Hannah R. Abrams
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hannahrabrams.bsky.social
Hannah R. Abrams
@hannahrabrams.bsky.social
2.3K followers 390 following 200 posts
Heme/Onc fellow at Fred Hutch, hoping to reduce costs & improve patient/caregiver experiences in cancer care. Social Media Editor @ JCO OP. Views are my own. #MedSky
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hannahrabrams.bsky.social
It's taken over 10 years for an erroneous reference to (almost) make it out of the citation chain.

Less about the reference itself (incorrect claim re: cisplatin ototoxicity) and more about our science.

Case report here @jco-asco.bsky.social:
ascopubs.org/doi/10.1200/...
Fig 1. Reference characteristics to the article by Ross et al by year of publication. Stacked area chart depicting the distribution of citation characteristics referencing the article by Ross et al, categorized by publication year (2010-2025). Each color represents a distinct citation characteristic: Affirmative, contrastive, assumptive, conceptual, methodologic, perfunctory, and negative. Vertical dashed lines mark two key regulatory events: the 2011 cisplatin label update and the 2015 label revision.
February 5, 2026 at 4:23 AM
hannahrabrams.bsky.social
Increasing options for chemotherapy-induced peripheral neuropathy: in a 38-patient RCT, low intensity vibration was safe, well adhered-to, and improved neuropathy + function:

ascopubs.org/doi/10.1200/... #oncsky @jco-asco.bsky.social @ohsuknight.bsky.social
Low-Intensity Vibration to Reduce Symptoms and Improve Physical Functioning in Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Pilot Randomized Trial | JCO Oncology Practice
PURPOSEChemotherapy-induced peripheral neuropathy (CIPN) can have deleterious effects on mobility and quality of life in people with cancer. Vibration therapy shows promise as a CIPN intervention but…
ascopubs.org
February 3, 2026 at 2:04 AM
Reposted by Hannah R. Abrams
fumikochino.bsky.social
Every now and again I catch up with xkcd and... well... I didn't expect to be crying in my office this morning.

Two years
Seven years
Ten years
Fifteen years

This is what we dream about when we talk of #survivorship #survonc 🖤
A multi panel comic depicting a survivorship journey over years including some scares of recurrence but many joyful interactions and nature trips A multi panel comic depicting a survivorship journey over years including some scares of recurrence but many joyful interactions and nature trips A multi panel comic depicting a survivorship journey over years including some scares of recurrence but many joyful interactions and nature trips A multi panel comic depicting a survivorship journey over years including some scares of recurrence but many joyful interactions and nature trips. Growing old with you is all I ever wanted.
February 2, 2026 at 5:49 PM
Reposted by Hannah R. Abrams
arrianna-planey.bsky.social
In my teaching (which jointly emphasizes methodological rigor and conceptual clarity), I use this slide:
Screenshot of a Powerpoint slide entitled "what is health equity research?". It features three blocks of text linked by three arrows. The first text block is entitled "Theoretically-grounded" - grounded in social and political theories that explain the allocation of resources and hazards that underlie all health disparities along the axes of "social difference." The next is entitled "Methodologically sound," and reads "Methodological rigor is not a substitute for theory, but emphasis on matching research questions, data, and methods is key." The third is entitled, "Grounded in Public Health Practice" and reads "Does this address a need for PH policy design or practice?
February 1, 2026 at 4:22 PM
hannahrabrams.bsky.social
"Curative hope" in oligometastatic breast cancer: ~50% of surveyed US medical oncologists recommend consolidative tx to all cancer sites.

It's a brave new world, and a setting where patients often deserve to get second/multiple opinions! @jco-asco.bsky.social #OncSky

ascopubs.org/doi/10.1200/...
February 1, 2026 at 5:39 PM
hannahrabrams.bsky.social
Time from cancer diagnosis → treatment is rising: 21 days in 2004 to 28 days in 2015.

Much of this is because of ⬆️ in stage 1 & there may be some good reasons - eg careful shared-decision making & planning. But how do we support people during the (often) anxious wait?

ascopubs.org/doi/full/10....
January 31, 2026 at 4:49 PM
hannahrabrams.bsky.social
"What dose?" is the name of the game this week @jco-asco.bsky.social as ghosts of 2000s haunt modern oncology.

1. We've known since 2010 nivo is active at low doses/long intervals. This week Vanita Noronha & team show just 20mg (vs 240mg) is active in 5 ca types.
ascopubs.org/doi/10.1200/...
January 31, 2026 at 3:30 AM
hannahrabrams.bsky.social
#Telehealth has been a huge boon to oncology: save pts time, see people who might not be able to travel.

Q in new study @jco-asco.bsky.social: is "webside manner" affecting quality? Are we just adding extra appts?

A: Largely, no! Similar communication, slight ⬆️ appts.

ascopubs.org/doi/full/10....
January 29, 2026 at 4:23 AM
hannahrabrams.bsky.social
In this small pilot study, #PanCan pancreatic cancer patients randomized to receive medical cannabis while starting chemotherapy had improvement in pain (44% vs 20%), appetite (56% vs 30%), and insomnia (67% vs 30%).
January 28, 2026 at 3:49 AM
Reposted by Hannah R. Abrams
arrianna-planey.bsky.social
"Nearly half of rural residents are uninsured or insured by public payers. This limited payer mix, coupled with relatively low reimbursement rates and high provision of uncompensated care compared to nonrural areas, poses challenges to the financial stability of rural primary care."
The State of Rural Primary Care in the United States
Rural Americans face significant barriers to accessing adequate primary care; tailored federal and state programs can help address some of these challenges.
www.commonwealthfund.org
January 28, 2026 at 1:08 AM
Reposted by Hannah R. Abrams
liposarcomasupport.bsky.social
Starting in 1 hour! Tune in to our webinar on radiation therapy in liposarcoma. Join us soon and learn how radiation plays a key role in care.
bit.ly/Radiation-We... #LipoEducation #RadiationTreatment #liposarcoma
January 27, 2026 at 4:23 PM
hannahrabrams.bsky.social
Where are US patients with cancer traveling for care?

Medicare claims analyzed in JCO CCI: unsurprisingly, community-based networks carry a large load. Notably, confined to 12h drive & unclear how satellite sites included, but a close look at the map may surprise you:

ascopubs.org/doi/10.1200/...
January 27, 2026 at 2:04 AM
hannahrabrams.bsky.social
From theory to practice: in #JCOOP, a conceptual model to describe how practices cope with losing a rural oncologist - and a new podcast interview with @fumikochino.bsky.social to really dive into a real-world example. #HealthPolicy
FIG 1. The inferred relationships between theme components.
January 26, 2026 at 6:28 PM
hannahrabrams.bsky.social
Just adding a "🚩 suspected cancer" flag reduced the time from referral to appointment by over 50%(and dropped the time from referral -> diagnosis of cancer by 63 days)
@nychealthsystem.bsky.social @jco-asco.bsky.social

ascopubs.org/doi/10.1200/...
Fig A3. Improvements in efficiency of care by age.
January 26, 2026 at 5:37 PM
hannahrabrams.bsky.social
How important is #HCT donor age in the #PTCy era? Large single-center study in JCO OP raises the question of how strongly age should be prioritized:

ascopubs.org/doi/10.1200/... @EJShpallMD
Fig 1. Association of donor age with OS. (A) The plot shows the unadjusted HR for death according to donor age. A linear model (red line) is compared with a more flexible spline model (blue line), which allows for a non-linear relationship. Shaded ribbons represent 95% CIs. The similarity between the two models and the fact that their CIs consistently overlap an HR of 1.0 indicates that there is no significant linear or nonlinear association between donor age and survival in this cohort. (B) Kaplan-Meier analysis of OS stratified by dichotomized donor age: donors younger than 32 years (red) versus those 32 years and older (blue). There was no statistically significant difference in survival between the two groups (log-rank P = .51). HR, hazard ratio; OS, overall survival.
January 17, 2026 at 12:55 AM
Reposted by Hannah R. Abrams
jeremyfaust.bsky.social
We have the CDC-funded Hepatitis Vaccine trial in Guinea-Bissau protocol.

It’s worse than you thought.

Check it out, first in Inside Medicine…

with @pauloffit.bsky.social David Boulware and others.

insidemedicine.substack.com/p/scoop-the-...
Scoop: The leaked protocol of the CDC-funded Hepatitis B vaccine trial in Guinea-Bissau. “This is another Tuskegee.”
The protocol reveals that the trial will withhold the Hepatitis B birth dose from thousands—without placebos, without universal maternal screening, and with endpoints critics call indefensible.
insidemedicine.substack.com
January 15, 2026 at 10:57 AM
hannahrabrams.bsky.social
SNF capacity is the bottleneck that keeps people waiting in ER hallways and make-shift hospital rooms. SNF beds are crucial to our health system. Since 2020, capacity is down 5%, with less slack, due to staffing shortages.

@jamainternalmed.com @mlbarnett.bsky.social: jamanetwork.com/journals/jam...
January 14, 2026 at 3:49 AM
hannahrabrams.bsky.social
🌅 Several studies have suggested checkpoint inhibitors dosed AM may be assoc w/ improved outcomes- but strong risk of confounding.

Out now in #JCOOP: review of literature & discussion of how practices could actually implement this. Suspect will be very dependent on local AM traffic!
Fig 2. Constraints related to the patient, the pharmacy, and the outpatient infusion centers to be taken into account when concentrating outpatient ICI administrations in a stipulated time window in the morning. ICI, immune checkpoint inhibitor. Pharmacy constraints: physiochemical stability, risk of waste. Patient: distance home-hospital, diurnal preference. Day unit: priority rankings, long multi drug regimens. Proposed Action We propose the following approaches to make early ToDA of ICI feasible in daily routine practice: • ASSESS: establish a nurse-led telephone assessment on the eve of ICI administration with full blood work-up available to confirm clinical and biologic permissiveness to ICI treatment; • AVOID (as far as possible and according to the habits of each center): do not schedule medical consultation and ICI treatment on the same day to reduce risks of delays in treatment administration (prefer teleconsultations the day before treatment for patients living far from the center); • ALWAYS administer ICI first when in combination with IV chemotherapy or other agents, unless reverse sequencing is recommended; • ALLOCATE: prioritize two or three ICI mornings per week and save the remaining two or three mornings for long-term combination treatments not including ICIs; • ANTICIPATE: whenever possible, cytotoxic reconstruction units could prepare ICIs in the evening of the eve so that they are ready to be administered early on the following morning.
December 21, 2025 at 5:39 PM
hannahrabrams.bsky.social
Potential for cure in metastatic gastric cancer with actionable biomarkers?

- 51 pts/1710 treated over 9 years in Japan
- "Potential cure" = PFS >3 years, NED, >1 year since last tx w/o progression (consolidative surgery allowed)
- dMMR 23%, CPS ≥10 30%, HER2+ 24%

ascopubs.org/doi/10.1200/...
December 20, 2025 at 8:17 PM
hannahrabrams.bsky.social
What are outcomes w/ histotripsy for liver tumors/mets in real world since FDA approval in 12/2023? Out now in #JCOOP: at 3 mo, ~95% local control, 7% distant POD.

Need longer term data, not enough to distinguish b/w local control options, but helpful to have a start.
ascopubs.org/doi/10.1200/...
Fig 1. (A and B) Thirty- and 90-day outcomes of intended complete treatment with histotripsy by histologic tumor treated and (C) time-to-event analysis for primary versus secondary malignancy. CCA, cholangiocarcinoma; CRLM, common cancer, with liver metastasis; HCC, hepatocellular carcinoma; HNSC, head and neck squamous cell; NET, neuroendocrine tumor; PDAC, pancreatic ductal adenocarcinoma.
December 20, 2025 at 4:49 PM
hannahrabrams.bsky.social
Really important perspective from Ramy Sedhom on FOLFIRINOX in #panCAN patients >70 years old ("OA"). Even in selected patients who receive this intensive regimen, even w/ preemptive dose reductions, 56% G3 AE or unplanned hospitalization.

ascopubs.org/doi/10.1200/... #JCOOP #GIOnc
At first glance, Collineau's findings seem to be predictable: FOLFIRINOX is toxic, and OAs are vulnerable. But the deeper issue is whether we are asking the right question. By focusing narrowly on which OA can endure FOLFIRINOX, we risk missing the more relevant point: what is the most tolerable approach to the care of OAs with PDAC, and who truly benefits? The Edison analogy is instructive here. His lasting legacy was not the brightest bulb, but the system that made light usable, safe, and enduring. In PDAC, the lesson is similar: the discovery of an intense regimen is useless unless it is embedded in a system that makes treatment tolerable and meaningful for patients. For OAs, that grid is built through geriatric assessment (GA), supportive interventions (nutrition, prehabilitation, psychosocial support), and integration of palliative care. From “Who Can Tolerate” to “Who Will Benefit” It is time for all of us to reimagine PDAC care in OA. The central question is no longer “who can tolerate FOLFIRINOX,” but “who will truly benefit?” Answering that requires 1. Routine GA to uncover vulnerabilities 2. Supportive interventions (comorbidity management, exercise, psychosocial support, nutritional support, and palliative integration) to enhance resilience 3. Trial designs that embed tolerability and quality of life as end points that complement response and survival 4. Exploration of objective aging biomarkers (inflammation, senescence, aging clocks, sarcopenia) for future stratification
December 18, 2025 at 4:23 AM
hannahrabrams.bsky.social
⏱️ Oncologists: save patients time & reduce infusion center overload - pembro in 10 minutes instead of 30. ⏱️

Safety data now out in #JCOOP, IRR low (4%) & similar to 30 min infusion. @oncoalert.bsky.social

ascopubs.org/doi/10.1200/...
Safety, Feasibility, and Patient Experience of Ten-Minute Pembrolizumab Infusions: A Prospective Cohort Study | JCO Oncology Practice
PURPOSERising cancer incidence and staff shortages demand more efficient outpatient oncology workflows. Pembrolizumab is conventionally administered over 30 minutes. This prospective study assessed…
ascopubs.org
December 17, 2025 at 10:49 PM
Reposted by Hannah R. Abrams
sabinekaram.bsky.social
The debate about kidney function estimation in cancer patients is not over. What is important to remember is that mCrCl is not mGFR
hannahrabrams.bsky.social Hannah R. Abrams @hannahrabrams.bsky.social · Dec 17
Significant overestimation of renal function by eGFR compared to measured CrCl in people with nonmetastatic RCC (including Cys C-adjusted).

Wide implications re: cystectomy cutoffs. #UroSky #NephSky is this part of your practice for people near cutoff?

ascopubs.org/doi/10.1200/... #MedSky #JCOOP
At a measured GFR of 45, corresponding eGFR values ranged from 53 to 59 mL/min/1.73 m2 Estimated Glomerular Filtration Rate Equations Overestimate Renal Function Compared With Measured Glomerular Filtration Rate Using 24-Hour Urine Creatinine Clearance Full abstract beyond alt text limits but is available publicly at https://ascopubs.org/doi/10.1200/OP-25-00895 Highlighting Methods and Results: Methods In this prospective study, 72 patients with nonmetastatic RCC undergoing preoperative evaluation completed serum creatinine, cystatin C, and 24-hour urine collections. eGFR values were calculated using multiple established equations, both race-inclusive and race-neutral. The agreement between eGFR and measured GFR was assessed using Passing-Bablok regression. Linear regression estimated the discrepancy between eGFR and measured GFR at clinically relevant cutoffs of 45 and 60 mL/min/1.73 m2. Results Across all equations, eGFR consistently overestimated renal function compared with measured GFR. At a measured GFR of 45, corresponding eGFR values ranged from 53 to 59 mL/m
December 17, 2025 at 12:21 PM
hannahrabrams.bsky.social
Significant overestimation of renal function by eGFR compared to measured CrCl in people with nonmetastatic RCC (including Cys C-adjusted).

Wide implications re: cystectomy cutoffs. #UroSky #NephSky is this part of your practice for people near cutoff?

ascopubs.org/doi/10.1200/... #MedSky #JCOOP
At a measured GFR of 45, corresponding eGFR values ranged from 53 to 59 mL/min/1.73 m2 Estimated Glomerular Filtration Rate Equations Overestimate Renal Function Compared With Measured Glomerular Filtration Rate Using 24-Hour Urine Creatinine Clearance Full abstract beyond alt text limits but is available publicly at https://ascopubs.org/doi/10.1200/OP-25-00895 Highlighting Methods and Results: Methods In this prospective study, 72 patients with nonmetastatic RCC undergoing preoperative evaluation completed serum creatinine, cystatin C, and 24-hour urine collections. eGFR values were calculated using multiple established equations, both race-inclusive and race-neutral. The agreement between eGFR and measured GFR was assessed using Passing-Bablok regression. Linear regression estimated the discrepancy between eGFR and measured GFR at clinically relevant cutoffs of 45 and 60 mL/min/1.73 m2. Results Across all equations, eGFR consistently overestimated renal function compared with measured GFR. At a measured GFR of 45, corresponding eGFR values ranged from 53 to 59 mL/m
December 17, 2025 at 3:49 AM
Reposted by Hannah R. Abrams
emilymoin.com
Observational research, broadly speaking, seeks to expand our knowledge of the the data-generating processes underlying reality.

Research using synthetic data expands our knowledge of the process that generated the synthetic dataset.

They are explicitly, trivially, and facially not the same thing.
sabrinanorwood.bsky.social Sabrina Norwood @sabrinanorwood.bsky.social · Dec 16
Did you know that from tomorrow, Qualtrics is offering synthetic panels (AI-generated participants)?

Follow me down a rabbit hole I'm calling "doing science is tough and I'm so busy, can't we just make up participants?"
Text reads: About synthetic panels Recruiting the right participants for a study can be difficult. You may not get the exact demographics you need, and the shorter the deadline, the less sure you can be that everyone will answer on time. One possible solution can be to use synthetic panels. Synthetic panels are powered by a first party proprietary AI model developed here at Qualtrics. Our synthetic panel is trained on thousands of responses from a variety of demographic backgrounds in order to more accurately predict how certain populations would respond to a survey. Our synthetic panel is based on the United States General Population, and is only available in English. This panel comes with ready-made quotas and target breakouts in order to represent your chosen population and make it easy to launch your survey right away. Text reads: Question-writing best practices To get the most reliable and actionable results from synthetic audiences, consider these question-writing best practices: Ask forward-looking and attitudinal questions. Synthetic panels perform best with perceptions, preferences, and intent-based questions. For example, “How likely are you to try…?” Synthetic panels are less applicable for studies on past behaviors, detailed recall, brand recall, or awareness questions. For example, “When did you last visit…?” Text reads: Discussion The current study aimed to conduct a meta-analysis of the TPB when applied to health behaviours which addressed the limitations of previous reviews by including only prospective tests of behaviour, applying RE meta-analytic procedures, correcting correlations for sampling and measurement error, and hierarchically analysing the effect of behaviour type and sample and methodological moderators. Some 237 tests were identified which examined relations amongst model components. Overall the analysis indicated that the TPB could explain 19.3% of the variance in behaviour and 44.3% of the variance in intention across studies. This level of prediction of behaviour is slightly lower than that of previous meta-analytic reviews which have found between 27% (Armitage & Conner, 2001; Hagger et al., 2002) and 36% (Trafimow et al., 2002) of the variance in behaviour to be explained by intention and PBC.
December 16, 2025 at 6:30 PM