A new paper from the Patrick Hsu and Silvana Konermann labs introduces RESPLICE, a dual CRISPR system that rewrites cellular transcripts by splicing new exons directly onto target mRNAs.

New-tech Rising Star talks #cmbe2025 by Haogang Cai using the Nanoruler for mechanobiology & by Deng Yanxiang on advanced spatial transcriptomics from embryos to brains! @nyulangone.bsky.social @nyutandon.bsky.social @pennpathlabmed.bsky.social @pennepigenetics.bsky.social @pennmedicine.bsky.social

DeepSpaceDB: a spatial transcriptomics atlas for interactive in-depth analysis of tissues and tissue microenvironments https://www.biorxiv.org/content/10.1101/2025.01.05.631419v1

1/10 We are thrilled to share our preprint on spatial transcriptomics in wheat spikes led by the amazing @katielong.bsky.social and Ashleigh Lister. We resolved expression of 200 genes to cellular resolution. Pre-print👉 tinyurl.com/c7t3kncf., @johninnescentre.bsky.social @earlhaminst.bsky.social

We are hiring! Several projects available in mucosal immunology and stem cell transplantation using functional genomics and spatial transcriptomics. Could you please help us spread the word? @ljiresearch.bsky.social

Proud to publish in @CD_AACR: aacrjournals.org/cancerdiscov.... To understand the ecosystems and cancer maps in gastric cancer, we combined spatial transcriptomics and single cell sequencing to reveal distinct intratumoral spatial heterogeneity, immune environments, and genetic drivers

New from Sebastian Jessberger’s group: how the mouse aging brain’s neurogenic region gets “grumpy” (my words) with age. Single-cell RNA sequencing (35,189 cells) and spatial transcriptomics (42,169 spots) deliver a heck of a paper 1/3 🧪🧠

CellSP: Module discovery and visualization for subcellular spatial transcriptomics data https://www.biorxiv.org/content/10.1101/2025.01.12.632553v1

Making space for spatial biology in the clinic
Spatial transcriptomics methods have been slow to move into clinical practice, but spatial proteomics are cheaper and more scalable, and could progress faster go.nature.com/3PoWPkz

This study introduces miTEA-HiRes, a method designed to facilitate the evaluation of miRNA activity at high resolution. The method applies to single cell transcriptomics, type-specific single cell populations, and spatial transcriptomics data.

www.nature.com/articles/s42...

The first Young Investigator selected talk @ the #SLDSummit is pure basic science 😍

Erika Paolini used spatial transcriptomics to map the metabolic zonation of hepatocytes in MASLD, showing that PNPLA3 affects zonation by impairing periportal function

🧫🔬⚗️🧬🧪

@easlnews.bsky.social #liversky

Very impressive paper by the Heeg and Goldrath labs using spatial transcriptomics to define CD8 Trm biology in the intestine in mice and humans. Congrats to @reinacampos.bsky.social and co-authors. #ImmunoSky

This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫