Cassie Clarke
@cassiejclarke.bsky.social
Associate Scientist at CRUK Scotland Institute | Honorary Lecturer University of Glasgow | Cancer Prevention | Immunometabolism | Microenvironment | Metastasis | Women in STEM | Views are my own
Pinned
Super proud to see our work featured on the cover of @emboreports.org today. Many thanks to @pedromics.bsky.social for this beautiful interpretation and depiction of our story. Read the associated paper here: www.embopress.org/doi/full/10....
Reposted by Cassie Clarke
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Cassie Clarke
We are delighted to be offering summer placements in 2026 with #In2research
Learn more about the programme and application process at their information session next week - Monday 15 September
👉Register for the session here: ow.ly/VNg750WP8bf
Learn more about the programme and application process at their information session next week - Monday 15 September
👉Register for the session here: ow.ly/VNg750WP8bf
2025/26 In2research Participant Information Sessions
Are you interested in doing a PhD but aren’t sure how to get there? Then get In2research!
ow.ly
September 9, 2025 at 2:57 PM
We are delighted to be offering summer placements in 2026 with #In2research
Learn more about the programme and application process at their information session next week - Monday 15 September
👉Register for the session here: ow.ly/VNg750WP8bf
Learn more about the programme and application process at their information session next week - Monday 15 September
👉Register for the session here: ow.ly/VNg750WP8bf
Super proud to see our work featured on the cover of @emboreports.org today. Many thanks to @pedromics.bsky.social for this beautiful interpretation and depiction of our story. Read the associated paper here: www.embopress.org/doi/full/10....
September 9, 2025 at 12:03 PM
Super proud to see our work featured on the cover of @emboreports.org today. Many thanks to @pedromics.bsky.social for this beautiful interpretation and depiction of our story. Read the associated paper here: www.embopress.org/doi/full/10....
Reposted by Cassie Clarke
RESEARCH |
@simonsterson.bsky.social @katajistolab.bsky.social et al.
Intestinal stem cells enriched for old mitochondria have enhanced ability to regenerate the epithelial niche 🧪
https://bit.ly/3HwPkb3 ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
@simonsterson.bsky.social @katajistolab.bsky.social et al.
Intestinal stem cells enriched for old mitochondria have enhanced ability to regenerate the epithelial niche 🧪
https://bit.ly/3HwPkb3 ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism
Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.
bit.ly
August 21, 2025 at 4:31 PM
RESEARCH |
@simonsterson.bsky.social @katajistolab.bsky.social et al.
Intestinal stem cells enriched for old mitochondria have enhanced ability to regenerate the epithelial niche 🧪
https://bit.ly/3HwPkb3 ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
@simonsterson.bsky.social @katajistolab.bsky.social et al.
Intestinal stem cells enriched for old mitochondria have enhanced ability to regenerate the epithelial niche 🧪
https://bit.ly/3HwPkb3 ?utm_source=bluesky&utm_medium=social&utm_campaign=natmetab
🧪🧪🧪 To the science feed you go... #neutrophils #metabolism #metastasis #BBCRadioScotland #GoodMorningScotland
It was a pleasure to speak to Lucy Whyte this morning on #BBCRadioScotland to discuss our recent @emboreports.org publication which has discovered how #neutrophil #metabolism facilitates #metastasis. Catch up with interview here: www.youtube.com/watch?v=tUUw...
Dr Cassie Clarke CRUK Scotland Institute - breast cancer research
YouTube video by Fiona MacLeod
www.youtube.com
July 28, 2025 at 3:23 PM
🧪🧪🧪 To the science feed you go... #neutrophils #metabolism #metastasis #BBCRadioScotland #GoodMorningScotland
It was a pleasure to speak to Lucy Whyte this morning on #BBCRadioScotland to discuss our recent @emboreports.org publication which has discovered how #neutrophil #metabolism facilitates #metastasis. Catch up with interview here: www.youtube.com/watch?v=tUUw...
Dr Cassie Clarke CRUK Scotland Institute - breast cancer research
YouTube video by Fiona MacLeod
www.youtube.com
July 28, 2025 at 3:21 PM
It was a pleasure to speak to Lucy Whyte this morning on #BBCRadioScotland to discuss our recent @emboreports.org publication which has discovered how #neutrophil #metabolism facilitates #metastasis. Catch up with interview here: www.youtube.com/watch?v=tUUw...
🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate
in the lung where they inhibit CD8+ T cells, promote fibr...
www.embopress.org
July 23, 2025 at 9:13 PM
🧪To the science feed you go... if you like #neutrophil #metabolism #metastasis #UPP1 #Uracil #fibronectin, then you are in for a treat 👇
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate
in the lung where they inhibit CD8+ T cells, promote fibr...
www.embopress.org
July 23, 2025 at 8:48 PM
Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....
Reposted by Cassie Clarke
- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
July 1, 2025 at 4:46 AM
- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
It was a pleasure to visit @sheffielduni.bsky.social
last week presenting our work "Neutrophil metabolism faciliates metastasis by influencing immune & ECM landscapes" at @mcb-sheffield.bsky.social seminar series.Thanks @erainerolab.bsky.social for the invitation & all who made it a memorable visit
last week presenting our work "Neutrophil metabolism faciliates metastasis by influencing immune & ECM landscapes" at @mcb-sheffield.bsky.social seminar series.Thanks @erainerolab.bsky.social for the invitation & all who made it a memorable visit
June 23, 2025 at 8:49 PM
It was a pleasure to visit @sheffielduni.bsky.social
last week presenting our work "Neutrophil metabolism faciliates metastasis by influencing immune & ECM landscapes" at @mcb-sheffield.bsky.social seminar series.Thanks @erainerolab.bsky.social for the invitation & all who made it a memorable visit
last week presenting our work "Neutrophil metabolism faciliates metastasis by influencing immune & ECM landscapes" at @mcb-sheffield.bsky.social seminar series.Thanks @erainerolab.bsky.social for the invitation & all who made it a memorable visit
Reposted by Cassie Clarke
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Kupffer cell programming by maternal obesity triggers fatty liver disease
Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
rdcu.be
June 18, 2025 at 4:41 PM
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Reposted by Cassie Clarke
Good morning, all. Science keeps making excellent progress. Check the curated summary of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
The boundary to what we can accept is the boundary to our freedom.
Tara Brach
The boundary to what we can accept is the boundary to our freedom.
Tara Brach
a penguin is reading a newspaper while another penguin looks on
ALT: a penguin is reading a newspaper while another penguin looks on
media.tenor.com
June 15, 2025 at 6:30 AM
Good morning, all. Science keeps making excellent progress. Check the curated summary of papers in #cancermetabolism and #mitochondrialbiology here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading
The boundary to what we can accept is the boundary to our freedom.
Tara Brach
The boundary to what we can accept is the boundary to our freedom.
Tara Brach
Reposted by Cassie Clarke
1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
@gounismichalis.bsky.social et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...
June 9, 2025 at 8:25 PM
1/ Beyond thrilled to see my #PhD work now published in @jcb.org
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados
Reposted by Cassie Clarke
@gounismichalis.bsky.social et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...
June 9, 2025 at 4:07 PM
@gounismichalis.bsky.social et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...
Delighted to share the work of @gounismichalis.bsky.social describing how metabolic reprogramming of micrometastatic cells influences EV release to generate invasive microenvironments.Michalis is an immense talent & it really is an honour to share his PhD work & my first senior author paper #ProudPI
@gounismichalis.bsky.social et al. show that cells that seed early lung #metastasis in #BreastCancer have altered #metabolism. These metabolic alterations lead them to release extracellular vesicles which engender a microenvironment conducive to invasive growth. rupress.org/jcb/article/...
June 9, 2025 at 7:16 PM
Delighted to share the work of @gounismichalis.bsky.social describing how metabolic reprogramming of micrometastatic cells influences EV release to generate invasive microenvironments.Michalis is an immense talent & it really is an honour to share his PhD work & my first senior author paper #ProudPI
Reposted by Cassie Clarke
New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...
May 26, 2025 at 10:29 AM
New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...
Reposted by Cassie Clarke
Our newest paper is out in NCB. @jrwconway.bsky.social designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...
May 26, 2025 at 10:13 AM
Our newest paper is out in NCB. @jrwconway.bsky.social designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...
Reposted by Cassie Clarke
Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions
#gdTcells @natmetabolism.nature.com
#gdTcells @natmetabolism.nature.com
Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions - Nature Metabolism
Kao et al. provide insight into the metabolic requirements of IL-17A-producing γδ T cells, offering an actionable target to treat psoriasis by inhibiting fatty acid synthesis.
www.nature.com
May 14, 2025 at 3:00 PM
Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions
#gdTcells @natmetabolism.nature.com
#gdTcells @natmetabolism.nature.com
Reposted by Cassie Clarke
Honored to have been elected with Patrick Caswell @mcrcellmatrix.bsky.social co-chair of the 2029 Gordon Research Conference on Fibronectin, Integrins, and Related Molecules!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
May 12, 2025 at 1:18 PM
Honored to have been elected with Patrick Caswell @mcrcellmatrix.bsky.social co-chair of the 2029 Gordon Research Conference on Fibronectin, Integrins, and Related Molecules!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!
Reposted by Cassie Clarke
Now online! m6A alters ribosome dynamics to initiate mRNA degradation
m6A alters ribosome dynamics to initiate mRNA degradation
m6A is a potent inducer of ribosome stalling and collisions that trigger YTHDF-mediated mRNA degradation, a process that highlights the ribosome as a critical sensor linking translation dynamics to m6A-dependent mRNA metabolism.
dlvr.it
May 5, 2025 at 10:38 PM
Now online! m6A alters ribosome dynamics to initiate mRNA degradation
Reposted by Cassie Clarke
New paper from the lab! Want to know if there is a difference in ribosome collisions between your samples? We show that you can detect this in the rRNA reads in your ribosome profiling data.
academic.oup.com/nargab/artic...
academic.oup.com/nargab/artic...
Detecting ribosome collisions with differential rRNA fragment analysis in ribosome profiling data
Abstract. It has become clear in recent years that ribosomes regularly stall during translation. Such translation impairment has many causes, including exp
academic.oup.com
May 8, 2025 at 11:32 AM
New paper from the lab! Want to know if there is a difference in ribosome collisions between your samples? We show that you can detect this in the rRNA reads in your ribosome profiling data.
academic.oup.com/nargab/artic...
academic.oup.com/nargab/artic...
Reposted by Cassie Clarke
@aseica.bsky.social young members do not miss this amazing conference for early researchers from the @helloeacr.bsky.social
One month left to register for the 2025 Early Career Researchers Conference!
In its fifth edition, this virtual conference has become a must-attend for early career researchers to discuss critical aspects of a scientific career in cancer research.
Don't miss it: eacr.org/conference/e...
In its fifth edition, this virtual conference has become a must-attend for early career researchers to discuss critical aspects of a scientific career in cancer research.
Don't miss it: eacr.org/conference/e...
May 10, 2025 at 7:03 AM
@aseica.bsky.social young members do not miss this amazing conference for early researchers from the @helloeacr.bsky.social
Reposted by Cassie Clarke
Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
Adhesion-derived condensates control component availability to regulate adhesion dynamics
Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...
www.biorxiv.org
May 9, 2025 at 2:23 PM
Happy to share our Tensin 1 phase separation project is now on bioRxiv.
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
www.biorxiv.org/content/10.1...
This wouldn't be possible without
@johannaivaska.bsky.social
@ivaskalab.bsky.social
#VattulainenLab
#MSCA by @ec.europa.eu
@turkubioscience.bsky.social
@inflames-flagship.bsky.social
Reposted by Cassie Clarke
New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics!
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Adhesion-derived condensates control component availability to regulate adhesion dynamics
Integrin adhesion complexes mediate cell-extracellular matrix (ECM) interactions and undergo dynamic remodelling to regulate cell adhesion and migration. Here, we demonstrate that tensin 1 (TNS1), a m...
www.biorxiv.org
May 10, 2025 at 7:37 AM
New preprint alert!📣 @midibu.bsky.social and team take a deep dive into Tensin1 liquid-liquid phase separation (LLPS) and the mechanisms of how it regulates adhesion dynamics!
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Check out the preprint here: www.biorxiv.org/content/10.1...
@johannaivaska.bsky.social
Reposted by Cassie Clarke
Not long after I started my lab, a prominent scientist told me it was “impossible” to be a successful PI and a mother
Don’t ever let the naysayers tell you it can’t be done - of course it can!
#HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰
Don’t ever let the naysayers tell you it can’t be done - of course it can!
#HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰
May 9, 2025 at 6:23 PM
Not long after I started my lab, a prominent scientist told me it was “impossible” to be a successful PI and a mother
Don’t ever let the naysayers tell you it can’t be done - of course it can!
#HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰
Don’t ever let the naysayers tell you it can’t be done - of course it can!
#HappyMothersDay this weekend to all the amazing scientist mamas raising their wonderful kids 🥰