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vou te estalar o coco
@bsoyuz.com
250 followers 260 following 690 posts
Esta turminha do barulho vai aprontar altas confusões no BlueSky
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vou te estalar o coco @bsoyuz.com · Nov 12
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djinnandtonic.bsky.social
"operation twink annihilation is a go, on your orders, sir"
Obama, Clinton, Biden, and many others, watching something on screen in the Situation Room
December 30, 2025 at 10:27 PM
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seantcollins.com
"Financially devastating but morally exhilarating" is a state of grace our enemies will never know
December 30, 2025 at 5:32 AM
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bodinholoiro.bsky.social
Michael Jackson encontrado no
fimose.scares.men Fimose no terreiro do Roblox @fimose.scares.men · 11h
terreiro de umbanda do roblox
December 30, 2025 at 1:51 PM
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adngui.bsky.social
Os negócio que a @moara.bsky.social lê é assim
December 30, 2025 at 3:55 AM
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irhottakes.bsky.social
Morality in Mass Effect is basically “do you want to have less content with worse outcomes, Y/N?”
sharonk.bsky.social Sharon @sharonk.bsky.social · 1d
I don't know why i always end up playing the Paragon/good side in RPGs, even though I sometimes plan to do the darker/bad choices

it happens every time.
December 29, 2025 at 5:51 PM
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valkyrie.hacker.gf
OpenAI has been openly chasing regulatory capture for years; even back in 2023 Altman was going around talking about requiring licensing if you use too many FLOPS to calculate something - absolute fucking sicko shit
aparker.io austin @aparker.io · 1d
one thing that drives me crazy about this whole thing is that OpenAI would love nothing _more_ than “regulations”. Regulatory capture is a thing!
December 29, 2025 at 5:34 PM
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noterika.bsky.social
Arthur Conan Doyle foi o primeiro a acontecer isso
December 29, 2025 at 2:34 PM
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pamesuaminica.bsky.social
Passaram aqui no site dizendo que só estamos reclamando do calor intenso pq chegou no sudeste sendo que norte e nordeste é assim o ano inteiro e ninguém fala nada

Pô eu não falo nada pq eu não tô lá né quem tá lá fala sim, minha amiga tá lá e ela fala "está muito calor" quando está muito calor
December 28, 2025 at 6:20 PM
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sailorrooscout.bsky.social
In preclinical models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers (in HUMAN models as well).
• case.edu/news/new-stu...

The study has been published in Cell. YES, it is PEER-REVIEWED.
• www.cell.com/cell-reports...

🧪🧵⬇️
Highlights •Severity of Alzheimer's disease (AD) correlates with NAD+ homeostasis dysregulation •Preserving brain NAD+ homeostasis prevents AD in mice • Restoring brain NAD+ homeostasis reverses advanced AD in mice • Multiomics across human and mouse AD brain identifies nodes for human AD reversal Summary Alzheimer's has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain's energy supply help drive the disease-and restoring that balance can reverse damage, even in advanced cases. In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer's biomarkers. The results offer fresh hope that recovery may be possible. Abstract Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care. Graphical Abstract (CREDIT: Cell Reports Medicine)
December 28, 2025 at 5:03 PM
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pedrofonseca.bsky.social
December 28, 2025 at 6:58 PM
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ouricodecarto.la
Na verdade não existe problema de lixo radioativo: ele pode e é reciclado na França.

Lixo radioativo so é um "problema" nos EUA, onde a reciclagem é proibida.
durolocus.bsky.social Vampetaço Climático @durolocus.bsky.social · 2d
o problema da nuclear na prática se limita a o que fazer com o lixo radioativo. É algo bem ruim mas me parece bem melhor e mais seguro que FUCKING TERMOELÉTRICAS E PETROLIFERAS
December 28, 2025 at 9:57 PM
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nome.bsky.social
We didn't survive and thrive as a species because we had warriors or hunters - pretty much every omnivore can manage that.

We did so because we developed Grandmothers, and domesticated Dogs.

Community is what defines us as a species, and every "self-reliant" libertarian shitweasel be damned.
taliabhatt.itch.io Talia "Brown/Trans/Les" Bhatt ♀︎♀︎ @taliabhatt.itch.io · Nov 14
"my least woke opinion is---"

That's enough. We've had enough people indulging in the "thrill of a little conservatism", as a treat. Of considering reactionary thought to be a salacious and taboo in a world descending into reactionary mania.

Give me your MOST woke opinions. We're bringing it back.
December 28, 2025 at 5:00 AM
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novomondo.bsky.social
December 27, 2025 at 11:42 PM
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lewownardo1.bsky.social
December 28, 2025 at 1:53 AM
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silvoca.bsky.social
caralho eu odeio gringo
Post do reddit que diz "I shower at night, my husband showers in the morning. The results are in..." e uma foto de dois travesseiros, um muito encardido e outro levemente sujo.
December 28, 2025 at 1:22 AM
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regimecpa.bsky.social
Logging onto this app is like logging into a parallel universe, the universe where everyone reads the news
December 28, 2025 at 12:19 AM
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boxelderdust.bsky.social
BlueAnon is better known simply as “reality”
droddman.bsky.social Dr Oddman - Fighting Fascism @droddman.bsky.social · 3d
Russia, Russia, Russia and Epstein behind
December 27, 2025 at 11:33 AM
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snufkinlib.bsky.social
December 27, 2025 at 11:25 PM
bsoyuz.com
post a perfect album from the 90s that isn't nirvana, pearl jam, soundgarden, or alice in chains
Aqua by Asia (1992) This album cover features a surreal painting set in space. The focus is a creature that combines the body of a dolphin with bat-like wings, soaring through the stars. It flies above a massive space station in the bottom left corner, while a large, ringed planet floats in the background to the right. At the very top, the band's name, "ASIA," and the album title, "AQUA," are displayed in their signature metallic, pyramid-style lettering.
December 27, 2025 at 11:24 PM
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opinionhaver.bsky.social
Mutual aid thing great example of the stancil discourse cycle:

-he takes strong position on complex issue with grey areas

-a few nuanced critiques are made

-drowned out by hundreds of insane people arguing with imaginary version of him

-shifts to different argument between him and inane people
December 27, 2025 at 9:56 PM
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segyges.bsky.social
If you want a picture of the future, imagine a man accidentally kicking himself in the balls with a robot he is controlling—forever.
jjvincent.bsky.social James Vincent @jjvincent.bsky.social · 3d
another robot highlight for 2025: man wearing humanoid mocap suit kicks himself in the balls
December 27, 2025 at 7:01 PM
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emoviolencedagama.bsky.social
Rápido, entre no cornomóvel
December 27, 2025 at 4:49 PM
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arthurtaytsohn.gamelodge.com.br
'primeiro gay nordestino a tomar café da manhã' com o ex-presidente Jair Bolsonaro seguiu você
pedradaloucura.bsky.social ceo da theystar gayco @pedradaloucura.bsky.social · 3d
Cearense foragido por atos golpistas do 8 de janeiro é rastreado na Colômbia e planeja fuga para os EUA

Apontado como um dos líderes, Scott Hunter, de 34 anos, se apresenta como 'primeiro gay nordestino a tomar café da manhã' com o ex-presidente Jair Bolsonaro.
December 27, 2025 at 3:26 PM
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fannvevo.bsky.social
Zambelli streifando com 500 de Ping pra ver se as detenta não estão esperando pra lhe dar um sacode seguiu você
December 26, 2025 at 9:58 PM
bsoyuz.com
ALBERT CAMUS.
AGORA EU ENTENDO PORQUE VOCÊ ATIROU NAQUELE CARA.

TÁ QUENTE PRA CARALHO E O BOGA TÁ SUADO.
EU REALMENTE DARIA QUATRO PAPOCOS NUMA SITUAÇÃO DESSA.
rushsanches.bsky.social Rodrigo Sanches @rushsanches.bsky.social · 4d
VAI SE FUDEEEEEEEEEEEEEEEERR
December 27, 2025 at 5:51 AM