Axel Olin
@axelolin.bsky.social
Immunology, technology, clinical microsampling | Researcher at KTH Royal Institute of Technology, CEO at Cytodelics
Trying to improve microsampling technology for immune analysis, decentralizing clinical trials.
Trying to improve microsampling technology for immune analysis, decentralizing clinical trials.
Pinned
Axel Olin
@axelolin.bsky.social
· Nov 12
Introductory post! I'm an immunologist who recently transitioned into developing engineering solutions for clinical microsampling. My main interests are population studies in human systems immunology and ways to simplify them.
If this interests you, give me a follow or send me a message!
If this interests you, give me a follow or send me a message!
In exploratory omics studies in humans, it is quite common to evaluate the prediction accuracy of demographic variables like age and sex using the omics variables.
In what situation would you actually need to do this? Isn't there some more natural statistical framework that makes more sense? 1/2
In what situation would you actually need to do this? Isn't there some more natural statistical framework that makes more sense? 1/2
April 9, 2025 at 12:45 PM
In exploratory omics studies in humans, it is quite common to evaluate the prediction accuracy of demographic variables like age and sex using the omics variables.
In what situation would you actually need to do this? Isn't there some more natural statistical framework that makes more sense? 1/2
In what situation would you actually need to do this? Isn't there some more natural statistical framework that makes more sense? 1/2
75% is insane. Government loans for scientific funding would be a crazy good investment for countries that can afford it.
The massive changes in US research brought about by the new administration of President Donald Trump are causing many scientists in the country to rethink their lives and careers
https://go.nature.com/41OhAgK
https://go.nature.com/41OhAgK
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
go.nature.com
March 27, 2025 at 3:18 PM
75% is insane. Government loans for scientific funding would be a crazy good investment for countries that can afford it.
Reposted by Axel Olin
13 chair positions open @inserm.fr to lead a junior research group in France covering #neuroscience, #immunology, #bioinformatics, #bioengineering, #biotherapy, #public health pro.inserm.fr/rubriques/co... 🧪🔬
pro.inserm.fr
March 24, 2025 at 8:20 PM
13 chair positions open @inserm.fr to lead a junior research group in France covering #neuroscience, #immunology, #bioinformatics, #bioengineering, #biotherapy, #public health pro.inserm.fr/rubriques/co... 🧪🔬
Reposted by Axel Olin
The best thing Americans can do right now is minimizing domestic spending and donating to Ukraine: u24.gov.ua
Europeans should also donate more, stop buying american, invest in EU defense stocks, and pressure their governments to donate more and ramp up defense spending.
Europeans should also donate more, stop buying american, invest in EU defense stocks, and pressure their governments to donate more and ramp up defense spending.
March 1, 2025 at 6:39 AM
The best thing Americans can do right now is minimizing domestic spending and donating to Ukraine: u24.gov.ua
Europeans should also donate more, stop buying american, invest in EU defense stocks, and pressure their governments to donate more and ramp up defense spending.
Europeans should also donate more, stop buying american, invest in EU defense stocks, and pressure their governments to donate more and ramp up defense spending.
Reposted by Axel Olin
Complete batshit lunacy on the president's Truth Social account. Yes, he really posted this.
February 26, 2025 at 5:11 AM
Complete batshit lunacy on the president's Truth Social account. Yes, he really posted this.
Reposted by Axel Olin
Today, the US stood with Russia and North Korea — and against our allies — in voting against a UN resolution to condemn Russia's aggression against Ukraine. Let that sink in.
This is a betrayal of the Ukrainian people, our allies, our interests and those who aspire for freedom.
This is a betrayal of the Ukrainian people, our allies, our interests and those who aspire for freedom.
February 24, 2025 at 6:19 PM
Today, the US stood with Russia and North Korea — and against our allies — in voting against a UN resolution to condemn Russia's aggression against Ukraine. Let that sink in.
This is a betrayal of the Ukrainian people, our allies, our interests and those who aspire for freedom.
This is a betrayal of the Ukrainian people, our allies, our interests and those who aspire for freedom.
Reposted by Axel Olin
Elon Musk literally just verified the account 'Adolf Hitler' as an official government account on his website.
It is time for EU to block it, just like they blocked the website of the russian state-sponsored media channel RT. It is the source of so much misinformation.
It is time for EU to block it, just like they blocked the website of the russian state-sponsored media channel RT. It is the source of so much misinformation.
February 23, 2025 at 7:19 AM
Elon Musk literally just verified the account 'Adolf Hitler' as an official government account on his website.
It is time for EU to block it, just like they blocked the website of the russian state-sponsored media channel RT. It is the source of so much misinformation.
It is time for EU to block it, just like they blocked the website of the russian state-sponsored media channel RT. It is the source of so much misinformation.
Elon Musk literally just verified the account 'Adolf Hitler' as an official government account on his website.
It is time for EU to block it, just like they blocked the website of the russian state-sponsored media channel RT. It is the source of so much misinformation.
It is time for EU to block it, just like they blocked the website of the russian state-sponsored media channel RT. It is the source of so much misinformation.
February 23, 2025 at 7:19 AM
Elon Musk literally just verified the account 'Adolf Hitler' as an official government account on his website.
It is time for EU to block it, just like they blocked the website of the russian state-sponsored media channel RT. It is the source of so much misinformation.
It is time for EU to block it, just like they blocked the website of the russian state-sponsored media channel RT. It is the source of so much misinformation.
Reposted by Axel Olin
This rate of validation suggests that antibodies should be considered non-specific until proven otherwise:
357 validated out of 1,124 tested.
.
357 validated out of 1,124 tested.
.
January 31, 2025 at 12:24 PM
This rate of validation suggests that antibodies should be considered non-specific until proven otherwise:
357 validated out of 1,124 tested.
.
357 validated out of 1,124 tested.
.
Reposted by Axel Olin
Here's our latest work on proteome profiling of self-sampled dried blood spots to gain insights into the heterogeneity of the immune response against infections and vaccinations. We enrolled random citizens by postal mail to learn more about the molecular effects beyond those seeking medical care.
Multi-molecular phenotyping in a self-sampling population https://www.medrxiv.org/content/10.1101/2025.01.14.25320405v1
January 15, 2025 at 6:40 PM
Here's our latest work on proteome profiling of self-sampled dried blood spots to gain insights into the heterogeneity of the immune response against infections and vaccinations. We enrolled random citizens by postal mail to learn more about the molecular effects beyond those seeking medical care.
Reposted by Axel Olin
🩸🔬 Introducing #CryoSCAPE, a groundbreaking technique that keeps blood cells alive in deep freeze. This innovation promises to expand the reach of cutting-edge single-cell technologies to rural or underserved populations. ✨ 🧵
#SingleCellTech #RNAseq
#SingleCellTech #RNAseq
January 6, 2025 at 4:14 PM
🩸🔬 Introducing #CryoSCAPE, a groundbreaking technique that keeps blood cells alive in deep freeze. This innovation promises to expand the reach of cutting-edge single-cell technologies to rural or underserved populations. ✨ 🧵
#SingleCellTech #RNAseq
#SingleCellTech #RNAseq
Reposted by Axel Olin
‼️‼️
Last few days to apply to join us as a
#PostDoc in #SystemsImmunology and explore mechanisms of #SexDifferences in #Human #Immunity at Lund University in #Sweden
More info on how to apply below (please RT)
Last few days to apply to join us as a
#PostDoc in #SystemsImmunology and explore mechanisms of #SexDifferences in #Human #Immunity at Lund University in #Sweden
More info on how to apply below (please RT)
Join our #SystemsImmunology Lab (Lund University, Sweden) as a #Postdoctoral Fellow!
🔬 Project: To investigate sex hormone regulation of human immune function using CRISPR, transcriptomics, and immunophenotyping. Fully funded 2-year position (more info attached).
🗓️ Apply by Jan 6, 2025
🔬 Project: To investigate sex hormone regulation of human immune function using CRISPR, transcriptomics, and immunophenotyping. Fully funded 2-year position (more info attached).
🗓️ Apply by Jan 6, 2025
January 3, 2025 at 10:51 AM
‼️‼️
Last few days to apply to join us as a
#PostDoc in #SystemsImmunology and explore mechanisms of #SexDifferences in #Human #Immunity at Lund University in #Sweden
More info on how to apply below (please RT)
Last few days to apply to join us as a
#PostDoc in #SystemsImmunology and explore mechanisms of #SexDifferences in #Human #Immunity at Lund University in #Sweden
More info on how to apply below (please RT)
Trump just casually hinting that territories of allied countries might have to be incorporated into the United States because of 'national security'.
December 23, 2024 at 8:25 AM
Trump just casually hinting that territories of allied countries might have to be incorporated into the United States because of 'national security'.
Reposted by Axel Olin
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
December 11, 2024 at 4:29 PM
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
Reposted by Axel Olin
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
December 3, 2024 at 8:38 AM
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
Reposted by Axel Olin
I demand that every study that uses fecal samples be renamed from a "gut microbiome" to "fecal microbiome" study, including in the title. Thus, researchers would have to focus on good study design rather than sensationalism. Stool samples are NOT representative for the gut.
November 30, 2024 at 8:56 PM
I demand that every study that uses fecal samples be renamed from a "gut microbiome" to "fecal microbiome" study, including in the title. Thus, researchers would have to focus on good study design rather than sensationalism. Stool samples are NOT representative for the gut.
Reposted by Axel Olin
I am excited about Pixelgen Technologies molecular pixelation assay for single cell spatial proteomics. They have a new new tech note out in collab with #illumina www.illumina.com/content/dam/...
www.illumina.com
November 28, 2024 at 9:56 AM
I am excited about Pixelgen Technologies molecular pixelation assay for single cell spatial proteomics. They have a new new tech note out in collab with #illumina www.illumina.com/content/dam/...
These types of solutions look very interesting for scientific publishing: curvenote.com
Producing manuscripts (especially figures) suck due to the poor software available. Reading is an equally terrible experience, having to zoom in on figures and scroll up and down to look at references.
Producing manuscripts (especially figures) suck due to the poor software available. Reading is an equally terrible experience, having to zoom in on figures and scroll up and down to look at references.
Curvenote | Scientific publishing infrastructure
Curvenote develops next-generation publishing infrastructure and writing tools to support open, reproducible research. A beautiful writing tool designed for technical writing, connected to Jupyter. Wr...
curvenote.com
November 28, 2024 at 9:12 AM
These types of solutions look very interesting for scientific publishing: curvenote.com
Producing manuscripts (especially figures) suck due to the poor software available. Reading is an equally terrible experience, having to zoom in on figures and scroll up and down to look at references.
Producing manuscripts (especially figures) suck due to the poor software available. Reading is an equally terrible experience, having to zoom in on figures and scroll up and down to look at references.
Reposted by Axel Olin
I created a starter pack for systems immunology - let me know if you would like to be added. Excited to be here on
@bsky.app
go.bsky.app/PjH2Fuj
@bsky.app
go.bsky.app/PjH2Fuj
November 17, 2024 at 4:55 PM
I created a starter pack for systems immunology - let me know if you would like to be added. Excited to be here on
@bsky.app
go.bsky.app/PjH2Fuj
@bsky.app
go.bsky.app/PjH2Fuj
Does anyone have experience in using AI tools dedicated to the research grant writing process and found them useful? I've found a few, but they still seem a bit too general and rudimentary.
November 23, 2024 at 8:43 AM
Does anyone have experience in using AI tools dedicated to the research grant writing process and found them useful? I've found a few, but they still seem a bit too general and rudimentary.
Reposted by Axel Olin
Fresh from #bioRxiv:
Longitudinal blood #microsampling and proteome monitoring facilitate timely intervention in experimental type 1 diabetes.
#Proteome #Diabetes #Prevention #teamscience
@scilifelab.bsky.social #KarolinskaInstitutet #KTH #TUM
www.biorxiv.org/content/10.1...
Longitudinal blood #microsampling and proteome monitoring facilitate timely intervention in experimental type 1 diabetes.
#Proteome #Diabetes #Prevention #teamscience
@scilifelab.bsky.social #KarolinskaInstitutet #KTH #TUM
www.biorxiv.org/content/10.1...
Longitudinal blood microsampling and proteome monitoring facilitate timely intervention in experimental type 1 diabetes
Symptoms of immune-mediated diseases (IMIDs) typically appear after irreversible tissue damage, making early interventions based on pre-symptomatic indicators crucial. Current efforts to identify mole...
www.biorxiv.org
November 22, 2024 at 6:41 AM
Fresh from #bioRxiv:
Longitudinal blood #microsampling and proteome monitoring facilitate timely intervention in experimental type 1 diabetes.
#Proteome #Diabetes #Prevention #teamscience
@scilifelab.bsky.social #KarolinskaInstitutet #KTH #TUM
www.biorxiv.org/content/10.1...
Longitudinal blood #microsampling and proteome monitoring facilitate timely intervention in experimental type 1 diabetes.
#Proteome #Diabetes #Prevention #teamscience
@scilifelab.bsky.social #KarolinskaInstitutet #KTH #TUM
www.biorxiv.org/content/10.1...
Data on the effects of preanalytical factors on single-cell omics are severely lacking (as indicated by the lack of refs in this paper). It is great that this is being investigated for ATACseq and that methods to mitigate it are developed.
Enhancing single-cell ATAC sequencing with formaldehyde fixation, cryopreservation, and multiplexing for flexible analysis https://www.biorxiv.org/content/10.1101/2024.11.20.624480v1
Enhancing single-cell ATAC sequencing with formaldehyde fixation, cryopreservation, and multiplexing for flexible analysis https://www.biorxiv.org/content/10.1101/2024.11.20.624480v1
The assay for transposase-accessible chromatin using sequencing (ATAC-seq) revolutionized the field
www.biorxiv.org
November 22, 2024 at 5:51 AM
Data on the effects of preanalytical factors on single-cell omics are severely lacking (as indicated by the lack of refs in this paper). It is great that this is being investigated for ATACseq and that methods to mitigate it are developed.
I've seen a range of medicine and biomedicine-related starter packs, but has anyone seen some that are more medtech- or medical engineering-related?
November 20, 2024 at 6:43 AM
I've seen a range of medicine and biomedicine-related starter packs, but has anyone seen some that are more medtech- or medical engineering-related?