Rui Castro
@ruicastrohd.bsky.social
Associate Professor @FFULisboa & PI @iMedULisboa | Metabolic liver diseases pathophysiology, biomarkers & treatment | Scientific Committee member @EASL
Leila Akkari herself spoke about the tumour microenvironment in the context of liver cancer evolution, with Serena Vegna delcing deeper into genetic differences affecting the TME
May 7, 2025 at 10:38 AM
Leila Akkari herself spoke about the tumour microenvironment in the context of liver cancer evolution, with Serena Vegna delcing deeper into genetic differences affecting the TME
Excited for #EASLCongress 2025! 🤩
As always, starting with the Basic Science Seminar, this year on Liver Tumours, Exposomics and Personalized Therapies, organised by Leila Akkari, @boulterlab.bsky.social and Jesus Bañales
@easlnews.bsky.social
As always, starting with the Basic Science Seminar, this year on Liver Tumours, Exposomics and Personalized Therapies, organised by Leila Akkari, @boulterlab.bsky.social and Jesus Bañales
@easlnews.bsky.social
May 7, 2025 at 6:45 AM
Excited for #EASLCongress 2025! 🤩
As always, starting with the Basic Science Seminar, this year on Liver Tumours, Exposomics and Personalized Therapies, organised by Leila Akkari, @boulterlab.bsky.social and Jesus Bañales
@easlnews.bsky.social
As always, starting with the Basic Science Seminar, this year on Liver Tumours, Exposomics and Personalized Therapies, organised by Leila Akkari, @boulterlab.bsky.social and Jesus Bañales
@easlnews.bsky.social
BS @easlnews.bsky.social Congress
Wed 7🗓️Whole-day seminar plus a wet lab on spatial biology (NEW THIS YEAR‼️)
Thu 8🗓️State of the Art by Lars Zender
Fri 9🗓️MTE sessions on MASLD & MetALD
Sat 10🗓️Microbiome session co-chaired by our own @debbieshawcross.bsky.social
& more!🔗https://tinyurl.com/4ky9r3x9
Wed 7🗓️Whole-day seminar plus a wet lab on spatial biology (NEW THIS YEAR‼️)
Thu 8🗓️State of the Art by Lars Zender
Fri 9🗓️MTE sessions on MASLD & MetALD
Sat 10🗓️Microbiome session co-chaired by our own @debbieshawcross.bsky.social
& more!🔗https://tinyurl.com/4ky9r3x9
April 15, 2025 at 3:55 PM
BS @easlnews.bsky.social Congress
Wed 7🗓️Whole-day seminar plus a wet lab on spatial biology (NEW THIS YEAR‼️)
Thu 8🗓️State of the Art by Lars Zender
Fri 9🗓️MTE sessions on MASLD & MetALD
Sat 10🗓️Microbiome session co-chaired by our own @debbieshawcross.bsky.social
& more!🔗https://tinyurl.com/4ky9r3x9
Wed 7🗓️Whole-day seminar plus a wet lab on spatial biology (NEW THIS YEAR‼️)
Thu 8🗓️State of the Art by Lars Zender
Fri 9🗓️MTE sessions on MASLD & MetALD
Sat 10🗓️Microbiome session co-chaired by our own @debbieshawcross.bsky.social
& more!🔗https://tinyurl.com/4ky9r3x9
In HCC, eIF3f|ACSL4 was shown to promote tumour malignancy by promoting fatty acid biosynthesis, with its targeting increasing anti-PD-1 efficacy
👉https://www.journal-of-hepatology.eu/article/S0168-8278(25)00206-5/fulltext
@jhepatology.bsky.social
👉https://www.journal-of-hepatology.eu/article/S0168-8278(25)00206-5/fulltext
@jhepatology.bsky.social
April 8, 2025 at 10:11 AM
In HCC, eIF3f|ACSL4 was shown to promote tumour malignancy by promoting fatty acid biosynthesis, with its targeting increasing anti-PD-1 efficacy
👉https://www.journal-of-hepatology.eu/article/S0168-8278(25)00206-5/fulltext
@jhepatology.bsky.social
👉https://www.journal-of-hepatology.eu/article/S0168-8278(25)00206-5/fulltext
@jhepatology.bsky.social
2️⃣ translational studies on surpassing therapeutic resistance in liver cancer in press @jhepatology.bsky.social
In CCA, cisplatin-induced INF2 degradation was identified as a mechanism of enhanced cisplatin resistance
👉https://journal-of-hepatology.eu/article/S0168-8278(25)00219-3/fulltext
In CCA, cisplatin-induced INF2 degradation was identified as a mechanism of enhanced cisplatin resistance
👉https://journal-of-hepatology.eu/article/S0168-8278(25)00219-3/fulltext
April 8, 2025 at 10:10 AM
2️⃣ translational studies on surpassing therapeutic resistance in liver cancer in press @jhepatology.bsky.social
In CCA, cisplatin-induced INF2 degradation was identified as a mechanism of enhanced cisplatin resistance
👉https://journal-of-hepatology.eu/article/S0168-8278(25)00219-3/fulltext
In CCA, cisplatin-induced INF2 degradation was identified as a mechanism of enhanced cisplatin resistance
👉https://journal-of-hepatology.eu/article/S0168-8278(25)00219-3/fulltext
In a related topic, more about MASLD in an amazing Nature Reviews Disease Primers article just published:
🔗 nature.com/articles/s41...
@jvlazarus.bsky.social
🔗 nature.com/articles/s41...
@jvlazarus.bsky.social
March 12, 2025 at 10:14 AM
In a related topic, more about MASLD in an amazing Nature Reviews Disease Primers article just published:
🔗 nature.com/articles/s41...
@jvlazarus.bsky.social
🔗 nature.com/articles/s41...
@jvlazarus.bsky.social
📢EASL Studio today!👇
In the week celebrating #IWD2025, Saskia van Mil, Sara Della Torre & Münevver Demir will address mechanisms driving sex disparities in MASLD
Tune in! 📺
🔗https://easl.eu/easl-studio-episode/s8e6/
In the week celebrating #IWD2025, Saskia van Mil, Sara Della Torre & Münevver Demir will address mechanisms driving sex disparities in MASLD
Tune in! 📺
🔗https://easl.eu/easl-studio-episode/s8e6/
March 12, 2025 at 10:10 AM
📢EASL Studio today!👇
In the week celebrating #IWD2025, Saskia van Mil, Sara Della Torre & Münevver Demir will address mechanisms driving sex disparities in MASLD
Tune in! 📺
🔗https://easl.eu/easl-studio-episode/s8e6/
In the week celebrating #IWD2025, Saskia van Mil, Sara Della Torre & Münevver Demir will address mechanisms driving sex disparities in MASLD
Tune in! 📺
🔗https://easl.eu/easl-studio-episode/s8e6/
& just published in @jhepatology.bsky.social
🧬Mitochondrial CMPK2 is upregulated in human & experimental MASH
📈Ensues disease progression through the Nlrp3 inflammasome & pyroptosis
💉Nordihydroguaiaretic acid is a novel CMPK2 inhibitor supressing MASH
📰 doi.org/10.1016/j.jh...
🧬Mitochondrial CMPK2 is upregulated in human & experimental MASH
📈Ensues disease progression through the Nlrp3 inflammasome & pyroptosis
💉Nordihydroguaiaretic acid is a novel CMPK2 inhibitor supressing MASH
📰 doi.org/10.1016/j.jh...
January 28, 2025 at 9:06 AM
& just published in @jhepatology.bsky.social
🧬Mitochondrial CMPK2 is upregulated in human & experimental MASH
📈Ensues disease progression through the Nlrp3 inflammasome & pyroptosis
💉Nordihydroguaiaretic acid is a novel CMPK2 inhibitor supressing MASH
📰 doi.org/10.1016/j.jh...
🧬Mitochondrial CMPK2 is upregulated in human & experimental MASH
📈Ensues disease progression through the Nlrp3 inflammasome & pyroptosis
💉Nordihydroguaiaretic acid is a novel CMPK2 inhibitor supressing MASH
📰 doi.org/10.1016/j.jh...
Great talk by YI E. Torrejón on how gut EV-kupffer cell interaction contributes to MASLD #SLDsummit
HFD gut-EVs carry Selenocysteine Lyase (SCLY) to Kupffer cells, attenuating pro-inflammatory activity. It also activates ZEB2, inhibiting fibrogenesis
@easlnews.bsky.social
HFD gut-EVs carry Selenocysteine Lyase (SCLY) to Kupffer cells, attenuating pro-inflammatory activity. It also activates ZEB2, inhibiting fibrogenesis
@easlnews.bsky.social
January 25, 2025 at 12:08 PM
Great talk by YI E. Torrejón on how gut EV-kupffer cell interaction contributes to MASLD #SLDsummit
HFD gut-EVs carry Selenocysteine Lyase (SCLY) to Kupffer cells, attenuating pro-inflammatory activity. It also activates ZEB2, inhibiting fibrogenesis
@easlnews.bsky.social
HFD gut-EVs carry Selenocysteine Lyase (SCLY) to Kupffer cells, attenuating pro-inflammatory activity. It also activates ZEB2, inhibiting fibrogenesis
@easlnews.bsky.social
Stijn Meijnikman on the role of auto-brewery 🍺🦠 in SLD
The goal for the future is to use personalised medicine to eliminate high-ethanol-producing bacteria (gut microbiota transplantation, phages, antibiotics, pre|probiotics)
@easlnews.bsky.social #SLDsummit @debbieshawcross.bsky.social #Liversky
The goal for the future is to use personalised medicine to eliminate high-ethanol-producing bacteria (gut microbiota transplantation, phages, antibiotics, pre|probiotics)
@easlnews.bsky.social #SLDsummit @debbieshawcross.bsky.social #Liversky
January 25, 2025 at 11:24 AM
Stijn Meijnikman on the role of auto-brewery 🍺🦠 in SLD
The goal for the future is to use personalised medicine to eliminate high-ethanol-producing bacteria (gut microbiota transplantation, phages, antibiotics, pre|probiotics)
@easlnews.bsky.social #SLDsummit @debbieshawcross.bsky.social #Liversky
The goal for the future is to use personalised medicine to eliminate high-ethanol-producing bacteria (gut microbiota transplantation, phages, antibiotics, pre|probiotics)
@easlnews.bsky.social #SLDsummit @debbieshawcross.bsky.social #Liversky
Martinez-Chantar addresses potential mitochondria-targeting therapies in MASLD, focusing on:
🎯 Methylation-controlled J protein (MCJ)
🎯 Glutaminase 1 (GLS1)
🎯 Mg2+ transporter CNNM4
using GalNAc-siRNA conjugates 💉
@easlnews.bsky.social #SLDsummit #Liversky
🎯 Methylation-controlled J protein (MCJ)
🎯 Glutaminase 1 (GLS1)
🎯 Mg2+ transporter CNNM4
using GalNAc-siRNA conjugates 💉
@easlnews.bsky.social #SLDsummit #Liversky
January 25, 2025 at 10:20 AM
Martinez-Chantar addresses potential mitochondria-targeting therapies in MASLD, focusing on:
🎯 Methylation-controlled J protein (MCJ)
🎯 Glutaminase 1 (GLS1)
🎯 Mg2+ transporter CNNM4
using GalNAc-siRNA conjugates 💉
@easlnews.bsky.social #SLDsummit #Liversky
🎯 Methylation-controlled J protein (MCJ)
🎯 Glutaminase 1 (GLS1)
🎯 Mg2+ transporter CNNM4
using GalNAc-siRNA conjugates 💉
@easlnews.bsky.social #SLDsummit #Liversky
Another great study, this time by Jerôme Eeckhoute: what drives hepatocyte-cholangiocyte transdifferentiation?
🔎 One requirement appears to be relieving epigenetic repression of cholangiocyte genes in hepatocytes ❗️
🔎 One requirement appears to be relieving epigenetic repression of cholangiocyte genes in hepatocytes ❗️
January 25, 2025 at 9:42 AM
Another great study, this time by Jerôme Eeckhoute: what drives hepatocyte-cholangiocyte transdifferentiation?
🔎 One requirement appears to be relieving epigenetic repression of cholangiocyte genes in hepatocytes ❗️
🔎 One requirement appears to be relieving epigenetic repression of cholangiocyte genes in hepatocytes ❗️
@rautoupe.bsky.social provides an update on endothelium-platelet interactions in SLD:
🎯 LSEC capillarisation increases with liver fibrosis in MASLD
🎯 Aspirin improves MASLD
🎯 Likely by inhibiting platelet accumulation and/or platelet EV release
@easlnews.bsky.social #SLDSummit
🎯 LSEC capillarisation increases with liver fibrosis in MASLD
🎯 Aspirin improves MASLD
🎯 Likely by inhibiting platelet accumulation and/or platelet EV release
@easlnews.bsky.social #SLDSummit
January 24, 2025 at 6:36 PM
@rautoupe.bsky.social provides an update on endothelium-platelet interactions in SLD:
🎯 LSEC capillarisation increases with liver fibrosis in MASLD
🎯 Aspirin improves MASLD
🎯 Likely by inhibiting platelet accumulation and/or platelet EV release
@easlnews.bsky.social #SLDSummit
🎯 LSEC capillarisation increases with liver fibrosis in MASLD
🎯 Aspirin improves MASLD
🎯 Likely by inhibiting platelet accumulation and/or platelet EV release
@easlnews.bsky.social #SLDSummit
Young Investigator Poster Tour @easlnews.bsky.social #SLDSummit
Huge attendance and interest! 👏🏼
@tom-marjot.bsky.social @madsisraelsen.bsky.social
Huge attendance and interest! 👏🏼
@tom-marjot.bsky.social @madsisraelsen.bsky.social
January 24, 2025 at 1:43 PM
Young Investigator Poster Tour @easlnews.bsky.social #SLDSummit
Huge attendance and interest! 👏🏼
@tom-marjot.bsky.social @madsisraelsen.bsky.social
Huge attendance and interest! 👏🏼
@tom-marjot.bsky.social @madsisraelsen.bsky.social
Alcohol use disorders increase after bariatric surgery. Why?
🎯 Increased consumption, sure, but also:
🎯 Alcohol pharmacokinetics
🎯 Gut hormone secretion changes
Anja Geerts @easlnews.bsky.social #SLDSummit #liversky
🎯 Increased consumption, sure, but also:
🎯 Alcohol pharmacokinetics
🎯 Gut hormone secretion changes
Anja Geerts @easlnews.bsky.social #SLDSummit #liversky
January 24, 2025 at 11:43 AM
Alcohol use disorders increase after bariatric surgery. Why?
🎯 Increased consumption, sure, but also:
🎯 Alcohol pharmacokinetics
🎯 Gut hormone secretion changes
Anja Geerts @easlnews.bsky.social #SLDSummit #liversky
🎯 Increased consumption, sure, but also:
🎯 Alcohol pharmacokinetics
🎯 Gut hormone secretion changes
Anja Geerts @easlnews.bsky.social #SLDSummit #liversky
The first Young Investigator selected talk @ the #SLDSummit is pure basic science 😍
Erika Paolini used spatial transcriptomics to map the metabolic zonation of hepatocytes in MASLD, showing that PNPLA3 affects zonation by impairing periportal function
🧫🔬⚗️🧬🧪
@easlnews.bsky.social #liversky
Erika Paolini used spatial transcriptomics to map the metabolic zonation of hepatocytes in MASLD, showing that PNPLA3 affects zonation by impairing periportal function
🧫🔬⚗️🧬🧪
@easlnews.bsky.social #liversky
January 24, 2025 at 10:11 AM
The first Young Investigator selected talk @ the #SLDSummit is pure basic science 😍
Erika Paolini used spatial transcriptomics to map the metabolic zonation of hepatocytes in MASLD, showing that PNPLA3 affects zonation by impairing periportal function
🧫🔬⚗️🧬🧪
@easlnews.bsky.social #liversky
Erika Paolini used spatial transcriptomics to map the metabolic zonation of hepatocytes in MASLD, showing that PNPLA3 affects zonation by impairing periportal function
🧫🔬⚗️🧬🧪
@easlnews.bsky.social #liversky
There is still a lot of debate on the fatty liver disease / SLD nomenclature change, almost 2 years after endorsement by the leading Hepatology societies.
Philip Newsome reflects on the importance to keep discussing the reasoning behind this change
@easlnews.bsky.social #SLDSummit #liversky
Philip Newsome reflects on the importance to keep discussing the reasoning behind this change
@easlnews.bsky.social #SLDSummit #liversky
January 24, 2025 at 8:58 AM
There is still a lot of debate on the fatty liver disease / SLD nomenclature change, almost 2 years after endorsement by the leading Hepatology societies.
Philip Newsome reflects on the importance to keep discussing the reasoning behind this change
@easlnews.bsky.social #SLDSummit #liversky
Philip Newsome reflects on the importance to keep discussing the reasoning behind this change
@easlnews.bsky.social #SLDSummit #liversky
@easlnews.bsky.social #SLDSummit kick-off! 🏃🏻♂️➡️⚽️
Introductory session & welcoming by the organisers
Helena Cortez-Pinto, Christophe Moreno, Bart Staels & Gema Martinez
Introductory session & welcoming by the organisers
Helena Cortez-Pinto, Christophe Moreno, Bart Staels & Gema Martinez
January 24, 2025 at 8:43 AM
@easlnews.bsky.social #SLDSummit kick-off! 🏃🏻♂️➡️⚽️
Introductory session & welcoming by the organisers
Helena Cortez-Pinto, Christophe Moreno, Bart Staels & Gema Martinez
Introductory session & welcoming by the organisers
Helena Cortez-Pinto, Christophe Moreno, Bart Staels & Gema Martinez
EASL|AASLD Masterclass in Savannah, Georgia!
Had so much fun talking about science communication and social media together with Patricia Bloom!
#LiverSky
Had so much fun talking about science communication and social media together with Patricia Bloom!
#LiverSky
December 8, 2024 at 7:25 PM
EASL|AASLD Masterclass in Savannah, Georgia!
Had so much fun talking about science communication and social media together with Patricia Bloom!
#LiverSky
Had so much fun talking about science communication and social media together with Patricia Bloom!
#LiverSky