Reposted
Pure, howling narcissism, and gleeful sadism. A sociopath that never bothered to learn how to emulate humanity beyond what his father and Cohn taught him that business boys do.
December 16, 2025 at 6:02 AM
Pure, howling narcissism, and gleeful sadism. A sociopath that never bothered to learn how to emulate humanity beyond what his father and Cohn taught him that business boys do.
Reposted
He is what’s left after 40 years of tax cuts. The unbounded pursuit of income has steamrolled every other human value.
December 16, 2025 at 4:40 AM
He is what’s left after 40 years of tax cuts. The unbounded pursuit of income has steamrolled every other human value.
Reposted
Trump is entirely bereft of even a single redeeming human quality. He is a golem formed from the distilled essence of the seven deadly sins.
December 16, 2025 at 6:25 AM
Trump is entirely bereft of even a single redeeming human quality. He is a golem formed from the distilled essence of the seven deadly sins.
Reposted
2) Not entirely sure which drug this refers to, but Scheibenbogen previously talked about doing a trial targeting plasma cells that produce antibodies, so it could be Isatuximab (which targets the cell marker CD38, the same as Daratumumab).
December 17, 2025 at 3:02 PM
2) Not entirely sure which drug this refers to, but Scheibenbogen previously talked about doing a trial targeting plasma cells that produce antibodies, so it could be Isatuximab (which targets the cell marker CD38, the same as Daratumumab).
Reposted
Nath: '“And lastly, we just got approval from the FDA to do a study with Checkpoint Inhibitors in Long COVID patients. The pilot study is only 10 individuals, a safety study, but nonetheless, I'm very excited about that possibility because if that works, we can actually reverse the entire process..
December 17, 2025 at 8:32 PM
Nath: '“And lastly, we just got approval from the FDA to do a study with Checkpoint Inhibitors in Long COVID patients. The pilot study is only 10 individuals, a safety study, but nonetheless, I'm very excited about that possibility because if that works, we can actually reverse the entire process..
Reposted
This is exactly what the expansion of the EU was supposed to achieve. A rising tide should raise all boats. But that’s not ok for the Mail. The superior British boat must float highest. Clowns.
December 13, 2025 at 11:38 PM
This is exactly what the expansion of the EU was supposed to achieve. A rising tide should raise all boats. But that’s not ok for the Mail. The superior British boat must float highest. Clowns.
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Thanks - I feel the same way about Britain. It's where I'm from and there's a lot to like about it, but the UK has made some really stupid choices this century, particularly austerity and Brexit. And it's the same forces that want to undermine democracy and make way for kleptocracy, in Poland or UK.
December 13, 2025 at 11:33 PM
Thanks - I feel the same way about Britain. It's where I'm from and there's a lot to like about it, but the UK has made some really stupid choices this century, particularly austerity and Brexit. And it's the same forces that want to undermine democracy and make way for kleptocracy, in Poland or UK.
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I’m Polish and I am immensely proud of the progress my country has made. A bit anxious of the Brexit virus spreading, aided by Russian influence on Polish far right.
Also, I live in the UK, and am deeply saddened by the self inflicted decline of such a brilliant country.
Also, I live in the UK, and am deeply saddened by the self inflicted decline of such a brilliant country.
December 13, 2025 at 10:13 PM
I’m Polish and I am immensely proud of the progress my country has made. A bit anxious of the Brexit virus spreading, aided by Russian influence on Polish far right.
Also, I live in the UK, and am deeply saddened by the self inflicted decline of such a brilliant country.
Also, I live in the UK, and am deeply saddened by the self inflicted decline of such a brilliant country.
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Many Poles arrive. Daily Mail: “THIS IS A CATASTROPHE OUR COUNTRY IS DYING”
Many Poles leave again. Daily Mail: “THIS IS A CATASTROPHE PUR COUNTRY IS DYING”
Do you want Poles or not?
Many Poles leave again. Daily Mail: “THIS IS A CATASTROPHE PUR COUNTRY IS DYING”
Do you want Poles or not?
December 13, 2025 at 6:43 PM
Many Poles arrive. Daily Mail: “THIS IS A CATASTROPHE OUR COUNTRY IS DYING”
Many Poles leave again. Daily Mail: “THIS IS A CATASTROPHE PUR COUNTRY IS DYING”
Do you want Poles or not?
Many Poles leave again. Daily Mail: “THIS IS A CATASTROPHE PUR COUNTRY IS DYING”
Do you want Poles or not?
Reposted
Vandaag zijn de langverwachte resultaten van de behandeling met Lidocaïne, voor LongCovid-patiënten, gepubliceerd.
Ik ben als Longcovid patiënt afhankelijk van dit medicijn, maar het wordt nu niet vergoed.
Kan jij helpen dit te verspreiden?
www.sciencedirect.com/science/arti...
Ik ben als Longcovid patiënt afhankelijk van dit medicijn, maar het wordt nu niet vergoed.
Kan jij helpen dit te verspreiden?
www.sciencedirect.com/science/arti...
Effect of subcutaneous lidocaine–hydroxypropyl-β-cyclodextrin (HP-β-CD) on quality of life in patients with post-COVID condition: a 36-week observational interrupted time series study
Post-COVID involves persistent, multisystem symptoms which are associated with inflammation, immune dysregulation, and autonomic dysfunction. The effe…
www.sciencedirect.com
December 4, 2025 at 2:27 PM
Vandaag zijn de langverwachte resultaten van de behandeling met Lidocaïne, voor LongCovid-patiënten, gepubliceerd.
Ik ben als Longcovid patiënt afhankelijk van dit medicijn, maar het wordt nu niet vergoed.
Kan jij helpen dit te verspreiden?
www.sciencedirect.com/science/arti...
Ik ben als Longcovid patiënt afhankelijk van dit medicijn, maar het wordt nu niet vergoed.
Kan jij helpen dit te verspreiden?
www.sciencedirect.com/science/arti...
Reposted
7) Link to the paper:
Sanchez et al. 2025. The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells.
Sanchez et al. 2025. The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells.
The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells
Fibromyalgia syndrome (FMS) is characterized by elevated levels of immunoglobulin G (IgG), altered bowel habits, and increased pain sensitivity, suggesting immune dysregulation, but the exact mechanism remains unclear. Here, we found that FMS-IgG binds to mast cells in a MRGPRX2/b2-dependent manner, leading to mast cell recruitment and IL-6 secretion. Transferring serum-IgG from FMS patients to mice induced FMS-like symptoms and increased skin mast cells, indicating that FMS-IgG acts through mast cell activation. The ablation of mice Mrgprb2 mast cells or deleting Mrgprb2 receptors prevented IgG-induced heightened sensitivity to mechanical and cold stimuli. Stimulating human LAD2 cells with FMS IgG elicited MRGPRX2-dependent IL-6 production. Consistent with mice findings, mast cell density and tryptase levels increased in human FMS skin samples compared to healthy controls. Taken together our results suggests that FMS IgG mediates hypersensitivity via activation of mast cells bearing the MRGPRX2 receptor and that these cells are a potential therapeutic target.
### Competing Interest Statement
X.D. is the scientific founder of and consultant for Escient Pharmaceuticals, a pharmaceutical company developing drugs targeting Mrgprs. X.D. collaborates with GlaxoSmithKline (GSK) on Mrgpr-related projects unrelated to this manuscript. Other authors declare no competing interests.
Howard Hughes Medical Institute, https://ror.org/006w34k90
Pain Relief Foundation, https://ror.org/0017mh436
Versus Arthritis, https://ror.org/02jkpm469, 22471
www.biorxiv.org
November 25, 2025 at 11:05 AM
7) Link to the paper:
Sanchez et al. 2025. The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells.
Sanchez et al. 2025. The sensitising effect of IgG in fibromyalgia syndrome is mediated by Mrgprb2 in mast cells.
Reposted
Here's the section where Fluge talks about the daratumumab research (see screenshot)
November 9, 2025 at 9:04 AM
Here's the section where Fluge talks about the daratumumab research (see screenshot)