Aydan Szeto
@aydanszeto.bsky.social
Immunologist @MRC-LMB | Views are my own | he/him 🏳️🌈 | I work towards manipulating the Yin and Yang of inflammation
#immunology #immunosky
#immunology #immunosky
Pinned
Aydan Szeto
@aydanszeto.bsky.social
· Aug 14
Mef2d potentiates type-2 immune responses and allergic lung inflammation
Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and protective immune responses. Their production depends on the transcription factor GATA3, which is further elevate...
www.science.org
Thrilled to share our newest study in @ScienceMagazine. We created Boolean mice and CRISPR screened the heck outta ILC2s
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
June 1, 2025 at 12:37 PM
Reposted by Aydan Szeto
If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
January 14, 2025 at 5:26 PM
If you're doing innovative research about #microbiota and received an MD &/or PhD in last 10 years don’t miss out on applying for the NOSTER & @science.org Microbiome Prize!
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
Grand Prize: $25K & your essay published in Science Magazine
Deadline: Feb 14th
Enter: https://buff.ly/4gS29ZH
My mind is completely blown by this paradigm-shifting finding. An important piece of work reporting negative results.
Mice lacking microglia (Csf1r∆FIRE/∆FIRE) have normal
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
-synapse number and maturation
-seizure susceptibility and hippocampal-prefrontal cortex coherence
-segregation of inputs into the lateral geniculate nucleus
-neuronal and astrocytic gene expression
www.nature.com/articles/s41...
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience
Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...
www.nature.com
January 8, 2025 at 12:09 PM
My mind is completely blown by this paradigm-shifting finding. An important piece of work reporting negative results.
Reposted by Aydan Szeto
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Aydan Szeto
From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells.
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
December 9, 2024 at 5:18 PM
From June '24: The transcription factor Mef2d augments type 2 immune responses during allergic lung inflammation, regulating differentiation of Th2 and ILC2 cells.
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
https://buff.ly/3BdtFkS
Work from @aydanszeto.bsky.social et al.
#Immunology #ILC2s @science.org
#immunosky
Soluble Notch agonist have the potential to bypass the need for feeder cell lines in the generation of therapeutic T cells and ILCs. Huge potential and can’t wait to try it out (if it’s available to researchers)!
www.nature.com/articles/d41...
Soluble Notch agonist have the potential to bypass the need for feeder cell lines in the generation of therapeutic T cells and ILCs. Huge potential and can’t wait to try it out (if it’s available to researchers)!
www.nature.com/articles/d41...
Notching up a win: fresh tools for activating Notch
Synthetic protein agonists could boost T-cell biomanufacturing and therapeutic strategies.
www.nature.com
December 1, 2024 at 6:58 PM
#immunosky
Soluble Notch agonist have the potential to bypass the need for feeder cell lines in the generation of therapeutic T cells and ILCs. Huge potential and can’t wait to try it out (if it’s available to researchers)!
www.nature.com/articles/d41...
Soluble Notch agonist have the potential to bypass the need for feeder cell lines in the generation of therapeutic T cells and ILCs. Huge potential and can’t wait to try it out (if it’s available to researchers)!
www.nature.com/articles/d41...
RORgt+ dendritic cells versus Zbtb46+ ILC3s. Same cell or different?
December 1, 2024 at 1:20 PM
RORgt+ dendritic cells versus Zbtb46+ ILC3s. Same cell or different?
Reposted by Aydan Szeto
New PhD opportunity in the lab with @profjudiallen.bsky.social and @douglaspdyer.bsky.social looking at interactions between ILCs and the extracellular matrix. Application deadline Jan 10th 2025 - spread the word Bluesky immunologists!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
(Bicentenary) ILC interactions with the extracellular matrix in inflamed barrier tissues at The University of Manchester on FindAPhD.com
PhD Project - (Bicentenary) ILC interactions with the extracellular matrix in inflamed barrier tissues at The University of Manchester, listed on FindAPhD.com
www.findaphd.com
November 28, 2024 at 3:06 PM
New PhD opportunity in the lab with @profjudiallen.bsky.social and @douglaspdyer.bsky.social looking at interactions between ILCs and the extracellular matrix. Application deadline Jan 10th 2025 - spread the word Bluesky immunologists!
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Aydan Szeto
#Immunosky #neuroskyence our team is expanding and we’re recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...
www.jobs.manchester.ac.uk
November 27, 2024 at 5:05 AM
#Immunosky #neuroskyence our team is expanding and we’re recruiting a colleague with a strong background in neuroscience (PhD level) to conduct curiosity-driven research into the role of adaptive immunity in controlling sleep. Details & how to apply here: www.jobs.manchester.ac.uk/Job/JobDetai...
A naturally occurring fungal symbiont that is missing in some lab mice maybe be contributing to inter-facility variation in type-2 immunity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature
Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.
www.nature.com
November 27, 2024 at 10:13 PM
A naturally occurring fungal symbiont that is missing in some lab mice maybe be contributing to inter-facility variation in type-2 immunity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Aydan Szeto
New blogpost:
deevybee.blogspot.com/2024/11/why-...
deevybee.blogspot.com/2024/11/why-...
Why I have resigned from the Royal Society
The Royal Society is a venerable institution founded in 1660, whose original members included such eminent men as Christopher Wren, Robert H...
deevybee.blogspot.com
November 25, 2024 at 7:49 AM
New blogpost:
deevybee.blogspot.com/2024/11/why-...
deevybee.blogspot.com/2024/11/why-...
Reposted by Aydan Szeto
🚨🚨one more week to apply for our Research Assistant position in Tissue Immunology in Manchester!
Interested in infection, immunometabolism & sickness behaviour? Then come join me & @juanquintana.bsky.social
#Immunosky #LGBTQSTEM 🏳️🌈🏳️⚧️🧪 #Academicsky
www.jobs.manchester.ac.uk/Job/JobDetai...
Interested in infection, immunometabolism & sickness behaviour? Then come join me & @juanquintana.bsky.social
#Immunosky #LGBTQSTEM 🏳️🌈🏳️⚧️🧪 #Academicsky
www.jobs.manchester.ac.uk/Job/JobDetai...
Research Assistant in Tissue Immunology:Oxford Road
www.jobs.manchester.ac.uk
November 24, 2024 at 1:32 PM
🚨🚨one more week to apply for our Research Assistant position in Tissue Immunology in Manchester!
Interested in infection, immunometabolism & sickness behaviour? Then come join me & @juanquintana.bsky.social
#Immunosky #LGBTQSTEM 🏳️🌈🏳️⚧️🧪 #Academicsky
www.jobs.manchester.ac.uk/Job/JobDetai...
Interested in infection, immunometabolism & sickness behaviour? Then come join me & @juanquintana.bsky.social
#Immunosky #LGBTQSTEM 🏳️🌈🏳️⚧️🧪 #Academicsky
www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Aydan Szeto
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Wonderful to see the #immunology community growing here.
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
November 19, 2024 at 12:33 AM
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
#immunosky
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
https://www.nature.com/articles/s41586-024-08216-z
t.co
November 23, 2024 at 8:37 PM
#immunosky
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
The power of spatial information! ILC2s specifically in the middle of the colon express microbiota-induced genes that are important for the structural adaptation of this part of the gut. Loads of spatial data across different states (homeostasis vs inflammation) for the community.
Reposted by Aydan Szeto
My lab in Aberdeen, in the stunning North East of Scotland, will soon be recruiting for a post-doc to studying immune-ECM interactions in the lung. If you love IL-13, Hyaluronan, ECM biology, pulmonary immune responses....Get in touch and keep an eye out for the position.
November 13, 2024 at 8:30 AM
My lab in Aberdeen, in the stunning North East of Scotland, will soon be recruiting for a post-doc to studying immune-ECM interactions in the lung. If you love IL-13, Hyaluronan, ECM biology, pulmonary immune responses....Get in touch and keep an eye out for the position.
#immunosky
B cell and TFH researchers:
Bioresearch Technologies recently discontinued their NP-OVA 😵 where do you get them now?
B cell and TFH researchers:
Bioresearch Technologies recently discontinued their NP-OVA 😵 where do you get them now?
November 18, 2024 at 9:32 AM
#immunosky
B cell and TFH researchers:
Bioresearch Technologies recently discontinued their NP-OVA 😵 where do you get them now?
B cell and TFH researchers:
Bioresearch Technologies recently discontinued their NP-OVA 😵 where do you get them now?
Reposted by Aydan Szeto
ok- sci bsky - trying this out. our latest paper with @arimolofskylab.bsky.social shows that "allergic" immune cells (ILC2s) have a healthy function in developing brain: formation of inhibitory synapses - key tuners of brain activity www.science.org/stoken/autho...
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior
The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. I...
www.science.org
November 19, 2024 at 4:50 AM
ok- sci bsky - trying this out. our latest paper with @arimolofskylab.bsky.social shows that "allergic" immune cells (ILC2s) have a healthy function in developing brain: formation of inhibitory synapses - key tuners of brain activity www.science.org/stoken/autho...
Reposted by Aydan Szeto
go.bsky.app/Eaua5Jk my starter for neuroimmunology
November 19, 2024 at 4:50 AM
go.bsky.app/Eaua5Jk my starter for neuroimmunology
Reposted by Aydan Szeto
A starter pack for scientists working on NK cells or ILCs. Happy to add more names as more people join.
go.bsky.app/AjNpW2h
November 17, 2024 at 4:10 AM
A starter pack for scientists working on NK cells or ILCs. Happy to add more names as more people join.
go.bsky.app/AjNpW2h
Reposted by Aydan Szeto
Wonderful to see the #immunology community growing here.
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
November 15, 2024 at 12:35 PM
Wonderful to see the #immunology community growing here.
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
#immunosky Obsessed with our robotic arm loading plates to our Sony ID7000 spectral analyser to dramatically increase our flow throughput. This cytometer literally never blocks so we have complete trust in the whole system to run samples overnight whilst we sleep 😴
November 15, 2024 at 11:18 PM
#immunosky Obsessed with our robotic arm loading plates to our Sony ID7000 spectral analyser to dramatically increase our flow throughput. This cytometer literally never blocks so we have complete trust in the whole system to run samples overnight whilst we sleep 😴
Reposted by Aydan Szeto
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism?
Then come join me & @juanquintana.bsky.social at the @lydiabeckeriii.bsky.social as a research assistant 🤓 Email to arrange an informal chat 🧪 #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...
Then come join me & @juanquintana.bsky.social at the @lydiabeckeriii.bsky.social as a research assistant 🤓 Email to arrange an informal chat 🧪 #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...
Research Assistant in Tissue Immunology:Oxford Road
www.jobs.manchester.ac.uk
November 12, 2024 at 8:35 AM
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism?
Then come join me & @juanquintana.bsky.social at the @lydiabeckeriii.bsky.social as a research assistant 🤓 Email to arrange an informal chat 🧪 #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...
Then come join me & @juanquintana.bsky.social at the @lydiabeckeriii.bsky.social as a research assistant 🤓 Email to arrange an informal chat 🧪 #ImmunoSky www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Aydan Szeto
#MicroscopyMonday is very much alive here and I'm loving it! My take for this week is Neuroinflammation! Under a microscope literally looks like the brain is on fire! 🔥🔬 Instead of gently touching the neurons, microglia changes shape, gets activated and start attacking them. How do we control this?
November 11, 2024 at 11:51 PM
#MicroscopyMonday is very much alive here and I'm loving it! My take for this week is Neuroinflammation! Under a microscope literally looks like the brain is on fire! 🔥🔬 Instead of gently touching the neurons, microglia changes shape, gets activated and start attacking them. How do we control this?
Reposted by Aydan Szeto
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism?
The advert to join me & @juanquintana.bsky.social as a research assistant is now live! Drop one of us an email to arrange an informal chat 🧪 #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
The advert to join me & @juanquintana.bsky.social as a research assistant is now live! Drop one of us an email to arrange an informal chat 🧪 #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
Research Assistant in Tissue Immunology:Oxford Road
www.jobs.manchester.ac.uk
November 11, 2024 at 3:43 PM
Interested in tissue immunity in infection, focusing on adipose tissue, brain and immunometabolism?
The advert to join me & @juanquintana.bsky.social as a research assistant is now live! Drop one of us an email to arrange an informal chat 🧪 #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
The advert to join me & @juanquintana.bsky.social as a research assistant is now live! Drop one of us an email to arrange an informal chat 🧪 #ImmunoSky
www.jobs.manchester.ac.uk/Job/JobDetai...
Reposted by Aydan Szeto
This is cool work from Ari and Anna Molofsky's labs
"Our study identifies a role for ILC2s in promoting inhibitory synapse formation, thus establishing these cells as important regulators of brain development." #ImmunoSky 🧪
"Our study identifies a role for ILC2s in promoting inhibitory synapse formation, thus establishing these cells as important regulators of brain development." #ImmunoSky 🧪
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior
The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. I...
www.science.org
November 1, 2024 at 1:00 PM
This is cool work from Ari and Anna Molofsky's labs
"Our study identifies a role for ILC2s in promoting inhibitory synapse formation, thus establishing these cells as important regulators of brain development." #ImmunoSky 🧪
"Our study identifies a role for ILC2s in promoting inhibitory synapse formation, thus establishing these cells as important regulators of brain development." #ImmunoSky 🧪