Yizhou Dong lab
@yizhoudonglab.bsky.social
Donglab.net
Our research is devoted to drug discovery and delivery for the treatment of genetic disorders, infectious diseases and cancers.
Our research is devoted to drug discovery and delivery for the treatment of genetic disorders, infectious diseases and cancers.
Reposted by Yizhou Dong lab
Paper out now in @natbiotech.nature.com by @yizhoudonglab.bsky.social describing new LNP mRNAs for combatting bacterial infections… helping the immune system clear the pathogens while limiting tissue damage…
#NatMicroPicks
Peptibody mRNA therapy for AMR infections! 💉🧬
mRNA-delivered peptibody AMPs eradicate MDR pneumonia and outperform FDA-approved antibiotics while reducing inflammation
#SynBio #MicroSky 🦠 @natbiotech.nature.com
www.nature.com/articles/s41...
Peptibody mRNA therapy for AMR infections! 💉🧬
mRNA-delivered peptibody AMPs eradicate MDR pneumonia and outperform FDA-approved antibiotics while reducing inflammation
#SynBio #MicroSky 🦠 @natbiotech.nature.com
www.nature.com/articles/s41...
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia - Nature Biotechnology
Antimicrobial peptides delivered to mouse lung as mRNA peptibodies eradicate multidrug-resistant pneumonia.
www.nature.com
November 30, 2025 at 11:04 PM
Paper out now in @natbiotech.nature.com by @yizhoudonglab.bsky.social describing new LNP mRNAs for combatting bacterial infections… helping the immune system clear the pathogens while limiting tissue damage…
Congratulations to Yonger Xue & Xucheng Hou for leading the wonderful work on peptibody mRNA! Thanks @miriammerad.bsky.social for the huge support! Thanks Rong Li @natbiotech.nature.com and reviewers for the amazing review process! Thanks @NIH @IcahnMountSinai!
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia - @yizhoudonglab.bsky.social @icahngenomics.bsky.social go.nature.com/3LZS6HD
Antimicrobial peptide delivery to lung as peptibody mRNA in anti-inflammatory lipids treats multidrug-resistant bacterial pneumonia - Nature Biotechnology
Antimicrobial peptides delivered to mouse lung as mRNA peptibodies eradicate multidrug-resistant pneumonia.
go.nature.com
November 26, 2025 at 7:21 PM
Congratulations to Yonger Xue & Xucheng Hou for leading the wonderful work on peptibody mRNA! Thanks @miriammerad.bsky.social for the huge support! Thanks Rong Li @natbiotech.nature.com and reviewers for the amazing review process! Thanks @NIH @IcahnMountSinai!
Chemical strategies for brain delivery of genomic therapy, a very nice Perspective with @ericjnestler.bsky.social! Congratulations to Haoyuan, Changyue, and Tami! Thanks Nature Reviews Chemistry! Thanks NIH& @mountsinainyc.bsky.social!
www.nature.com/articles/s41...
rdcu.be/eRKLA
www.nature.com/articles/s41...
rdcu.be/eRKLA
Chemical strategies for brain delivery of genomic therapy - Nature Reviews Chemistry
Genomic therapy offers a promising strategy for addressing central nervous system disorders. This Review highlights recent advances in chemical strategies and delivery platforms, such as lipid nanopar...
www.nature.com
November 25, 2025 at 7:26 PM
Chemical strategies for brain delivery of genomic therapy, a very nice Perspective with @ericjnestler.bsky.social! Congratulations to Haoyuan, Changyue, and Tami! Thanks Nature Reviews Chemistry! Thanks NIH& @mountsinainyc.bsky.social!
www.nature.com/articles/s41...
rdcu.be/eRKLA
www.nature.com/articles/s41...
rdcu.be/eRKLA
Reposted by Yizhou Dong lab
NOT TO MISS! In @mountsinainyc.bsky.social's 2025 issue of Science & Medicine magazine, Dean @ericjnestler.bsky.social discusses his vision for Icahn Mount Sinai, and how his distinguished academic career & research expertise have prepared him. 👉 scienceandmedicine.mountsinai.org/article/2025...
November 25, 2025 at 2:58 PM
NOT TO MISS! In @mountsinainyc.bsky.social's 2025 issue of Science & Medicine magazine, Dean @ericjnestler.bsky.social discusses his vision for Icahn Mount Sinai, and how his distinguished academic career & research expertise have prepared him. 👉 scienceandmedicine.mountsinai.org/article/2025...
Reposted by Yizhou Dong lab
Comment of the day on the petition calling for a funding institute to elevate biomedical research across New York State! Sign & share!
November 25, 2025 at 4:09 PM
Comment of the day on the petition calling for a funding institute to elevate biomedical research across New York State! Sign & share!
Reposted by Yizhou Dong lab
The 2025 issue of @mountsinainyc.bsky.social's Science & Medicine magazine is now live! At this pivotal moment for health care, Mount Sinai fearlessly embraces its leadership role in medical education, scientific research & patient-centered clinical care. READ👉 scienceandmedicine.mountsinai.org/2025
November 24, 2025 at 7:17 PM
The 2025 issue of @mountsinainyc.bsky.social's Science & Medicine magazine is now live! At this pivotal moment for health care, Mount Sinai fearlessly embraces its leadership role in medical education, scientific research & patient-centered clinical care. READ👉 scienceandmedicine.mountsinai.org/2025
Reposted by Yizhou Dong lab
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Sign the Petition
Support a New York State Biomedical Institute for a Healthier, More Affordable Future
c.org
November 24, 2025 at 3:53 PM
📢 SIGN & SHARE THE PETITION! 📢
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW
Reposted by Yizhou Dong lab
A Special Congratulations to @ericjnestler.bsky.social on receiving the 2025 Synapsy Prize. This prestigious award celebrates lifelong dedication to translating fundamental neuroscience discoveries into tangible clinical advancements in mental health. Learn More 👉 www.eurekalert.org/news-release...
November 14, 2025 at 7:16 PM
A Special Congratulations to @ericjnestler.bsky.social on receiving the 2025 Synapsy Prize. This prestigious award celebrates lifelong dedication to translating fundamental neuroscience discoveries into tangible clinical advancements in mental health. Learn More 👉 www.eurekalert.org/news-release...
Reposted by Yizhou Dong lab
We ❤️❤️❤️ New York State — but life here could be fairer and healthier for all. If you agree, sign up at www.nycures.org!
💔 Over 154,000 NYC public school students experienced houselessness last year. @sunyofficial.bsky.social estimates 8% of undergrads and 5% of grad students face housing insecurity.
💔 Over 154,000 NYC public school students experienced houselessness last year. @sunyofficial.bsky.social estimates 8% of undergrads and 5% of grad students face housing insecurity.
New York Cures – NY-CURESNew York Cures Website
www.nycures.org
November 14, 2025 at 8:49 PM
We ❤️❤️❤️ New York State — but life here could be fairer and healthier for all. If you agree, sign up at www.nycures.org!
💔 Over 154,000 NYC public school students experienced houselessness last year. @sunyofficial.bsky.social estimates 8% of undergrads and 5% of grad students face housing insecurity.
💔 Over 154,000 NYC public school students experienced houselessness last year. @sunyofficial.bsky.social estimates 8% of undergrads and 5% of grad students face housing insecurity.
Reposted by Yizhou Dong lab
Our latest work @mitkochinstitute.bsky.social is now published in @natnano.nature.com ! By optimizing lipid nanoparticle design, we significantly improved #mRNA expression and immune responses — paving the way for a new class of delivery systems for #vaccine.
Free access - rdcu.be/eOLjb
#biotech
Free access - rdcu.be/eOLjb
#biotech
November 8, 2025 at 3:19 PM
Our latest work @mitkochinstitute.bsky.social is now published in @natnano.nature.com ! By optimizing lipid nanoparticle design, we significantly improved #mRNA expression and immune responses — paving the way for a new class of delivery systems for #vaccine.
Free access - rdcu.be/eOLjb
#biotech
Free access - rdcu.be/eOLjb
#biotech
Reposted by Yizhou Dong lab
🧬 mRNA has emerged as a powerful new class of therapeutic molecules—extending far beyond vaccines to cancer immunotherapy, protein replacement, and gene editing.
🧩 But designing mRNAs with strong, lasting protein expression remains a major challenge.
🧩 But designing mRNAs with strong, lasting protein expression remains a major challenge.
November 14, 2025 at 8:36 PM
🧬 mRNA has emerged as a powerful new class of therapeutic molecules—extending far beyond vaccines to cancer immunotherapy, protein replacement, and gene editing.
🧩 But designing mRNAs with strong, lasting protein expression remains a major challenge.
🧩 But designing mRNAs with strong, lasting protein expression remains a major challenge.
Reposted by Yizhou Dong lab
In @natchembio.nature.com, @yizhoudonglab.bsky.social highlights GEMORNA, an AI framework that directly generates mRNA & circRNA sequences by jointly modeling CDSs & UTRs, for coordinated optimization of expression and stability.
An elegant tool to help design mRNAs!
www.nature.com/articles/s41...
An elegant tool to help design mRNAs!
www.nature.com/articles/s41...
AI-powered design accelerates the development of mRNA therapeutics - Nature Chemical Biology
mRNA has emerged as an important class of therapeutic molecules. Now, an artificial intelligence (AI)-driven framework, which can design mRNA sequences with enhanced stability and translational effici...
www.nature.com
November 14, 2025 at 8:41 PM
In @natchembio.nature.com, @yizhoudonglab.bsky.social highlights GEMORNA, an AI framework that directly generates mRNA & circRNA sequences by jointly modeling CDSs & UTRs, for coordinated optimization of expression and stability.
An elegant tool to help design mRNAs!
www.nature.com/articles/s41...
An elegant tool to help design mRNAs!
www.nature.com/articles/s41...
Reposted by Yizhou Dong lab
For readers interested in lipid nanoparticles for nucleic acid delivery, here's a perspective by Cullis and Feldner on the evolution of the field
rdcu.be/eMpeO
nature.com/articles/s41...
rdcu.be/eMpeO
nature.com/articles/s41...
The 60-year evolution of lipid nanoparticles for nucleic acid delivery
Nature Reviews Drug Discovery - Lipid nanoparticle-based systems are increasingly being utilized for the delivery of nucleic acid-based vaccines and therapeutics. In this Perspective, Cullis and...
rdcu.be
October 23, 2025 at 3:09 PM
For readers interested in lipid nanoparticles for nucleic acid delivery, here's a perspective by Cullis and Feldner on the evolution of the field
rdcu.be/eMpeO
nature.com/articles/s41...
rdcu.be/eMpeO
nature.com/articles/s41...
Reposted by Yizhou Dong lab
"The way forward has become very clear"- Dr. Brendan G. Carr
A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!
A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!
October 23, 2025 at 9:39 PM
"The way forward has become very clear"- Dr. Brendan G. Carr
A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!
A HUGE CONGRATULATIONS to @ericjnestler.bsky.social named Anne & Joel Ehrenkranz Dean of the Icahn School of Medicine. We’re thrilled about the exciting new direction Icahn Mount Sinai will take under Dr. Nestler's visionary leadership!
Reposted by Yizhou Dong lab
With co-authors Bram Teunissen & @yizhoudonglab.bsky.social, we dive into emerging ways to make LNPs more precise—from tuning their chemistry to reprogramming RNA expression and even controlling protein stability & localization >>> a road🗺️ for more intelligent delivery & broader applications ahead.
October 17, 2025 at 5:22 PM
With co-authors Bram Teunissen & @yizhoudonglab.bsky.social, we dive into emerging ways to make LNPs more precise—from tuning their chemistry to reprogramming RNA expression and even controlling protein stability & localization >>> a road🗺️ for more intelligent delivery & broader applications ahead.
Reposted by Yizhou Dong lab
The BIGGEST impact you can have with 1 minute today ⏱️
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
New York Cures – NY-CURESNew York Cures Website
NY-CURES is working to advance bold, state-backed investment in biomedical research—on the scale of successful initiatives in California and Texas—to grow New York’s leadership in science, innovation, and health.
www.nycures.org
October 2, 2025 at 4:23 PM
The BIGGEST impact you can have with 1 minute today ⏱️
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
Add your name to show NY is ready for a statewide biomedical institute.
CA’s CIRM & TX’s CPRIT proved it works—billions returned, jobs created, cures accelerated. Let’s do even better for New York.
✍️ www.nycures.org/
Reposted by Yizhou Dong lab
🚨 AIMBE calls on the scientific community to urge Congress to ensure timely passage of the FY2026 budget 👇
Strong, sustained funding for our nation's health and science agencies is essential for economic prosperity, U.S. global competitiveness, and public heath.
takeaction.io/aimbe/protec...
Strong, sustained funding for our nation's health and science agencies is essential for economic prosperity, U.S. global competitiveness, and public heath.
takeaction.io/aimbe/protec...
Protect Research: Finalize FY2026 Budget Now
Use AIMBE's letter template below to send an email to your Members of Congress on issues that matter. We encourage you to edit and personalize the note, sharing your individual experience. Please note...
takeaction.io
September 23, 2025 at 3:19 PM
🚨 AIMBE calls on the scientific community to urge Congress to ensure timely passage of the FY2026 budget 👇
Strong, sustained funding for our nation's health and science agencies is essential for economic prosperity, U.S. global competitiveness, and public heath.
takeaction.io/aimbe/protec...
Strong, sustained funding for our nation's health and science agencies is essential for economic prosperity, U.S. global competitiveness, and public heath.
takeaction.io/aimbe/protec...
Reposted by Yizhou Dong lab
PRESS RELEASE! @mountsinainyc.bsky.social receives $8 million grant from DataPhilanthropy to fuel research into #CADASIL This transformational grant will launch new Center led by Dr @fanny-elahi.bsky.social to pursue trtmnts for understudied neurovascular diseases👉 www.mountsinai.org/about/newsro...
September 18, 2025 at 12:47 PM
PRESS RELEASE! @mountsinainyc.bsky.social receives $8 million grant from DataPhilanthropy to fuel research into #CADASIL This transformational grant will launch new Center led by Dr @fanny-elahi.bsky.social to pursue trtmnts for understudied neurovascular diseases👉 www.mountsinai.org/about/newsro...
Reposted by Yizhou Dong lab
📝NEW STUDY📝 Cancer's first punch when battling the immune system may be rewiring myeloid progenitors in bone marrow so they become suppressive tumor macrophages blunting T-cell attacks. Find out how in @nature.com from @samhegde.bsky.social & @miriammerad.bsky.social 🧐 www.nature.com/articles/s41...
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
www.nature.com
September 18, 2025 at 3:16 PM
📝NEW STUDY📝 Cancer's first punch when battling the immune system may be rewiring myeloid progenitors in bone marrow so they become suppressive tumor macrophages blunting T-cell attacks. Find out how in @nature.com from @samhegde.bsky.social & @miriammerad.bsky.social 🧐 www.nature.com/articles/s41...
Reposted by Yizhou Dong lab
💫Through the #SURP4US program, under the mentorship of
@yizhoudonglab.bsky.social, Alister (Jia) Ng gained research experience & developed an interest in drug design & delivery. Inspired by her family's history w/ #Antidepressants; she aspires to pursue a career in pharmaceutical research.
@yizhoudonglab.bsky.social, Alister (Jia) Ng gained research experience & developed an interest in drug design & delivery. Inspired by her family's history w/ #Antidepressants; she aspires to pursue a career in pharmaceutical research.
August 8, 2025 at 8:26 PM
💫Through the #SURP4US program, under the mentorship of
@yizhoudonglab.bsky.social, Alister (Jia) Ng gained research experience & developed an interest in drug design & delivery. Inspired by her family's history w/ #Antidepressants; she aspires to pursue a career in pharmaceutical research.
@yizhoudonglab.bsky.social, Alister (Jia) Ng gained research experience & developed an interest in drug design & delivery. Inspired by her family's history w/ #Antidepressants; she aspires to pursue a career in pharmaceutical research.
Reposted by Yizhou Dong lab
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
September 4, 2025 at 4:32 PM
🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.
Sign up. Stay informed. Join the movement: www.nycures.org/
Reposted by Yizhou Dong lab
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
July 17, 2025 at 1:25 AM
A big day for preventing mitochondrial diseases from transmitting to the next generation
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nature.com/articles/d41...
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Yizhou Dong lab
🚨 Out now in @nature.com: it's time to de-Americanize global science. We need:🌍 Equitable funding 🔄 Shared governance 🔐 Resilient data infra🆘 Emergency support for scientists at risk. The next crisis can’t break global research again. Nova Medical School
🔗 rdcu.be/ewp6K
🔗 rdcu.be/ewp6K
July 16, 2025 at 12:01 PM
🚨 Out now in @nature.com: it's time to de-Americanize global science. We need:🌍 Equitable funding 🔄 Shared governance 🔐 Resilient data infra🆘 Emergency support for scientists at risk. The next crisis can’t break global research again. Nova Medical School
🔗 rdcu.be/ewp6K
🔗 rdcu.be/ewp6K
Reposted by Yizhou Dong lab
RNA chemistry and therapeutics www.nature.com/articles/s41...
rdcu.be/ewkq0
This new Review covers synthetic methods applied to RNA therapeutics in multiple classes and chemical modification strategies being used to enhance their properties
@yizhoudonglab.bsky.social
rdcu.be/ewkq0
This new Review covers synthetic methods applied to RNA therapeutics in multiple classes and chemical modification strategies being used to enhance their properties
@yizhoudonglab.bsky.social
July 15, 2025 at 1:59 PM
RNA chemistry and therapeutics www.nature.com/articles/s41...
rdcu.be/ewkq0
This new Review covers synthetic methods applied to RNA therapeutics in multiple classes and chemical modification strategies being used to enhance their properties
@yizhoudonglab.bsky.social
rdcu.be/ewkq0
This new Review covers synthetic methods applied to RNA therapeutics in multiple classes and chemical modification strategies being used to enhance their properties
@yizhoudonglab.bsky.social
Reposted by Yizhou Dong lab
Misinformation is winning not because it's true, but because it’s loud, emotional, and everywhere.
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
Beyond the lab: trust, storytelling and the fight for America’s attention - Nature Reviews Immunology
Shruti Naik, an immunologist and a strong advocate for diversity in science, has joined forces with Aaron Mertz, who leads programmes that help to explain, connect and maximize the benefits of science...
www.nature.com
May 8, 2025 at 4:36 PM
Misinformation is winning not because it's true, but because it’s loud, emotional, and everywhere.
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social
It’s time for science to fight back. Aaron Mertz and I dissect the issue and offer solutions 👇
📖 www.nature.com/articles/s41...
#SciComm @sinaiimmuno.bsky.social @aspeninstitute.bsky.social