Deniz Atasoy
@denizatasoy.bsky.social
Assoc. Prof. @ U-Iowa Neuroscience and Pharmacology, interested in neural circuits for appetite & metabolism, circadian regulation, obesity & hypoglycemia. Atlas' & Zeus'(pitsky) dad. https://orcid.org/0000-0002-3325-8820
Iowa sky tonight.
November 12, 2025 at 3:20 AM
Iowa sky tonight.
Reposted by Deniz Atasoy
Drs. Michael Welsh, Jesús González, and Paul Negulescu have won the 2025 Lasker–DeBakey Clinical Medical Research Award for their roles in developing treatments for cystic fibrosis. Learn more: nej.md/41L3UCI
#MedSky #PulmSky #Genetics
#MedSky #PulmSky #Genetics
September 11, 2025 at 1:07 PM
Drs. Michael Welsh, Jesús González, and Paul Negulescu have won the 2025 Lasker–DeBakey Clinical Medical Research Award for their roles in developing treatments for cystic fibrosis. Learn more: nej.md/41L3UCI
#MedSky #PulmSky #Genetics
#MedSky #PulmSky #Genetics
Reposted by Deniz Atasoy
Discovery of a brain center (BNST) that controls consumption (including sweets, fats, salt and other foods) in mice
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
A brain center that controls consummatory responses
The BNST brain region integrates a broad range of external and internal signals to
flexibly regulate consumption, revealing a unified control over consummatory responses.
www.cell.com
September 10, 2025 at 2:56 PM
Discovery of a brain center (BNST) that controls consumption (including sweets, fats, salt and other foods) in mice
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Deniz Atasoy
We are proud of Omprakash Singh's new study just out in Cell Reports. Supported by Sepideh Sheybani-Deloui et al, Om's work identifies GHSR expressing SCN neurons as regulating food intake + feed efficiency at a single time of day, accounting for at least 7% of a mouse's BW
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
September 4, 2025 at 2:20 AM
We are proud of Omprakash Singh's new study just out in Cell Reports. Supported by Sepideh Sheybani-Deloui et al, Om's work identifies GHSR expressing SCN neurons as regulating food intake + feed efficiency at a single time of day, accounting for at least 7% of a mouse's BW
doi.org/10.1016/j.ce...
doi.org/10.1016/j.ce...
Reposted by Deniz Atasoy
Excited to share work led by my PhD student Hayley McMorrow now published in @jclinical-invest.bsky.social. Hayley showed that GIP and GLP-1 receptor agonists rapidly inhibit AgRP neurons and that endogenous GIP is important for nutrient-mediated AgRP neuron inhibition. doi.org/10.1172/JCI1...
JCI -
Incretin receptor agonism rapidly inhibits AgRP neurons to suppress food intake in mice
doi.org
August 30, 2025 at 5:05 PM
Excited to share work led by my PhD student Hayley McMorrow now published in @jclinical-invest.bsky.social. Hayley showed that GIP and GLP-1 receptor agonists rapidly inhibit AgRP neurons and that endogenous GIP is important for nutrient-mediated AgRP neuron inhibition. doi.org/10.1172/JCI1...
Reposted by Deniz Atasoy
The hindbrain cAMP pathway is essential for GLP-1R dependent #weightloss www.biorxiv.org/content/10.1...
August 16, 2025 at 7:16 PM
The hindbrain cAMP pathway is essential for GLP-1R dependent #weightloss www.biorxiv.org/content/10.1...
Reposted by Deniz Atasoy
Amid lots of uncertainty, anger, and exhaustion I am excited to share this work from my incredibly talented MSTP and @nuincomm.bsky.social student Haley Province. In it we explore the fascinating and powerful anti-aversive properties of GIPR agonists
GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits https://www.biorxiv.org/content/10.1101/2025.08.12.669936v1
August 16, 2025 at 6:20 PM
Amid lots of uncertainty, anger, and exhaustion I am excited to share this work from my incredibly talented MSTP and @nuincomm.bsky.social student Haley Province. In it we explore the fascinating and powerful anti-aversive properties of GIPR agonists
Reposted by Deniz Atasoy
How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️ www.nature.com/articles/s41...
A hypothalamic circuit that modulates feeding and parenting behaviours - Nature
Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.
www.nature.com
July 30, 2025 at 4:35 PM
How do animals decide if they should forage for food or stay home to take care of newborn offspring? Whose needs come first? For my PhD work now out in Nature, we examined how hunger and parenting neurons interact and are reshaped postpartum in mice 🧵⬇️ www.nature.com/articles/s41...
Reposted by Deniz Atasoy
Very excited for this review to be out! A dive into PET/MRS techniques for measuring brain glucose concentrations and cerebral metabolic rate of glucose in the context of diabetes and obesity. #neuroimaging #obesity #diabetes #metabolism #neuroendocrinology
link.springer.com/article/10.1...
link.springer.com/article/10.1...
July 28, 2025 at 5:01 PM
Very excited for this review to be out! A dive into PET/MRS techniques for measuring brain glucose concentrations and cerebral metabolic rate of glucose in the context of diabetes and obesity. #neuroimaging #obesity #diabetes #metabolism #neuroendocrinology
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Deniz Atasoy
Studies in mice of CNS GLP-1R circuits reveals that state-dependent synaptic regulation by GLP-1 in PVNGLP-1R→DVC descending circuits is important for energy homeostasis @natmetabolism.nature.com www.nature.com/articles/s42...
State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis - Nature Metabolism
In this paper, the authors describe the energy state-dependent regulation of the PVNGLP-1R to DVC circuit, resulting in altered food intake and metabolic health, mediated by GLP-1 receptor signalling.
www.nature.com
June 4, 2025 at 9:18 AM
Studies in mice of CNS GLP-1R circuits reveals that state-dependent synaptic regulation by GLP-1 in PVNGLP-1R→DVC descending circuits is important for energy homeostasis @natmetabolism.nature.com www.nature.com/articles/s42...
Reposted by Deniz Atasoy
Excited to share our latest paper led by Kuldeep Shrivastava out now in @natcomms.nature.com
www.nature.com/articles/s41...
1/
www.nature.com/articles/s41...
1/
Energy state guides reward seeking via an extended amygdala to lateral hypothalamus pathway - Nature Communications
The lateral hypothalamic area (LHA) mediates reward seeking. Here, the authors show how LHA afferent connections promote reward seeking by shaping synaptic strength according to energy state, processe...
www.nature.com
May 14, 2025 at 2:30 PM
Excited to share our latest paper led by Kuldeep Shrivastava out now in @natcomms.nature.com
www.nature.com/articles/s41...
1/
www.nature.com/articles/s41...
1/
Reposted by Deniz Atasoy
Nice article in NY Times today about AgRP neurons, GLP1s, and hunger. By Gina Kolata. www.nytimes.com/2025/04/26/h...
What Nearly Brainless Rodents Know About Weight Loss and Hunger
www.nytimes.com
April 26, 2025 at 3:21 PM
Nice article in NY Times today about AgRP neurons, GLP1s, and hunger. By Gina Kolata. www.nytimes.com/2025/04/26/h...
Reposted by Deniz Atasoy
The plan for NIH is in, source with full 64 page proposal for all of HHS is linked. Reported in WaPo. This is catastrophic. Reduction to 8 centers. 40% cut in budget. 15% IDC cap. This will decimate science across America open.substack.com/pub/insideme...
April 16, 2025 at 11:34 PM
The plan for NIH is in, source with full 64 page proposal for all of HHS is linked. Reported in WaPo. This is catastrophic. Reduction to 8 centers. 40% cut in budget. 15% IDC cap. This will decimate science across America open.substack.com/pub/insideme...
Reposted by Deniz Atasoy
Dysregulated cell metabolism in sleep deprivation www.science.org/doi/10.1126/...
Sleep loss is a metabolic disorder
Sleep deprivation shifts metabolic resources and deprioritizes processes that support cognition.
www.science.org
April 8, 2025 at 6:53 PM
Dysregulated cell metabolism in sleep deprivation www.science.org/doi/10.1126/...
Reposted by Deniz Atasoy
Even Pikachu is out protesting Erdogan in Turkey.
🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣
🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣
March 27, 2025 at 12:41 PM
Even Pikachu is out protesting Erdogan in Turkey.
🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣
🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣
Reposted by Deniz Atasoy
Why does obesity change the pleasure of eating, the dopamine rush from hedonic foods? A neural circuit mechanism involving explanation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Changes in neurotensin signalling drive hedonic devaluation in obesity - Nature
In mice, prolonged consumption of a high-fat diet decreases interest in calorie-rich foods as a result of reduced neurotensin expression and signalling, which uncouples hedonic feeding behaviour linke...
www.nature.com
March 26, 2025 at 5:00 PM
Why does obesity change the pleasure of eating, the dopamine rush from hedonic foods? A neural circuit mechanism involving explanation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Deniz Atasoy
🚨iGluSnFR4 is finally out!🚨🧪
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
March 25, 2025 at 12:10 PM
🚨iGluSnFR4 is finally out!🚨🧪
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
We present iGluSnFR4f and 4s, a novel pair of genetically-encoded glutamate indicators designed for high-fidelity imaging of synaptic activity in the living brain. ⬇️
www.biorxiv.org/content/10.1...
🎥 Below: iGluSnFR4s detecting minis in cultures w/ TTX
#Neuroscience
Reposted by Deniz Atasoy
New from Prof Satch Panda and colleagues. Time of day variation in metabolic phenotypes and implications for basic science research #circadian @naturemetabolism.bsky.social @salkinstitute.bsky.social www.nature.com/articles/s42...
The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism
This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...
www.nature.com
March 17, 2025 at 2:19 PM
New from Prof Satch Panda and colleagues. Time of day variation in metabolic phenotypes and implications for basic science research #circadian @naturemetabolism.bsky.social @salkinstitute.bsky.social www.nature.com/articles/s42...
Reposted by Deniz Atasoy
Today, the study section I am a member of is one of 26 out of 26 canceled. No new post on the federal registry and councils are postponed indefinitely.
Universities focused on overhead cuts considering these a challenge to their survival. But *no grant at all* seems like the issue to battle first..
Universities focused on overhead cuts considering these a challenge to their survival. But *no grant at all* seems like the issue to battle first..
The NIH continues to be fully halted. 11/11 study sections canceled today, which includes the study section my grant was meant to be reviewed at. This is never ending and so damaging.
www.csr.nih.gov/RevPanelsAnd...
www.csr.nih.gov/RevPanelsAnd...
Review Dates
www.csr.nih.gov
February 27, 2025 at 4:06 PM
Today, the study section I am a member of is one of 26 out of 26 canceled. No new post on the federal registry and councils are postponed indefinitely.
Universities focused on overhead cuts considering these a challenge to their survival. But *no grant at all* seems like the issue to battle first..
Universities focused on overhead cuts considering these a challenge to their survival. But *no grant at all* seems like the issue to battle first..
Reposted by Deniz Atasoy
Nothing else to say.
February 19, 2025 at 12:38 AM
Nothing else to say.
Reposted by Deniz Atasoy
Whenever you hear someone sneer about scientific research that seems useless to them — “they’re studying the spit of lizards?!” — remind them that’s exactly how we got Ozempic.
globalnews.ca/news/9793403...
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 5:38 PM
Whenever you hear someone sneer about scientific research that seems useless to them — “they’re studying the spit of lizards?!” — remind them that’s exactly how we got Ozempic.
globalnews.ca/news/9793403...
globalnews.ca/news/9793403...
Reposted by Deniz Atasoy
