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club-cfc.bsky.social
club CFC
@club-cfc.bsky.social
51 followers 28 following 15 posts
The club “Cils, Flagelles et Centrosome” federates groups from France working on #cilia #flagella #centrosome #ciliopathies and organizes symposia and biennial meetings in collaboration with European #cilia networks!
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Reposted by club CFC
mick-lab.bsky.social
Another fantastic technology development paper by @davidbreslowlab.bsky.social. Being able to perform microscopy-based CRISPR screens on fixed cells is big. And TZMP1 is a fascinating transition zone proteins. We may be missing many more of these #microproteins. Congrats to all authors!
davidbreslowlab.bsky.social David Breslow Lab @davidbreslowlab.bsky.social · 6d
Ever wanted to do a genome-scale CRISPR screen for a microscopy phenotype? Pooled CRISPR screens are amazing, but hard to combine with imaging... Excited to share our latest work in Dev Cell on a technology platform for imaging screens and applications to primary cilia: www.cell.com/developmenta...
A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology
Sun et al. develop a microscopy-based CRISPR screening platform that combines ease of implementation with flexible analysis of live-cell or antibody-based markers. Screens in human cells using a serie...
www.cell.com
November 23, 2025 at 9:11 AM
club-cfc.bsky.social
Hello everyone, just to announce that our next afternoon symposium on #cilia #flagella and #ciliopathies will take place @institutimagine.bsky.social on Wednesday afternoon March 18 2026. Save the date!
November 20, 2025 at 10:51 AM
club-cfc.bsky.social
www.cell.com/cell/abstrac...
A conserved mechanism for the retrieval of polyubiquitinated proteins from cilia
CFAP36, a conserved cilia-specific ubiquitin reader, partners with the ARL3 GTPase to enable the selective and directional retrieval of polyubiquitinated proteins from cilia, a process essential for m...
www.cell.com
November 14, 2025 at 10:39 AM
club-cfc.bsky.social
www.jci.org/articles/vie...
JCI - Ciliopathy-related B9 protein complex regulates ciliary axonemal microtubule post-translational modifications and initiation of ciliogenesis
www.jci.org
October 31, 2025 at 8:40 AM
club-cfc.bsky.social
www.science.org/doi/10.1126/...
A CRISPR activation screen reveals a cilia disassembly pathway mutated in focal cortical dysplasia
A gain-of-function screen uncovers a cilia disassembly pathway linked to genes somatically mutated in neurodevelopmental disease.
www.science.org
October 31, 2025 at 8:39 AM
Reposted by club CFC
bastinlab.bsky.social
Great issue! Bonus: includes Daniel's work on incorporation of tagged tubulin in flagella!
October 28, 2025 at 8:55 AM
Reposted by club CFC
embojournal.org
Drosophila Alms1 proteins are general regulators of #centriolar cartwheel assembly, exhibiting distinct centriolar localization patterns and enabling Plk4-Ana2 interaction
#RefereedPreprint c/o @reviewcommons.org by Véronique Morel, Bénédicte Durand and colleagues
www.embopress.org/doi/full/10....
March 3, 2025 at 5:28 PM
Reposted by club CFC
elife.bsky.social
The protein KIF7 plays a crucial role in shaping the brain’s cortex. By fine-tuning Sonic Hedgehog signalling, it guides neuron development and connectivity. When KIF7 is missing, brain wiring is disrupted. #Neuroscience
buff.ly/ZHSAeIE
September 22, 2025 at 10:44 AM
Reposted by club CFC
bastinlab.bsky.social
Thank you @jcb.org Cynthia and Yameng for this commentary on our IFT paper!
September 18, 2025 at 12:32 PM
Reposted by club CFC
mariezelena.bsky.social
Our collaboration with @mbonhivers.bsky.social is now out in @plosbiology.org! 🎉Using U-ExM, we mapped the formation of the flagellar pocket collar in T. brucei. Huge thanks to everyone involved — one step closer to #PhDone!

#ExM #oneringtorulethemall #Bilbo1 #trypanosoma #protistsonsky
plosbiology.org PLOS Biology @plosbiology.org · Oct 10
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
A Trypanosoma brucei cell visualized by confocal microscopy after ultrastructure expansion. The cell was immunolabelled for the BILBO1 protein (yellow) and stained with fluorescent NHS-ester (grey). The flagellar pocket is highlighted in pink. Credit: Marie Zelená
October 10, 2025 at 6:47 PM
Reposted by club CFC
bastinlab.bsky.social
Many thanks to all participants to the CFC2025 meeting last week for having made it such a vibrant experience! So much exciting research on #cilia
October 21, 2025 at 11:35 AM
Reposted by club CFC
bastinlab.bsky.social
Special thanks to our keynote lectures for fantastic talks! @micromotility.bsky.social @mick-lab.bsky.social
October 21, 2025 at 11:39 AM
Reposted by club CFC
cilialab.bsky.social
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
October 21, 2025 at 6:11 PM
Reposted by club CFC
cilib.bsky.social
Fresh online: our paper on Glis2 - project started years ago, and it’s finally out! Congratulations and a big thank you to Lena, Gisela, and the whole team!
tinyurl.com/Glis2

#Cilia #nephrology #ciliopathy
#DDR #nephrolab @ajpseditor.bsky.social @uniklinikkoeln.bsky.social @cecad.bsky.social
Detail from the graphical abstract: mouse with deletion of the gene Glis2, Glis2 interaction network and the link to DNA damage. Generated with biorender.com.
July 26, 2025 at 12:32 PM
Reposted by club CFC
embojournal.org
Primary #cilia dysfunction as in Bardet-Biedl syndrome compromises normal adipogenic differentiation in favor of fibrogenic transition, predisposing to obesity
@wachtenlab.bsky.social and collaborators
www.embopress.org/doi/full/10....
September 1, 2025 at 10:43 AM
Reposted by club CFC
naelnadifkasri-lab.bsky.social
New #cilia preprint alert

Our latest manuscript is now live on bioRxiv:
"The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity"

We hope you enjoy reading it!

www.biorxiv.org/content/10.1...
The Neuronal Primary Cilium is a Key Regulator of Homeostatic Plasticity
The capacity of neurons to maintain stable activity levels through homeostatic plasticity is essential for proper brain function. Primary cilia, which are non-motile, antenna-like organelles projectin...
www.biorxiv.org
September 1, 2025 at 10:12 PM
Reposted by club CFC
jcb.org
Spotlight: Yameng Huang and Cynthia He discuss recent advances from Araujo Alves et al. @bastinlab.bsky.social (rupress.org/jcb/article/...), describing how intraflagellar transport trains in T. brucei selectively associate with axonemal doublet #microtubules. rupress.org/jcb/article/...

#Cilia
September 16, 2025 at 4:45 PM
Reposted by club CFC
jcb.org
How do trypanosome IFT trains choose special tracks? Yameng Huang and Cynthia He (National University of Singapore) discuss recent advances from @bastinlab.bsky.social (rupress.org/jcb/article/...), in Spotlight: rupress.org/jcb/article/...

#Biochemistry #Organelles #Cilia #Flagella #Trypanosomes
Intraflagellar transport selectivity occurs within the proximal portion of the trypanosome flagellum
In Trypanosoma brucei, IFT trains selectively associate with specific axonemal microtubules. Using advanced microscopy, Araujo Alves et al. reveal how this
rupress.org
September 23, 2025 at 7:45 PM
Reposted by club CFC
hansenjn.bsky.social
So proud and happy to share that our study on the #proteome, heterogeneity, and cell-type specificity of primary #cilia is published now at Cell 🎉

Big thank you to all the many people that made this possible, at the Lundberg Lab, Human Protein Atlas, Lindstrand lab, and Hsien-Sheu lab.
September 27, 2025 at 5:28 PM
Reposted by club CFC
cilialab.bsky.social
We have something for everyone- CSF flow & #neurodegeneration, ciliary trafficking of PKD2 complexes, cilia & #actin dynamics, #DNADamageResponse & multiciliation, cilia & pituitary development & transcriptional control of ciliogenesis... Great breaking science & rising talent to be showcased...🧪
July 29, 2025 at 10:17 AM
Reposted by club CFC
kattoropova.bsky.social
Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️

➡️ www.nature.com/articles/s41...

Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆
July 29, 2025 at 9:04 AM
Reposted by club CFC
eurocilia.bsky.social
Save the date!
March 2027 on beautiful lake Maggiore right outside #Milan, are you ready for #Cilia2027? 🥳
Stay tuned for more info!
July 29, 2025 at 8:50 AM
Reposted by club CFC
sardeliza.bsky.social
🎉Excited to see my master’s work contributed to this amazing paper! 🎥 🧠

Congrats to all co-authors 👏
Grateful for my time in Dr. Isabelle Caillé & Pr. Alain Trembleau’s lab #IBPS. Isabelle’s passion for science will keep inspiring me ✨

doi.org/10.1126/scia...
GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration
Primary cilium senses mechanical cues to regulate young neuron migration via GPR161 signaling.
doi.org
July 31, 2025 at 4:08 PM
Reposted by club CFC
abberior.rocks
#Trypanosoma, fixed, expanded, and imaged with #STED, stained for tubulin. Scale bar refers to expanded specimen, original structures are 3-3x smaller.
Image courtesy: @mbonhivers.bsky.social, MFP, CNRS, Univ. Bordeaux, France
#fluorescencefriday #ExM #STEDmicroscopy
June 27, 2025 at 9:31 AM
Reposted by club CFC
hkd-l.bsky.social
New interesting paper on MAPKBP1, which sheds new light on its localization and function at #cilia! Many thanks to Ria and Jan for inviting us to participate in this exciting work! Congratulations to all collaborators!
#ciliopathies #kidney #nephronophthisis

www.kireports.org/article/S246...
Structure-Activity Analysis Reveals Perturbed Cilia-Jun N-Terminal Kinase Signaling in MAPKBP1-Associated Kidney Disease
Nephronophthisis (NPH) is a renal ciliopathy characterized by chronic tubulointerstitial fibrosis. Despite discovery of multiple disease genes, mechanisms of NPH-associated kidney degeneration remain ...
www.kireports.org
June 27, 2025 at 9:50 AM