brian_delisle
@bpdelisle.bsky.social
Prof of Physiology; Heart Disease; Cardiac EP; LQTS; Ion Channels; Biophysics; Chronobiology; Reviewer 2; He, him, his; Opinions/retweets/likes are my own
https://orcid.org/0000-0002-2146-327X
https://orcid.org/0000-0002-2146-327X
🚨🆕🧪🔬 Hyperglycemia 👊🏻 the brain hard 🧠🔥 Miao, Mohiuddin et al shows GLUT1 is essential for brain endothelial cell survival under high glucose, w/o it, cells lose homeostasis and barrier function yikes😧
#Neurovascular #Diabetes #Physiology
journals.physiology.org/doi/full/10....
#Neurovascular #Diabetes #Physiology
journals.physiology.org/doi/full/10....
November 15, 2025 at 12:52 PM
🚨🆕🧪🔬 Hyperglycemia 👊🏻 the brain hard 🧠🔥 Miao, Mohiuddin et al shows GLUT1 is essential for brain endothelial cell survival under high glucose, w/o it, cells lose homeostasis and barrier function yikes😧
#Neurovascular #Diabetes #Physiology
journals.physiology.org/doi/full/10....
#Neurovascular #Diabetes #Physiology
journals.physiology.org/doi/full/10....
🚨🆕🧪🔬That “wild-type” Nav1.5 variant everyone’s been using may not be so WT after all. Melgari et al. reveal T559A causes loss-of-function ⚡️❌ decades of WT controls weren’t truly WT, time to double-check those studies🧐🧬
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
November 11, 2025 at 11:46 AM
🚨🆕🧪🔬That “wild-type” Nav1.5 variant everyone’s been using may not be so WT after all. Melgari et al. reveal T559A causes loss-of-function ⚡️❌ decades of WT controls weren’t truly WT, time to double-check those studies🧐🧬
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
#IonChannel #Physiology #Reproducibility
journals.physiology.org/doi/full/10....
🚨🆕🧪🔬 Not all gut-brain signals follow the clock🕒🥣 Arnold and colleagues show CCK receptors + signaling in vagal afferents stay steady across day & night 🌞🌙 despite circadian rhythms 🧠➡️🍽️
#GutBrainAxis #Circadian #Physiology #Neuroscience
journals.physiology.org/doi/full/10....
#GutBrainAxis #Circadian #Physiology #Neuroscience
journals.physiology.org/doi/full/10....
November 10, 2025 at 12:01 PM
🚨🆕🧪🔬 Not all gut-brain signals follow the clock🕒🥣 Arnold and colleagues show CCK receptors + signaling in vagal afferents stay steady across day & night 🌞🌙 despite circadian rhythms 🧠➡️🍽️
#GutBrainAxis #Circadian #Physiology #Neuroscience
journals.physiology.org/doi/full/10....
#GutBrainAxis #Circadian #Physiology #Neuroscience
journals.physiology.org/doi/full/10....
If you are at #AHA25 go check out Dr. Prabhat’s @abhiprabhat.bsky.social poster- where he identifies feeding behavior as a potential modifiable risk factor for regulating autonomic input to the heart- It is TODAY 11:30am-12:30pm (Central) MC.APB.04
eppro02.ativ.me/web/index.ph...
#heart #CardioSky
eppro02.ativ.me/web/index.ph...
#heart #CardioSky
November 9, 2025 at 3:43 PM
If you are at #AHA25 go check out Dr. Prabhat’s @abhiprabhat.bsky.social poster- where he identifies feeding behavior as a potential modifiable risk factor for regulating autonomic input to the heart- It is TODAY 11:30am-12:30pm (Central) MC.APB.04
eppro02.ativ.me/web/index.ph...
#heart #CardioSky
eppro02.ativ.me/web/index.ph...
#heart #CardioSky
🚨 🆕 🔬 💥 Suzuki et al reveal Kir2.1 channels hyperpolarize macrophages, crank up CRAC channel–mediated Ca²⁺ entry ⚡and migration w/o touching phagocytosis or M2 polarization 🧫 It’s all about that K⁺ flow and CaMK–Pyk2 activation🧠🔥#Physiology #IonChannels
👉 journals.physiology.org/doi/full/10....
👉 journals.physiology.org/doi/full/10....
July 19, 2025 at 5:01 PM
🚨 🆕 🔬 💥 Suzuki et al reveal Kir2.1 channels hyperpolarize macrophages, crank up CRAC channel–mediated Ca²⁺ entry ⚡and migration w/o touching phagocytosis or M2 polarization 🧫 It’s all about that K⁺ flow and CaMK–Pyk2 activation🧠🔥#Physiology #IonChannels
👉 journals.physiology.org/doi/full/10....
👉 journals.physiology.org/doi/full/10....
🚨 🆕 🔬 Pereira Jr. et al. show that MitoKATP channels are vital for brown adipocyte 🔥 growth—but are switched off for thermogenic blast 💥 in mature cells. Cold? NE? Block the channel, burn the fuel. ❄️🧬 👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Physiology
#IonChannels #Physiology
July 18, 2025 at 11:10 AM
🚨 🆕 🔬 Pereira Jr. et al. show that MitoKATP channels are vital for brown adipocyte 🔥 growth—but are switched off for thermogenic blast 💥 in mature cells. Cold? NE? Block the channel, burn the fuel. ❄️🧬 👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Physiology
#IonChannels #Physiology
🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1...
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
July 16, 2025 at 11:03 AM
🚨 🆕 🔬 Melgari et al show widely used “WT”cardiac🫀Na+ channel (SCN5A, Nav1.5) clone carries the rare T559A variant 🧬. T559A shows loss-of-function, halved Na+ current, & altered kinetics 🧪 👉 journals.physiology.org/doi/abs/10.1...
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
#Electrophysiology #IonChannels #Arrhythmias #Physiology #Cardiosky
🚨 New 💪 🔬 Naughton et al. reveal NOMO as a force-bearing ER protein that shapes ER structure & drives muscle cell fate—Its Ig-domain handles piconewton-scale tension, delete it, and myogenesis breaks down 🧬
🔧👉 rupress.org/jcb/article/...
#Physiology #Cell #Science #Muscle
🔧👉 rupress.org/jcb/article/...
#Physiology #Cell #Science #Muscle
July 16, 2025 at 10:03 AM
🚨 New 💪 🔬 Naughton et al. reveal NOMO as a force-bearing ER protein that shapes ER structure & drives muscle cell fate—Its Ig-domain handles piconewton-scale tension, delete it, and myogenesis breaks down 🧬
🔧👉 rupress.org/jcb/article/...
#Physiology #Cell #Science #Muscle
🔧👉 rupress.org/jcb/article/...
#Physiology #Cell #Science #Muscle
🚨🆕🔬Eosinophil clocks disrupted with asthma? Teppan et al show that disrupted circadian clocks in eosinophils fuel airway inflammation 🫁 Resetting the clock with a ROR inhibitor ⬇️ mucus, ⬆️ lung function👉 journals.physiology.org/doi/pdf/10.1...
#Physiology #Science #Circadian #Asthma
#Physiology #Science #Circadian #Asthma
March 30, 2025 at 3:15 PM
🚨🆕🔬Eosinophil clocks disrupted with asthma? Teppan et al show that disrupted circadian clocks in eosinophils fuel airway inflammation 🫁 Resetting the clock with a ROR inhibitor ⬇️ mucus, ⬆️ lung function👉 journals.physiology.org/doi/pdf/10.1...
#Physiology #Science #Circadian #Asthma
#Physiology #Science #Circadian #Asthma
🚨🆕🔬Three meals, same calories, different metabolism 🧬 Dörner et al show that our bodies shift from🔥carbs in the morning to fat by dinner- Glucose handling dips 📉 but metabolic resilience rises📈 w/ triglyceride use 👉 journals.physiology.org/doi/abs/10.1...
#Physiology #Science #Circadian #Metabolism
#Physiology #Science #Circadian #Metabolism
March 29, 2025 at 11:58 AM
🚨🆕🔬Three meals, same calories, different metabolism 🧬 Dörner et al show that our bodies shift from🔥carbs in the morning to fat by dinner- Glucose handling dips 📉 but metabolic resilience rises📈 w/ triglyceride use 👉 journals.physiology.org/doi/abs/10.1...
#Physiology #Science #Circadian #Metabolism
#Physiology #Science #Circadian #Metabolism
🚨🆕🫁 🔬 Fan et al reveal how ECM remodeling shapes ARDS progression- Collagen III, IV & lumican 📉 drop as damage worsens, while fibronectin & total collagen surge 📈 in late stage👉 journals.physiology.org/doi/abs/10.1...
#ARDS #Pulmonary #Physiology #Science 🧪
#ARDS #Pulmonary #Physiology #Science 🧪
March 16, 2025 at 6:01 PM
🚨🆕🫁 🔬 Fan et al reveal how ECM remodeling shapes ARDS progression- Collagen III, IV & lumican 📉 drop as damage worsens, while fibronectin & total collagen surge 📈 in late stage👉 journals.physiology.org/doi/abs/10.1...
#ARDS #Pulmonary #Physiology #Science 🧪
#ARDS #Pulmonary #Physiology #Science 🧪
🚨🆕🔬 Zhao et al model statin-induced myopathy using hiPSC-derived muscle cells-🧬 Statins disrupt proteostasis, triggering muscle atrophy via the FOXO1-Atrogin-1 axis 👉 journals.physiology.org/doi/abs/10.1...
#Physiology #Science #Muscle
#Physiology #Science #Muscle
March 16, 2025 at 12:10 PM
🚨🆕🔬 Zhao et al model statin-induced myopathy using hiPSC-derived muscle cells-🧬 Statins disrupt proteostasis, triggering muscle atrophy via the FOXO1-Atrogin-1 axis 👉 journals.physiology.org/doi/abs/10.1...
#Physiology #Science #Muscle
#Physiology #Science #Muscle
🚨🆕 NIH-funded🔬by Garvin et al show ACE inhibitor in male & female SHR 🐀 shields from Ang II-induced fibrosis, but only males limit collagen🧬expression- understanding sex-specific efficacy of antihypertensive med👉 journals.physiology.org/doi/abs/10.1...
#CardioSky #Physiology #Hypertension #Science 🧪
#CardioSky #Physiology #Hypertension #Science 🧪
March 11, 2025 at 11:06 AM
🚨🆕 NIH-funded🔬by Garvin et al show ACE inhibitor in male & female SHR 🐀 shields from Ang II-induced fibrosis, but only males limit collagen🧬expression- understanding sex-specific efficacy of antihypertensive med👉 journals.physiology.org/doi/abs/10.1...
#CardioSky #Physiology #Hypertension #Science 🧪
#CardioSky #Physiology #Hypertension #Science 🧪
🚨🆕📚Review by Read et al discusses phosphodiesterases as potential targets for atrial fibrillation🫀 PDE2-5 & PDE8 regulate Ca²⁺ handling & electrical activity- PDE-based drugs for AF? 👉 journals.physiology.org/doi/abs/10.1...
#CardioSky #Arrhythmia #Physiology #AtrialFibrillation #Science 🧪
#CardioSky #Arrhythmia #Physiology #AtrialFibrillation #Science 🧪
March 10, 2025 at 10:54 AM
🚨🆕📚Review by Read et al discusses phosphodiesterases as potential targets for atrial fibrillation🫀 PDE2-5 & PDE8 regulate Ca²⁺ handling & electrical activity- PDE-based drugs for AF? 👉 journals.physiology.org/doi/abs/10.1...
#CardioSky #Arrhythmia #Physiology #AtrialFibrillation #Science 🧪
#CardioSky #Arrhythmia #Physiology #AtrialFibrillation #Science 🧪
🚨🆕🔬 Wang et al show FBP1 deficiency rewires liver metabolism- Without this enzyme, ChREBP ramps up lipid synthesis, fueling fatty liver but also shields against energy crisis. 👉 journals.physiology.org/doi/abs/10.1...
#Metabolism #FattyLiver #Science #Physiology
#Metabolism #FattyLiver #Science #Physiology
March 9, 2025 at 12:33 PM
🚨🆕🔬 Wang et al show FBP1 deficiency rewires liver metabolism- Without this enzyme, ChREBP ramps up lipid synthesis, fueling fatty liver but also shields against energy crisis. 👉 journals.physiology.org/doi/abs/10.1...
#Metabolism #FattyLiver #Science #Physiology
#Metabolism #FattyLiver #Science #Physiology
🚨New🫀🔬by Noort et al study the ‘Newfoundland Curse’- a deadly form of arrhythmogenic cardiomyopathy💔⚡ TMEM43-S358L iPSC-cardiomyocytes from patients arrhythmias but GSK3 inhibition restores stability 👉 journals.physiology.org/doi/abs/10.1...
#CardioSky #Science #Physiology #Arrhythmia
#CardioSky #Science #Physiology #Arrhythmia
March 8, 2025 at 1:00 PM
🚨New🫀🔬by Noort et al study the ‘Newfoundland Curse’- a deadly form of arrhythmogenic cardiomyopathy💔⚡ TMEM43-S358L iPSC-cardiomyocytes from patients arrhythmias but GSK3 inhibition restores stability 👉 journals.physiology.org/doi/abs/10.1...
#CardioSky #Science #Physiology #Arrhythmia
#CardioSky #Science #Physiology #Arrhythmia
🚨🆕NIH-funded💪🔬by Foster et al show phosphate & acidosis can impair aging muscle by slowing myosin cross-bridge kinetics- dATP boosts force recovery- can metabolic tweaks counteract 💪 fatigue in 👴🏼 👵🏻 👉 journals.physiology.org/doi/abs/10.1...
#Aging #Muscle #Metabolism #Physiology #Science 🧪
#Aging #Muscle #Metabolism #Physiology #Science 🧪
March 6, 2025 at 1:03 PM
🚨🆕NIH-funded💪🔬by Foster et al show phosphate & acidosis can impair aging muscle by slowing myosin cross-bridge kinetics- dATP boosts force recovery- can metabolic tweaks counteract 💪 fatigue in 👴🏼 👵🏻 👉 journals.physiology.org/doi/abs/10.1...
#Aging #Muscle #Metabolism #Physiology #Science 🧪
#Aging #Muscle #Metabolism #Physiology #Science 🧪
🚨🆕NIH-funded🔬by Harissa et al show TRPV4 mutations may disrupt chondrocyte 🦴 mechanotransduction- cartilage loses important gene responses to mechanical load, altering growth & ossification👉 journals.physiology.org/doi/abs/10.1...
#Cartilage #Science #TRPV4 #Physiology
#Cartilage #Science #TRPV4 #Physiology
March 4, 2025 at 12:04 PM
🚨🆕NIH-funded🔬by Harissa et al show TRPV4 mutations may disrupt chondrocyte 🦴 mechanotransduction- cartilage loses important gene responses to mechanical load, altering growth & ossification👉 journals.physiology.org/doi/abs/10.1...
#Cartilage #Science #TRPV4 #Physiology
#Cartilage #Science #TRPV4 #Physiology
🚨🆕NIH-funded research🔬by Ducharme et al identify a hidden driver of cancer cachexia- senescent cells🧬-in pancreatic tumor-bearing mice, skeletal muscle accumulates p16+ cells, worsening w/ chemotherapy 👉 journals.physiology.org/doi/abs/10.1...
#Cancer #Senescence #Physiology #muscle #Science #NIH 🧪
#Cancer #Senescence #Physiology #muscle #Science #NIH 🧪
March 3, 2025 at 12:07 PM
🚨🆕NIH-funded research🔬by Ducharme et al identify a hidden driver of cancer cachexia- senescent cells🧬-in pancreatic tumor-bearing mice, skeletal muscle accumulates p16+ cells, worsening w/ chemotherapy 👉 journals.physiology.org/doi/abs/10.1...
#Cancer #Senescence #Physiology #muscle #Science #NIH 🧪
#Cancer #Senescence #Physiology #muscle #Science #NIH 🧪
Congrats @abhiprabhat.bsky.social on generating an amazing cover for the @jmccardiology.bsky.social March issue!
March 2, 2025 at 1:42 AM
Congrats @abhiprabhat.bsky.social on generating an amazing cover for the @jmccardiology.bsky.social March issue!
🚨 🆕 NIH-funded 🔬 byYu et al reveal how MARCKS-like protein 1 (MLP1) modifies endothelial sodium channel (EnNaC) activity🧬-Phosphorylation of MLP1 decreases EnNaC function👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Endothelium #Physiology #Science #NIH 🧪
#IonChannels #Endothelium #Physiology #Science #NIH 🧪
March 1, 2025 at 1:30 PM
🚨 🆕 NIH-funded 🔬 byYu et al reveal how MARCKS-like protein 1 (MLP1) modifies endothelial sodium channel (EnNaC) activity🧬-Phosphorylation of MLP1 decreases EnNaC function👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Endothelium #Physiology #Science #NIH 🧪
#IonChannels #Endothelium #Physiology #Science #NIH 🧪
🚨new🫀🔬by Xu et al suggests Bif-1 is important in driving heart damage post-MI🧬-it’s upregulation➡️ER stress & disrupts lipid metabolism, worsening cardiac function-Knockdown preserves heart health❤️🩹👉 journals.physiology.org/doi/abs/10.1...
#CardioSky #Physiology #Science 🧪
#CardioSky #Physiology #Science 🧪
February 26, 2025 at 10:03 AM
🚨new🫀🔬by Xu et al suggests Bif-1 is important in driving heart damage post-MI🧬-it’s upregulation➡️ER stress & disrupts lipid metabolism, worsening cardiac function-Knockdown preserves heart health❤️🩹👉 journals.physiology.org/doi/abs/10.1...
#CardioSky #Physiology #Science 🧪
#CardioSky #Physiology #Science 🧪
🚨New NIH- funded🔬by Ma et al show how CALHM1 ion channels open & close 🧬 Voltage⚡️& extracellular Ca2+ regulate gating- but the N-terminal region isn’t the gate- TM1 is key🔑 👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Neuroscience #Physiology #Science 🧪 #NIH
#IonChannels #Neuroscience #Physiology #Science 🧪 #NIH
February 26, 2025 at 9:11 AM
🚨New NIH- funded🔬by Ma et al show how CALHM1 ion channels open & close 🧬 Voltage⚡️& extracellular Ca2+ regulate gating- but the N-terminal region isn’t the gate- TM1 is key🔑 👉 journals.physiology.org/doi/abs/10.1...
#IonChannels #Neuroscience #Physiology #Science 🧪 #NIH
#IonChannels #Neuroscience #Physiology #Science 🧪 #NIH
🚨🫀🔬 Little et al reveal cardiac fibroblasts as major producers of high molecular weight hyaluronan post-heart attack heart ❤️🩹 Driven by HAS2- this ECM component accumulates but doesn’t impact fibroblast function 👉 journals.physiology.org/doi/abs/10.1...
#CardioSky #Physiology #Science
#CardioSky #Physiology #Science
February 22, 2025 at 12:58 PM
🚨🫀🔬 Little et al reveal cardiac fibroblasts as major producers of high molecular weight hyaluronan post-heart attack heart ❤️🩹 Driven by HAS2- this ECM component accumulates but doesn’t impact fibroblast function 👉 journals.physiology.org/doi/abs/10.1...
#CardioSky #Physiology #Science
#CardioSky #Physiology #Science
🚨🧠🔬 Constantino et al show how KATP channels are metabolic gatekeepers for sleep & arousal ⏰ Loss of Kir6.2 shifts glucose to glycolysis⚡️⬇️ neurotransmitters & disrupting EEG & sleep/wake transitions💤👉 www.pnas.org/doi/10.1073/...
#Sleep #Neuroscience #Metabolism #Physiology #Circadian #IonChannels
#Sleep #Neuroscience #Metabolism #Physiology #Circadian #IonChannels
February 19, 2025 at 12:10 PM
🚨🧠🔬 Constantino et al show how KATP channels are metabolic gatekeepers for sleep & arousal ⏰ Loss of Kir6.2 shifts glucose to glycolysis⚡️⬇️ neurotransmitters & disrupting EEG & sleep/wake transitions💤👉 www.pnas.org/doi/10.1073/...
#Sleep #Neuroscience #Metabolism #Physiology #Circadian #IonChannels
#Sleep #Neuroscience #Metabolism #Physiology #Circadian #IonChannels