Institutionen för molekylär biovetenskap, Wenner-Gren Institutet (MBW) är en av de största institutionerna vid Naturvetenskapliga fakulteten vid Stockholms universitet med mer än 30 forskargruppe

Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease posing a major global health concern, closely related to the rising prevalence of obesity. Liver fibrosis is the ...

Multimodal data from 347 deeply phenotyped individuals including healthy, prediabetic individuals and individuals with T2D report remotely acquired patterns of glucose control via continuous glucose m...

Four scientists share the emotional toll of pursuing science far from home — and the strategies that help them to protect their mental health.

Adipose tissue browning, the conversion of white adipose tissue (WAT) into brown or beige adipose tissue, offers potential for combating obesity and metabolic disorders. This review delves in to the t...

This study, together with a companion manuscript, shows that in mice, weight loss as a result of GIP receptor antagonism requires and potentiates functional GLP-1 receptor signalling in the brain, exp...

Design of compounds with divergent signaling reveals GRK2-biased β2AR agonists that demonstrate efficacy and safety in preclinical models of metabolic disease and are well tolerated in a phase 1 clini...

The authors describe how reduced dietary availability and systemic loss of cysteine leads to adipose tissue browning and rapid weight loss in mice and humans.

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Nature Metabolism, Published online: 29 April 2025; doi:10.1038/s42255-025-01294-xThis study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, explaining how both GIP receptor agonists and antagonists trigger weight loss through different mechanisms.

Nature Metabolism, Published online: 28 April 2025; doi:10.1038/s42255-025-01289-8Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a key metabolite in central carbon metabolism.

A collection of Protocols and Tutorials covering a range of microscopy approaches, and including the build of microscopy setups and the use of microscopy ...

Nature Reviews Endocrinology, Published online: 14 April 2025; doi:10.1038/s41574-025-01118-8The growing population of older adults with type 1 diabetes mellitus presents unique challenges, including frailty, comorbidities and polypharmacy. A holistic multidisciplinary approach is crucial to address this population’s complex needs, improve care delivery, and ensure their independence and quality of life amid the realities of ageing with this lifelong condition.

Nature Reviews Endocrinology, Published online: 07 March 2025; doi:10.1038/s41574-025-01100-4This Review discusses how levels of glucose, amino acids and lipids influence islet hormone secretion. The authors also discuss how crosstalk between α-cells,…

Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.

The Physiology of Obesity: From Mechanisms to Medicine 2025 is the first in-person Physiology M2M conference which will explore diverse topics in the field of obesity.

Disruptions of circadian rhythms are widespread in modern society and lead to accelerated and worsened symptoms of metabolic syndrome. In healthy m...

This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

Acta Pharmacologica Sinica - Semaglutide ameliorates metabolic disorders in offspring via regulation of oocyte ROS of pre-pregnancy obesity mice

Nature Metabolism, Published online: 03 March 2025; doi:10.1038/s42255-025-01225-wZuhra and Petrosino et al. report evidence that cyanide acts as a regulatory gasotransmitter in mammalian cells, where it is shown to affect cellular bioenergetics, most…

Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...

Tan and Hedbacker report that rapamycin, an mTOR inhibitor, reduces food intake and fat mass in diet-induced obese mice but not in leptin-deficient animals. Increased mTOR activity in POMC neurons cau...