Anna Molofsky Lab
@annamolofskylab.bsky.social
brain immune communication throughout the lifespan and in neuropsychiatric diseases
Amazing story from @arimolofskylab.bsky.social led by the fearless @nathanec.bsky.social now online @nature.com
Nature research paper: Dynamic fibroblast–immune interactions shape recovery after brain injury
go.nature.com/46smMbh
go.nature.com/46smMbh
Dynamic fibroblast–immune interactions shape recovery after brain injury - Nature
Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local immune response and lead to beneficial scar tissue formation.
go.nature.com
September 7, 2025 at 6:49 PM
Amazing story from @arimolofskylab.bsky.social led by the fearless @nathanec.bsky.social now online @nature.com
Reposted by Anna Molofsky Lab
I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness.
www.kpbs.org/podcasts/kpb...
www.kpbs.org/podcasts/kpb...
Nobel laureate on how Trump's cuts are hurting science
Neuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche...
www.kpbs.org
June 19, 2025 at 12:27 AM
I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness.
www.kpbs.org/podcasts/kpb...
www.kpbs.org/podcasts/kpb...
Reposted by Anna Molofsky Lab
I am saddened by this news. Atul was a vibrant colleague and tireless proponent of using data to unravel the complexity of disease.
June 15, 2025 at 5:57 AM
I am saddened by this news. Atul was a vibrant colleague and tireless proponent of using data to unravel the complexity of disease.
Reposted by Anna Molofsky Lab
New pre-print from our lab here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Detection of astrocyte epigenetic memory in in vitro systems, experimental autoimmune encephalomyelitis and multiple sclerosis samples
We recently described astrocyte pro-inflammatory epigenetic memory based on multiple complementary in vivo and in vitro studies, and the analysis of multiple sclerosis samples. Based on bioinformatic ...
www.biorxiv.org
June 11, 2025 at 9:03 PM
New pre-print from our lab here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Anna Molofsky Lab
Have you registered yet for #ReThinkNeuroimmunology in October?
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more
#ReThinkNeuroimmunology
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/
.@washumedicine.bsky.social @weizmanninstitute.bsky.social @genelayinstitute.bsky.social @massgenbrigham.bsky.social
June 12, 2025 at 11:26 PM
Have you registered yet for #ReThinkNeuroimmunology in October?
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more
Reposted by Anna Molofsky Lab
We're now appreciating how the immune and nervous systems communicate across body & brain, and there's still more to explore!
Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠
Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠
Cross-regulation between the nervous system and type 2 immunity
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues.
www.science.org
May 23, 2025 at 11:28 PM
We're now appreciating how the immune and nervous systems communicate across body & brain, and there's still more to explore!
Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠
Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠
Reposted by Anna Molofsky Lab
Review @sciimmunology.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social @nickmroz.bsky.social @phagocyticpai.bsky.social
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters
www.science.org/doi/10.1126/...
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters
www.science.org/doi/10.1126/...
May 16, 2025 at 6:11 PM
Review @sciimmunology.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social @nickmroz.bsky.social @phagocyticpai.bsky.social
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters
www.science.org/doi/10.1126/...
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters
www.science.org/doi/10.1126/...
Reposted by Anna Molofsky Lab
This month in #Science #Immunology: @nickmroz.bsky.social, @phagocyticpai.bsky.social, @annamolofskylab.bsky.social, & @arimolofskylab.bsky.social pen an insightful & timely Review on crosstalk between the #nervous system & #type2 immunity! #WeekendRead
#neuroimmunology #allergy #Alzheimers #itch
#neuroimmunology #allergy #Alzheimers #itch
Cross-regulation between the nervous system and type 2 immunity
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues.
www.science.org
May 23, 2025 at 9:41 AM
This month in #Science #Immunology: @nickmroz.bsky.social, @phagocyticpai.bsky.social, @annamolofskylab.bsky.social, & @arimolofskylab.bsky.social pen an insightful & timely Review on crosstalk between the #nervous system & #type2 immunity! #WeekendRead
#neuroimmunology #allergy #Alzheimers #itch
#neuroimmunology #allergy #Alzheimers #itch
Reposted by Anna Molofsky Lab
Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social @
April 16, 2025 at 1:25 AM
Reposted by Anna Molofsky Lab
#ReThinkNeuroimmunology
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/
.@washumedicine.bsky.social @weizmanninstitute.bsky.social @genelayinstitute.bsky.social @massgenbrigham.bsky.social
April 23, 2025 at 2:10 AM
#ReThinkNeuroimmunology
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/
3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology.
Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
Registrations 🔗 genelayinstitute.org/rtn/
Reposted by Anna Molofsky Lab
This was the last @hhmi.org conference Lilly and Yuh-Nung Jan attended as investigators. They're becoming HHMI emeritus but still run a thriving NIH-funded lab. From cloning the first potassium ion channel (Shaker) to decoding neuronal development, the Jans have made a huge impact.
April 10, 2025 at 3:25 PM
This was the last @hhmi.org conference Lilly and Yuh-Nung Jan attended as investigators. They're becoming HHMI emeritus but still run a thriving NIH-funded lab. From cloning the first potassium ion channel (Shaker) to decoding neuronal development, the Jans have made a huge impact.
Reposted by Anna Molofsky Lab
Thousands of federal health workers woke up on April 1 to find they had been fired or laid off. Scientists and civil servants at the FDA, CDC, and NIH were let go as part of Robert F. Kennedy Jr.'s pledge to cut jobs at the country’s most important disease-fighting agencies.
The Department Of Health And Human Services Cuts 10,000 Jobs
The cuts hit multiple agencies, affecting work on HIV, gun violence prevention, vaccines, minority health research, and more.
www.sciencefriday.com
April 7, 2025 at 5:42 PM
Thousands of federal health workers woke up on April 1 to find they had been fired or laid off. Scientists and civil servants at the FDA, CDC, and NIH were let go as part of Robert F. Kennedy Jr.'s pledge to cut jobs at the country’s most important disease-fighting agencies.
www.wired.com/story/doctor... “To get rid of 11 of our senior PIs … we’re hoping that’s a mistake, because we can’t figure out why they would want to do that,”
Doctor Behind Award-Winning Parkinson’s Research Among Scientists Purged From NIH
Leading scientists at the National Institutes of Health, the US’s leading medical research agency, were swept up Tuesday in the Trump administration’s latest firing blitz.
www.wired.com
April 2, 2025 at 7:08 PM
www.wired.com/story/doctor... “To get rid of 11 of our senior PIs … we’re hoping that’s a mistake, because we can’t figure out why they would want to do that,”
Reposted by Anna Molofsky Lab
Removing the top leadership at NIAID, NIH and other health agencies, including the CDC and FDA, will damage America’s position as a leader in groundbreaking research in disease prevention and treatment. That puts us all at risk. Read our statement: asm.org/Press-Releas...
ASM Statement on Removal of NIH & NIAID Leadership
Removing the top leadership at NIAID, NIH and other health agencies including CDC and FDA will damage America’s position as a leader in groundbreaking research in disease prevention and treatment.
asm.org
April 1, 2025 at 4:53 PM
Removing the top leadership at NIAID, NIH and other health agencies, including the CDC and FDA, will damage America’s position as a leader in groundbreaking research in disease prevention and treatment. That puts us all at risk. Read our statement: asm.org/Press-Releas...
Reposted by Anna Molofsky Lab
Go John and Boaz! new gene therapy for Dravet
Good news! Thanks to brain research, there's new hope for a future cure for Dravet syndrome - a devastating condition impacting children and their families.
We spoke with @fox13seattle.bsky.social's @mireyag.bsky.social about the incredible success of the gene therapy in mice and what's next.
🧠📈
We spoke with @fox13seattle.bsky.social's @mireyag.bsky.social about the incredible success of the gene therapy in mice and what's next.
🧠📈
March 27, 2025 at 6:52 PM
Go John and Boaz! new gene therapy for Dravet
Reposted by Anna Molofsky Lab
Dysfunctional meningeal lymphatics interfere with the inhibitory synaptic inputs and disrupt excitatory/inhibitory balance on cortical neurons in a microglia-IL-6-dependent manner @cellcellpress.bsky.social @jonykipnis.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
March 21, 2025 at 7:00 PM
Dysfunctional meningeal lymphatics interfere with the inhibitory synaptic inputs and disrupt excitatory/inhibitory balance on cortical neurons in a microglia-IL-6-dependent manner @cellcellpress.bsky.social @jonykipnis.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Anna Molofsky Lab
We have no memories for events from our earliest childhood years (aka infantile amnesia). Is it because we can't form them or can't keep them? Our Perspective on exciting new work from @tristansyates.bsky.social and colleagues.
Babies form fleeting memories | Science www.science.org/doi/10.1126/...
Babies form fleeting memories | Science www.science.org/doi/10.1126/...
Babies form fleeting memories
The human hippocampus constructs short-lived memories from around 1 year of age
www.science.org
March 20, 2025 at 6:42 PM
We have no memories for events from our earliest childhood years (aka infantile amnesia). Is it because we can't form them or can't keep them? Our Perspective on exciting new work from @tristansyates.bsky.social and colleagues.
Babies form fleeting memories | Science www.science.org/doi/10.1126/...
Babies form fleeting memories | Science www.science.org/doi/10.1126/...
Reposted by Anna Molofsky Lab
“This review belongs in the canon of papers that inspire deep theory work,” writes Stephanie Palmer about a groundbreaking review by her mentor—Allison Doupe—and Patricia Kuhl that helped the field define the neural and evolutionary dynamics of speech.
#neuroskyence
#neuroskyence
Stephanie Palmer on human speech, birdsong and a mentor
A groundbreaking review by Allison Doupe, who was Palmer’s mentor, and Patricia Kuhl shaped the field of neural and evolutionary dynamics of speech.
www.thetransmitter.org
March 18, 2025 at 2:26 PM
“This review belongs in the canon of papers that inspire deep theory work,” writes Stephanie Palmer about a groundbreaking review by her mentor—Allison Doupe—and Patricia Kuhl that helped the field define the neural and evolutionary dynamics of speech.
#neuroskyence
#neuroskyence
Reposted by Anna Molofsky Lab
This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH
March 15, 2025 at 5:32 PM
This is horrible to post, but I may as well post it. We are essentially shutting down research operations in my group, which is focused on treatments for pediatric brain cancer. I’m a well funded investigator, and there’s no choice. Science can’t function without the stability of NIH
Reposted by Anna Molofsky Lab
This is one of the best features I have seen on blue sky yet- a custom feed of papers from people you follow. I had to un-follow the various biorxiv channels, as it was dominant, but now I am seeing lots of cool papers from people I follow.
Great work on this feed, @paper-feed.bsky.social team!
Great work on this feed, @paper-feed.bsky.social team!
Welcome to your personalized Paper Skygest, a curated feed showing posts from your network.
📌 To pin this feed, select the pin icon at the top right of the feed. When you pin it, you'll see it up above here!
➡️ Follow this account for Skygest updates!
📌 To pin this feed, select the pin icon at the top right of the feed. When you pin it, you'll see it up above here!
➡️ Follow this account for Skygest updates!
March 14, 2025 at 5:46 PM
This is one of the best features I have seen on blue sky yet- a custom feed of papers from people you follow. I had to un-follow the various biorxiv channels, as it was dominant, but now I am seeing lots of cool papers from people I follow.
Great work on this feed, @paper-feed.bsky.social team!
Great work on this feed, @paper-feed.bsky.social team!
Reposted by Anna Molofsky Lab
Reposted by Anna Molofsky Lab
Where does TrumpElon think innovation for all their favorite biotech corporations comes from? PCR only exists because somebody was looking for bacteria in hot springs at Yellowstone. I’m just a private practice ophthalmologist who barely understands p values but even I know this shit is important.
This is my institution. These are the people I work with making these decisions. The situation is heartbreaking. Public medical schools have no other choice; there is no other source of funding, and everyone in academia is at extreme risk right now.
March 13, 2025 at 2:12 PM
Where does TrumpElon think innovation for all their favorite biotech corporations comes from? PCR only exists because somebody was looking for bacteria in hot springs at Yellowstone. I’m just a private practice ophthalmologist who barely understands p values but even I know this shit is important.
Reposted by Anna Molofsky Lab
A recent study found that cervical cancer deaths in young women have plummeted since the introduction of the human papillomavirus vaccine.
As Cervical Cancer Deaths Plummet, Experts Credit HPV Vaccine
HPV can cause a variety of cancers, including cervical. New mortality data for women under 25 point to the success of the HPV vaccine.
buff.ly
March 11, 2025 at 12:37 PM
A recent study found that cervical cancer deaths in young women have plummeted since the introduction of the human papillomavirus vaccine.
Reposted by Anna Molofsky Lab
Dendrite specific linking of memories over time - a cool extension of the work from @sjo09.bsky.social, @denisejcai.bsky.social, and others:
www.nature.com/articles/s41...
#neuroscience 🧪
www.nature.com/articles/s41...
#neuroscience 🧪
Compartmentalized dendritic plasticity in the mouse retrosplenial cortex links contextual memories formed close in time - Nature Neuroscience
Sehgal et al. show that branch-specific dendritic plasticity mechanisms in the retrosplenial cortex link memories acquired close in time such that, unlike independent memories, linked memories are enc...
www.nature.com
March 11, 2025 at 2:02 PM
Dendrite specific linking of memories over time - a cool extension of the work from @sjo09.bsky.social, @denisejcai.bsky.social, and others:
www.nature.com/articles/s41...
#neuroscience 🧪
www.nature.com/articles/s41...
#neuroscience 🧪