Bruno Castro
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Bruno Castro
@brunommcastro.bsky.social
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Senior Editor @NatureMaterials. Views are my own.
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Reposted by Bruno Castro
natmater.nature.com
Our last issue of 2025 issue is online!

Featuring a Focus on scalable quantum photonics and articles on qubit quantum sensors, 2D polyamide for anode-free batteries, plasmonic printing of metal electronics, hermetic stretchable seals and more. See it below!👇

go.nature.com/48mFlP0
Nature Materials - Quantum photonics on a chip
Photonic technologies enable on-chip, scalable solutions for applications in quantum communications, quantum sensing and quantum computing.See Wang et al.
go.nature.com
November 28, 2025 at 2:02 PM
Reposted by Bruno Castro
deniswirtz.bsky.social
We have observed a beautifully strange phenomenon of phase separation by human monocytes placed on soft matrix, which do it for survival.

We model it by incorporating the Cahn–Hilliard equation with a Turing mechanism of local activation/global inhibition

More here: www.nature.com/articles/s41...
Mechano-induced patterned domain formation by monocytes - Nature Materials
Human primary monocytes reversibly phase separate into regular, multicellular, multilayered domains on soft matrices with physiological stiffness due to local activation and global inhibition processe...
www.nature.com
November 5, 2025 at 12:41 PM
Reposted by Bruno Castro
natmater.nature.com
Mechano-induced patterns of monocytes.

go.nature.com/4hKDwPY
Mechano-induced patterned domain formation by monocytes - Nature Materials
Human primary monocytes reversibly phase separate into regular, multicellular, multilayered domains on soft matrices with physiological stiffness due to local activation and global inhibition processe...
go.nature.com
November 7, 2025 at 9:03 AM
Reposted by Bruno Castro
natmater.nature.com
IL-12-releasing nanoparticles for ovarian cancer immunotherapy.

go.nature.com/4oOPNVR
IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer - Nature Materials
Polymer-coated liposomes specifically target and deliver interleukin-12 to metastatic ovarian cancer, strongly sensitizing the tumours to combination therapy with immune checkpoint inhibitors.
go.nature.com
November 5, 2025 at 10:13 AM
Reposted by Bruno Castro
natmater.nature.com
Ultrasound mechanogenetics for CAR T therapy.

go.nature.com/43Tvpeb
Tumour priming by ultrasound mechanogenetics for CAR T therapy - Nature Materials
A focused-ultrasound-mediated mechanogenetics approach enables the genetic modification of cancer cells near solid tumours to activate chimeric antigen receptor T cell response and achieve tumour supp...
go.nature.com
November 4, 2025 at 2:28 PM
Reposted by Bruno Castro
natmater.nature.com
Our November 2025 issue is online!
Featuring a Focus on PEG alternatives for RNA therapeutics and pieces on halide electrolytes for all-solid-state batteries, reprogrammable morphogenesis in free-standing 3D structures and more. Read it below.👇

go.nature.com/3WE9ALM
November 3, 2025 at 10:09 AM
Reposted by Bruno Castro
labwaggoner.bsky.social
IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer @natmater.nature.com
www.nature.com/articles/s41...
October 31, 2025 at 8:59 PM
Reposted by Bruno Castro
katemiro.bsky.social
Amazing to have our work finally out!!! 😍🤩😍
September 29, 2025 at 6:38 PM
Reposted by Bruno Castro
felixmendu.bsky.social
Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio
September 29, 2025 at 6:12 PM
Reposted by Bruno Castro
natmater.nature.com
Join the team!

We’re seeking for an Associate or Senior Editor with a research background in the fields of energy materials or catalysis. Deadline: October the 13th.

Apply here 👇
springernature.wd3.myworkdayjobs.com/en-US/Spring...

@natureportfolio.nature.com
Associate or Senior Editor, Nature Materials
Title: Associate or Senior Editor, Nature Materials Organization: Nature Portfolio Locations: New York, Jersey City, Shanghai or Beijing Application Deadline: October 13th, 2025 About Springer Nature ...
springernature.wd3.myworkdayjobs.com
September 22, 2025 at 2:47 PM
Reposted by Bruno Castro
henriqueslab.bsky.social
🚨Join us! We're soon opening 3 postdoctoral positions in #AIDrivenBiology. Seeking biologists (especially microbiology and infection biology), computer scientists, and microscopy developers. Ideal candidates are those eager to use or develop next-gen tech for cell biology. Get in touch (DM/email)
July 10, 2025 at 8:34 AM
Reposted by Bruno Castro
magdalenaskipper.bsky.social
The phase II clinical trial in China tested CAR T cells in people with advanced gastric cancer or gastro-oesophageal junction cancer - one of the first times this therapy has worked against solid tumours

🧪 #MedSky

www.nature.com/articles/d41...
Cancer-fighting CAR T cells show promising results for hard-to-treat tumours
Trial in China is one of the first times the immune therapy has worked against solid tumours.
www.nature.com
June 3, 2025 at 6:05 AM
Reposted by Bruno Castro
magdalenaskipper.bsky.social
A single dose of commercial CAR-T therapy costs around $500,000.

So a great deal of work is going into in vivo treatments - engineering T cells inside the body- that might cost an order of magnitude less.

Fascinating!
🧪
@nature.com

www.nature.com/articles/d41...
Cancer-fighting immune cells could soon be engineered inside our bodies
Manufacturing CAR T cells in the laboratory is expensive and time-consuming. An in vivo approach could get the powerful therapy to more people.
www.nature.com
May 28, 2025 at 1:01 AM
Reposted by Bruno Castro
natbiotech.nature.com
Organoid avatars of colorectal cancer and its microenvironment model immune interactions and drug efficacy go.nature.com/3LblcjH
rdcu.be/em3Z8
Patient-derived mini-colons enable long-term modeling of tumor–microenvironment complexity - Nature Biotechnology
Organoid avatars of colorectal cancer and its microenvironment model immune interactions and drug efficacy.
go.nature.com
May 28, 2025 at 1:18 AM
Reposted by Bruno Castro
natrevbioeng.nature.com
Registration and abstract submission for our Nature Conference 'Engineered models of human disease' are now open! Take advantage of early-bird rates and send us an abstract!
Register here: go.nature.com/41isWrM

#AcademicSky #organonchips #TissueEngineering #WomenInSTEM
April 9, 2025 at 5:54 AM
Reposted by Bruno Castro
eliasbarrigalab.bsky.social
REPOSTING this here just to officially leave "the other place"

Our work on the role of endogenous electric fields in guiding collective cell migration during #morphogenesis is out @naturematerials.bsky.social
nature.com/articles/s41...
Stretch-induced endogenous electric fields drive directed collective cell migration in vivo - Nature Materials
Electric fields guide collective cell migration in developing embryos of Xenopus laevis via a voltage-sensitive phosphatase.
nature.com
April 7, 2025 at 9:46 AM
Reposted by Bruno Castro
jcb.org
In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...
March 21, 2025 at 4:18 PM
Reposted by Bruno Castro
natrevbioeng.nature.com
The agenda for our Nature Conference 'Engineered models of human disease' is taking shape 😍 We have sessions on organoids, microphysiological systems, disease-specific models, women's health, computational approaches and the immune system!
Check it out: go.nature.com/3R4ueSk
Engineered Models of Human Disease
SAVE THE DATE!Join biologists, bioengineers, clinical researchers, and industry professionals in Belgrade on 28-29 October for a cutting-edge conference focused on the design of human-relevant disease...
go.nature.com
March 12, 2025 at 12:37 PM
Reposted by Bruno Castro
sarawickstrom.bsky.social
Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...
Measuring and manipulating mechanical forces during development - Nature Cell Biology
This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...
www.nature.com
March 10, 2025 at 1:33 PM
Reposted by Bruno Castro
magdalenaskipper.bsky.social
Great minds… within 24 hrs both us at @nature.com and @science.org make similar appeals to the research community. And @holdenthorp.bsky.social and I didn’t even exchange notes about it ;-)
🧪

www.nature.com/articles/d41...

www.science.org/doi/10.1126/...
Come together, right now
The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...
www.science.org
February 25, 2025 at 7:51 PM
Reposted by Bruno Castro
yizhoudonglab.bsky.social
Blood–brain-barrier-crossing lipid nanoparticles (BLNPs). Wonderful academia and industry collaborations @IcahnMountSinai @Biogen @OhioState! Thanks @NIGMS & @NIDA! Thanks @Nature Materials editor and reviewers!
February 18, 2025 at 8:17 PM
Reposted by Bruno Castro
magdalenaskipper.bsky.social
The ruling temporarily halts a policy slashing research overhead costs in 22 states, which filed a lawsuit against the biomedical agency.

🧪 #AcademicSky
@nature.com

www.nature.com/articles/d41...
‘Devastating’ cuts to NIH grants by Trump’s team put on hold by US judge
The ruling temporarily halts a policy slashing research overhead costs in 22 states, which filed a lawsuit against the biomedical agency.
www.nature.com
February 11, 2025 at 11:35 AM
Reposted by Bruno Castro
magdalenaskipper.bsky.social
Scientists globally are engaging in a mass-archiving effort in response to the US CDC removing some of its web pages. The aim is to save vital health databases taken down in response to the executive orders issued by President Trump 🧪

www.nature.com/articles/d41...
Scientists globally are racing to save vital health databases taken down amid Trump chaos
The mass-archiving effort is in response to the US Centers for Disease Control and Prevention removing some of its web pages.
www.nature.com
February 7, 2025 at 2:29 PM
Reposted by Bruno Castro
philipcball.bsky.social
I have run out of patience with the apparent silence of most US science institutions (and not just US) in the face of Trump & Musk's rampage. There are of so many facets of that, but in this column for @chemistryworld.com I talk about the assaults on inclusion.
www.chemistryworld.com/opinion/scie...
Scientific institutions have a long history of anticipatory obedience
Societies should learn from this and speak up to support inclusion
www.chemistryworld.com
February 7, 2025 at 3:02 PM
Reposted by Bruno Castro
magdalenaskipper.bsky.social
Diseases, especially infectious diseases, do not respect borders. If countries genuinely want & value an organization that champions health for all, they must all step up to support WHO

(Our editorial this week)
#MedSky
@nature.com
@who.int
www.nature.com/articles/d41...
How the World Health Organization can thrive without the United States
If the 193 remaining member nations want the WHO to succeed, they must find a way to pay for it.
www.nature.com
February 4, 2025 at 9:34 PM