to an external random process like a physical noise source or the current rate of US tariffs on a given country.
April 10, 2025 at 4:45 PM
Burn
Someone needs to do a dramatic reenactment of this
Govt: Don't know what members of the admin who were listening in to call
Judge: You can't think of anyone else?
Govt: No?
Judge: Anyone you *believe* were listening in?
Govt: Maybe covered by atty/client privilege?
Judge: ... Why?
Judge: You can't think of anyone else?
Govt: No?
Judge: Anyone you *believe* were listening in?
Govt: Maybe covered by atty/client privilege?
Judge: ... Why?
April 3, 2025 at 7:28 PM
Someone needs to do a dramatic reenactment of this
Is this the legal equivalent of questioning a 4 year old that is denying having eaten chocolate while they have chocolate smeared all over their face?
HAPPENING NOW: Judge Boasberg holds a "show cause" hearing on whether the government defied his orders when it deported Venezuelans accused of being members of Tren de Aragua to a nightmarish Salvadoran prison
April 3, 2025 at 7:20 PM
Is this the legal equivalent of questioning a 4 year old that is denying having eaten chocolate while they have chocolate smeared all over their face?
Reposted by Devon Ryan
April 3, 2025 at 11:09 AM
Great, let’s loosen controls on snake oil, just what we need more of.
Big setback to regulate tests ProPublica wrote about:
How Prenatal Screenings Have Escaped Regulation www.propublica.org/article/how-...
How Prenatal Screenings Have Escaped Regulation www.propublica.org/article/how-...
April 1, 2025 at 5:41 AM
Great, let’s loosen controls on snake oil, just what we need more of.
Reposted by Devon Ryan
There are trans Americans right now looking out at this world and wondering if anyone is going to stand up for them and for their simple right to exist.
Well, I am. We are. We will.
Well, I am. We are. We will.
March 31, 2025 at 4:16 PM
There are trans Americans right now looking out at this world and wondering if anyone is going to stand up for them and for their simple right to exist.
Well, I am. We are. We will.
Well, I am. We are. We will.
How many others had Latin back in the day and read this as SPQR chemistry at first?
Real results, real improvements! #PacBio customers using #SPRQ chemistry on the #Revio system are seeing increased HiFi yield, longer reads, and greater confidence in their results.
See the difference: bit.ly/3Y0Ds6Z
See the difference: bit.ly/3Y0Ds6Z
March 26, 2025 at 6:08 PM
How many others had Latin back in the day and read this as SPQR chemistry at first?