Darragh Duffy
@darraghduffy.bsky.social
Immunologist at Institut Pasteur Paris
Interested in immune response variability - causes & consequences
Interested in immune response variability - causes & consequences
Reposted by Darragh Duffy
🚨 1 week left to apply for the Pasteur-Paris University International PhD Program (PPU)!
Join an international community of scientists at the Institut Pasteur 🌍 Dedicated support, mentorship & world-class labs included.
📅Deadline: Oct 20, 2025
🎓Program start: October 2026
👉 Apply: bit.ly/CallPPU
Join an international community of scientists at the Institut Pasteur 🌍 Dedicated support, mentorship & world-class labs included.
📅Deadline: Oct 20, 2025
🎓Program start: October 2026
👉 Apply: bit.ly/CallPPU
October 13, 2025 at 11:58 AM
🚨 1 week left to apply for the Pasteur-Paris University International PhD Program (PPU)!
Join an international community of scientists at the Institut Pasteur 🌍 Dedicated support, mentorship & world-class labs included.
📅Deadline: Oct 20, 2025
🎓Program start: October 2026
👉 Apply: bit.ly/CallPPU
Join an international community of scientists at the Institut Pasteur 🌍 Dedicated support, mentorship & world-class labs included.
📅Deadline: Oct 20, 2025
🎓Program start: October 2026
👉 Apply: bit.ly/CallPPU
Reposted by Darragh Duffy
In general I think it's hard to combat scientific misinformation when some of the best research is locked behind an academic paywall, while lots of nonsense gets published free for everyone to read in predatory journals.
September 28, 2025 at 5:25 PM
In general I think it's hard to combat scientific misinformation when some of the best research is locked behind an academic paywall, while lots of nonsense gets published free for everyone to read in predatory journals.
Reposted by Darragh Duffy
Our latest study explains the link between the ABO blood type and its known associated differential susceptibility to thrombotic vascular diseases:
onlinelibrary.wiley.com/doi/10.1111/... lead by Tianai Lou @jamiesugrue.bsky.social with @darraghduffy.bsky.social & @clionaofarrelly.bsky.social
onlinelibrary.wiley.com/doi/10.1111/... lead by Tianai Lou @jamiesugrue.bsky.social with @darraghduffy.bsky.social & @clionaofarrelly.bsky.social
Altered DNA methylation of the ABO gene is associated with differential plasma levels of von willebrand factor and E‐selectin
Background The ABO blood group system is associated with differential susceptibility to thrombotic vascular diseases. ABO is also known to be a strong trans-protein quantitative trait locus for plas...
onlinelibrary.wiley.com
September 15, 2025 at 11:50 AM
Our latest study explains the link between the ABO blood type and its known associated differential susceptibility to thrombotic vascular diseases:
onlinelibrary.wiley.com/doi/10.1111/... lead by Tianai Lou @jamiesugrue.bsky.social with @darraghduffy.bsky.social & @clionaofarrelly.bsky.social
onlinelibrary.wiley.com/doi/10.1111/... lead by Tianai Lou @jamiesugrue.bsky.social with @darraghduffy.bsky.social & @clionaofarrelly.bsky.social
Reposted by Darragh Duffy
Disease prevalence in US states before & after vaccine introduction 🧪
From Edward Tufte & graphics.wsj.com/infectious-d...
From Edward Tufte & graphics.wsj.com/infectious-d...
September 4, 2025 at 6:01 PM
Disease prevalence in US states before & after vaccine introduction 🧪
From Edward Tufte & graphics.wsj.com/infectious-d...
From Edward Tufte & graphics.wsj.com/infectious-d...
Reposted by Darragh Duffy
Fever isn’t just a symptom, it's a window into immunity.
Maloney et al. show how temperature fluctuations, from tissues to T cell mitochondria, shape immune responses. Rising global temps make this research more critical than ever. 🔬🌡️
https://bit.ly/4cZ8gu7
Maloney et al. show how temperature fluctuations, from tissues to T cell mitochondria, shape immune responses. Rising global temps make this research more critical than ever. 🔬🌡️
https://bit.ly/4cZ8gu7
September 4, 2025 at 12:29 PM
Fever isn’t just a symptom, it's a window into immunity.
Maloney et al. show how temperature fluctuations, from tissues to T cell mitochondria, shape immune responses. Rising global temps make this research more critical than ever. 🔬🌡️
https://bit.ly/4cZ8gu7
Maloney et al. show how temperature fluctuations, from tissues to T cell mitochondria, shape immune responses. Rising global temps make this research more critical than ever. 🔬🌡️
https://bit.ly/4cZ8gu7
Reposted by Darragh Duffy
🧵How to write and manage your first research budgets
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
September 3, 2025 at 4:03 PM
🧵How to write and manage your first research budgets
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
Reposted by Darragh Duffy
Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):
September 1, 2025 at 7:32 PM
Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):
Reposted by Darragh Duffy
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
June 25, 2025 at 10:01 AM
Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential.
🔗 All positions: ki.se/en/about-ki/...
🔗 All positions: ki.se/en/about-ki/...
This analysis suggests that at least 13.5% of 2024 abstracts were processed with LLMs, reaching 40% for some subcorpora
The appearance of large language models caused a drastic shift in the vocabulary of academic writing, according to an analysis in #ScienceAdvances of more than 15 million biomedical abstracts published from 2010 to 2024.
Learn more:
Learn more:
Delving into LLM-assisted writing in biomedical publications through excess vocabulary
Large language models (LLMs) like ChatGPT can generate and revise text with human-level performance. These models come with clear limitations, can produce inaccurate information, and reinforce existing biases.
scim.ag
August 10, 2025 at 6:53 PM
This analysis suggests that at least 13.5% of 2024 abstracts were processed with LLMs, reaching 40% for some subcorpora
Reposted by Darragh Duffy
We’re hiring for a major role in the US, an investigative journalist to cover what’s happening with science in the US and beyond. This is extremely important territory for us. 🧪
workforus.theguardian.com/jobs/795 The Guardian :: Senior Science Investigative Reporter
workforus.theguardian.com/jobs/795 The Guardian :: Senior Science Investigative Reporter
The Guardian :: Senior Science Investigative Reporter
workforus.theguardian.com
July 26, 2025 at 6:02 AM
We’re hiring for a major role in the US, an investigative journalist to cover what’s happening with science in the US and beyond. This is extremely important territory for us. 🧪
workforus.theguardian.com/jobs/795 The Guardian :: Senior Science Investigative Reporter
workforus.theguardian.com/jobs/795 The Guardian :: Senior Science Investigative Reporter
Reposted by Darragh Duffy
There's no 'new normal' until we stop burning fossil fuels - it just keeps getting worse & worse.
Spain records highs of 46C and France under alert as Europe swelters in heatwave
- Extreme heat ‘the new normal’, says UN chief, as authorities across the continent issue health warnings
#climatecrisis
www.theguardian.com/environment/...
- Extreme heat ‘the new normal’, says UN chief, as authorities across the continent issue health warnings
#climatecrisis
www.theguardian.com/environment/...
Spain records highs of 46C and France under alert as Europe swelters in heatwave
Extreme heat ‘the new normal’, says UN chief, as authorities across the continent issue health warnings
www.theguardian.com
July 1, 2025 at 9:21 AM
There's no 'new normal' until we stop burning fossil fuels - it just keeps getting worse & worse.
Delighted to be in beautiful Tartu sharing our experience studying immune variability in @milieuinterieur.bsky.social with SySAge & University Tartu
June 18, 2025 at 7:54 AM
Delighted to be in beautiful Tartu sharing our experience studying immune variability in @milieuinterieur.bsky.social with SySAge & University Tartu
« neural-network models were outperformed by linear regression models for both genetic-only and genetic+environmental input scenarios »
📣 Latest from the lab: Performance of deep-learning-based approaches to improve polygenic scores www.nature.com/articles/s41...
Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.
Its thought deep learning will substantially improve PGS but the reality is MANY have tried but no/little gain has been seen so far. Here we report our negative results.
June 6, 2025 at 5:51 PM
« neural-network models were outperformed by linear regression models for both genetic-only and genetic+environmental input scenarios »
Reposted by Darragh Duffy
This is what the science machine does. No massive breakthrough. No single cure. Just lots and lots of cumulative knowledge that makes things better…
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
UK cancer survival rate doubles since 1970s amid ‘golden age’, report says
Half of those diagnosed will now survive for 10 years or more after advances in diagnosis and treatment
www.theguardian.com
June 3, 2025 at 5:35 AM
This is what the science machine does. No massive breakthrough. No single cure. Just lots and lots of cumulative knowledge that makes things better…
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
« this comparison shows the value of genotype information fell by more than two orders of magnitude within a decade »
Anatomy of the 23andMe fall and implications for consumer genomics go.nature.com/3Hf6sBE
Anatomy of the 23andMe fall and implications for consumer genomics - Nature Biotechnology
23andMe’s bankruptcy serves as a moment of reflection for the direct-to-consumer (DTC) genomics industry. We analyzed 23andMe financial data and business practices to reveal the factors behind the fal...
go.nature.com
May 29, 2025 at 4:14 PM
« this comparison shows the value of genotype information fell by more than two orders of magnitude within a decade »
Reposted by Darragh Duffy
Calling diagnostics developers.
If you know any companies in your network that can develop portable readers for RDTs, please check out the following request for proposals coordinated by FIND.
Can include standalone readers or mobile-phone based systems.
urldefense.com/v3/__https:/...
If you know any companies in your network that can develop portable readers for RDTs, please check out the following request for proposals coordinated by FIND.
Can include standalone readers or mobile-phone based systems.
urldefense.com/v3/__https:/...
Calls for partners - FIND
urldefense.com
May 26, 2025 at 7:52 PM
Calling diagnostics developers.
If you know any companies in your network that can develop portable readers for RDTs, please check out the following request for proposals coordinated by FIND.
Can include standalone readers or mobile-phone based systems.
urldefense.com/v3/__https:/...
If you know any companies in your network that can develop portable readers for RDTs, please check out the following request for proposals coordinated by FIND.
Can include standalone readers or mobile-phone based systems.
urldefense.com/v3/__https:/...
Reposted by Darragh Duffy
⚡⚡ Don't miss this! 👇
The Michelson Prizes: Next Generation Grants offer $150,000 💰 to support early career researchers in immunology-related fields.
Apply by June 22, 2025 🗓️
More info ℹ️:
www.michelsonmedicalresearch.org/michelson-pr...
#Immunology #Grants #EarlyCareerResearchers
The Michelson Prizes: Next Generation Grants offer $150,000 💰 to support early career researchers in immunology-related fields.
Apply by June 22, 2025 🗓️
More info ℹ️:
www.michelsonmedicalresearch.org/michelson-pr...
#Immunology #Grants #EarlyCareerResearchers
May 19, 2025 at 5:30 PM
⚡⚡ Don't miss this! 👇
The Michelson Prizes: Next Generation Grants offer $150,000 💰 to support early career researchers in immunology-related fields.
Apply by June 22, 2025 🗓️
More info ℹ️:
www.michelsonmedicalresearch.org/michelson-pr...
#Immunology #Grants #EarlyCareerResearchers
The Michelson Prizes: Next Generation Grants offer $150,000 💰 to support early career researchers in immunology-related fields.
Apply by June 22, 2025 🗓️
More info ℹ️:
www.michelsonmedicalresearch.org/michelson-pr...
#Immunology #Grants #EarlyCareerResearchers
Reposted by Darragh Duffy
Join the 1st EFIS Sex Differences in Immunity Congress – October 23, 2025 @pasteur.fr @sexdiffimmunity.bsky.social Registration link lnkd.in/emerimQc abstracts welcome from all researchers, scientists, clinicians #immunosky
May 12, 2025 at 8:31 PM
Join the 1st EFIS Sex Differences in Immunity Congress – October 23, 2025 @pasteur.fr @sexdiffimmunity.bsky.social Registration link lnkd.in/emerimQc abstracts welcome from all researchers, scientists, clinicians #immunosky
Reposted by Darragh Duffy
The Gulbenkian Institute of Molecular Medicine (GIMM) is one of the best research institutes in Portugal. It's currently recruiting for three Group Leaders (junior or senior) across different areas, including systems biology and bioinformatics.
gimm.pt/jobs/open-ca...
gimm.pt/jobs/open-ca...
Research Group Leaders – GIMMResearch Group Leaders – GIMM
Thank you very much for your generous donation and for sharing your testimony.We hope
to more people feel inspired to join this mission of discovery and innovation!
gimm.pt
May 1, 2025 at 8:06 AM
The Gulbenkian Institute of Molecular Medicine (GIMM) is one of the best research institutes in Portugal. It's currently recruiting for three Group Leaders (junior or senior) across different areas, including systems biology and bioinformatics.
gimm.pt/jobs/open-ca...
gimm.pt/jobs/open-ca...
Reposted by Darragh Duffy
Mark your calendars for this year's Day of Immunology on April 29th, 2025! This year's theme is "Brain and Immunity: Immunological insights into neurologic disorders".
Be sure to register for our webinar from 15:00-18:00 CEST at: loom.ly/gMqUDLs !
Be sure to register for our webinar from 15:00-18:00 CEST at: loom.ly/gMqUDLs !
March 18, 2025 at 6:39 PM
Mark your calendars for this year's Day of Immunology on April 29th, 2025! This year's theme is "Brain and Immunity: Immunological insights into neurologic disorders".
Be sure to register for our webinar from 15:00-18:00 CEST at: loom.ly/gMqUDLs !
Be sure to register for our webinar from 15:00-18:00 CEST at: loom.ly/gMqUDLs !
Reposted by Darragh Duffy
Our second online seminar will take place next week:
🗓 Date: Friday, April 25th 2025
🕒 Time: 14:00 CET
💻 Location: Online
🗓 Date: Friday, April 25th 2025
🕒 Time: 14:00 CET
💻 Location: Online
April 19, 2025 at 12:00 PM
Our second online seminar will take place next week:
🗓 Date: Friday, April 25th 2025
🕒 Time: 14:00 CET
💻 Location: Online
🗓 Date: Friday, April 25th 2025
🕒 Time: 14:00 CET
💻 Location: Online
Reposted by Darragh Duffy
1/ One of the most intriguing enigmas of the #COVID19 pandemic was the sudden and unprecedented outbreak of chilblains that accompanied the early waves of #SARSCoV2 infections. Our new study in @jem.org uncovers the underlying immunological mechanism
rupress.org/jem/article/...
rupress.org/jem/article/...
April 18, 2025 at 9:54 PM
1/ One of the most intriguing enigmas of the #COVID19 pandemic was the sudden and unprecedented outbreak of chilblains that accompanied the early waves of #SARSCoV2 infections. Our new study in @jem.org uncovers the underlying immunological mechanism
rupress.org/jem/article/...
rupress.org/jem/article/...
Reposted by Darragh Duffy
Chilblains were reported in #SARSCoV2–exposed individuals without PCR- or serologically defined #COVID19. Saidoune, Gilliet , @ahmad-yatim.bsky.social et al. show that excessive TLR7 responses to SARS-CoV-2 by pDCs are linked to I-IFN–driven chilblain development. rupress.org/jem/article/...
April 14, 2025 at 4:21 PM
Chilblains were reported in #SARSCoV2–exposed individuals without PCR- or serologically defined #COVID19. Saidoune, Gilliet , @ahmad-yatim.bsky.social et al. show that excessive TLR7 responses to SARS-CoV-2 by pDCs are linked to I-IFN–driven chilblain development. rupress.org/jem/article/...
Reposted by Darragh Duffy
Excellent programme d'exposés scientifiques in Paris @pintofscience.fr
Including talks in English from Elizabeth Maloney @pasteur.fr & Laura Finn @institutcochin.bsky.social on a topic we care strongly about - sex differences in #immunity & disease May 21 at Les Marquises
Including talks in English from Elizabeth Maloney @pasteur.fr & Laura Finn @institutcochin.bsky.social on a topic we care strongly about - sex differences in #immunity & disease May 21 at Les Marquises
April 12, 2025 at 1:41 PM
Excellent programme d'exposés scientifiques in Paris @pintofscience.fr
Including talks in English from Elizabeth Maloney @pasteur.fr & Laura Finn @institutcochin.bsky.social on a topic we care strongly about - sex differences in #immunity & disease May 21 at Les Marquises
Including talks in English from Elizabeth Maloney @pasteur.fr & Laura Finn @institutcochin.bsky.social on a topic we care strongly about - sex differences in #immunity & disease May 21 at Les Marquises