Daniela Cecalev
@danielacecalev.bsky.social
PhD candidate in Rafael Galupa’s lab 🐹playing with genes on the X-chromosome 🧬
Reposted by Daniela Cecalev
Happy to share the 2nd part of my PhD @natsmb.nature.com!
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 5:04 PM
Happy to share the 2nd part of my PhD @natsmb.nature.com!
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
Reposted by Daniela Cecalev
Bye forever, WeTransfer.
July 14, 2025 at 11:57 PM
Bye forever, WeTransfer.
Reposted by Daniela Cecalev
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
A male-essential miRNA is key for avian sex chromosome dosage compensation - Nature
Birds have evolved a unique sex chromosome dosage compensation mechanism involving the male-biased microRNA (miR-2954), which is essential for male survival by regulating the expression of dosage-sens...
www.nature.com
July 16, 2025 at 3:23 PM
Our study on a male-essential microRNA and the evolution of other dosage compensation mechanisms in birds is now out in Nature! www.nature.com/articles/s41...
Reposted by Daniela Cecalev
We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵
Divergent DNA methylation dynamics in marsupial and eutherian embryos - Nature
A study reports on the DNA methylation dynamics during embryogenesis in marsupials, showing that these differ from those occurring during embryogenesis in eutherian mammals.
www.nature.com
May 14, 2025 at 4:01 PM
We're excited to publish our latest study led by Bryony Leeke @bryonyleeke.bsky.social and Wazeer Varsally, now out in @nature.com 🍾This study focusses on the epigenome of marsupial embryos 🦘 mapping DNA methylation in embryo development to specific embryo events www.nature.com/articles/s41... 🧵
It was such a fun night! 🤩
A big round of applause for the Pub quiz winners at #EMBLChromatin 👏 We had a blast!
May 14, 2025 at 11:44 AM
It was such a fun night! 🤩
Reposted by Daniela Cecalev
Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
March 29, 2025 at 12:46 PM
Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
Reposted by Daniela Cecalev
Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genetic coupling of enhancer activity and connectivity in gene expression control - Nature Communications
Here, the authors study the effects of expression quantitative trait loci on enhancer activity and promoter contacts in primary monocytes isolated from male individuals, suggesting an inherent genetic...
www.nature.com
January 27, 2025 at 2:49 PM
Our new paper is finally out, showing that the same enhancer sequences - and likely the same transcription factors recruited to them - affect the activity of distal enhancers and their looping over to target gene promoters.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
❗️A fantastic opportunity for Moldova🇲🇩
If you’re a researcher looking for funding, ERC grants can provide you with top financial support.
Don’t miss the chance to highlight your work and put Moldova on the global stage! 🌟
If you’re a researcher looking for funding, ERC grants can provide you with top financial support.
Don’t miss the chance to highlight your work and put Moldova on the global stage! 🌟
In #Moldova? Thinking of applying for an ERC grant?
Join our upcoming webinar on 25 March to learn how ERC funding schemes can support your research career.
Register here: bit.ly/4iELKZ9
Join our upcoming webinar on 25 March to learn how ERC funding schemes can support your research career.
Register here: bit.ly/4iELKZ9
March 14, 2025 at 1:47 PM
❗️A fantastic opportunity for Moldova🇲🇩
If you’re a researcher looking for funding, ERC grants can provide you with top financial support.
Don’t miss the chance to highlight your work and put Moldova on the global stage! 🌟
If you’re a researcher looking for funding, ERC grants can provide you with top financial support.
Don’t miss the chance to highlight your work and put Moldova on the global stage! 🌟
Reposted by Daniela Cecalev
I am thrilled to share our latest work, released today 🤩
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
January 21, 2025 at 10:34 AM
I am thrilled to share our latest work, released today 🤩
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
www-nature-com.insb.bib.cnrs.fr/articles/s41...
It results from years of hard work by the team and long-time collaborators, with special thanks to PhD student Clara Roidor and collaborator Laurène Syx.
Reposted by Daniela Cecalev
I will soon be recruiting at all levels. Stay tuned for more updates soon!
🎓 We will recruit PhD students via the MPI-IE IMPRS PhD program this year www.ie-freiburg.mpg.de/IMPRS-PhD-Pr...
🚨 Deadline for application is February 28th🚨
🎓 We will recruit PhD students via the MPI-IE IMPRS PhD program this year www.ie-freiburg.mpg.de/IMPRS-PhD-Pr...
🚨 Deadline for application is February 28th🚨
IMPRS PhD Program
The IMPRS-EBM is an international PhD program that lies at the intersection of Epigenetics, Biophysics and Metabolism. It integrates strategies from molecular biology and biochemistry with biophysical...
www.ie-freiburg.mpg.de
January 16, 2025 at 6:38 PM
I will soon be recruiting at all levels. Stay tuned for more updates soon!
🎓 We will recruit PhD students via the MPI-IE IMPRS PhD program this year www.ie-freiburg.mpg.de/IMPRS-PhD-Pr...
🚨 Deadline for application is February 28th🚨
🎓 We will recruit PhD students via the MPI-IE IMPRS PhD program this year www.ie-freiburg.mpg.de/IMPRS-PhD-Pr...
🚨 Deadline for application is February 28th🚨