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cneuma.bsky.social
@cneuma.bsky.social
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wemeze.bsky.social
#Wissenschaftsfeindlichkeit @cdrosten.bsky.social
»Die extremen Auswüchse der neuen Wissenschaftsfeindlichkeit lassen sich bereits jetzt in den USA beobachten. Hier in Berlin- Mitte, rund um die Luisenstraße, haben wir die alten Charité-Hörsäle, in denen die Porträts hängen – von den Kollegen, die in den dreißiger Jahren die Charité verlassen mussten. Auch wenn die Motive heute andere sind: Wir alle innerhalb der Wissenschaft sollten nicht glauben, dass sich solche Dinge in ihren Grundzügen nicht wiederholen können.« Christian Drosten https://www.diw.de/de/diw_01.c.932545.de/100_jahre_diw/wissenschaft_ist_freiheit_und_pflicht.html
December 19, 2025 at 8:47 PM
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hannahrabrams.bsky.social
Really important perspective from Ramy Sedhom on FOLFIRINOX in #panCAN patients >70 years old ("OA"). Even in selected patients who receive this intensive regimen, even w/ preemptive dose reductions, 56% G3 AE or unplanned hospitalization.

ascopubs.org/doi/10.1200/... #JCOOP #GIOnc
At first glance, Collineau's findings seem to be predictable: FOLFIRINOX is toxic, and OAs are vulnerable. But the deeper issue is whether we are asking the right question. By focusing narrowly on which OA can endure FOLFIRINOX, we risk missing the more relevant point: what is the most tolerable approach to the care of OAs with PDAC, and who truly benefits? The Edison analogy is instructive here. His lasting legacy was not the brightest bulb, but the system that made light usable, safe, and enduring. In PDAC, the lesson is similar: the discovery of an intense regimen is useless unless it is embedded in a system that makes treatment tolerable and meaningful for patients. For OAs, that grid is built through geriatric assessment (GA), supportive interventions (nutrition, prehabilitation, psychosocial support), and integration of palliative care. From “Who Can Tolerate” to “Who Will Benefit” It is time for all of us to reimagine PDAC care in OA. The central question is no longer “who can tolerate FOLFIRINOX,” but “who will truly benefit?” Answering that requires 1. Routine GA to uncover vulnerabilities 2. Supportive interventions (comorbidity management, exercise, psychosocial support, nutritional support, and palliative integration) to enhance resilience 3. Trial designs that embed tolerability and quality of life as end points that complement response and survival 4. Exploration of objective aging biomarkers (inflammation, senescence, aging clocks, sarcopenia) for future stratification
December 18, 2025 at 4:23 AM
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wiegold.de
Warum der Staat zu dumm ist mit Geheimnissen umzugehen, Vol. XXXVX
December 15, 2025 at 9:10 PM
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kampfmitkette.bsky.social
Brandenburg ist jetzt in den Rang einer Supermacht aufgestiegen
marisakabas.bsky.social Marisa Kabas @marisakabas.bsky.social · 11d
NEW — Trump has signed an executive order "designating illicit fentanyl and its core precursor chemical as weapons of mass destruction (WMD)." www.whitehouse.gov/presidential...

As a reminder, The Handbasket had the scoop that this was coming back in MARCH:
Trump to declare 'illicit' fentanyl 'Weapon of Mass Destruction,' per draft EO
A copy of the draft was obtained and reviewed by The Handbasket.
www.thehandbasket.co
December 15, 2025 at 10:45 PM
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warinthefuture.bsky.social
In the midst of the darkest of times, a hero stands up for what is right. The brutal, deliberate attack against Jewish Australians celebrating Hanukkah at #Bondi Beach today is an abomination. For those murdered while celebrating the 1st day of the Festival of Lights, may their memory be a blessing.
tendar.bsky.social (((Tendar))) @tendar.bsky.social · 12d
This guy disarming the terrorist at Bondi Beach, Australia, can only be described as hero.
December 14, 2025 at 10:15 AM
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kampfmitkette.bsky.social
i remember when a peanut farm was a conflict of interest
December 4, 2025 at 5:35 PM
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rikefranke.bsky.social
It’s getting cold outside, better prepare.
November 5, 2024 at 10:31 AM
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sicherheitspod.de
Wurde auch wieder viel gelacht, trotz allem.
#SicherheitshalberLive
October 31, 2025 at 10:37 PM
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sicherheitspod.de
- Clip -
@richardcschneider.bsky.social in der aktuellen Folge zur israelischen Haltung zu einem Palästinenserstaat.

Jetzt überall, wo es Podcasts gibt.
October 22, 2025 at 7:46 AM
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rikefranke.bsky.social
How do people with kids get anything done, ever?
I’m serious, whenever I see someone roughly my age accomplish anything these days, first thing I do is check whether they have kids. Written a book? Cool. Written a book *while having kids*? You’re a GOD.
October 19, 2025 at 7:17 PM
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rikefranke.bsky.social
“Time may no longer be on Russia’s side. … Russia can now prevail only if it prevents them from turning their collective latent strength into usable superiority by undermining their resolve. This compels it to accelerate its theory of victory”
The Russia–Ukraine war has entered a new phase
Recent policy choices by America, Europe and China, and domestic economic strains, are reshaping Russia’s calculus. Since time may no longer be on its side, it is challenging Western resolve in more risky and aggressive ways. This is certain to escalate unless Europe responds.
www.iiss.org
October 15, 2025 at 3:20 PM
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drfranksauer.bsky.social
bekanntes thema. mir schicken vermeintlich smarte junge menschen ihre exposés, um bei mir zu promovieren. darin im literaturverzeichnis dann diverse "artikel" von mir - die ich natürlich nie geschrieben habe. das fällt schnell auf! 🤦

wir werden in blödheit und AI slop ersaufen. in dem zusammenhang:
SORA: the all Ai TikTok Clone. will slop end creativity?
YouTube video by CaseyNeistat
youtu.be
October 7, 2025 at 10:28 AM
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nejm.org
FLAIR phase 3 trial: Long-term therapy for chronic lymphocytic leukemia can lead to resistance and toxic effects. Research findings on measurable residual disease–guided treatment with ibrutinib–venetoclax are summarized in a new Quick Take video. nej.md/46RcQt4

#MedSky #Hematology
An illustration of ibrutinib plus venetoclax for treating patients with chronic lymphocytic leukemia
September 28, 2025 at 7:02 PM
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kampfmitkette.bsky.social
Erst wenn die erste Drohne in einen Passagierflieger kracht wird man sich endlich um das Problem kümmern
September 26, 2025 at 2:54 PM
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pulmcrit.bsky.social
"bUt tHe WhiTe cOuNT iS nOrmAL"

I see this pattern of laboratory evaluation almost every day in the ICU

anyone involved in evaluating acutely ill patients must be able to recognize this evolution, like the face of an old friend

what is going on here? #EMIMCC 🧵 #1/5
September 22, 2025 at 1:35 PM
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paulnwilliams.bsky.social
Re-upping my most-liked Twitter thread, since it's that time of year again. I haven't done inpatient since COVID, so these may seem quaint and archaic. But hopefully they help someone!
paulnwilliams.bsky.social Paul Williams @paulnwilliams.bsky.social · Jul 25
*How to round with Paul Williams*

Tips for medical students, interns, and the curious - a thread

Just in case this might be helpful. Your mileage may vary with other attendings, who may violently disagree with these. (1/16)
July 25, 2025 at 1:12 AM
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kampfmitkette.bsky.social
Die russische Föderation nachdem ein ehemaliger deutscher Ministerpräsident (SPD) zum 13ten mal nach Moskau gereist ist
July 21, 2025 at 6:40 PM
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sicherheitspod.de
Wir haben Geburtstag!
(Und die Geburtstagsfolge ist schon online!)
claudiasalowski.bsky.social Claudia Salowski @claudiasalowski.bsky.social · Jul 19
Hab ich das richtig in Erinnerung, dass der @sicherheitspod.de heute Geburtstag hat? Wenn ja: Happy Birthday! 🥳🎂🍾
Wenn nein (wobei: eigentlich so oder so): Wann nächste Folge? 😎
July 19, 2025 at 1:02 PM
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kardioklick.bsky.social
Wow - this atherosclerosis etiology is completely new to me but proves those right who’ve been enthusiastic about the microbiome.

#cardiosky.
July 17, 2025 at 4:04 AM
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rikefranke.bsky.social
Worth watching. Assessment by German Army’s chief inspector on Russian military capabilities.
June 29, 2025 at 12:31 PM
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drfranksauer.bsky.social
1/29 Ich weiß ich wiederhole mich. Aber aus gegebenem Anlass (bzw. aus gegebenen Anlässen) ein Thread zu der Frage, ob wir nicht mal etwas mehr nüchterne strategische Analyse statt Panikmache bräuchten.
May 1, 2025 at 2:29 PM
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pulmcrit.bsky.social
what steroid is the fairest of them all?

for PNA/sepsis, hydrocortisone might be the best (least CNS penetration, so least deleriogenic 🤡)

mineralocorticoid activity may cause fluid retention & hypoK, but it's easy to follow lytes & diurese as needed

discussion: emcrit.org/ibcc/adrenal... #EMIMCC
April 30, 2025 at 12:01 PM
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guerreroespejo.bsky.social
A 29-y-o ♂️with well-controlled HIV infection, a 4-week history of painful ulcers on the scrotum: a 1-week of a painful, whitish discoloration on his tongue (smooth, pink, guttate macules within a white coating).
1/2

DOI: 10.1056/NEJMicm2411077
#infectious #Health
March 11, 2025 at 10:33 AM
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drfranksauer.bsky.social
Das ist wie wenn sich Europa nach 9/11 auf die Seite der Taliban geschlagen hätte.
March 1, 2025 at 1:59 PM
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sargsyanz.bsky.social
Rabih Geha @cpsolvers.bsky.social likes to say the more cell lines are down, the more likely it is to be a problem with factory (bone marrow). This graphic shows it nicely
nejm.org NEJM.org @nejm.org · Mar 1
Case Record of the MGH: A 65-year-old woman was evaluated for back pain and pancytopenia. A peripheral-blood smear was notable for nucleated red cells, large platelets, and immature granulocytes. A diagnosis was made. Full case details: nej.md/4bfXXBf

#MedSky #Oncology
Case Records of the Massachusetts General Hospital A 65-Year-Old Woman with Weakness, Back Pain, and Pancytopenia A Venn diagram of the causes of acquired cytopenias.
March 1, 2025 at 6:59 PM