Jordan Meier
@doc-jlmeier.bsky.social
Chemical biologist, basketball aficianado, proud homebody. I take my science, not my posts, seriously. Personal account.
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Jordan Meier
@doc-jlmeier.bsky.social
· May 30
Last week the group celebrated the last day for Alayna Hu, our awesome high school intern!
Alayna developed computational approaches to predict HAT-TF interactions and will attend Duke this Fall.
Sometimes it is nice to remember the good things happening. Below is a lab 🧵, Spring 2025:
Alayna developed computational approaches to predict HAT-TF interactions and will attend Duke this Fall.
Sometimes it is nice to remember the good things happening. Below is a lab 🧵, Spring 2025:
Reposted by Jordan Meier
Pilot just came on and said that in addition to turbulence, “We are flying today with an unusually large number of tubes. Please make sure you exit the plane with the correct tube.” Non #SFN25 passengers very confused 😂
November 15, 2025 at 1:43 PM
Pilot just came on and said that in addition to turbulence, “We are flying today with an unusually large number of tubes. Please make sure you exit the plane with the correct tube.” Non #SFN25 passengers very confused 😂
Reposted by Jordan Meier
For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists.
🎉 Learn more about the work: https://scim.ag/4qVpK1a
🎉 Learn more about the work: https://scim.ag/4qVpK1a
November 13, 2025 at 8:34 PM
For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists.
🎉 Learn more about the work: https://scim.ag/4qVpK1a
🎉 Learn more about the work: https://scim.ag/4qVpK1a
Current group mood 🚀 🚀
November 14, 2025 at 1:22 AM
Current group mood 🚀 🚀
Every time I open a Capri Sun:
a close up of a woman 's face with a piercing in her nose
ALT: a close up of a woman 's face with a piercing in her nose
media.tenor.com
November 9, 2025 at 6:23 PM
Every time I open a Capri Sun:
Reading this, it truly resonates how fortunate we were that Jim Watson never took an interest in social media.
A Sharon Begley byline, almost 5 years after her death.
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
Upon hearing the news James Watson had died, a STAT reporter said in our Slack, "I wish I could read what Sharon would have written."
Incredible news: Sharon in fact did pre-write a Watson obit. And it is masterful and excoriating.
🧪🧬🧫
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 8, 2025 at 9:41 PM
Reading this, it truly resonates how fortunate we were that Jim Watson never took an interest in social media.
Reposted by Jordan Meier
Huge congratulations to @craigmcrews.bsky.social on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery.
#ChemSky #ChemBio #TPD
#ChemSky #ChemBio #TPD
November 7, 2025 at 10:20 AM
Huge congratulations to @craigmcrews.bsky.social on being awarded the #Havinga medal at the #Reedijk Symposium of the Leiden Institute of Chemistry for his groundbreaking work on induced proximity, including targeted protein degradation, as a new paradigm for #DrugDiscovery.
#ChemSky #ChemBio #TPD
#ChemSky #ChemBio #TPD
Reposted by Jordan Meier
I think about this post every day 🧪
November 7, 2025 at 12:15 PM
I think about this post every day 🧪
Reposted by Jordan Meier
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
Beautiful discovery by the Huber and Kubicek labs and a wonderful example of using targeted protein degradation to probe novel non-catalytic functions.
New in @science.org 🧬
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
What if an enzyme you thought you knew turned out to control metabolism in a completely new way?
We found that NUDT5 acts as a molecular handbrake on purine synthesis, reshaping how cells make DNA building blocks and respond to cancer drugs.
www.science.org/doi/10.1126/...
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
www.science.org
November 6, 2025 at 8:12 PM
Beautiful discovery by the Huber and Kubicek labs and a wonderful example of using targeted protein degradation to probe novel non-catalytic functions.
Reposted by Jordan Meier
Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants https://www.biorxiv.org/content/10.1101/2025.11.04.686643v1
November 6, 2025 at 6:48 PM
Bronsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants https://www.biorxiv.org/content/10.1101/2025.11.04.686643v1
Reposted by Jordan Meier
Flying Squirrel Loves It Every Time
November 5, 2025 at 11:00 PM
Flying Squirrel Loves It Every Time
Reposted by Jordan Meier
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer
Nature Genetics - Analysis of 14,106 tumor genomes highlights recurrent mutations in mitochondrial ribosomal RNA encoded within the mitochondrial genome. Mutations occur at hotspot positions and...
rdcu.be
November 3, 2025 at 11:15 AM
Excited to share our latest work in collaboration with the @edreznik.bsky.social lab @mskcancercenter.bsky.social, where we describe functionally dominant mitochondrial DNA mutations in patient tumors. So, what is functional dominance in mitochondrial genetics, I hear you ask?
rdcu.be/eN1jm
rdcu.be/eN1jm
Reposted by Jordan Meier
Required reading for cell biologists to get a sense of basic statistical principles!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ten essential tips for robust statistics in cell biology - Nature Cell Biology
Statistical thinking is a core part of solid, trustworthy biology. However, many studies still include insufficient sample sizes, have poor experimental design or select an incorrect statistical metho...
www.nature.com
November 4, 2025 at 7:23 PM
Required reading for cell biologists to get a sense of basic statistical principles!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Every scientist’s secret aspiration is to make it into this Pubmed alert:
November 1, 2025 at 8:37 PM
Every scientist’s secret aspiration is to make it into this Pubmed alert:
Reposted by Jordan Meier
If you’re the parent of two trick-or-treaters who want to trade candy, it’s your job to act as commissioner to oversee any trades to avoid any Nico Harrison situations.
November 1, 2025 at 12:16 PM
If you’re the parent of two trick-or-treaters who want to trade candy, it’s your job to act as commissioner to oversee any trades to avoid any Nico Harrison situations.
Reposted by Jordan Meier
Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime
www.youtube.com/watch?v=tdNn...
www.youtube.com/watch?v=tdNn...
www.youtube.com
October 31, 2025 at 4:24 PM
Science brings us new miracles every day. Update from a mother whose son was the first patient dosed with Grace Science's gene therapy for NGly1 deficiency (GS-100). Video can be seen on YouTube. #glycotime
www.youtube.com/watch?v=tdNn...
www.youtube.com/watch?v=tdNn...
Chemoproteomics v. Boltz-2:
"These cases...point to the need to re-train ML co-folding tools on datasets enriched in more diverse types of small molecule-protein interactions...to avoid biased predictions derived from memorization of common orthosteric ligand poses"
www.biorxiv.org/content/10.1...
"These cases...point to the need to re-train ML co-folding tools on datasets enriched in more diverse types of small molecule-protein interactions...to avoid biased predictions derived from memorization of common orthosteric ligand poses"
www.biorxiv.org/content/10.1...
Tryptoline Stereoprobe Elaboration Identifies Inhibitors of the GRPEL1-HSPA9 Chaperone Complex
Activity-based protein profiling has identified hundreds of proteins from diverse classes that react at specific cysteine residues with stereochemically defined electrophilic compounds (stereoprobes) ...
www.biorxiv.org
October 27, 2025 at 6:31 PM
Chemoproteomics v. Boltz-2:
"These cases...point to the need to re-train ML co-folding tools on datasets enriched in more diverse types of small molecule-protein interactions...to avoid biased predictions derived from memorization of common orthosteric ligand poses"
www.biorxiv.org/content/10.1...
"These cases...point to the need to re-train ML co-folding tools on datasets enriched in more diverse types of small molecule-protein interactions...to avoid biased predictions derived from memorization of common orthosteric ligand poses"
www.biorxiv.org/content/10.1...
Reposted by Jordan Meier
Review @natrevcancer.nature.com @stjuderesearch.bsky.social
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
Epigenetic regulation of T cell exhaustion in cancer - Nature Reviews Cancer
Transcriptional and epigenetic mechanisms governing T cell exhaustion substantially impact immunotherapy effectiveness. In this Review, Kang et al. outline epigenetic regulatory programmes that i...
www.nature.com
October 27, 2025 at 3:40 PM
Review @natrevcancer.nature.com @stjuderesearch.bsky.social
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
Epigenetic regulation of T cell exhaustion in cancer
www.nature.com/articles/s41...
This graph is jaw-dropping and tracks anecdotal academic experience so well.
October 26, 2025 at 12:08 AM
This graph is jaw-dropping and tracks anecdotal academic experience so well.
Fed employee mood this weekend:
a man and a woman are standing next to each other in a living room and talking .
ALT: a man and a woman are standing next to each other in a living room and talking .
media.tenor.com
October 25, 2025 at 1:17 PM
Fed employee mood this weekend:
Reposted by Jordan Meier
Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....
A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells
Photoswitchable fluorophores are critical for advanced bioimaging. Here, we develop a photoswitchable self-labeling HaloTag that can reversibly modulate the emission of a bound fluorogenic dye via a ....
onlinelibrary.wiley.com
October 25, 2025 at 8:56 AM
Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....
Reading 'The Witches' to my girls and the point near the end when the boy who has been turned into a mouse asks, "Grandma, how long do mice live?" has got to be one of the most emotionally destroying segues ever in a children's book.
October 25, 2025 at 1:35 AM
Reading 'The Witches' to my girls and the point near the end when the boy who has been turned into a mouse asks, "Grandma, how long do mice live?" has got to be one of the most emotionally destroying segues ever in a children's book.
Amazing paper from collaborators Schraga Schwartz and Moran Shalev-Benami at Weizmann. Nucleotide resolution sequencing of 16 RNA modifications from diverse organisms cultured under basal and 'extreme' conditions + enzymology, structure, synthesis, and biophysics.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying
it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing
modifications to support...
www.cell.com
October 24, 2025 at 5:20 PM
Amazing paper from collaborators Schraga Schwartz and Moran Shalev-Benami at Weizmann. Nucleotide resolution sequencing of 16 RNA modifications from diverse organisms cultured under basal and 'extreme' conditions + enzymology, structure, synthesis, and biophysics.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Jordan Meier
So excited to see this out in @natgenet.nature.com! An amazing collaboration with @gagneurlab.bsky.social, I am happy I was (a small) part of. Nucleotide dependencies can capture regulatory elements, including #RNA structures! Congrats to the whole team! Check it out: www.nature.com/articles/s41...
Nucleotide dependency analysis of genomic language models detects functional elements - Nature Genetics
Mapping pairwise nucleotide dependencies by leveraging genomic language models highlights functional genomic elements and predicts deleterious genetic variants more effectively than alignment-based conservation metrics.
www.nature.com
October 11, 2025 at 2:00 PM
So excited to see this out in @natgenet.nature.com! An amazing collaboration with @gagneurlab.bsky.social, I am happy I was (a small) part of. Nucleotide dependencies can capture regulatory elements, including #RNA structures! Congrats to the whole team! Check it out: www.nature.com/articles/s41...
Reposted by Jordan Meier
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
The functional landscape of the human ubiquitinome
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...
www.biorxiv.org
October 9, 2025 at 7:07 AM
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...