Ruben Bierings
@bieringslab.bsky.social
Associate Professor Hematology 🩸 @Erasmus MC, Rotterdam
endothelial cell biology ftw! 🔬🧫🧬
Von Willebrand factor 🩹 | Weibel-Palade bodies 🥒 | exocytosis 🎆
endothelial cell biology ftw! 🔬🧫🧬
Von Willebrand factor 🩹 | Weibel-Palade bodies 🥒 | exocytosis 🎆
Reposted by Ruben Bierings
We're having a great Functional Imaging and Super-Resolution Microscopy course this year again. With engaged students learning about FRAP, FRET, STED, FLIM and many more (not necessarily 4 letter) fluorescent microscopy techniques.
But also a really nice talk by Ben Giepmans about ColorEM.
But also a really nice talk by Ben Giepmans about ColorEM.
November 14, 2025 at 11:00 AM
We're having a great Functional Imaging and Super-Resolution Microscopy course this year again. With engaged students learning about FRAP, FRET, STED, FLIM and many more (not necessarily 4 letter) fluorescent microscopy techniques.
But also a really nice talk by Ben Giepmans about ColorEM.
But also a really nice talk by Ben Giepmans about ColorEM.
Reposted by Ruben Bierings
💥Fireworks for #FluorescenceFriday!
Timelapse of an endothelial cell releasing Weibel-Palade bodies after stimulation with 100 µM histamine. Granules are fluorescently labeled with mStayGold.
Timelapse of an endothelial cell releasing Weibel-Palade bodies after stimulation with 100 µM histamine. Granules are fluorescently labeled with mStayGold.
October 24, 2025 at 1:59 PM
💥Fireworks for #FluorescenceFriday!
Timelapse of an endothelial cell releasing Weibel-Palade bodies after stimulation with 100 µM histamine. Granules are fluorescently labeled with mStayGold.
Timelapse of an endothelial cell releasing Weibel-Palade bodies after stimulation with 100 µM histamine. Granules are fluorescently labeled with mStayGold.
Reposted by Ruben Bierings
Wetenschappers van het Erasmus MC hebben ontdekt dat de bloedstollingsziekte van Von Willebrand niet altijd veroorzaakt wordt door een fout in het gelijknamige gen. Ook een probleem bij de uitscheiding van het stollingseiwit kan de ziekte teweegbrengen. amazingerasmusmc.nl/interne-gene...
Nieuwe oorzaak gevonden voor stollingsziekte van Von Willebrand - Amazing Erasmus MC
Wetenschappers van het Erasmus MC hebben ontdekt dat de bloedstollingsziekte van Von Willebrand niet altijd veroorzaakt wordt door een fout in het gelijknamige gen. Ook een probleem bij de uitscheidin...
amazingerasmusmc.nl
July 23, 2025 at 8:31 AM
Wetenschappers van het Erasmus MC hebben ontdekt dat de bloedstollingsziekte van Von Willebrand niet altijd veroorzaakt wordt door een fout in het gelijknamige gen. Ook een probleem bij de uitscheiding van het stollingseiwit kan de ziekte teweegbrengen. amazingerasmusmc.nl/interne-gene...
Newly minted Dr. Pastoors. Congratulations!
Yesterday I successfully defended my PhD thesis!!! It was a fantastic day where I got to celebrate with many colleagues, friends and family (this smile was on my face all day long)
June 28, 2025 at 5:58 AM
Newly minted Dr. Pastoors. Congratulations!
Reposted by Ruben Bierings
Well deserved recognition for team Clotterdam's very own @mandylauw.bsky.social #YoungEHA Congratulations Mandy!
We are HemaSphere proud at #EHA2025, where 2 of our editors received special EHA awards! Congrats to Jan Cools, Ed in Chief, for the education & mentoring award; and to Mandy Lauw, Scientific Ed, for the YoungEHA award. Well deserved 👏 @jancools.bsky.social @mandylauw.bsky.social
June 13, 2025 at 8:22 AM
Well deserved recognition for team Clotterdam's very own @mandylauw.bsky.social #YoungEHA Congratulations Mandy!
Reposted by Ruben Bierings
Spotted fellow #erasmusmcblood PhD candidate @shordijk.bsky.social at the #EHA wall of fame for her Mobility grant 🤩🤩 Congratulations !! @clotterdam.bsky.social
June 12, 2025 at 10:49 AM
Spotted fellow #erasmusmcblood PhD candidate @shordijk.bsky.social at the #EHA wall of fame for her Mobility grant 🤩🤩 Congratulations !! @clotterdam.bsky.social
Congratulations Fiona and the Verhage lab!
RIM and MUNC13 membrane-binding domains are essential for neuropeptide secretion, say Fiona Murphy, Matthijs Verhage and colleagues @amsterdamumc.bsky.social: rupress.org/jcb/article/...
#Neuroscience #Organelles
#Neuroscience #Organelles
May 19, 2025 at 2:12 PM
Congratulations Fiona and the Verhage lab!
Hard work by Bas Laan, Jessica Del Castillo Alferez and Iris van Moort finally pays off!
@tromboseleiden.bsky.social @clotterdam.bsky.social
@tromboseleiden.bsky.social @clotterdam.bsky.social
Why do some patients not respond to treatment with DDAVP? Read here 👇
DDAVP response and its determinants in bleeding disorders: a systematic review and meta-analysis
ashpublications.org/blood/articl...
DDAVP response and its determinants in bleeding disorders: a systematic review and meta-analysis
ashpublications.org/blood/articl...
DDAVP response and its determinants in bleeding disorders: a systematic review and meta-analysis
Key PointsThis study is the first large-scale meta-analysis to assess the response rate to DDAVP in different bleeding disorders.The differences in DDAVP r
ashpublications.org
May 2, 2025 at 2:20 PM
Hard work by Bas Laan, Jessica Del Castillo Alferez and Iris van Moort finally pays off!
@tromboseleiden.bsky.social @clotterdam.bsky.social
@tromboseleiden.bsky.social @clotterdam.bsky.social
Reposted by Ruben Bierings
This is how we roll....
(in Dutch, but that can be easily solved with your favorite AI-tool)
www.sciencelink.net/verdieping/f...
(in Dutch, but that can be easily solved with your favorite AI-tool)
www.sciencelink.net/verdieping/f...
Fluorescent gereedschap
Fluorescerende eiwitten en biosensoren zijn niet meer weg te denken uit biologisch onderzoek. Naast kleur en intensiteit, richten onderzoek van de Universiteit van Amsterdam zich nu op de levensduur a...
www.sciencelink.net
April 9, 2025 at 10:52 AM
This is how we roll....
(in Dutch, but that can be easily solved with your favorite AI-tool)
www.sciencelink.net/verdieping/f...
(in Dutch, but that can be easily solved with your favorite AI-tool)
www.sciencelink.net/verdieping/f...
Reposted by Ruben Bierings
I love taking photos of blood vessels in the brain! Here are some of my favorite shots, which one resonates with you the most?
#MicroscopyMonday
#MicroscopyMonday
April 7, 2025 at 4:47 PM
I love taking photos of blood vessels in the brain! Here are some of my favorite shots, which one resonates with you the most?
#MicroscopyMonday
#MicroscopyMonday
More and more sacrifices on a bonfire of science denial. Shocking doesn't even come close.
Chilling to see this list of terminated NIH grants. Research on Alzheimer's, HIV, rare diseases, vaccines -- gone. Cancer centers closed, training grants & fellowships terminated. Young scientists stranded. Patients waiting for treatments that'll never come. Just sad.
taggs.hhs.gov/Content/Data...
taggs.hhs.gov/Content/Data...
taggs.hhs.gov
March 19, 2025 at 10:32 AM
More and more sacrifices on a bonfire of science denial. Shocking doesn't even come close.
Reposted by Ruben Bierings
Interested in research on cell-cell junctions and vascular biology? We are recruiting a PhD student!
werkenbij.amsterdamumc.org/en/vacatures...
werkenbij.amsterdamumc.org/en/vacatures...
Vacatures - PhD vascular cell biology - Amsterdam UMC
Are you a motivated researcher with a passion for cell biology and blood vessels? Do you want to uncover the molecular mechanisms that drive vascular function? Join our team and apply now!
werkenbij.amsterdamumc.org
February 4, 2025 at 2:10 PM
Interested in research on cell-cell junctions and vascular biology? We are recruiting a PhD student!
werkenbij.amsterdamumc.org/en/vacatures...
werkenbij.amsterdamumc.org/en/vacatures...
Reposted by Ruben Bierings
Let’s all welcome @beckyzon.bsky.social to #HemeSky by thanking her for finding this video. She sent it to me today because she knows me so well.
I ❤️ TXA
I ❤️ TXA
January 29, 2025 at 12:58 AM
Let’s all welcome @beckyzon.bsky.social to #HemeSky by thanking her for finding this video. She sent it to me today because she knows me so well.
I ❤️ TXA
I ❤️ TXA
Reposted by Ruben Bierings
Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back!
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
January 15, 2025 at 7:59 PM
Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back!
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...
Reposted by Ruben Bierings
Interested in #organelle biogenesis, subcellular #protein targeting, physicochemical #membrane properties or #LipidMetabolism?
👉 We are hiring! #PhDstudent #postdoc
Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry available.
👉 We are hiring! #PhDstudent #postdoc
Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry available.
January 8, 2025 at 1:47 PM
Interested in #organelle biogenesis, subcellular #protein targeting, physicochemical #membrane properties or #LipidMetabolism?
👉 We are hiring! #PhDstudent #postdoc
Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry available.
👉 We are hiring! #PhDstudent #postdoc
Interdisciplinary projects combining #Biochemistry & #CellBiology with Computational Modeling & Physical Chemistry available.
Reposted by Ruben Bierings
Excited to share our preprint on #HemeSky: "MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia"! @delwelruud.bsky.social and co-authors! www.biorxiv.org/content/10.1... [1/15]
MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia
Enhancer translocations, due to 3q26 rearrangements, drive out-of-context MECOM expression in an aggressive subtype of acute myeloid leukemia (AML). Direct depletion of MECOM using an endogenous auxin...
www.biorxiv.org
January 6, 2025 at 3:46 PM
Excited to share our preprint on #HemeSky: "MECOM is a master repressor of myeloid differentiation through dose control of CEBPA in acute myeloid leukemia"! @delwelruud.bsky.social and co-authors! www.biorxiv.org/content/10.1... [1/15]
Reposted by Ruben Bierings
Looking for a fully funded PhD position in wonderful Vienna? The CeMM PhD program is now open for applications! 🎓 🥼 🧫
We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇
We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇
December 19, 2024 at 2:43 PM
Looking for a fully funded PhD position in wonderful Vienna? The CeMM PhD program is now open for applications! 🎓 🥼 🧫
We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇
We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇
Reposted by Ruben Bierings
Although still in 'First Edition' style, I am happy to finally share our latest article on DNMT3A double mutant AML. Hope to be able to share the way-easier-to-read print version of the paper soon! (1/2) #hemesky ashpublications.org/bloodadvance...
Double mutant DNMT3A AML: a unique subtype experiencing increased DNA damage and poor prognosis
Key Points. 1. Wildtype DNMT3A enhances TDG-mediated repair, whereas mutant DNMT3A impairs this process.2. Double mutant DNMT3A AML exhibits increased DNA
ashpublications.org
December 20, 2024 at 4:34 PM
Although still in 'First Edition' style, I am happy to finally share our latest article on DNMT3A double mutant AML. Hope to be able to share the way-easier-to-read print version of the paper soon! (1/2) #hemesky ashpublications.org/bloodadvance...
Reposted by Ruben Bierings
Everything you wanted to know about our humanized #VWD-type 1 mouse model (hVWD1 mice) is now available here ⬇️
haematologica.org/article/view...
#InsermU1176 #HITh
haematologica.org/article/view...
#InsermU1176 #HITh
December 10, 2024 at 8:31 PM
Everything you wanted to know about our humanized #VWD-type 1 mouse model (hVWD1 mice) is now available here ⬇️
haematologica.org/article/view...
#InsermU1176 #HITh
haematologica.org/article/view...
#InsermU1176 #HITh
Reposted by Ruben Bierings
Saying hi to our amazing @isth-official.bsky.social team #ASH24, and look what they had in store fore me! The must-have coagulation clock designed by @jhmorrissey.bsky.social.
Join us in Washington DC in June 2025. This will be the PREMIER event in #thrombosis and #haemostasis of 2025!!
Join us in Washington DC in June 2025. This will be the PREMIER event in #thrombosis and #haemostasis of 2025!!
December 9, 2024 at 9:49 PM
Saying hi to our amazing @isth-official.bsky.social team #ASH24, and look what they had in store fore me! The must-have coagulation clock designed by @jhmorrissey.bsky.social.
Join us in Washington DC in June 2025. This will be the PREMIER event in #thrombosis and #haemostasis of 2025!!
Join us in Washington DC in June 2025. This will be the PREMIER event in #thrombosis and #haemostasis of 2025!!
At least #Schiphol didn't cancel my flight to #ASH24 😅.
Come and see me if you want to discuss all things Weibel, Willebrand and @shordijk.bsky.social's latest work on MADD and VWD🩸.
Come and see me if you want to discuss all things Weibel, Willebrand and @shordijk.bsky.social's latest work on MADD and VWD🩸.
December 6, 2024 at 8:51 AM
At least #Schiphol didn't cancel my flight to #ASH24 😅.
Come and see me if you want to discuss all things Weibel, Willebrand and @shordijk.bsky.social's latest work on MADD and VWD🩸.
Come and see me if you want to discuss all things Weibel, Willebrand and @shordijk.bsky.social's latest work on MADD and VWD🩸.