Till Schwämmle
@tschwammle.bsky.social
Postdoc Krebs Lab @EMBL Heidelberg
Joint with Kundaje Lab @Stanford
Previously PhD Schulz Lab @MPI-MG
Joint with Kundaje Lab @Stanford
Previously PhD Schulz Lab @MPI-MG
Reposted by Till Schwämmle
🧬 Interested in dissecting dose-dependent transcriptional regulation through epigenome editing and synthetic biology for your PhD? Apply by 07.01.2026 to join the lab of @eddaschulz.bsky.social @molgen.mpg.de & #IMPRS-BAC #gradschool.
👉 www.molgen.mpg.de/5099133/schu...
👉 www.molgen.mpg.de/5099133/schu...
November 4, 2025 at 11:19 AM
🧬 Interested in dissecting dose-dependent transcriptional regulation through epigenome editing and synthetic biology for your PhD? Apply by 07.01.2026 to join the lab of @eddaschulz.bsky.social @molgen.mpg.de & #IMPRS-BAC #gradschool.
👉 www.molgen.mpg.de/5099133/schu...
👉 www.molgen.mpg.de/5099133/schu...
Reposted by Till Schwämmle
Using a CRISPR screening approach, first author @tschwammle.bsky.social identified new regulators of Xist, and discovered a two-step process that controls and regulates this important gene behind X-inactivation
Read more: www.molgen.mpg.de/2025-10-06-s...
Publication: doi.org/10.1038/s415...
2/2
Read more: www.molgen.mpg.de/2025-10-06-s...
Publication: doi.org/10.1038/s415...
2/2
A switch and a dial
A study by the Schulz lab describes a novel regulatory principle involved in X-chromosome inactivation during development
www.molgen.mpg.de
October 8, 2025 at 11:34 AM
Using a CRISPR screening approach, first author @tschwammle.bsky.social identified new regulators of Xist, and discovered a two-step process that controls and regulates this important gene behind X-inactivation
Read more: www.molgen.mpg.de/2025-10-06-s...
Publication: doi.org/10.1038/s415...
2/2
Read more: www.molgen.mpg.de/2025-10-06-s...
Publication: doi.org/10.1038/s415...
2/2
Happy to share the 2nd part of my PhD @natsmb.nature.com!
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
October 6, 2025 at 5:04 PM
Happy to share the 2nd part of my PhD @natsmb.nature.com!
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
Using CRISPR screens, we uncover the TF-RE wiring underlying Xist regulation. Since the preprint, we've added a titration of Xist, showing that XCI is directly dependent on Xist levels.
Check the Bluetorial by @eddaschulz.bsky.social 👇
Reposted by Till Schwämmle
New online: Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus
Nature Structural & Molecular Biology, Published online: 06 October 2025; doi:10.1038/s41594-025-01686-3Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
go.nature.com
October 6, 2025 at 12:34 PM
New online: Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus
Reposted by Till Schwämmle
@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease.
Details below
careersearch.stanford.edu/jobs/computa...
Plz RT
Details below
careersearch.stanford.edu/jobs/computa...
Plz RT
August 19, 2025 at 12:29 AM
@jengreitz.bsky.social l & my lab want to co-hire a computational biologist/biostatistician with project management expertise to help map the regulatory code of the human genome and discover genetic mechanisms of disease.
Details below
careersearch.stanford.edu/jobs/computa...
Plz RT
Details below
careersearch.stanford.edu/jobs/computa...
Plz RT
Reposted by Till Schwämmle
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
August 18, 2025 at 1:00 PM
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
Reposted by Till Schwämmle
CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly www.nature.com/articles/s4...
May 31, 2025 at 2:15 PM
CRISPR screen decodes SWI/SNF chromatin remodeling complex assembly www.nature.com/articles/s4...
Reposted by Till Schwämmle
🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics
Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...
doi.org
April 14, 2025 at 8:08 PM
🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Reposted by Till Schwämmle
Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11
April 8, 2025 at 1:52 PM
Happy to share the latest story from @arnaudkr.bsky.social's lab @embl.org! With @guidobarzaghi.bsky.social, we used Single Molecule Footprinting to quantify how often chromatin is accessible at enhancers after TF and chromatin environment changes! Check our preprint bit.ly/3XQMFxN + thread ⬇️ 1/11
Reposted by Till Schwämmle
The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...
April 2, 2025 at 8:47 AM
The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...
Reposted by Till Schwämmle
It’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!
January 16, 2025 at 6:38 PM
It’s official 🎉 I am excited to share that I will start my lab this spring at the Max Planck Institute for Immunobiology and Epigenetics @mpi-ie.bsky.social in beautiful Freiburg 🤩🗻☀️ I am looking forward to new collaborations and working with the fantastic community in Freiburg & its surroundings!
Reposted by Till Schwämmle
A throwback to last month's 'Quantitative biology to molecular mechanisms' conference – time to introduce the poster prize winners! #EMBLOmics
A round of applause for:
🏅 Max Trauernicht
🏅 @ingridpelaez.bsky.social
🏅 Honorine Destain
🏅 Óscar García Blay
Read on 👉🏻 s.embl.org/omx24-01-blog
@embl.org
A round of applause for:
🏅 Max Trauernicht
🏅 @ingridpelaez.bsky.social
🏅 Honorine Destain
🏅 Óscar García Blay
Read on 👉🏻 s.embl.org/omx24-01-blog
@embl.org
December 19, 2024 at 2:22 PM
A throwback to last month's 'Quantitative biology to molecular mechanisms' conference – time to introduce the poster prize winners! #EMBLOmics
A round of applause for:
🏅 Max Trauernicht
🏅 @ingridpelaez.bsky.social
🏅 Honorine Destain
🏅 Óscar García Blay
Read on 👉🏻 s.embl.org/omx24-01-blog
@embl.org
A round of applause for:
🏅 Max Trauernicht
🏅 @ingridpelaez.bsky.social
🏅 Honorine Destain
🏅 Óscar García Blay
Read on 👉🏻 s.embl.org/omx24-01-blog
@embl.org
Reposted by Till Schwämmle
I attended the ‘Quantitative Biology to Molecular Mechanisms’ conference at EMBL Heidelberg last week and had the incredible honor of winning one of the Poster Prizes! 🏆
A big thanks to the organizers and all the amazing speakers who shared their inspiring research with us. ✨
#EMBLOmics
A big thanks to the organizers and all the amazing speakers who shared their inspiring research with us. ✨
#EMBLOmics
November 27, 2024 at 9:26 AM
I attended the ‘Quantitative Biology to Molecular Mechanisms’ conference at EMBL Heidelberg last week and had the incredible honor of winning one of the Poster Prizes! 🏆
A big thanks to the organizers and all the amazing speakers who shared their inspiring research with us. ✨
#EMBLOmics
A big thanks to the organizers and all the amazing speakers who shared their inspiring research with us. ✨
#EMBLOmics