Andrew Oldfield
@serialchiper.bsky.social
''Epigenetics'', ''Pioneer factors'', Distal Regulatory Elements and how they affect gene regulation and cell identity
📍IGH,Montpellier,France
Our work: https://www.igh.cnrs.fr/en/research/departments/genome-dynamics/biology-of-distal-regulatory-elements
📍IGH,Montpellier,France
Our work: https://www.igh.cnrs.fr/en/research/departments/genome-dynamics/biology-of-distal-regulatory-elements
Reposted by Andrew Oldfield
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Cadherins modulate the self-organizing potential of pseudo-embryos
Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization.
Mayran et al. uncover that this competence depends on a cadherin switch regulated
by Snai1-driven E-cadhe...
www.cell.com
November 17, 2025 at 10:37 AM
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Reposted by Andrew Oldfield
Pleased to announce launching Institut Cochin Foundation, on Sept. 18 at 6 p.m., upon registration, either in the Rosalind Franklin room, 22 rue Méchain, Paris or via video conference: presentation of @institutcochin.bsky.social, meet researchers and call for donations-thanks for your support!
September 6, 2025 at 6:46 AM
Pleased to announce launching Institut Cochin Foundation, on Sept. 18 at 6 p.m., upon registration, either in the Rosalind Franklin room, 22 rue Méchain, Paris or via video conference: presentation of @institutcochin.bsky.social, meet researchers and call for donations-thanks for your support!
Reposted by Andrew Oldfield
I am happy, excited and very humbled to have obtained an ERC starting grant to study the interplay betweeen nuclear pores and chromatin organization! Keep posted for job advertisements and pretty microscopy pictures ;-)
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 2:43 PM
I am happy, excited and very humbled to have obtained an ERC starting grant to study the interplay betweeen nuclear pores and chromatin organization! Keep posted for job advertisements and pretty microscopy pictures ;-)
Reposted by Andrew Oldfield
“Our findings suggest the existence of tens of thousands of enhancers that remain undiscovered by currently available chromatin data, underscoring the continued need for expanding resources for enhancer discovery.”
Great paper and very important finding - many congrats Axel & team! 👏👏
Great paper and very important finding - many congrats Axel & team! 👏👏
August 8, 2025 at 8:51 PM
“Our findings suggest the existence of tens of thousands of enhancers that remain undiscovered by currently available chromatin data, underscoring the continued need for expanding resources for enhancer discovery.”
Great paper and very important finding - many congrats Axel & team! 👏👏
Great paper and very important finding - many congrats Axel & team! 👏👏
Amazing work by @charleneboumendil.bsky.social and her team addressing the crucial role of nuclear pores in chromatin organization. A highly recommended read!
Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!
Biomolecular condensates at the nuclear pore basket maintain global chromatin organization https://www.biorxiv.org/content/10.1101/2025.07.18.665545v1
July 22, 2025 at 11:12 PM
Amazing work by @charleneboumendil.bsky.social and her team addressing the crucial role of nuclear pores in chromatin organization. A highly recommended read!
Reposted by Andrew Oldfield
OK, this is wild.
In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them.
It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*.
What the HELL?
1/
In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them.
It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*.
What the HELL?
1/
May 12, 2025 at 3:20 PM
OK, this is wild.
In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them.
It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*.
What the HELL?
1/
In September 2023, geophysicists across the world started monitoring a very odd signal coming from the ground under them.
It was picked up in the Arctic. And Antarctica. It was detected everywhere, every 90 seconds, as regular as a metronome, for *nine days*.
What the HELL?
1/
Reposted by Andrew Oldfield
Happy to share our collaborative effort showing a temporal decoupling between morphogenesis and transcription during gastruloids self-organization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Size-dependent temporal decoupling of morphogenesis and transcriptional programs in gastruloids
Understanding the interplay between cell fate specification and morphogenetic changes remains a central challenge in developmental biology. Gastruloids, self-organizing stem cell-based models of post-...
www.biorxiv.org
December 24, 2024 at 3:47 PM
Happy to share our collaborative effort showing a temporal decoupling between morphogenesis and transcription during gastruloids self-organization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Andrew Oldfield
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Redirecting
doi.org
December 2, 2024 at 4:44 PM
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Reposted by Andrew Oldfield
Hi Bluesky! I made a 3D chromatin starter pack.
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ
November 13, 2024 at 5:55 PM
Hi Bluesky! I made a 3D chromatin starter pack.
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ
Let me know if you would like to be added.
go.bsky.app/6tTQdqQ
Reposted by Andrew Oldfield
In this review @gracebower.bsky.social & I discuss recent evidence showing that, unlike canonical enhancers, long-range enhancers located hundreds of kb from their targets rely on additional mechanisms to ensure robust gene activation during mammal development. www.sciencedirect.com/science/arti...
November 22, 2024 at 8:20 PM
In this review @gracebower.bsky.social & I discuss recent evidence showing that, unlike canonical enhancers, long-range enhancers located hundreds of kb from their targets rely on additional mechanisms to ensure robust gene activation during mammal development. www.sciencedirect.com/science/arti...
Reposted by Andrew Oldfield
REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers.
New preprint from a collaboration led by Grace Bower and Evgeny Kvon.
doi.org/10.1101/2024...
New preprint from a collaboration led by Grace Bower and Evgeny Kvon.
doi.org/10.1101/2024...
May 27, 2024 at 4:26 PM
REX - a mammalian "range extender" element that can turn short-distance enhancers into long-distance enhancers.
New preprint from a collaboration led by Grace Bower and Evgeny Kvon.
doi.org/10.1101/2024...
New preprint from a collaboration led by Grace Bower and Evgeny Kvon.
doi.org/10.1101/2024...
Reposted by Andrew Oldfield
Hi all, just to say thanks for all the enthusiasm about the #epigenetics, Chromatin and Gene Regulation starter pack. The interface is a bit unreliable so a few people I added got missed off 😬. If you notice this applies to you, just message me and I'll try again. go.bsky.app/TKp9YAn
November 12, 2024 at 3:56 PM
Hi all, just to say thanks for all the enthusiasm about the #epigenetics, Chromatin and Gene Regulation starter pack. The interface is a bit unreliable so a few people I added got missed off 😬. If you notice this applies to you, just message me and I'll try again. go.bsky.app/TKp9YAn
Reposted by Andrew Oldfield
Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg
November 10, 2024 at 9:43 PM
Putting together packs of transcription and Chromatin people - Nominate others to add! go.bsky.app/5zgpZfg
Just finished hosting @PengyiYang82 and lab members for an amazing week @IGH_MTP filled with learning about scMultiomics, brainstorming and maybe a drink or 3. So proud to see how far we've come since our postdocs in @Jothi_Lab 🍻
July 9, 2024 at 5:08 PM
Just finished hosting @PengyiYang82 and lab members for an amazing week @IGH_MTP filled with learning about scMultiomics, brainstorming and maybe a drink or 3. So proud to see how far we've come since our postdocs in @Jothi_Lab 🍻
🚨Job offer alert: looking for a friendly and enthusiastic research assistant (IE) to help us understand how enhancer activity is orchestrated during the EMT.🚨
Location: 🌞 Montpellier, France.
Duration: up to 3 years. Apply here: tinyurl.com/3dn86pmz
Retweets appreciated 🙏🏼
Location: 🌞 Montpellier, France.
Duration: up to 3 years. Apply here: tinyurl.com/3dn86pmz
Retweets appreciated 🙏🏼
November 21, 2023 at 6:26 PM
🚨Job offer alert: looking for a friendly and enthusiastic research assistant (IE) to help us understand how enhancer activity is orchestrated during the EMT.🚨
Location: 🌞 Montpellier, France.
Duration: up to 3 years. Apply here: tinyurl.com/3dn86pmz
Retweets appreciated 🙏🏼
Location: 🌞 Montpellier, France.
Duration: up to 3 years. Apply here: tinyurl.com/3dn86pmz
Retweets appreciated 🙏🏼