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joergstuelke.bsky.social
Cool new paper on the structure and possible function of the type VII ABC transporter YtrEF in cell wall remodeling in Bacillus subtilis!
#SubtiWiki

www.sciencedirect.com/science/arti...
Structural analysis of a Gram-positive type VII ABC transporter induced by cell wall-targeting antibiotics
Bacteria utilize a variety of mechanisms to remodel the cell wall in response to environmental and antimicrobial stress. In the model organism Bacillu…
www.sciencedirect.com
October 29, 2025 at 3:28 PM
joergstuelke.bsky.social
Today @c-elfmann.bsky.social , the mastermind of #SubtiWiki successfully defended his PhD thesis! The 50. PhD graduate from the group! Congratulations, Christoph!
@uni-goettingen.de @imprsgs.bsky.social
October 17, 2025 at 3:49 PM
joergstuelke.bsky.social
We have started to add references to the #SubtiWiki metabolite pages. Please leg us know if your paper/ metabolite is missing!
@c-elfmann.bsky.social @imprsgs.bsky.social @johnhelmann.bsky.social
October 16, 2025 at 4:38 PM
joergstuelke.bsky.social
Sneak preview of the next upcoming #SubtiWiki feature: All proteins are assigned to clusters sharing similar structures!
Brought to you by Oskar Geissel and @c-elfmann.bsky.social .
@imprsgs.bsky.social
October 10, 2025 at 12:23 PM
molmicrounihoh.bsky.social
🫴🏻 Binding of Bacillus subtilis dynamin‐like protein DynA to the bacterial membrane is essential for effective phage defense:

Shafqat - The FEBS Journal - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1111/...

#subtiwiki
FEBS Press
The bacterial dynamin-like protein DynA from Bacillus subtilis plays a key role in phage defense. It binds the plasma membrane through a unique paddle domain in its D1 subunit. This membrane associat...
febs.onlinelibrary.wiley.com
October 10, 2025 at 8:27 AM
joergstuelke.bsky.social
Identification of genetic interactions in Bacillus subtilis cell division. Congratulations, Byoung-Mo Koo, Carol Gross, and all involved!
@cp-cellsystems.bsky.social #subtiwiki

www.cell.com/cell-systems...
Comprehensive genetic interaction analysis of the Bacillus subtilis envelope using double-CRISPRi
Koo et al. apply genome-scale double-CRISPRi to map cell envelope gene interactions in Bacillus subtilis, revealing >1,000 genetic interactions and uncovering gene networks in envelope biogenesis and ...
www.cell.com
October 4, 2025 at 10:16 AM
joergstuelke.bsky.social
Very much looking fo to the PhD defense of the brain behind #SubtiWiki, @c-elfmann.bsky.social . It will take place on October 17 at 2 pm.
@imprsgs.bsky.social
September 23, 2025 at 11:44 AM
molmicrounihoh.bsky.social
🫴 Wow: ComFB is a widespread family of c-di-NMP receptor proteins!

👇👇👇

www.pnas.org/doi/10.1073/...

@pnas.org #subtiwiki #subtilis
ComFB, a widespread family of c-di-NMP receptor proteins | PNAS
Cyclic dimeric-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates a variety of cellular processes, including motility, biofil...
www.pnas.org
September 19, 2025 at 6:01 AM
joergstuelke.bsky.social
Read a Limerick on B. subtilis on the #SubtiWiki homepage!
Source: The Omnificent English Dictionary in Limerick Form (oedilf.com)!
September 12, 2025 at 2:58 PM
molmicrounihoh.bsky.social
🫴 MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore:

pubmed.ncbi.nlm.nih.gov/40086879/

#subtiwiki
MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore - PubMed
Bacterial protein degradation machinery consists of chaperone-protease complexes that play vital roles in bacterial growth and development and have sparked interest as novel antimicrobial targets. Clp...
pubmed.ncbi.nlm.nih.gov
March 17, 2025 at 10:30 AM
joergstuelke.bsky.social
The #SubtiWiki paper of the month for January 2025 has been selected. It is a paper from Angelika Gründling on the discovery of the last unicorn in Gram-positive phospholipid biosynthesis!

subtiwiki.uni-goettingen.de/wiki/index.p...
January 29, 2025 at 4:54 PM
joergstuelke.bsky.social
Don't miss the 1st Symposium on Interconnections of Gene Expression Processes this September in Göttingen!
Great lineup of speakers and plenty of chances for ECRs to present & discuss their work!
Link: sfb1565.uni-goettingen.de/symposion/
@rnasociety.bsky.social @uni-goettingen.de #subtiwiki
June 18, 2025 at 9:12 AM
molmicrounihoh.bsky.social
🥸 The resulting generalization of Fick's law has been proposed in the context of chemotaxis and is mathematically related to the "turbulent pumping" in magnetohydrodynamics:

www.pnas.org/doi/10.1073/...

#subtiwiki #subtilis @pnas.org
Dynamics of an algae–bacteria microcosm: Photosynthesis, chemotaxis, and expulsion in inhomogeneous active matter | PNAS
In nature, there are significant relationships known between microorganisms from two kingdoms of life, as in the supply of vitamin B12 by bacteria ...
www.pnas.org
March 18, 2025 at 7:53 AM
joergstuelke.bsky.social
Happy to share Christoph Elfmann's new paper that is now out in Trends in Microbiology! Discover tools to make the most out of AlphaFold and its iterations!
@c-elfmann.bsky.social @cp-trendsmicrobiol.bsky.social @unigoettingen.bsky.social @imprsgs.bsky.social #subtiwiki
www.cell.com/trends/micro...
Cutting-edge tools for structural biology: bringing AlphaFold to the people
The recent application of artificial intelligence-based prediction of protein and protein complex structures by AlphaFold has revolutionized biology. Here, we give an overview of the tools that make this revolution accessible to experimental microbiologists without training in bioinformatics or sophisticated computer equipment, and show how this helps to gain new insights.
www.cell.com
May 5, 2025 at 12:02 PM
selimlab.bsky.social
#SubtiWiki
August 21, 2025 at 7:51 PM
molmicrounihoh.bsky.social
🫴 Next BACELL meeting:

bacell2025.eu

#subtilis #subtiwiki #amsterdam
February 18, 2025 at 2:18 PM
joergstuelke.bsky.social
Shakespeare adapted to Bacillus subtilis 🥹

@annualreviews.bsky.social #SubtiWiki

www.annualreviews.org/content/jour...
To Sporulate or Not to Sporulate: Developmental Checkpoints Monitoring Bacillus subtilis Sporulation | Annual Reviews
Developmental processes are carefully regulated programs that are present in multiple kingdoms of life and that generally result in cell differentiation and specialization. This regulation can be medi...
www.annualreviews.org
June 12, 2025 at 7:11 AM
molmicrounihoh.bsky.social
🫴 A conserved nuclease facilitates environmental DNA uptake in Bacillus subtilis and related bacteria!

@narjournal.bsky.social #subtiwiki

👇

academic.oup.com/nar/article/...
A conserved nuclease facilitates environmental DNA uptake
Abstract. Bacteria acquire new traits through the uptake of genetic material from the environment, a process requiring DNA processing. However, the molecul
academic.oup.com
May 28, 2025 at 7:36 AM
molmicrounihoh.bsky.social
Bcd is a promiscuous GDH with a rather weak activity against glutamate. A very interesting study but it is rather unclear whether Bcd contributes to glutamate degradation (check the amount of protein used for the activity assays...).

#subtiwiki #glutamate

www.nature.com/articles/s41...
A promiscuous Bcd amino acid dehydrogenase promotes biofilm development in Bacillus subtilis - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - A promiscuous Bcd amino acid dehydrogenase promotes biofilm development in Bacillus subtilis
www.nature.com
June 21, 2025 at 11:10 PM
molmicrounihoh.bsky.social
🫴 Phenazines contribute to microbiome dynamics by targeting topoisomerase IV:

pubmed.ncbi.nlm.nih.gov/40935925/

@natureportfolio.nature.com #subtiwiki
Phenazines contribute to microbiome dynamics by targeting topoisomerase IV - PubMed
Phenazines are highly prevalent, natural bioactive substances secreted by microbes. However, their mode of action and potential involvement in shaping microbiomes remain elusive. Here we performed a c...
pubmed.ncbi.nlm.nih.gov
September 12, 2025 at 7:14 AM
joergstuelke.bsky.social
Absolutely amazing paper from the lab of Carol Gross! So inspiring!
@biorxiv-microbiol.bsky.social
#mycoplasma #subtiwiki

www.biorxiv.org/content/10.1...
Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3
Accurate prediction of protein complex structures by AlphaFold3 and similar programs has been successfully used to predict the presence of protein-protein interactions (PPIs), but this technique has n...
www.biorxiv.org
July 5, 2025 at 7:49 PM
agatastarosta.bsky.social
Our first B. subtilis paper, published at NatureComms.
Translation in Bacillus subtilis is spatially and temporally coordinated during sporulation. #subtiwiki #bacillus www.nature.com/articles/s41...
Funded by FNP_org_pl and EMBO_YIP
November 14, 2024 at 2:29 PM
joergstuelke.bsky.social
Professorship in Microbial Genetics @ University of Göttingen. Don't miss this chance to become my colleague!
uni-goettingen.de/en/699057.html
#SubtiWiki
W1-TT-W2 Microbial Genetics - Georg-August-University Göttingen
Website of the Georg-August-University Göttingen
uni-goettingen.de
August 14, 2025 at 1:13 PM
joergstuelke.bsky.social
Hey Chris, congrats to you and your team on the paper!
One remark: if you add hashtag SubtiWiki, your Bluesy posts will be displayed on all SubtiWiki in the bluesy feed!
Best regards,

Jörg
July 4, 2025 at 12:12 PM
joergstuelke.bsky.social
Metals are essential for life, but they can also be toxic. Here, @johnhelmann.bsky.social gives an excellent overview on bacterial metal physiology!
@natrevmicro.nature.com #SubtiWiki

www.nature.com/articles/s41...
Microbial metal physiology: ions to ecosystems - Nature Reviews Microbiology
Metal ions are required for all cells, and their homeostasis relies on ancient mechanisms that facilitate their import, distribution and storage. In this Review, Helmann discusses the key chemical con...
www.nature.com
July 25, 2025 at 10:46 AM