Rui Castro
@ruicastrohd.bsky.social
Associate Professor @FFULisboa & PI @iMedULisboa | Metabolic liver diseases pathophysiology, biomarkers & treatment | Scientific Committee member @EASL
Excited for #EASLCongress 2025! 🤩
As always, starting with the Basic Science Seminar, this year on Liver Tumours, Exposomics and Personalized Therapies, organised by Leila Akkari, @boulterlab.bsky.social and Jesus Bañales
@easlnews.bsky.social
As always, starting with the Basic Science Seminar, this year on Liver Tumours, Exposomics and Personalized Therapies, organised by Leila Akkari, @boulterlab.bsky.social and Jesus Bañales
@easlnews.bsky.social
May 7, 2025 at 6:45 AM
Excited for #EASLCongress 2025! 🤩
As always, starting with the Basic Science Seminar, this year on Liver Tumours, Exposomics and Personalized Therapies, organised by Leila Akkari, @boulterlab.bsky.social and Jesus Bañales
@easlnews.bsky.social
As always, starting with the Basic Science Seminar, this year on Liver Tumours, Exposomics and Personalized Therapies, organised by Leila Akkari, @boulterlab.bsky.social and Jesus Bañales
@easlnews.bsky.social
BS @easlnews.bsky.social Congress
Wed 7🗓️Whole-day seminar plus a wet lab on spatial biology (NEW THIS YEAR‼️)
Thu 8🗓️State of the Art by Lars Zender
Fri 9🗓️MTE sessions on MASLD & MetALD
Sat 10🗓️Microbiome session co-chaired by our own @debbieshawcross.bsky.social
& more!🔗https://tinyurl.com/4ky9r3x9
Wed 7🗓️Whole-day seminar plus a wet lab on spatial biology (NEW THIS YEAR‼️)
Thu 8🗓️State of the Art by Lars Zender
Fri 9🗓️MTE sessions on MASLD & MetALD
Sat 10🗓️Microbiome session co-chaired by our own @debbieshawcross.bsky.social
& more!🔗https://tinyurl.com/4ky9r3x9
April 15, 2025 at 3:55 PM
BS @easlnews.bsky.social Congress
Wed 7🗓️Whole-day seminar plus a wet lab on spatial biology (NEW THIS YEAR‼️)
Thu 8🗓️State of the Art by Lars Zender
Fri 9🗓️MTE sessions on MASLD & MetALD
Sat 10🗓️Microbiome session co-chaired by our own @debbieshawcross.bsky.social
& more!🔗https://tinyurl.com/4ky9r3x9
Wed 7🗓️Whole-day seminar plus a wet lab on spatial biology (NEW THIS YEAR‼️)
Thu 8🗓️State of the Art by Lars Zender
Fri 9🗓️MTE sessions on MASLD & MetALD
Sat 10🗓️Microbiome session co-chaired by our own @debbieshawcross.bsky.social
& more!🔗https://tinyurl.com/4ky9r3x9
2️⃣ translational studies on surpassing therapeutic resistance in liver cancer in press @jhepatology.bsky.social
In CCA, cisplatin-induced INF2 degradation was identified as a mechanism of enhanced cisplatin resistance
👉https://journal-of-hepatology.eu/article/S0168-8278(25)00219-3/fulltext
In CCA, cisplatin-induced INF2 degradation was identified as a mechanism of enhanced cisplatin resistance
👉https://journal-of-hepatology.eu/article/S0168-8278(25)00219-3/fulltext
April 8, 2025 at 10:10 AM
2️⃣ translational studies on surpassing therapeutic resistance in liver cancer in press @jhepatology.bsky.social
In CCA, cisplatin-induced INF2 degradation was identified as a mechanism of enhanced cisplatin resistance
👉https://journal-of-hepatology.eu/article/S0168-8278(25)00219-3/fulltext
In CCA, cisplatin-induced INF2 degradation was identified as a mechanism of enhanced cisplatin resistance
👉https://journal-of-hepatology.eu/article/S0168-8278(25)00219-3/fulltext
📢EASL Studio today!👇
In the week celebrating #IWD2025, Saskia van Mil, Sara Della Torre & Münevver Demir will address mechanisms driving sex disparities in MASLD
Tune in! 📺
🔗https://easl.eu/easl-studio-episode/s8e6/
In the week celebrating #IWD2025, Saskia van Mil, Sara Della Torre & Münevver Demir will address mechanisms driving sex disparities in MASLD
Tune in! 📺
🔗https://easl.eu/easl-studio-episode/s8e6/
March 12, 2025 at 10:10 AM
📢EASL Studio today!👇
In the week celebrating #IWD2025, Saskia van Mil, Sara Della Torre & Münevver Demir will address mechanisms driving sex disparities in MASLD
Tune in! 📺
🔗https://easl.eu/easl-studio-episode/s8e6/
In the week celebrating #IWD2025, Saskia van Mil, Sara Della Torre & Münevver Demir will address mechanisms driving sex disparities in MASLD
Tune in! 📺
🔗https://easl.eu/easl-studio-episode/s8e6/
Great talk by YI E. Torrejón on how gut EV-kupffer cell interaction contributes to MASLD #SLDsummit
HFD gut-EVs carry Selenocysteine Lyase (SCLY) to Kupffer cells, attenuating pro-inflammatory activity. It also activates ZEB2, inhibiting fibrogenesis
@easlnews.bsky.social
HFD gut-EVs carry Selenocysteine Lyase (SCLY) to Kupffer cells, attenuating pro-inflammatory activity. It also activates ZEB2, inhibiting fibrogenesis
@easlnews.bsky.social
January 25, 2025 at 12:08 PM
Great talk by YI E. Torrejón on how gut EV-kupffer cell interaction contributes to MASLD #SLDsummit
HFD gut-EVs carry Selenocysteine Lyase (SCLY) to Kupffer cells, attenuating pro-inflammatory activity. It also activates ZEB2, inhibiting fibrogenesis
@easlnews.bsky.social
HFD gut-EVs carry Selenocysteine Lyase (SCLY) to Kupffer cells, attenuating pro-inflammatory activity. It also activates ZEB2, inhibiting fibrogenesis
@easlnews.bsky.social
Stijn Meijnikman on the role of auto-brewery 🍺🦠 in SLD
The goal for the future is to use personalised medicine to eliminate high-ethanol-producing bacteria (gut microbiota transplantation, phages, antibiotics, pre|probiotics)
@easlnews.bsky.social #SLDsummit @debbieshawcross.bsky.social #Liversky
The goal for the future is to use personalised medicine to eliminate high-ethanol-producing bacteria (gut microbiota transplantation, phages, antibiotics, pre|probiotics)
@easlnews.bsky.social #SLDsummit @debbieshawcross.bsky.social #Liversky
January 25, 2025 at 11:24 AM
Stijn Meijnikman on the role of auto-brewery 🍺🦠 in SLD
The goal for the future is to use personalised medicine to eliminate high-ethanol-producing bacteria (gut microbiota transplantation, phages, antibiotics, pre|probiotics)
@easlnews.bsky.social #SLDsummit @debbieshawcross.bsky.social #Liversky
The goal for the future is to use personalised medicine to eliminate high-ethanol-producing bacteria (gut microbiota transplantation, phages, antibiotics, pre|probiotics)
@easlnews.bsky.social #SLDsummit @debbieshawcross.bsky.social #Liversky
Martinez-Chantar addresses potential mitochondria-targeting therapies in MASLD, focusing on:
🎯 Methylation-controlled J protein (MCJ)
🎯 Glutaminase 1 (GLS1)
🎯 Mg2+ transporter CNNM4
using GalNAc-siRNA conjugates 💉
@easlnews.bsky.social #SLDsummit #Liversky
🎯 Methylation-controlled J protein (MCJ)
🎯 Glutaminase 1 (GLS1)
🎯 Mg2+ transporter CNNM4
using GalNAc-siRNA conjugates 💉
@easlnews.bsky.social #SLDsummit #Liversky
January 25, 2025 at 10:20 AM
Martinez-Chantar addresses potential mitochondria-targeting therapies in MASLD, focusing on:
🎯 Methylation-controlled J protein (MCJ)
🎯 Glutaminase 1 (GLS1)
🎯 Mg2+ transporter CNNM4
using GalNAc-siRNA conjugates 💉
@easlnews.bsky.social #SLDsummit #Liversky
🎯 Methylation-controlled J protein (MCJ)
🎯 Glutaminase 1 (GLS1)
🎯 Mg2+ transporter CNNM4
using GalNAc-siRNA conjugates 💉
@easlnews.bsky.social #SLDsummit #Liversky
🤩🤩🤩 Loved your presentation @dinatiniakos.bsky.social ! Great overview of where liver biopsy and pathology fits within the new MASLD nomenclature; and what the future holds with upcoming innovations! 👏🏼
@EASLnews.bsky.social in #Estoril 🇵🇹 from 2004 1️⃣st #NAFLD Monothematic Conference to 2025 #SLDsummit. Same place, same subject, 21 years apart. Time flies, #liver biopsy🔬remains central for steatohepatitis dx! @myueg.bsky.social @liverpath.bsky.social @aasld-heptoxsig.bsky.social
January 24, 2025 at 6:41 PM
🤩🤩🤩 Loved your presentation @dinatiniakos.bsky.social ! Great overview of where liver biopsy and pathology fits within the new MASLD nomenclature; and what the future holds with upcoming innovations! 👏🏼
@rautoupe.bsky.social provides an update on endothelium-platelet interactions in SLD:
🎯 LSEC capillarisation increases with liver fibrosis in MASLD
🎯 Aspirin improves MASLD
🎯 Likely by inhibiting platelet accumulation and/or platelet EV release
@easlnews.bsky.social #SLDSummit
🎯 LSEC capillarisation increases with liver fibrosis in MASLD
🎯 Aspirin improves MASLD
🎯 Likely by inhibiting platelet accumulation and/or platelet EV release
@easlnews.bsky.social #SLDSummit
January 24, 2025 at 6:36 PM
@rautoupe.bsky.social provides an update on endothelium-platelet interactions in SLD:
🎯 LSEC capillarisation increases with liver fibrosis in MASLD
🎯 Aspirin improves MASLD
🎯 Likely by inhibiting platelet accumulation and/or platelet EV release
@easlnews.bsky.social #SLDSummit
🎯 LSEC capillarisation increases with liver fibrosis in MASLD
🎯 Aspirin improves MASLD
🎯 Likely by inhibiting platelet accumulation and/or platelet EV release
@easlnews.bsky.social #SLDSummit
Reposted by Rui Castro
Happy to join Bluesky.
My main priority will be to contribute building a community of patient-oriented liver lovers.
I also want to post about humanism, creativity, photos….
I was playing this morning to create a logo for the liver community.
Cheers to all.
My main priority will be to contribute building a community of patient-oriented liver lovers.
I also want to post about humanism, creativity, photos….
I was playing this morning to create a logo for the liver community.
Cheers to all.
January 24, 2025 at 6:16 AM
Happy to join Bluesky.
My main priority will be to contribute building a community of patient-oriented liver lovers.
I also want to post about humanism, creativity, photos….
I was playing this morning to create a logo for the liver community.
Cheers to all.
My main priority will be to contribute building a community of patient-oriented liver lovers.
I also want to post about humanism, creativity, photos….
I was playing this morning to create a logo for the liver community.
Cheers to all.
Young Investigator Poster Tour @easlnews.bsky.social #SLDSummit
Huge attendance and interest! 👏🏼
@tom-marjot.bsky.social @madsisraelsen.bsky.social
Huge attendance and interest! 👏🏼
@tom-marjot.bsky.social @madsisraelsen.bsky.social
January 24, 2025 at 1:43 PM
Young Investigator Poster Tour @easlnews.bsky.social #SLDSummit
Huge attendance and interest! 👏🏼
@tom-marjot.bsky.social @madsisraelsen.bsky.social
Huge attendance and interest! 👏🏼
@tom-marjot.bsky.social @madsisraelsen.bsky.social
Alcohol use disorders increase after bariatric surgery. Why?
🎯 Increased consumption, sure, but also:
🎯 Alcohol pharmacokinetics
🎯 Gut hormone secretion changes
Anja Geerts @easlnews.bsky.social #SLDSummit #liversky
🎯 Increased consumption, sure, but also:
🎯 Alcohol pharmacokinetics
🎯 Gut hormone secretion changes
Anja Geerts @easlnews.bsky.social #SLDSummit #liversky
January 24, 2025 at 11:43 AM
Alcohol use disorders increase after bariatric surgery. Why?
🎯 Increased consumption, sure, but also:
🎯 Alcohol pharmacokinetics
🎯 Gut hormone secretion changes
Anja Geerts @easlnews.bsky.social #SLDSummit #liversky
🎯 Increased consumption, sure, but also:
🎯 Alcohol pharmacokinetics
🎯 Gut hormone secretion changes
Anja Geerts @easlnews.bsky.social #SLDSummit #liversky
Reposted by Rui Castro
🎯Lancet Review Series 2024
@thelancet.bsky.social
Natural history and progression of metabolic dysfunction-associated steatotic liver disease
Image: MASLD progression
Read more
www.thelancet.com/journals/lan...
@thelancet.bsky.social
Natural history and progression of metabolic dysfunction-associated steatotic liver disease
Image: MASLD progression
Read more
www.thelancet.com/journals/lan...
December 1, 2024 at 4:00 AM
🎯Lancet Review Series 2024
@thelancet.bsky.social
Natural history and progression of metabolic dysfunction-associated steatotic liver disease
Image: MASLD progression
Read more
www.thelancet.com/journals/lan...
@thelancet.bsky.social
Natural history and progression of metabolic dysfunction-associated steatotic liver disease
Image: MASLD progression
Read more
www.thelancet.com/journals/lan...
The first Young Investigator selected talk @ the #SLDSummit is pure basic science 😍
Erika Paolini used spatial transcriptomics to map the metabolic zonation of hepatocytes in MASLD, showing that PNPLA3 affects zonation by impairing periportal function
🧫🔬⚗️🧬🧪
@easlnews.bsky.social #liversky
Erika Paolini used spatial transcriptomics to map the metabolic zonation of hepatocytes in MASLD, showing that PNPLA3 affects zonation by impairing periportal function
🧫🔬⚗️🧬🧪
@easlnews.bsky.social #liversky
January 24, 2025 at 10:11 AM
The first Young Investigator selected talk @ the #SLDSummit is pure basic science 😍
Erika Paolini used spatial transcriptomics to map the metabolic zonation of hepatocytes in MASLD, showing that PNPLA3 affects zonation by impairing periportal function
🧫🔬⚗️🧬🧪
@easlnews.bsky.social #liversky
Erika Paolini used spatial transcriptomics to map the metabolic zonation of hepatocytes in MASLD, showing that PNPLA3 affects zonation by impairing periportal function
🧫🔬⚗️🧬🧪
@easlnews.bsky.social #liversky
There is still a lot of debate on the fatty liver disease / SLD nomenclature change, almost 2 years after endorsement by the leading Hepatology societies.
Philip Newsome reflects on the importance to keep discussing the reasoning behind this change
@easlnews.bsky.social #SLDSummit #liversky
Philip Newsome reflects on the importance to keep discussing the reasoning behind this change
@easlnews.bsky.social #SLDSummit #liversky
January 24, 2025 at 8:58 AM
There is still a lot of debate on the fatty liver disease / SLD nomenclature change, almost 2 years after endorsement by the leading Hepatology societies.
Philip Newsome reflects on the importance to keep discussing the reasoning behind this change
@easlnews.bsky.social #SLDSummit #liversky
Philip Newsome reflects on the importance to keep discussing the reasoning behind this change
@easlnews.bsky.social #SLDSummit #liversky
@easlnews.bsky.social #SLDSummit kick-off! 🏃🏻♂️➡️⚽️
Introductory session & welcoming by the organisers
Helena Cortez-Pinto, Christophe Moreno, Bart Staels & Gema Martinez
Introductory session & welcoming by the organisers
Helena Cortez-Pinto, Christophe Moreno, Bart Staels & Gema Martinez
January 24, 2025 at 8:43 AM
@easlnews.bsky.social #SLDSummit kick-off! 🏃🏻♂️➡️⚽️
Introductory session & welcoming by the organisers
Helena Cortez-Pinto, Christophe Moreno, Bart Staels & Gema Martinez
Introductory session & welcoming by the organisers
Helena Cortez-Pinto, Christophe Moreno, Bart Staels & Gema Martinez
Reposted by Rui Castro
FIRST BlueSky post
Thrilled to be back at AASLD/EASL masterclass
In just an hour our incredible team combined their different skills/interests into one beautiful team science proposal
GO TEAMMAIT study 🥇
#LiverSky
Thrilled to be back at AASLD/EASL masterclass
In just an hour our incredible team combined their different skills/interests into one beautiful team science proposal
GO TEAMMAIT study 🥇
#LiverSky
December 7, 2024 at 3:20 PM
FIRST BlueSky post
Thrilled to be back at AASLD/EASL masterclass
In just an hour our incredible team combined their different skills/interests into one beautiful team science proposal
GO TEAMMAIT study 🥇
#LiverSky
Thrilled to be back at AASLD/EASL masterclass
In just an hour our incredible team combined their different skills/interests into one beautiful team science proposal
GO TEAMMAIT study 🥇
#LiverSky
EASL|AASLD Masterclass in Savannah, Georgia!
Had so much fun talking about science communication and social media together with Patricia Bloom!
#LiverSky
Had so much fun talking about science communication and social media together with Patricia Bloom!
#LiverSky
December 8, 2024 at 7:25 PM
EASL|AASLD Masterclass in Savannah, Georgia!
Had so much fun talking about science communication and social media together with Patricia Bloom!
#LiverSky
Had so much fun talking about science communication and social media together with Patricia Bloom!
#LiverSky