brian_delisle
@bpdelisle.bsky.social
Prof of Physiology; Heart Disease; Cardiac EP; LQTS; Ion Channels; Biophysics; Chronobiology; Reviewer 2; He, him, his; Opinions/retweets/likes are my own
https://orcid.org/0000-0002-2146-327X
https://orcid.org/0000-0002-2146-327X
Pinned
BMAL1 mediates sex-specific circadian regulation of cardiac ion channels and temporal arrhythmia vulnerability
www.sciencedirect.com
🚨🆕🧪🔬on 💓🕒 Delisle et al. 😉show the circadian clock gene BMAL1 drives sex-specific daily patterns in cardiac ion channels ⚡️❤️🔥 in 🐭, shaping when arrhythmias may strike in males vs females 🧠➡️❤️
#Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky
www.sciencedirect.com/science/arti...
#Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky
www.sciencedirect.com/science/arti...
🚨🆕🧪🔬 Hyperglycemia 👊🏻 the brain hard 🧠🔥 Miao, Mohiuddin et al shows GLUT1 is essential for brain endothelial cell survival under high glucose, w/o it, cells lose homeostasis and barrier function yikes😧
#Neurovascular #Diabetes #Physiology
journals.physiology.org/doi/full/10....
#Neurovascular #Diabetes #Physiology
journals.physiology.org/doi/full/10....
November 15, 2025 at 12:52 PM
🚨🆕🧪🔬 Hyperglycemia 👊🏻 the brain hard 🧠🔥 Miao, Mohiuddin et al shows GLUT1 is essential for brain endothelial cell survival under high glucose, w/o it, cells lose homeostasis and barrier function yikes😧
#Neurovascular #Diabetes #Physiology
journals.physiology.org/doi/full/10....
#Neurovascular #Diabetes #Physiology
journals.physiology.org/doi/full/10....
🚨🆕🧪🔬That “wild-type” Nav1.5 variant everyone’s been using may not be so WT after all. Melgari et al. reveal T559A causes loss-of-function ⚡️❌ decades of WT controls weren’t truly WT, time to double-check those studies🧐🧬
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
November 11, 2025 at 11:46 AM
🚨🆕🧪🔬That “wild-type” Nav1.5 variant everyone’s been using may not be so WT after all. Melgari et al. reveal T559A causes loss-of-function ⚡️❌ decades of WT controls weren’t truly WT, time to double-check those studies🧐🧬
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
🚨🆕🧪🔬 Not all gut-brain signals follow the clock🕒🥣 Arnold and colleagues show CCK receptors + signaling in vagal afferents stay steady across day & night 🌞🌙 despite circadian rhythms 🧠➡️🍽️
#GutBrainAxis #Circadian #Physiology #Neuroscience
journals.physiology.org/doi/full/10....
#GutBrainAxis #Circadian #Physiology #Neuroscience
journals.physiology.org/doi/full/10....
November 10, 2025 at 12:01 PM
🚨🆕🧪🔬 Not all gut-brain signals follow the clock🕒🥣 Arnold and colleagues show CCK receptors + signaling in vagal afferents stay steady across day & night 🌞🌙 despite circadian rhythms 🧠➡️🍽️
#GutBrainAxis #Circadian #Physiology #Neuroscience
journals.physiology.org/doi/full/10....
#GutBrainAxis #Circadian #Physiology #Neuroscience
journals.physiology.org/doi/full/10....
If you are at #AHA25 go check out Dr. Prabhat’s @abhiprabhat.bsky.social poster- where he identifies feeding behavior as a potential modifiable risk factor for regulating autonomic input to the heart- It is TODAY 11:30am-12:30pm (Central) MC.APB.04
eppro02.ativ.me/web/index.ph...
#heart #CardioSky
eppro02.ativ.me/web/index.ph...
#heart #CardioSky
November 9, 2025 at 3:43 PM
If you are at #AHA25 go check out Dr. Prabhat’s @abhiprabhat.bsky.social poster- where he identifies feeding behavior as a potential modifiable risk factor for regulating autonomic input to the heart- It is TODAY 11:30am-12:30pm (Central) MC.APB.04
eppro02.ativ.me/web/index.ph...
#heart #CardioSky
eppro02.ativ.me/web/index.ph...
#heart #CardioSky
🚨🆕🧪🔬on 💓🕒 Delisle et al. 😉show the circadian clock gene BMAL1 drives sex-specific daily patterns in cardiac ion channels ⚡️❤️🔥 in 🐭, shaping when arrhythmias may strike in males vs females 🧠➡️❤️
#Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky
www.sciencedirect.com/science/arti...
#Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky
www.sciencedirect.com/science/arti...
BMAL1 mediates sex-specific circadian regulation of cardiac ion channels and temporal arrhythmia vulnerability
www.sciencedirect.com
November 9, 2025 at 1:01 PM
🚨🆕🧪🔬on 💓🕒 Delisle et al. 😉show the circadian clock gene BMAL1 drives sex-specific daily patterns in cardiac ion channels ⚡️❤️🔥 in 🐭, shaping when arrhythmias may strike in males vs females 🧠➡️❤️
#Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky
www.sciencedirect.com/science/arti...
#Circadian #Physiology #Heart #Arrhythmia #Sex #Science #Cardiosky
www.sciencedirect.com/science/arti...
Reposted by brian_delisle
Thrilled to share our Creative Concepts paper published in Heart Rhythm on how the circadian clock gene Bmal1 mediates sex specific cardiac ion channel expression. authors.elsevier.com/a/1m1jJ5VtUy... @kaesser.bsky.social @bpdelisle.bsky.social @abhiprabhat.bsky.social
authors.elsevier.com
November 2, 2025 at 4:30 PM
Thrilled to share our Creative Concepts paper published in Heart Rhythm on how the circadian clock gene Bmal1 mediates sex specific cardiac ion channel expression. authors.elsevier.com/a/1m1jJ5VtUy... @kaesser.bsky.social @bpdelisle.bsky.social @abhiprabhat.bsky.social
🚨 🆕 🔬 💥 Suzuki et al reveal Kir2.1 channels hyperpolarize macrophages, crank up CRAC channel–mediated Ca²⁺ entry ⚡and migration w/o touching phagocytosis or M2 polarization 🧫 It’s all about that K⁺ flow and CaMK–Pyk2 activation🧠🔥#Physiology #IonChannels
👉 journals.physiology.org/doi/full/10....
👉 journals.physiology.org/doi/full/10....
July 19, 2025 at 5:01 PM
🚨 🆕 🔬 💥 Suzuki et al reveal Kir2.1 channels hyperpolarize macrophages, crank up CRAC channel–mediated Ca²⁺ entry ⚡and migration w/o touching phagocytosis or M2 polarization 🧫 It’s all about that K⁺ flow and CaMK–Pyk2 activation🧠🔥#Physiology #IonChannels
👉 journals.physiology.org/doi/full/10....
👉 journals.physiology.org/doi/full/10....
🚨 🆕 🫀🔬🔥 Wang et al: Asprosin 💥 protects the diabetic heart by dialing down overactive autophagy via the AMPK/mTOR/ULK1 pathway 🧬 No Asprosin = more fibrosis & more apoptosis 😱 💉🧠 #CardioSky #Physiology #autophagy
👉 journals.physiology.org/doi/full/10....
👉 journals.physiology.org/doi/full/10....
Asprosin attenuates diabetic cardiomyopathy through inhibiting autophagy mediated by AMPK/mTOR/ULK1 pathway | American Journal of Physiology-Cell Physiology | American Physiological Society
Aberrant autophagy mediated by AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/unc-51 like kinase 1 (ULK1) pathway (a canonical autophagy pathway) plays important roles in dia...
journals.physiology.org
July 18, 2025 at 11:04 PM
🚨 🆕 🫀🔬🔥 Wang et al: Asprosin 💥 protects the diabetic heart by dialing down overactive autophagy via the AMPK/mTOR/ULK1 pathway 🧬 No Asprosin = more fibrosis & more apoptosis 😱 💉🧠 #CardioSky #Physiology #autophagy
👉 journals.physiology.org/doi/full/10....
👉 journals.physiology.org/doi/full/10....
🚨 🆕 🔬 Pereira Jr. et al. show that MitoKATP channels are vital for brown adipocyte 🔥 growth—but are switched off for thermogenic blast 💥 in mature cells. Cold? NE? Block the channel, burn the fuel. ❄️🧬 👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Physiology
#IonChannels #Physiology
July 18, 2025 at 11:10 AM
🚨 🆕 🔬 Pereira Jr. et al. show that MitoKATP channels are vital for brown adipocyte 🔥 growth—but are switched off for thermogenic blast 💥 in mature cells. Cold? NE? Block the channel, burn the fuel. ❄️🧬 👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Physiology
#IonChannels #Physiology
🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1...
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
July 16, 2025 at 11:03 AM
🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1...
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
🚨 New 💪 🔬 Naughton et al. reveal NOMO as a force-bearing ER protein that shapes ER structure & drives muscle cell fate—Its Ig-domain handles piconewton-scale tension, delete it, and myogenesis breaks down 🧬
🔧👉 rupress.org/jcb/article/...
#Physiology #Cell #Science #Muscle
🔧👉 rupress.org/jcb/article/...
#Physiology #Cell #Science #Muscle
July 16, 2025 at 10:03 AM
🚨 New 💪 🔬 Naughton et al. reveal NOMO as a force-bearing ER protein that shapes ER structure & drives muscle cell fate—Its Ig-domain handles piconewton-scale tension, delete it, and myogenesis breaks down 🧬
🔧👉 rupress.org/jcb/article/...
#Physiology #Cell #Science #Muscle
🔧👉 rupress.org/jcb/article/...
#Physiology #Cell #Science #Muscle
Reposted by brian_delisle
Bhlhe40 (a known negative regulator of BMAL/CLOCK activity) as a transcriptional activator of SMC-to-foam cell transition in #Atherosclerosis
Ldlr-/- Myh11-CreERT2 ROSA26-ZsGreen1🐭
CITE-seq (119 Ab)
Only 1~3% (Not 30%!) Mφ-like cells are SMC-derived 🤓
bioRxiv 2025
www.biorxiv.org/content/10.1...
Ldlr-/- Myh11-CreERT2 ROSA26-ZsGreen1🐭
CITE-seq (119 Ab)
Only 1~3% (Not 30%!) Mφ-like cells are SMC-derived 🤓
bioRxiv 2025
www.biorxiv.org/content/10.1...
June 7, 2025 at 11:45 AM
Bhlhe40 (a known negative regulator of BMAL/CLOCK activity) as a transcriptional activator of SMC-to-foam cell transition in #Atherosclerosis
Ldlr-/- Myh11-CreERT2 ROSA26-ZsGreen1🐭
CITE-seq (119 Ab)
Only 1~3% (Not 30%!) Mφ-like cells are SMC-derived 🤓
bioRxiv 2025
www.biorxiv.org/content/10.1...
Ldlr-/- Myh11-CreERT2 ROSA26-ZsGreen1🐭
CITE-seq (119 Ab)
Only 1~3% (Not 30%!) Mφ-like cells are SMC-derived 🤓
bioRxiv 2025
www.biorxiv.org/content/10.1...
Reposted by brian_delisle
📢 Final call! Submit your abstracts to present your research at our meeting, ‘Cross-Talk of Cells in the Heart 2025’ at the University of Birmingham on 3-4 Sept. Showcase your findings on the mechanisms of heart disease and arrhythmias.
📝 Submit by 2 June ⬇️
📝 Submit by 2 June ⬇️
Cross-Talk of Cells in the Heart 2025: Novel Mechanisms of Disease and Arrhythmias
Cross-Talk of Cells in the Heart 2025, an exciting two-day meeting at University of Birmingham (UK) to discuss the latest breakthroughs in cardiac arrhythmia and disease research. Join us
buff.ly
May 29, 2025 at 4:56 PM
📢 Final call! Submit your abstracts to present your research at our meeting, ‘Cross-Talk of Cells in the Heart 2025’ at the University of Birmingham on 3-4 Sept. Showcase your findings on the mechanisms of heart disease and arrhythmias.
📝 Submit by 2 June ⬇️
📝 Submit by 2 June ⬇️
Reposted by brian_delisle
Its taken a few years but finally had science fun collaborating with @andyjudge24.bsky.social, @sarahjudge.bsky.social and the talented postdoc @jbducharme.bsky.social with support from Miguel Gutierrez-Monreal. Cancer and the muscle clock. 1/ www.cell.com/cell-reports...
Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia
Ducharme et al. investigate the impact and crosstalk between cancer and FoxP1 on the
skeletal-muscle circadian transcriptome that mediates time-of-day-dependent biological
functions. They reveal cance...
www.cell.com
May 11, 2025 at 5:18 PM
Its taken a few years but finally had science fun collaborating with @andyjudge24.bsky.social, @sarahjudge.bsky.social and the talented postdoc @jbducharme.bsky.social with support from Miguel Gutierrez-Monreal. Cancer and the muscle clock. 1/ www.cell.com/cell-reports...
Reposted by brian_delisle
Excited to see (newly Dr) Greg Milburn's paper on cardiac amyloidosis in human myocardium with cell-level mechanics, histology, and gel-based analysis of sarcomeric proteins.
Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis
doi.org/10.1016/j.ja...
Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis
doi.org/10.1016/j.ja...
May 10, 2025 at 5:24 PM
Excited to see (newly Dr) Greg Milburn's paper on cardiac amyloidosis in human myocardium with cell-level mechanics, histology, and gel-based analysis of sarcomeric proteins.
Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis
doi.org/10.1016/j.ja...
Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis
doi.org/10.1016/j.ja...
Reposted by brian_delisle
We are very pleased to share that our paper on sexual dimorphism in circadian rhythms has been published in @plosbiology.org. This work was led by the very talented Aishwarya Iyer and includes contributions from three undergraduate co-authors.
You can read the full study here:
You can read the full study here:
Sexual dimorphism in the #Drosophila #circadian pacemaker. @aishwaryaramak6.bsky.social @mariadelapax.bsky.social &co show that female flies are more resilient to disruptions in circadian rhythms caused by changes in the PDF pathway or pacemaker cell clock speed @plosbiology.org 🧪 plos.io/4kbWuzg
May 7, 2025 at 12:25 PM
We are very pleased to share that our paper on sexual dimorphism in circadian rhythms has been published in @plosbiology.org. This work was led by the very talented Aishwarya Iyer and includes contributions from three undergraduate co-authors.
You can read the full study here:
You can read the full study here:
Reposted by brian_delisle
For the last 3 yrs, I was the director for the Science of Science program at the NSF. We funded projects on science communication - science communication to the public, communication of public priorities to scientists, citizens engagement & participation in science. 🧵
April 24, 2025 at 12:56 AM
For the last 3 yrs, I was the director for the Science of Science program at the NSF. We funded projects on science communication - science communication to the public, communication of public priorities to scientists, citizens engagement & participation in science. 🧵
Reposted by brian_delisle
Please read this.
For the last 3 yrs, I was the director for the Science of Science program at the NSF. We funded projects on science communication - science communication to the public, communication of public priorities to scientists, citizens engagement & participation in science. 🧵
April 24, 2025 at 11:46 AM
Please read this.
Reposted by brian_delisle
GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15
December 18, 2024 at 5:39 PM
GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15
Reposted by brian_delisle
#FreeToRead 👀
CONGRATULATIONS!
An ovary-intact #postmenopausal #HFpEF mouse model; #menopause is more than just #estrogen deficiency
Mei Methawasin, et al.
➡️doi.org/10.1152/ajph...
CONGRATULATIONS!
An ovary-intact #postmenopausal #HFpEF mouse model; #menopause is more than just #estrogen deficiency
Mei Methawasin, et al.
➡️doi.org/10.1152/ajph...
April 3, 2025 at 2:19 PM
#FreeToRead 👀
CONGRATULATIONS!
An ovary-intact #postmenopausal #HFpEF mouse model; #menopause is more than just #estrogen deficiency
Mei Methawasin, et al.
➡️doi.org/10.1152/ajph...
CONGRATULATIONS!
An ovary-intact #postmenopausal #HFpEF mouse model; #menopause is more than just #estrogen deficiency
Mei Methawasin, et al.
➡️doi.org/10.1152/ajph...
Reposted by brian_delisle
David J Paterson of @oxforddpag.bsky.social & Kalyanam Shivkumar of @uclaupdates.bsky.social present this preface #Editorial for our latest special issue 'Cardiac Neurobiology: Concepts to Clinic' which is dedicated to Jeffrey L. Ardell (1952–2025)
📜 physoc.onlinelibrary.wiley.com/doi/full/10....
📜 physoc.onlinelibrary.wiley.com/doi/full/10....
April 1, 2025 at 1:00 PM
David J Paterson of @oxforddpag.bsky.social & Kalyanam Shivkumar of @uclaupdates.bsky.social present this preface #Editorial for our latest special issue 'Cardiac Neurobiology: Concepts to Clinic' which is dedicated to Jeffrey L. Ardell (1952–2025)
📜 physoc.onlinelibrary.wiley.com/doi/full/10....
📜 physoc.onlinelibrary.wiley.com/doi/full/10....
Reposted by brian_delisle
Diet-induced obesity dampens temporal oscillation of hepatic mitochondrial lipids
Our study revealed that obesity altered the mitochondrial lipid composition & hampered the rhythmicity of mitochondrial lipids, oxygen consumption rate & Parkin levels in liver
www.sciencedirect.com/science/arti...
Our study revealed that obesity altered the mitochondrial lipid composition & hampered the rhythmicity of mitochondrial lipids, oxygen consumption rate & Parkin levels in liver
www.sciencedirect.com/science/arti...
April 2, 2025 at 7:23 AM
Diet-induced obesity dampens temporal oscillation of hepatic mitochondrial lipids
Our study revealed that obesity altered the mitochondrial lipid composition & hampered the rhythmicity of mitochondrial lipids, oxygen consumption rate & Parkin levels in liver
www.sciencedirect.com/science/arti...
Our study revealed that obesity altered the mitochondrial lipid composition & hampered the rhythmicity of mitochondrial lipids, oxygen consumption rate & Parkin levels in liver
www.sciencedirect.com/science/arti...
Reposted by brian_delisle
🔓Editorial From Timothy Musch et al.
“APS Initiatives and Milestones: a Year in Review and a Look Ahead”
➡️doi.org/10.1152/phys...
“APS Initiatives and Milestones: a Year in Review and a Look Ahead”
➡️doi.org/10.1152/phys...
April 1, 2025 at 12:00 PM
🔓Editorial From Timothy Musch et al.
“APS Initiatives and Milestones: a Year in Review and a Look Ahead”
➡️doi.org/10.1152/phys...
“APS Initiatives and Milestones: a Year in Review and a Look Ahead”
➡️doi.org/10.1152/phys...
🚨🆕🔬Eosinophil clocks disrupted with asthma? Teppan et al show that disrupted circadian clocks in eosinophils fuel airway inflammation 🫁 Resetting the clock with a ROR inhibitor ⬇️ mucus, ⬆️ lung function👉 journals.physiology.org/doi/pdf/10.1...
#Physiology #Science #Circadian #Asthma
#Physiology #Science #Circadian #Asthma
March 30, 2025 at 3:15 PM
🚨🆕🔬Eosinophil clocks disrupted with asthma? Teppan et al show that disrupted circadian clocks in eosinophils fuel airway inflammation 🫁 Resetting the clock with a ROR inhibitor ⬇️ mucus, ⬆️ lung function👉 journals.physiology.org/doi/pdf/10.1...
#Physiology #Science #Circadian #Asthma
#Physiology #Science #Circadian #Asthma
Reposted by brian_delisle
Unsurprisingly, @tressiemcphd.bsky.social is spot-on in this analysis: “A.I.’s most revolutionary potential is helping experts apply their expertise better and faster. But for that to work, there has to be experts.”
www.nytimes.com/2025/03/29/o...
www.nytimes.com/2025/03/29/o...
Opinion | Actually, A.I. Is Pretty Mid (Gift Article)
A.I. is just what we need in the post-fact era: less research and more predicting what we want to hear.
www.nytimes.com
March 29, 2025 at 11:30 AM
Unsurprisingly, @tressiemcphd.bsky.social is spot-on in this analysis: “A.I.’s most revolutionary potential is helping experts apply their expertise better and faster. But for that to work, there has to be experts.”
www.nytimes.com/2025/03/29/o...
www.nytimes.com/2025/03/29/o...