Charlène Boumendil (She/Her)
@charleneboumendil.bsky.social
Group leader @Institute of Human Genetics, chromatin lover, inclusive feminist, mother of three.
Pinned
Biomolecular condensates at the nuclear pore basket maintain global chromatin organization https://www.biorxiv.org/content/10.1101/2025.07.18.665545v1
Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!
Highly recommend!!
My lab is recruiting a post-doc ! please share ! emploi.cnrs.fr/Offres/CDD/U...
November 15, 2025 at 5:22 AM
Highly recommend!!
Very happy to share our technical paper led by our fantastic research assistant, Axelle Donjon, in which we share our image analysis pipeline to study nucleocytoplasmic transport dynamics using LEXY and LINuS (tools from the di Ventura lab). Thread below!
www.jove.com/t/68585/usin...
www.jove.com/t/68585/usin...
Using LEXY and LINuS Optogenetics Tools and Automated Image Analysis to Quantify Nucleocytoplasmic Transport Dynamics in Live Cells
Université de Montpellier, CNRS, UMR9002. This protocol describes how to efficiently set up and perform automated analyses of live cell imaging data obtained from tracking the nucleocytoplasmic trans...
www.jove.com
October 7, 2025 at 6:54 PM
Very happy to share our technical paper led by our fantastic research assistant, Axelle Donjon, in which we share our image analysis pipeline to study nucleocytoplasmic transport dynamics using LEXY and LINuS (tools from the di Ventura lab). Thread below!
www.jove.com/t/68585/usin...
www.jove.com/t/68585/usin...
Reposted by Charlène Boumendil (She/Her)
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Charlène Boumendil (She/Her)
Congrats to my friends in the Boettiger lab for this really beautiful live imaging work. A big leap forward in understanding the dynamic side of genome organization. www.science.org/doi/10.1126/...
Kinetic organization of the genome revealed by ultraresolution multiscale live imaging
Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian c...
www.science.org
September 19, 2025 at 6:20 AM
Congrats to my friends in the Boettiger lab for this really beautiful live imaging work. A big leap forward in understanding the dynamic side of genome organization. www.science.org/doi/10.1126/...
Reposted by Charlène Boumendil (She/Her)
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Computational image analyst (m/f/d)
The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a
jobs.mpi-muenster.mpg.de
September 12, 2025 at 6:17 AM
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Fantastic recognition for seminal work in the phase séparation field. And guess what? Work from the Gohrlich lab focuses on my favourite compartment: The nuclear pore complexes! I told you they are fascinating!
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
September 11, 2025 at 3:16 PM
Fantastic recognition for seminal work in the phase séparation field. And guess what? Work from the Gohrlich lab focuses on my favourite compartment: The nuclear pore complexes! I told you they are fascinating!
I am happy, excited and very humbled to have obtained an ERC starting grant to study the interplay betweeen nuclear pores and chromatin organization! Keep posted for job advertisements and pretty microscopy pictures ;-)
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 2:43 PM
I am happy, excited and very humbled to have obtained an ERC starting grant to study the interplay betweeen nuclear pores and chromatin organization! Keep posted for job advertisements and pretty microscopy pictures ;-)
Reposted by Charlène Boumendil (She/Her)
It is with infinite sadness that we learned of the passing of Clarisse Orniacki.
She joined @vdoye.bsky.social lab and defended her thesis in December 2022 and pursued her career with a postdoc in @tedfon.bsky.social at McGill University in Montreal .
Tribute 🔗 www.ijm.fr/tribute-to-c...
She joined @vdoye.bsky.social lab and defended her thesis in December 2022 and pursued her career with a postdoc in @tedfon.bsky.social at McGill University in Montreal .
Tribute 🔗 www.ijm.fr/tribute-to-c...
August 4, 2025 at 10:28 AM
It is with infinite sadness that we learned of the passing of Clarisse Orniacki.
She joined @vdoye.bsky.social lab and defended her thesis in December 2022 and pursued her career with a postdoc in @tedfon.bsky.social at McGill University in Montreal .
Tribute 🔗 www.ijm.fr/tribute-to-c...
She joined @vdoye.bsky.social lab and defended her thesis in December 2022 and pursued her career with a postdoc in @tedfon.bsky.social at McGill University in Montreal .
Tribute 🔗 www.ijm.fr/tribute-to-c...
Reposted by Charlène Boumendil (She/Her)
The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n)
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
Lamin B1 and LAP2β resist cytoskeletal force to maintain lamin A/C meshwork organization and preserve nuclear integrity | Molecular Biology of the Cell
The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. ...
www.molbiolcell.org
July 21, 2025 at 5:46 PM
The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n)
www.molbiolcell.org/doi/10.1091/...
www.molbiolcell.org/doi/10.1091/...
Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!
Biomolecular condensates at the nuclear pore basket maintain global chromatin organization https://www.biorxiv.org/content/10.1101/2025.07.18.665545v1
July 21, 2025 at 5:52 PM
Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!
DNA methylation and inflammation, what else?
Check out our most recent preprint where we describe Mecp2 as a régulatrice of cGAS-STING associated signaling. 🧪🔥
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling https://www.biorxiv.org/content/10.1101/2025.01.30.635818v1
February 6, 2025 at 6:51 AM
DNA methylation and inflammation, what else?
Reposted by Charlène Boumendil (She/Her)
Academia??? Please!!!
November 29, 2024 at 2:04 PM
Academia??? Please!!!
Reposted by Charlène Boumendil (She/Her)
Kotb, N. M., Ulukaya, G., Chavan, A., Nguyen, S. C., Proskauer, L., Joyce, E., Hasson, D., Jagannathan, M., Rangan, P. (2023). Genome organization regulates nuclear pore complex formation and promotes differentiation during #Drosophila oogenesis. bioRxiv, www.biorxiv.org/content/10.1...
July 10, 2024 at 1:31 PM
Kotb, N. M., Ulukaya, G., Chavan, A., Nguyen, S. C., Proskauer, L., Joyce, E., Hasson, D., Jagannathan, M., Rangan, P. (2023). Genome organization regulates nuclear pore complex formation and promotes differentiation during #Drosophila oogenesis. bioRxiv, www.biorxiv.org/content/10.1...
Reposted by Charlène Boumendil (She/Her)
🚨 New publication! What cellular structure is as intricate as the arms of an octopus? 🐙 The nuclear pore basket - a filamentous structure on the NPC. Edvinas Stankunas and Alwin Köhler reveal the basket's structure and docking mechanisms in Nature Cell Biology ➡️ tinyurl.com/yc69dhx3
August 13, 2024 at 9:06 AM
🚨 New publication! What cellular structure is as intricate as the arms of an octopus? 🐙 The nuclear pore basket - a filamentous structure on the NPC. Edvinas Stankunas and Alwin Köhler reveal the basket's structure and docking mechanisms in Nature Cell Biology ➡️ tinyurl.com/yc69dhx3
Reposted by Charlène Boumendil (She/Her)
Nucleoporin Nup153 docks the splicing machinery to the nuclear pore for efficient mRNA processing https://www.biorxiv.org/content/10.1101/2024.09.30.615666v1
Nucleoporin Nup153 docks the splicing machinery to the nuclear pore for efficient mRNA processing https://www.biorxiv.org/content/10.1101/2024.09.30.615666v1
The nuclear pore complex (NPC), composed of proteins termed nucleoporins (Nups), intercalates the nu
www.biorxiv.org
October 1, 2024 at 12:30 PM
Nucleoporin Nup153 docks the splicing machinery to the nuclear pore for efficient mRNA processing https://www.biorxiv.org/content/10.1101/2024.09.30.615666v1
Reposted by Charlène Boumendil (She/Her)
Did you know that nuclear pore complexes can show up outside the ☢️ ✉️? This study by Jenny Sachweh and her colleagues uncovers that the surrounding cellular milieu determines NPC composition via the nuclear transport system. #teamtomo #NPC #cryoET ❄️🔬
The small GTPase Ran defines Nuclear Pore Complex asymmetry https://www.biorxiv.org/content/10.1101/2024.10.10.617378v1
The small GTPase Ran defines Nuclear Pore Complex asymmetry https://www.biorxiv.org/content/10.1101/2024.10.10.617378v1
Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic excha
www.biorxiv.org
October 13, 2024 at 2:48 PM
Reposted by Charlène Boumendil (She/Her)
Ever wondered if nuclear pore architecture and function changes during germ cell differentiation? In human spermatogenesis it does, and radically!!
Check out our first lab preprint @AliaCSantos et al! www.biorxiv.org/content/10.1...
Check out our first lab preprint @AliaCSantos et al! www.biorxiv.org/content/10.1...
November 1, 2024 at 12:34 PM
Ever wondered if nuclear pore architecture and function changes during germ cell differentiation? In human spermatogenesis it does, and radically!!
Check out our first lab preprint @AliaCSantos et al! www.biorxiv.org/content/10.1...
Check out our first lab preprint @AliaCSantos et al! www.biorxiv.org/content/10.1...
Reposted by Charlène Boumendil (She/Her)
'Here, we report that (S)-ACE-OH, a metabolite of the antipsychotic drug acepromazine, acts as a molecular glue to induce an interaction between the E3 ubiquitin ligase TRIM21 & the nucleoporin NUP98, leading to the degradation of nuclear pore proteins & disruption of nucleocytoplasmic trafficking'
Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders
Discovery of a molecular glue promoting TRIM21 and NUP98 interaction enables the rational
design of TRIM21-based PROTAC degraders for the selective elimination of multimeric
proteins.
www.cell.com
November 2, 2024 at 9:06 PM
'Here, we report that (S)-ACE-OH, a metabolite of the antipsychotic drug acepromazine, acts as a molecular glue to induce an interaction between the E3 ubiquitin ligase TRIM21 & the nucleoporin NUP98, leading to the degradation of nuclear pore proteins & disruption of nucleocytoplasmic trafficking'
Reposted by Charlène Boumendil (She/Her)
www.cell.com/cell/fulltex...
The chromosome folding problem and how cells solve it
Great review by @jobdekker.bsky.social & Leonid Mirny
The chromosome folding problem and how cells solve it
Great review by @jobdekker.bsky.social & Leonid Mirny
The chromosome folding problem and how cells solve it
All cells must fold their chromosomes. The combined action of a small set of conserved
molecular and biophysical mechanisms fold chromosomes in a variety of ways across
the cell cycle and tree of life...
www.cell.com
November 16, 2024 at 2:40 AM
www.cell.com/cell/fulltex...
The chromosome folding problem and how cells solve it
Great review by @jobdekker.bsky.social & Leonid Mirny
The chromosome folding problem and how cells solve it
Great review by @jobdekker.bsky.social & Leonid Mirny
Reposted by Charlène Boumendil (She/Her)
Here is the link to video of introduction course @cdf1530 on biological information. A historical perspective on evolution of representations of the genome, highlighting contributions of von Neumann, Jacob&Monod, Waddington, Alberch etc.
Video (french)+pdf (english):
tinyurl.com/y4k44cd4
Video (french)+pdf (english):
tinyurl.com/y4k44cd4
November 16, 2024 at 9:53 AM
Here is the link to video of introduction course @cdf1530 on biological information. A historical perspective on evolution of representations of the genome, highlighting contributions of von Neumann, Jacob&Monod, Waddington, Alberch etc.
Video (french)+pdf (english):
tinyurl.com/y4k44cd4
Video (french)+pdf (english):
tinyurl.com/y4k44cd4
Fantastic opportunity, highly recommend!
🚨Job offer alert: looking for a friendly and enthusiastic research assistant (IE) to help us understand how enhancer activity is orchestrated during the EMT.🚨
Location: 🌞 Montpellier, France.
Duration: up to 3 years. Apply here: tinyurl.com/3dn86pmz
Retweets appreciated 🙏🏼
Location: 🌞 Montpellier, France.
Duration: up to 3 years. Apply here: tinyurl.com/3dn86pmz
Retweets appreciated 🙏🏼
November 15, 2024 at 11:46 AM
Fantastic opportunity, highly recommend!