The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. Here, we present a pan-disease resource to enable the study of divers...

The Spanish National Cancer Research Centre (CNIO), thanks to our philanthropic initiative CNIO Friends, has opened a new call for four postdoctoral fellowships. Each fellowship will fully fund a three-year CNIO Friends research contract and are open to all areas of cancer research. Candidates –researchers from any nationality who wish to develop a research project […]

imageimageActivation of quiescent fibroblasts contributes to adverse ventricular remodeling following myocardial injuries, leading to heart failure. The DNA demethylase TET3 trans-activates the mechan...

The layoffs jeopardize this resource, which has served more than 4,000 labs for about three decades.

A study presents ALPACA, a computational method for inferring clone- and allele-specific copy numbers of individual clones from multi-sample bulk DNA-sequencing data, and demonstrates its use to study...

Many patients with irritable bowel syndrome (IBS) believe gluten or wheat triggers their symptoms. We compared symptomatic responses to wheat and glut…

Nature Reviews Cancer, Published online: 22 July 2025; doi:10.1038/s41568-025-00854-3Rising rates of early-onset oestrogen receptor-positive (ER+) breast cancer in women without genetic risk suggest a shift in disease biology. Endocrine-disrupting chemicals (EDCs) may accelerate tissue ageing, destabilize epigenetic regulation and impair immune surveillance. Chronic and cumulative EDC exposure may induce field cancerization in the breast, warranting urgent attention from researchers, regulators and public health leaders.

Conventional chemotherapy remains a cornerstone of cancer treatment and is highly effective in the adjuvant and neoadjuvant settings. However, therapeutic resistance, especially in the metastatic cont...

View details and apply for this Higher or Senior Scientific Officer vacancy in Sutton. Salary : Salary from 39,805 to 49,023 Reporting to: Prof Trevor Graham Duration of ...

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing through cellular differentiation at scale.