Asya Minervina
@asya-minervina.bsky.social
Reposted by Asya Minervina
Viral immunologist @pgtimmune.bsky.social, who recently joined Fred Hutch's Vaccine and Infectious Diseases Division, aims to harness the "incredible potential" of the immune system to advance diagnostics, vaccines and cancer therapies. bit.ly/3WJVpos
Viral immunologist taps ‘incredible potential’ of immune system
New Fred Hutch Cancer Center viral immunologist Dr. Paul Thomas is working to turn the "incredible potential" of the immune system into real-life diagnostic and therapeutic applications. He studies ho...
bit.ly
November 7, 2025 at 6:08 PM
Viral immunologist @pgtimmune.bsky.social, who recently joined Fred Hutch's Vaccine and Infectious Diseases Division, aims to harness the "incredible potential" of the immune system to advance diagnostics, vaccines and cancer therapies. bit.ly/3WJVpos
Reposted by Asya Minervina
excited to announce that this January we are relocating to Yale to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI): @yalecsei.bsky.social
looking to hire 2 postdocs to join us in this endeavor.
more details can be found here: sites.google.com/uw.edu/statp...
looking to hire 2 postdocs to join us in this endeavor.
more details can be found here: sites.google.com/uw.edu/statp...
SPE - join us
Postdoctoral position:
In January 2026, we are relocating to Yale university to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI).
We are looking for talented postd...
sites.google.com
October 27, 2025 at 8:47 PM
excited to announce that this January we are relocating to Yale to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI): @yalecsei.bsky.social
looking to hire 2 postdocs to join us in this endeavor.
more details can be found here: sites.google.com/uw.edu/statp...
looking to hire 2 postdocs to join us in this endeavor.
more details can be found here: sites.google.com/uw.edu/statp...
Reposted by Asya Minervina
excited that this paper is finally out in @pnas.org :
www.pnas.org/doi/10.1073/...
Led by Gian Marco Visani (effort initiated by Michael Pun), fantastic collaboration with @pgtimmune.bsky.social @asya-minervina.bsky.social and Phil Bradley.
www.pnas.org/doi/10.1073/...
Led by Gian Marco Visani (effort initiated by Michael Pun), fantastic collaboration with @pgtimmune.bsky.social @asya-minervina.bsky.social and Phil Bradley.
October 16, 2025 at 7:39 PM
excited that this paper is finally out in @pnas.org :
www.pnas.org/doi/10.1073/...
Led by Gian Marco Visani (effort initiated by Michael Pun), fantastic collaboration with @pgtimmune.bsky.social @asya-minervina.bsky.social and Phil Bradley.
www.pnas.org/doi/10.1073/...
Led by Gian Marco Visani (effort initiated by Michael Pun), fantastic collaboration with @pgtimmune.bsky.social @asya-minervina.bsky.social and Phil Bradley.
Reposted by Asya Minervina
If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
October 3, 2025 at 6:07 PM
If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?
I’d go with the team.
Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
Reposted by Asya Minervina
After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people.
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Vaccination with an mRNA-encoded membrane-bound HIV envelope trimer induces neutralizing antibodies in animal models
An HIV envelope trimer mRNA vaccine enables membrane-bound expression and produces a functional immunogen in preclinical mammalian models.
www.science.org
July 30, 2025 at 7:15 PM
After 30+ years of HIV vaccine clinical trials, this is the first time that neutralizing antibodies against an HIV clinical isolate has been generated in vaccinated people.
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
* "Tier 2" neutralizing antibodies, induced consistently.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Asya Minervina
How much of the TCR repertoire can we make sense of? Can your TCR and GEX data be put in the context of other conditions/tissues? How many varieties of T cells are in the repertoire zoo? All these questions (& more) addressed in our latest preprint: MetaCoNGA www.biorxiv.org/content/10.1... . a 🧵
Diverse modes of T cell receptor sequence convergence define unique functional and cellular phenotypes
Single-cell techniques allow concurrent study of gene activity and T cell receptor (TCR) sequences, identifying connections between TCR structure and cell traits. Expanding on our CoNGA software, we p...
www.biorxiv.org
July 14, 2025 at 11:52 PM
How much of the TCR repertoire can we make sense of? Can your TCR and GEX data be put in the context of other conditions/tissues? How many varieties of T cells are in the repertoire zoo? All these questions (& more) addressed in our latest preprint: MetaCoNGA www.biorxiv.org/content/10.1... . a 🧵
Reposted by Asya Minervina
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Replaying germinal center evolution on a quantified affinity landscape
Darwinian evolution of immunoglobulin genes within germinal centers (GC) underlies the progressive increase in antibody affinity following antigen exposure. Whereas the mechanics of how competition be...
www.biorxiv.org
June 5, 2025 at 2:28 PM
Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Asya Minervina
The recent "Mal-ID" paper in Science diagnoses diseases from immune repertoires. But a powerful model like Mal-ID can learn differences between groups of immune repertoires that are unrelated to the diseases of interest. We explore these pitfalls in our eLetter response.
Disease diagnostics using machine learning of B cell and T cell receptor sequences
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen ...
www.science.org
March 19, 2025 at 10:35 PM
The recent "Mal-ID" paper in Science diagnoses diseases from immune repertoires. But a powerful model like Mal-ID can learn differences between groups of immune repertoires that are unrelated to the diseases of interest. We explore these pitfalls in our eLetter response.
Reposted by Asya Minervina
Dear TCR researchers of #immunosky, you may be interested to know that our tool Stitchr - for the automated production of full-length T cell receptor sequences - has just had a nice little update:
jamieheather.github.io/stitchr/
jamieheather.github.io/stitchr/
stitchr — stitchr documentation
jamieheather.github.io
February 25, 2025 at 4:24 AM
Dear TCR researchers of #immunosky, you may be interested to know that our tool Stitchr - for the automated production of full-length T cell receptor sequences - has just had a nice little update:
jamieheather.github.io/stitchr/
jamieheather.github.io/stitchr/
Reposted by Asya Minervina
Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
www.science.org
February 21, 2025 at 10:32 PM
Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
Reposted by Asya Minervina
Building on the UShER tree of millions of SARS-CoV-2 genomes maintained by Angie Hinrichs, Hugh Haddox and Georg Angehrn (and others in @matsen.bsky.social lab and @jbloomlab.bsky.social) have looked into how the neutral mutation rate varies along the genome:
[1/N]
www.biorxiv.org/content/10.1...
[1/N]
www.biorxiv.org/content/10.1...
The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure
RNA viruses like SARS-CoV-2 have a high mutation rate, which contributes to their rapid evolution. The rate of mutations depends on the mutation type (e.g., A→C, A→G, etc.) and can vary between sites ...
www.biorxiv.org
January 11, 2025 at 5:37 PM
Building on the UShER tree of millions of SARS-CoV-2 genomes maintained by Angie Hinrichs, Hugh Haddox and Georg Angehrn (and others in @matsen.bsky.social lab and @jbloomlab.bsky.social) have looked into how the neutral mutation rate varies along the genome:
[1/N]
www.biorxiv.org/content/10.1...
[1/N]
www.biorxiv.org/content/10.1...
Reposted by Asya Minervina
9/9 Thanks to all our collaborators who helped out with the study, and congrats to Mitchell, who persevered through a lot of possible activation marker combinations!
December 20, 2024 at 3:39 AM
9/9 Thanks to all our collaborators who helped out with the study, and congrats to Mitchell, who persevered through a lot of possible activation marker combinations!
Reposted by Asya Minervina
How to learn generalizable rules across complex sequence-function maps? 💡In our new preprint we propose a framework for learning two-point statistics and use it to discover biophysical rules of TCR co-specificity that generalize to unseen ligands ! ✨ arxiv.org/abs/2412.13722
December 19, 2024 at 11:14 AM
How to learn generalizable rules across complex sequence-function maps? 💡In our new preprint we propose a framework for learning two-point statistics and use it to discover biophysical rules of TCR co-specificity that generalize to unseen ligands ! ✨ arxiv.org/abs/2412.13722
Reposted by Asya Minervina
ALSO! We are hiring for the last open position (Bioinformatics Research Scientist) in the TIRTL group! Love coding, math, robotics, and uncovering the immune system's secrets? You know you do, so join us! (stjude.wd1.myworkdayjobs.com/stjude/job/M...).
Bioinformatics Research Scientist (TIRTL Bluesky)
The Bioinformatics Research Scientist is responsible for designing, developing, improving, modifying, and operating data analysis pipelines. Manages projects and coordinates other efforts related to a...
stjude.wd1.myworkdayjobs.com
November 26, 2024 at 7:42 PM
ALSO! We are hiring for the last open position (Bioinformatics Research Scientist) in the TIRTL group! Love coding, math, robotics, and uncovering the immune system's secrets? You know you do, so join us! (stjude.wd1.myworkdayjobs.com/stjude/job/M...).
Reposted by Asya Minervina
Calling all T-cell aficionado's.
Come and join us next year (27-28 May 2025) for the fourth Antwerp T-Cell Receptor conference organised by @pmeysman.bsky.social, @krislaukens.bsky.social and Benson Ogunjimi.
I'll also be there!
www.uantwerpen.be/en/conferenc...
#ImmunoSky
Come and join us next year (27-28 May 2025) for the fourth Antwerp T-Cell Receptor conference organised by @pmeysman.bsky.social, @krislaukens.bsky.social and Benson Ogunjimi.
I'll also be there!
www.uantwerpen.be/en/conferenc...
#ImmunoSky
November 21, 2024 at 2:45 PM
Calling all T-cell aficionado's.
Come and join us next year (27-28 May 2025) for the fourth Antwerp T-Cell Receptor conference organised by @pmeysman.bsky.social, @krislaukens.bsky.social and Benson Ogunjimi.
I'll also be there!
www.uantwerpen.be/en/conferenc...
#ImmunoSky
Come and join us next year (27-28 May 2025) for the fourth Antwerp T-Cell Receptor conference organised by @pmeysman.bsky.social, @krislaukens.bsky.social and Benson Ogunjimi.
I'll also be there!
www.uantwerpen.be/en/conferenc...
#ImmunoSky
Reposted by Asya Minervina
We’ve jumped on board fully here on 🦋
A starter pack of those working on our favourite cell … the T cell 🥰🙈🥰
If you want an add let us know
go.bsky.app/8B5P25c
A starter pack of those working on our favourite cell … the T cell 🥰🙈🥰
If you want an add let us know
go.bsky.app/8B5P25c
November 19, 2024 at 10:11 PM
We’ve jumped on board fully here on 🦋
A starter pack of those working on our favourite cell … the T cell 🥰🙈🥰
If you want an add let us know
go.bsky.app/8B5P25c
A starter pack of those working on our favourite cell … the T cell 🥰🙈🥰
If you want an add let us know
go.bsky.app/8B5P25c
Reposted by Asya Minervina
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Wonderful to see the #immunology community growing here.
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
November 19, 2024 at 12:33 AM
Friends, the second #immunology starter pack filled in 3 days! I started a third to help folks new to BlueSky rebuild their network
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Below are the links
If you're an immunologist and I have missed you so far, let me know 🧪
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/6aT6qDS
Reposted by Asya Minervina
OK, #immunology Bluesky LFG!
If, like me, you're trying to reconstruct the vibrant scientific network we had at the other place, these starter packs are a great start:
go.bsky.app/2bqX3T7
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/AjNpW2h
go.bsky.app/SinqoJU
go.bsky.app/DmphBCT
If, like me, you're trying to reconstruct the vibrant scientific network we had at the other place, these starter packs are a great start:
go.bsky.app/2bqX3T7
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/AjNpW2h
go.bsky.app/SinqoJU
go.bsky.app/DmphBCT
November 18, 2024 at 7:06 PM
OK, #immunology Bluesky LFG!
If, like me, you're trying to reconstruct the vibrant scientific network we had at the other place, these starter packs are a great start:
go.bsky.app/2bqX3T7
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/AjNpW2h
go.bsky.app/SinqoJU
go.bsky.app/DmphBCT
If, like me, you're trying to reconstruct the vibrant scientific network we had at the other place, these starter packs are a great start:
go.bsky.app/2bqX3T7
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
go.bsky.app/AjNpW2h
go.bsky.app/SinqoJU
go.bsky.app/DmphBCT
Reposted by Asya Minervina
Inspired by @rodrahimi.bsky.social 's noble efforts linking immunologists together over here, let's try and get more specifically TCR/BCR/AIRR/repertoire chat going with this starter park
go.bsky.app/Gi2dcGd
Drop me a beep to get added or suggest others!
go.bsky.app/Gi2dcGd
Drop me a beep to get added or suggest others!
November 18, 2024 at 5:21 AM
Inspired by @rodrahimi.bsky.social 's noble efforts linking immunologists together over here, let's try and get more specifically TCR/BCR/AIRR/repertoire chat going with this starter park
go.bsky.app/Gi2dcGd
Drop me a beep to get added or suggest others!
go.bsky.app/Gi2dcGd
Drop me a beep to get added or suggest others!