Ben
@benjaminwu.bsky.social
Physician-scientist; pulmonologist; intensivist; lung microbiome researcher; human; pre-clinical models; il-17 enthusiast; reading; alkaline trio
Reposted by Ben
📣 Happy to share our review on host-microbiome genomics!
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
June 4, 2025 at 11:02 PM
📣 Happy to share our review on host-microbiome genomics!
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
Reposted by Ben
Who's taking a Post Graduate course today? So much science to be shared! #ATS2025 #RCMBatATS
May 17, 2025 at 5:08 PM
Who's taking a Post Graduate course today? So much science to be shared! #ATS2025 #RCMBatATS
Reposted by Ben
Happy World #sarcoidosis day! Will you #saysarcoidosis with us? #raiseawareness #foracure #forourpatients
April 13, 2025 at 7:46 PM
Happy World #sarcoidosis day! Will you #saysarcoidosis with us? #raiseawareness #foracure #forourpatients
Reposted by Ben
#WeekendRead! #NotOnlyInterferons! @nanyanlab.bsky.social &co show @cp-molecularcell.bsky.social that other than inducing pathogenic IFNs in lysosomal storage disorders, STING also play protective functions as a proton channel activating TFEB & inducing lysosomal repair www.cell.com/molecular-ce...
STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders
STING signaling in the innate immune system is well known for its role in the antiviral
type I interferon response. Tang et al. find that STING acts as an immune sensor of
lysosomal activity. When the...
www.cell.com
April 5, 2025 at 3:08 PM
#WeekendRead! #NotOnlyInterferons! @nanyanlab.bsky.social &co show @cp-molecularcell.bsky.social that other than inducing pathogenic IFNs in lysosomal storage disorders, STING also play protective functions as a proton channel activating TFEB & inducing lysosomal repair www.cell.com/molecular-ce...
Reposted by Ben
So excited that our study made the cover of Nature Genetics this month!
March 17, 2025 at 3:21 PM
So excited that our study made the cover of Nature Genetics this month!
Reposted by Ben
One of the amazing things about science is we will never run out of mysteries.
Take "Naturwissenschaften (2003) 90:495–500", which performed a survey of 10,000 dinosaur fossils for evidence of tumors in the bone.
I was prepared for yes, no, but what I wasn't prepared for was:
"only in hadrosaurs."
Take "Naturwissenschaften (2003) 90:495–500", which performed a survey of 10,000 dinosaur fossils for evidence of tumors in the bone.
I was prepared for yes, no, but what I wasn't prepared for was:
"only in hadrosaurs."
March 15, 2025 at 11:48 PM
One of the amazing things about science is we will never run out of mysteries.
Take "Naturwissenschaften (2003) 90:495–500", which performed a survey of 10,000 dinosaur fossils for evidence of tumors in the bone.
I was prepared for yes, no, but what I wasn't prepared for was:
"only in hadrosaurs."
Take "Naturwissenschaften (2003) 90:495–500", which performed a survey of 10,000 dinosaur fossils for evidence of tumors in the bone.
I was prepared for yes, no, but what I wasn't prepared for was:
"only in hadrosaurs."
Reposted by Ben
February 22, 2025 at 7:21 PM
Reposted by Ben
My fellow made this teaching tool to teach our residents about choosing IV access and I am obsessed.
February 12, 2025 at 6:10 PM
My fellow made this teaching tool to teach our residents about choosing IV access and I am obsessed.
Reposted by Ben
Sharing this official @atscommunity.bsky.social statement I was proud to be a part of. My takeaway: We need to standardize reporting and understand the impact of incidental findings in lung cancer screening. And also harness their findings for CVD prevention.
www.atsjournals.org/doi/10.1164/...
www.atsjournals.org/doi/10.1164/...
Lung Cancer Screening and Incidental Findings: A Research Agenda. An Official American Thoracic Society Research Statement | American Journal of Respiratory and Critical Care Medicine | Articles in Pr...
www.atsjournals.org
February 12, 2025 at 3:38 PM
Sharing this official @atscommunity.bsky.social statement I was proud to be a part of. My takeaway: We need to standardize reporting and understand the impact of incidental findings in lung cancer screening. And also harness their findings for CVD prevention.
www.atsjournals.org/doi/10.1164/...
www.atsjournals.org/doi/10.1164/...
Reposted by Ben
ICU ID - Pneumonia:
Since we are still facing a tsunami of respiratory tract infections, it's a good idea to review the 2023 clinical practice recommendations for diagnosis, empirical treatment, & antibiotic therapy for severe community-acquired pneumonia (sCAP)
Since we are still facing a tsunami of respiratory tract infections, it's a good idea to review the 2023 clinical practice recommendations for diagnosis, empirical treatment, & antibiotic therapy for severe community-acquired pneumonia (sCAP)
February 11, 2025 at 2:13 PM
ICU ID - Pneumonia:
Since we are still facing a tsunami of respiratory tract infections, it's a good idea to review the 2023 clinical practice recommendations for diagnosis, empirical treatment, & antibiotic therapy for severe community-acquired pneumonia (sCAP)
Since we are still facing a tsunami of respiratory tract infections, it's a good idea to review the 2023 clinical practice recommendations for diagnosis, empirical treatment, & antibiotic therapy for severe community-acquired pneumonia (sCAP)
Reposted by Ben
Hi #MedSky #ImpSci. I'm hiring a new staff scientist in my lab based in Seattle. We do #healthequity research in tobacco cessation, lung cancer and lung cancer screening. Please share with your networks and reach out directly if interested!
careers-fhcrc.icims.com/jobs/29239/j...
careers-fhcrc.icims.com/jobs/29239/j...
Fred Hutchinson Cancer Center
Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.
careers-fhcrc.icims.com
February 7, 2025 at 8:51 PM
Hi #MedSky #ImpSci. I'm hiring a new staff scientist in my lab based in Seattle. We do #healthequity research in tobacco cessation, lung cancer and lung cancer screening. Please share with your networks and reach out directly if interested!
careers-fhcrc.icims.com/jobs/29239/j...
careers-fhcrc.icims.com/jobs/29239/j...
Reposted by Ben
A benefit of prior vaccination when there's a breakthrough infection: putting the brakes on a maladaptive innate immune response
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Prior vaccination prevents overactivation of innate immune responses during COVID-19 breakthrough infection
SARS-CoV-2 breakthrough infections in previously vaccinated individuals are characterized by reduced activation of innate immune responses.
www.science.org
January 29, 2025 at 7:18 PM
A benefit of prior vaccination when there's a breakthrough infection: putting the brakes on a maladaptive innate immune response
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Ben
After 7 years of work and 1.5 years winding its way through publication, the paper I’ve wanted to share with you all for so long is finally out in @microbiomej.bsky.social
microbiomejournal.biomedcentral.com/articles/10....
#neosky #medsky #scisky #microbiome #fungi #mycobiome #newPI #science
microbiomejournal.biomedcentral.com/articles/10....
#neosky #medsky #scisky #microbiome #fungi #mycobiome #newPI #science
The fungal microbiota modulate neonatal oxygen-induced lung injury - Microbiome
Background The immature lungs of very preterm infants are exposed to supraphysiologic oxygen, contributing to bronchopulmonary dysplasia (BPD), a chronic lung disease that is the most common morbidity...
microbiomejournal.biomedcentral.com
January 27, 2025 at 11:16 PM
After 7 years of work and 1.5 years winding its way through publication, the paper I’ve wanted to share with you all for so long is finally out in @microbiomej.bsky.social
microbiomejournal.biomedcentral.com/articles/10....
#neosky #medsky #scisky #microbiome #fungi #mycobiome #newPI #science
microbiomejournal.biomedcentral.com/articles/10....
#neosky #medsky #scisky #microbiome #fungi #mycobiome #newPI #science
Reposted by Ben
Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
January 27, 2025 at 11:26 PM
Spatial multi-omics has just gone to the next level!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
—Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm
—"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"
Reposted by Ben
An immunome in 550 older adults and young adult controls demonstrated age-related changes at high-resolution along with some unique immune signatures
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits
This study provides one of the most comprehensive immune profiles of elderly individuals,
uncovering high-resolution immune changes associated with aging. Our findings highlight
clinically relevant im...
www.thelancet.com
January 27, 2025 at 11:40 PM
An immunome in 550 older adults and young adult controls demonstrated age-related changes at high-resolution along with some unique immune signatures
www.thelancet.com/journals/ebi...
www.thelancet.com/journals/ebi...
Reposted by Ben
wow I’ve always wondered about this and never got a good explaination. #EMIMCC
The problem with H/H is the pKa is not always 6.1 and can go up or down (a little) depending on lipids, temp, and pH.
January 26, 2025 at 2:03 AM
wow I’ve always wondered about this and never got a good explaination. #EMIMCC
Reposted by Ben
How a heart medication—digoxin—might help prevent cancer spread by dissolving clusters of circulating tumor cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 24, 2025 at 2:50 PM
How a heart medication—digoxin—might help prevent cancer spread by dissolving clusters of circulating tumor cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ben
A pro-inflammatory protein panel signature that accurately identified Long Covid in kids compared with controls
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 24, 2025 at 2:55 PM
A pro-inflammatory protein panel signature that accurately identified Long Covid in kids compared with controls
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ben
Not a lot of surprises in this study but nice to see the data! 60% weaned off and 63% of those survived. Cardiac arrest before VA-ECMO associated with failure to wean, lactate clearance within 24 hours associated with success and CRRT & bleeding associated with death.
January 24, 2025 at 1:02 PM
Not a lot of surprises in this study but nice to see the data! 60% weaned off and 63% of those survived. Cardiac arrest before VA-ECMO associated with failure to wean, lactate clearance within 24 hours associated with success and CRRT & bleeding associated with death.
Reposted by Ben
Anyway, betwixt everything, here is a really cool discovery that could potentially really help in the treatment of cancer in the future:
Tumors prevent effective immune responses from T cells by transferring their mitochondria (which have mutations) and having those replace...
Tumors prevent effective immune responses from T cells by transferring their mitochondria (which have mutations) and having those replace...
Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature
Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.
www.nature.com
January 23, 2025 at 10:43 PM
Anyway, betwixt everything, here is a really cool discovery that could potentially really help in the treatment of cancer in the future:
Tumors prevent effective immune responses from T cells by transferring their mitochondria (which have mutations) and having those replace...
Tumors prevent effective immune responses from T cells by transferring their mitochondria (which have mutations) and having those replace...
Reposted by Ben
In a cohort of over 146,000 veterans RSV vaccine effectiveness was estimated at 78·7% (72·2–84·8) against RSV-associated emergency department or urgent care encounters, and 80·3% (65·8–90·1) against RSV-associated hospitalisation.
The #vaccines work.🧪#IDSky
www.thelancet.com/journals/lan...
The #vaccines work.🧪#IDSky
www.thelancet.com/journals/lan...
Respiratory syncytial virus vaccine effectiveness among US veterans, September, 2023 to March, 2024: a target trial emulation study
RSV vaccination was effective in preventing RSV-related illness, including associated
health-care use, in adults aged 60 years and older during the 2023–24 respiratory
illness season, supporting curre...
www.thelancet.com
January 23, 2025 at 11:01 PM
In a cohort of over 146,000 veterans RSV vaccine effectiveness was estimated at 78·7% (72·2–84·8) against RSV-associated emergency department or urgent care encounters, and 80·3% (65·8–90·1) against RSV-associated hospitalisation.
The #vaccines work.🧪#IDSky
www.thelancet.com/journals/lan...
The #vaccines work.🧪#IDSky
www.thelancet.com/journals/lan...
Reposted by Ben
We’re all in the bad place but my collaboration with NIH/NCI researchers has been published.
January 23, 2025 at 6:42 PM
We’re all in the bad place but my collaboration with NIH/NCI researchers has been published.
Reposted by Ben
How to keep warm in the chill! The microbiome of some arctic worms protects them from the freeze by making cryoprotective compounds including the polyamine spermidine. 🧪
Bacteria Help Worms Brave the Harsh Antarctic Cold
The microbiome of Antarctic worms helps them cope with extremely cold conditions, providing insights into the role of the microbiome in host health and adaptation.
www.the-scientist.com
January 23, 2025 at 7:38 PM
How to keep warm in the chill! The microbiome of some arctic worms protects them from the freeze by making cryoprotective compounds including the polyamine spermidine. 🧪
Reposted by Ben
#immunosky #microbiomesky FREE LINK @cp-immunity.bsky.social!
Fat diet, dysbiosis, inflammation & chemicals induce gut barrier disruption! Systemic dissemination of gut microbiota mediates a Mincle-dependent induction of trained immunity in myeloid bone marrow cells
www.cell.com/immunity/ful...
Fat diet, dysbiosis, inflammation & chemicals induce gut barrier disruption! Systemic dissemination of gut microbiota mediates a Mincle-dependent induction of trained immunity in myeloid bone marrow cells
www.cell.com/immunity/ful...
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
Robles-Vera et al. unveil the capacity of gut microbiota translocation, particularly
Enterococcus faecalis, to mediate a Mincle-dependent induction of trained immunity
in myeloid bone marrow progenito...
www.cell.com
January 23, 2025 at 11:04 AM
#immunosky #microbiomesky FREE LINK @cp-immunity.bsky.social!
Fat diet, dysbiosis, inflammation & chemicals induce gut barrier disruption! Systemic dissemination of gut microbiota mediates a Mincle-dependent induction of trained immunity in myeloid bone marrow cells
www.cell.com/immunity/ful...
Fat diet, dysbiosis, inflammation & chemicals induce gut barrier disruption! Systemic dissemination of gut microbiota mediates a Mincle-dependent induction of trained immunity in myeloid bone marrow cells
www.cell.com/immunity/ful...
Reposted by Ben
This epic study, which took more than three years to get published, deserves special consideration.
#immunology
#microbiome
#allergy
#immunology
#microbiome
#allergy
RELMβ sets the threshold for microbiome-dependent oral tolerance - Nature
RELMβ mediates a gut immune–epithelial circuit regulating tolerance to food antigens, offering targetable candidates for the prevention and treatment of food allergies.
www.nature.com
January 23, 2025 at 2:48 AM
This epic study, which took more than three years to get published, deserves special consideration.
#immunology
#microbiome
#allergy
#immunology
#microbiome
#allergy