Caleb Cheng
@djcalebc.bsky.social
✝️🇹🇼🇺🇸 MD/PhD student at the University of Michigan. Cellular and Molecular Biology candidate in Arul Chinnaiyan and Costas Lyssiotis laboratories
Reposted by Caleb Cheng
In a recent Nature paper, @djcalebc.bsky.social et al. explore how PIKfyve regulates lysosomal lipid recycling in PDAC. This opens up a therapeutic window: co-inhibition of PIKfyve and the KRAS–MAPK pathway leads to synthetic lethality & tumor regression.
View it here >>> nature.com/articles/s41...
View it here >>> nature.com/articles/s41...
June 19, 2025 at 12:40 PM
In a recent Nature paper, @djcalebc.bsky.social et al. explore how PIKfyve regulates lysosomal lipid recycling in PDAC. This opens up a therapeutic window: co-inhibition of PIKfyve and the KRAS–MAPK pathway leads to synthetic lethality & tumor regression.
View it here >>> nature.com/articles/s41...
View it here >>> nature.com/articles/s41...
Reposted by Caleb Cheng
more from last week www.nature.com/articles/s41...
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer - Nature
A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.
www.nature.com
May 1, 2025 at 8:13 AM
more from last week www.nature.com/articles/s41...
My team and I are at #AACR25 and have posters to discuss parts of the project (and some future directions) tomorrow! Rüya Pakkan will present on Tuesday AM Abstract #4158 Sec 13 board 8. I will present on Tuesday PM #5384 Sec 12 board 12. Come visit!
Nature research paper: Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
https://go.nature.com/3GmBnvc
https://go.nature.com/3GmBnvc
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer - Nature
A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.
go.nature.com
April 28, 2025 at 11:58 PM
My team and I are at #AACR25 and have posters to discuss parts of the project (and some future directions) tomorrow! Rüya Pakkan will present on Tuesday AM Abstract #4158 Sec 13 board 8. I will present on Tuesday PM #5384 Sec 12 board 12. Come visit!
Thanks @bryantkl.bsky.social for the shoutout!! Look forward to seeing your future work including target PIKfyve as well as RAS in PDAC 💪
Congrats @djcalebc.bsky.social on this tour de force and beautiful study highlighting the important role of PIKfyve in orchestrating lipid metabolism in #pancreatic cancer. Excited by the prospect of a better anti-autophagy target to pair with #RAS inhibitors!
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!
April 26, 2025 at 9:49 PM
Thanks @bryantkl.bsky.social for the shoutout!! Look forward to seeing your future work including target PIKfyve as well as RAS in PDAC 💪
Thanks for this writeup and for highlighting our work!!
Pancreatic cancer is a leading cause of cancer-related death. U-M researchers, including @djcalebc.bsky.social and @lyssiotislab.bsky.social, have discovered that simultaneously targeting two key pathways can eliminate tumors.
Learn more about their work in @nature.com at michmed.org/Zx7wD.
Learn more about their work in @nature.com at michmed.org/Zx7wD.
Drug targets identified for pancreatic cancer
U-M researchers have discovered that simultaneously targeting PIKfyve and KRAS-MAPK can eliminate tumors in preclinical human and mouse models.
michmed.org
April 26, 2025 at 9:45 PM
Thanks for this writeup and for highlighting our work!!
Reposted by Caleb Cheng
🔥Smoking hot new paper and tweetorial from @djcalebc.bsky.social (collab with Chinnaiyan Lab)! 🔥
We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!
April 24, 2025 at 8:20 PM
🔥Smoking hot new paper and tweetorial from @djcalebc.bsky.social (collab with Chinnaiyan Lab)! 🔥
We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
We are over the moon about this new work and its therapeutic implications for pancreatic cancer. Please have a read and share your thoughts/feedback! 🙏🏼
Reposted by Caleb Cheng
Excited to be part of this #AACR25 (@theaacr.bsky.social @rickbuck.bsky.social) Social Media Ambassadorship!!
Look out for updates on the #Tumor-microenvironment ( #TME )-relevant events and highlights. I’ll be posting from Sunday afternoon to midday Wednesday 😎
Look out for updates on the #Tumor-microenvironment ( #TME )-relevant events and highlights. I’ll be posting from Sunday afternoon to midday Wednesday 😎
🚨The #AACR25 buzz is building! I’m thrilled to be a Social Media Ambassador for this year’s #AACR Annual Meeting.
👉🏼Please join me & all the ambassadors as we spotlight the exciting science. Research matters—and so does sharing it. Join the convo with @theaacr.bsky.social @rickbuck.bsky.social
👉🏼Please join me & all the ambassadors as we spotlight the exciting science. Research matters—and so does sharing it. Join the convo with @theaacr.bsky.social @rickbuck.bsky.social
April 24, 2025 at 9:28 PM
Excited to be part of this #AACR25 (@theaacr.bsky.social @rickbuck.bsky.social) Social Media Ambassadorship!!
Look out for updates on the #Tumor-microenvironment ( #TME )-relevant events and highlights. I’ll be posting from Sunday afternoon to midday Wednesday 😎
Look out for updates on the #Tumor-microenvironment ( #TME )-relevant events and highlights. I’ll be posting from Sunday afternoon to midday Wednesday 😎
Thank you for the highlight!!
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
“targeting PIKfyve and KRAS–MAPK resulted in the elimination of the tumour burden in numerous preclinical human and mouse models”
www.nature.com/articles/s41...
“targeting PIKfyve and KRAS–MAPK resulted in the elimination of the tumour burden in numerous preclinical human and mouse models”
www.nature.com/articles/s41...
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer - Nature
A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.
www.nature.com
April 24, 2025 at 3:22 PM
Thank you for the highlight!!
Thanks for the highlight!!!
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
www.nature.com/articles/s41...
Congrats to the @lyssiotislab.bsky.social and all the others involved
www.nature.com/articles/s41...
Congrats to the @lyssiotislab.bsky.social and all the others involved
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer - Nature
A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.
www.nature.com
April 24, 2025 at 3:21 PM
Thanks for the highlight!!!
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!
April 24, 2025 at 3:20 PM
Beyond grateful to share that my main PhD thesis project, Targeting PIKfyve-driven lipid metabolism in pancreatic cancer (@lyssiotislab.bsky.social + Arul Chinnaiyan lab), has just been published in @nature.com!
Reposted by Caleb Cheng
Congrats to @djcalebc.bsky.social and @lyssiotislab.bsky.social for this awesome work🤩
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer - Nature
A study of human and mouse models of pancreatic cancer finds that inhibiting the lipid kinase PIKfyve interferes with the cancer’s lipid homeostasis, making it a potential target for drug development.
www.nature.com
April 23, 2025 at 4:58 PM
Congrats to @djcalebc.bsky.social and @lyssiotislab.bsky.social for this awesome work🤩
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Caleb Cheng
Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell!
We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!
www.sciencedirect.com/science/arti...
We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!
www.sciencedirect.com/science/arti...
Mitochondria-organelle crosstalk in establishing compartmentalized metabolic homeostasis
Mitochondria serve as central hubs in cellular metabolism by sensing, integrating, and responding to metabolic demands. This integrative function is a…
www.sciencedirect.com
April 17, 2025 at 9:24 PM
Happy to share our most recent review on mitochondria-organelle metabolic communication with Yatrik Shah and Costas Lyssiotis now online at Molecular Cell!
We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!
www.sciencedirect.com/science/arti...
We explored aspect of lipid transfer, organelle membrane contacts, ROS, metabolites, and metals!
www.sciencedirect.com/science/arti...
Excited for this!
Registration is live for the 1st ever Midwest Metabolism & TRiMAD dual meeting, hosted jointly by VAI + U of M in Ann Arbor, MI November 10-11, 2025! We have some exciting speakers but most will come from abstracts so submit your best #mitochondria & #metabolism research! www.vai.org/event/2025-m...
2025 Midwest Metabolism Meeting
Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.
www.vai.org
March 30, 2025 at 2:42 AM
Excited for this!
Reposted by Caleb Cheng
An incredible tour de force in biochemistry and cell biology by superstar @robzonculab.bsky.social lab postdoc @aakritijain.bsky.social
LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells.
www.science.org/doi/10.1126/...
LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells.
www.science.org/doi/10.1126/...
Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins
Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...
www.science.org
March 28, 2025 at 7:13 PM
An incredible tour de force in biochemistry and cell biology by superstar @robzonculab.bsky.social lab postdoc @aakritijain.bsky.social
LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells.
www.science.org/doi/10.1126/...
LyLAP - a new lysosomal protease responsible for degrading integral membrane proteins in highly phagocytic cells like #PDAC cells.
www.science.org/doi/10.1126/...
Reposted by Caleb Cheng
Short but very fun visit to UNC Chapel Hill! Definitely one of the most beautiful college campuses.
March 26, 2025 at 2:54 AM
Short but very fun visit to UNC Chapel Hill! Definitely one of the most beautiful college campuses.
Reposted by Caleb Cheng
Yesterday, the House passed an FY25 budget bill that slashes funding to the Pancreatic Cancer Research Program by 57%.
Research for pancreatic cancer is already woefully underfunded, and now the only program exclusively funding pancreatic cancer research is one step closer to devastating cuts.
Research for pancreatic cancer is already woefully underfunded, and now the only program exclusively funding pancreatic cancer research is one step closer to devastating cuts.
March 13, 2025 at 12:20 AM
Yesterday, the House passed an FY25 budget bill that slashes funding to the Pancreatic Cancer Research Program by 57%.
Research for pancreatic cancer is already woefully underfunded, and now the only program exclusively funding pancreatic cancer research is one step closer to devastating cuts.
Research for pancreatic cancer is already woefully underfunded, and now the only program exclusively funding pancreatic cancer research is one step closer to devastating cuts.
Reposted by Caleb Cheng
A beautiful thesis defense from Narges Pourmandi for CMB, Michigan Medicine. Back to the hospital next week to complete her medical training ❤️🙌🏼🩺
We are so proud of her many accomplishments! @YatrikShahLab
We are so proud of her many accomplishments! @YatrikShahLab
March 12, 2025 at 4:07 PM
A beautiful thesis defense from Narges Pourmandi for CMB, Michigan Medicine. Back to the hospital next week to complete her medical training ❤️🙌🏼🩺
We are so proud of her many accomplishments! @YatrikShahLab
We are so proud of her many accomplishments! @YatrikShahLab