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coachkleb.bsky.social
@coachkleb.bsky.social
150 followers 130 following 51 posts
Microbiologist - full-time tormentor of Klebsiella
Posts Replies Media Videos
Reposted
vivekmutalik.bsky.social
😳
Reversible phenotypic resistance to phage infection via capsule downregulation in Klebsiella pneumoniae
#phage #phageky

www.cell.com/iscience/ful...
Reversible phenotypic resistance to phage infection via capsule downregulation in Klebsiella pneumoniae
Molecular biology; Microbiology; Cell biology
www.cell.com
December 6, 2025 at 4:07 AM
Reposted
markowenmartin.bsky.social
Episode 112 of #MattersMicrobial! Dr. Petra Levin joins the #QualityQuorum to discuss bacterial cell size, pH, and antibiotic sensitivity. PLEASE spread the #GoodMicrobialWord. Petra is inspirational. @univpugetsound @asmicrobiology @microbe.tv

youtu.be/YPNAvJYAq-s?...
October 17, 2025 at 5:26 PM
Reposted
emmseveri.bsky.social
www.biorxiv.org/content/10.1...

#microsky
A load-bearing function for the cytoplasmic membrane of Escherichia coli
The structural integrity of bacterial cells is traditionally attributed to the peptidoglycan cell wall, and more recently to the outer membrane, with the cytoplasmic membrane assumed to be mechanicall...
www.biorxiv.org
October 7, 2025 at 6:29 AM
Reposted
reactorsff.bsky.social
EVERYONE STOP EVERYTHING Mychal the Librarian is hosting the Reading Rainbow revival!!!

reactormag.com/reading-rain...
Reading Rainbow Is Back, With Mychal the Librarian Hosting! - Reactor
The butterfly is back in the sky; can’t wait to fly twice as high.
reactormag.com
September 29, 2025 at 7:34 PM
Reposted
jordanjastrab.bsky.social
Thrilled to share my work from the @jkagan1.bsky.social lab!

TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!

www.biorxiv.org/content/10.1...

#microsky #immunosky
Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus
Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...
www.biorxiv.org
September 26, 2025 at 11:31 AM
Reposted
zeynepbaharoglu.bsky.social
So excited our antibiotic potentiation story is out 🤩 Led by the extraordinary @manonlang.bsky.social with @fox-science.bsky.social & @amazeld.bsky.social +amazing collaborators @immunobladder.bsky.social @imaneelmeouche.bsky.social 🦠 We believe it can make a difference in #AMR infections!
Uridine as a potentiator of aminoglycosides through activation of carbohydrate transporters
Uridine boosts aminoglycoside treatment efficiency against antibiotic-susceptible as well as antibiotic-resistant E. coli strains.
www.science.org
September 6, 2025 at 9:35 AM
Reposted
embojournal.org
Bacterial cell widening alters periplasmic size and activates envelope stress responses
Kerwyn Huang, @typaslab.bsky.social et al find that E. coli outer-membrane protein RcsF senses reduced periplasm thickness due to increased cell width, & activates Rcs signaling
www.embopress.org/doi/full/10....
September 4, 2025 at 9:39 AM
Reposted
asm.org
As national medical, scientific, public health and patient organizations, we call for the resignation of HHS Secretary Robert F. Kennedy Jr. to ensure the health of the American people. Read our statement: asm.org/press-releas...
Joint Statement Calling for Secretary Kennedy Resignation
The American Society for Microbiology released a joint statement calling for the resignation of HHS Secretary Robert F. Kennedy Jr.
asm.org
September 3, 2025 at 11:10 PM
coachkleb.bsky.social
I cannot overstate how *LITTLE* I care about the Cracker Barrel logo...
August 27, 2025 at 3:15 AM
Reposted
evolvedbiofilm.bsky.social
Remodeling of RNA-binding proteome and RNA-mediated regulation as a new layer of control of sporulation
#Bacillussubtilis

#mSystems from @clemdf.bsky.social

journals.asm.org/doi/10.1128/...
August 17, 2025 at 8:47 AM
Reposted
ajlopatkin.bsky.social
If you ever find yourself needing evidence for ‘Plasmids are just as common in microbes without resistance genes,’ we’ve got you covered! Check our new paper, out today:

www.microbiologyresearch.org/content/jour...
Plasmid prevalence is independent of antibiotic resistance in environmental Enterobacteriaceae
The rapid rise of antibiotic-resistant pathogens poses a critical threat to the treatment of infectious diseases. While the spread of antibiotic resistance genes (ARGs) via plasmid conjugation has bee...
www.microbiologyresearch.org
August 12, 2025 at 5:14 PM
Reposted
peterhotezmdphd.bsky.social
My comments with Good Morning America www.goodmorningamerica.com/video/124406...
Implications of HHS canceling mRNA vaccine funding
He claimed mRNA vaccines weren't effective against certain infections.
www.goodmorningamerica.com
August 7, 2025 at 1:49 AM
Reposted
laurenpalmer.bsky.social
Super excited to share our paper online 🚨today🚨 in Cell Host & Microbe‬! Xiaomei Ren @xiaomeiren.bsky.social and Mason Clark @rmasonclark.bsky.social‬ co-led discovery of ecological factors for Acinetobacter baumannii carriage in the gut, a reservoir for pathogen spread. 🎉

tinyurl.com/443kfefk
August 4, 2025 at 8:26 PM
Reposted
mroghanian.bsky.social
The wonderful dynamics of (p)ppGpp, big thank you to everyone involved with this story

www.nature.com/articles/s41...
(p)ppGpp imposes graded transcriptional changes to impair motility and promote antibiotic tolerance in biofilms - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - (p)ppGpp imposes graded transcriptional changes to impair motility and promote antibiotic tolerance in biofilms
www.nature.com
August 1, 2025 at 7:15 PM
Reposted
katypatras.bsky.social
Excited to share a new preclinical model, human bladder organoids, to study UTI, novel therapies, and beyond! Developed with Dr. Sarah Blutt, the BCM Organoid Core, and @tailor-labs.bsky.social www.biorxiv.org/content/10.1...
Human bladder organoids model urinary tract infection and bacteriophage therapy
Urinary tract infections (UTIs), primarily caused by uropathogenic Escherichia coli (UPEC), are among the most common antibiotic-resistant infections. Despite this, currently available preclinical UTI...
www.biorxiv.org
July 31, 2025 at 12:18 PM
Reposted
harmitmalik.bsky.social
NIH wants to hear from you. No really.

Request for Information on Maximizing Research Funds by Limiting Allowable Publishing Costs
grants.nih.gov/grants/guide...
NOT-OD-25-138: Request for Information on Maximizing Research Funds by Limiting Allowable Publishing Costs
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information on Maximizing Research Funds by Limiting Allowable Publishing Costs NOT-OD-25-138. NIH
grants.nih.gov
July 31, 2025 at 3:21 AM
Reposted
joergstuelke.bsky.social
Metals are essential for life, but they can also be toxic. Here, @johnhelmann.bsky.social gives an excellent overview on bacterial metal physiology!
@natrevmicro.nature.com #SubtiWiki

www.nature.com/articles/s41...
Microbial metal physiology: ions to ecosystems - Nature Reviews Microbiology
Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review, Helmann discusses the key chemical con...
www.nature.com
July 25, 2025 at 10:46 AM
Reposted
jeremymberg.bsky.social
This is going to get messy…Council members do important work and having appropriate expertise is important.

In the past, there was no concern about political alignments.
maxkozlov.bsky.social Max Kozlov @maxkozlov.bsky.social · Jul 14
NEW: In an unprecedented move, the NIH will soon disinvite dozens of scientists about to take positions on advisory councils that make final decisions on grant funding.

NIH staff were told to select others aligned with the Trump administration and told to expect placements by political appointees.
Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities
The move would undo years of work, leaving advisory councils understaffed, and without the full expertise needed for reviews.
www.nature.com
July 15, 2025 at 12:16 AM
Reposted
biorxiv-microbiol.bsky.social
Conditional filamentation enhances bacterial survival in toxic environments https://www.biorxiv.org/content/10.1101/2025.05.13.653778v1
May 14, 2025 at 3:18 AM
Reposted
biorxiv-microbiol.bsky.social
A periplasmic protein complex mediates cell envelope integrity and intrinsic multidrug resistance in Mycobacterium tuberculosis https://www.biorxiv.org/content/10.1101/2025.07.08.663683v1
July 9, 2025 at 4:17 AM
coachkleb.bsky.social
Thankful for pretty things. #gardening
July 10, 2025 at 2:01 AM
Reposted
luckytran.com
BREAKING: Scientists are staging a “science fair” in the lobby of a Congressional building to tell elected officials about the critical knowledge the US will lose because their research grants have been canceled.
July 8, 2025 at 3:31 PM
Reposted
maxkozlov.bsky.social
The full ruling explaining why NIH grant cuts are illegal came out today.

It's just as blistering as the judge's oral remarks. And it uncovers fresh details in DOGE's role orchestrating the cuts — and on the cuts at Columbia.

Here are my top highlights from the 103-page ruling. 🧵
maxkozlov.bsky.social Max Kozlov @maxkozlov.bsky.social · Jun 17
After ruling the NIH grant cuts were illegal yesterday, Judge Young, a Reagan appointee on the bench since 1985, ended the hearing with a blistering 15-minute speech.

I've cleaned up my notes — here are his remarks in full. 🧵
Judge rules against NIH grant cuts — and calls them discriminatory
The decision means that the US biomedical agency has to restore funding to hundreds of research projects, but the government will likely appeal.
www.nature.com
July 2, 2025 at 11:55 PM
Reposted
runandpipette.bsky.social
@cornellasap.bsky.social my McClintock letter in the Petersburg Observer! Research helps everyone, including farmers 👩‍🌾🚜🌽
June 30, 2025 at 3:29 PM
Reposted
gregggonsalves.bsky.social
This is unprecedented. The AMA and other medical professional societies speak as one on respiratory virus vaccines and in their own way, say the Trump Administration cannot be trusted with your health. www.ama-assn.org/delivering-c...
An open letter to the American public on respiratory virus vaccines
Read an open letter to the general public from the AMA and medical societies reaffirming support for vaccination to protect against flu, COVID-19, and RSV.
www.ama-assn.org
June 27, 2025 at 9:28 AM