Nature Reviews Nephrology, Published online: 26 November 2025; doi:10.1038/s41581-025-01037-xEffective kidney-targeted therapeutics require careful consideration of both the cargo and carrier. In the past year, considerable progress has been made in the development of viral and non-viral delivery vehicles, by leveraging endogenous biological mechanisms, screening across multiple species and administration routes, and artificial intelligence to drive kidney selectivity.

Nature Reviews Nephrology, Published online: 25 November 2025; doi:10.1038/s41581-025-01025-1Cell–cell crosstalk is essential for the maintenance of organ and whole-body homeostasis. This Review summarizes current understanding of cell–cell crosstalk in the kidney in health and disease and describes how intercellular crosstalk shapes cell states and tissue organization to influence kidney homeostasis, injury responses and disease progression.

In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidne...

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This article is published as part of a supplement sponsored by Kidney Disease: Improving Global Outcomes (KDIGO). The opinions or views expressed in this supplement are those of the authors and do not...

In patients with refractory systemic lupus erythematosus, in vivo generation of CD19 CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease activity, and no major toxi...