Kilian Schober
@kischober.bsky.social
MD Microbiology & Virology. Understanding & Engineering Human T Cell Immunity in Erlangen, Germany (www.schoberlab.de). Cycling. BVB. Cinema. Family.
Pinned
Kilian Schober
@kischober.bsky.social
· Oct 8
TCR activation impairs CAR-T cytotoxicity against separate target cells
Chimeric antigen receptor T cells (CAR-T) are effective therapeutics against cancer and autoimmunity, but whether the endogenous T cell receptor (TCR) is beneficial, detrimental or irrelevant for CAR ...
www.biorxiv.org
When a T cell carries both its natural TCR and an engineered CAR, do these two receptors cooperate - or compete?
Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.
www.biorxiv.org/content/10.1...
Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.
www.biorxiv.org/content/10.1...
Reposted by Kilian Schober
New Comment
Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
www.thelancet.com/journals/lan...
Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
www.thelancet.com/journals/lan...
Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
Long COVID is an umbrella term for the heterogeneous long-term consequences of SARS-CoV-2
infection. It encompasses a wide spectrum of phenotypes (sometimes overlapping), and
its underlying mechanisms...
www.thelancet.com
November 9, 2025 at 7:52 PM
New Comment
Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
www.thelancet.com/journals/lan...
Negative results in long COVID clinical trials: choosing outcome measures for a heterogeneous disease
www.thelancet.com/journals/lan...
Reposted by Kilian Schober
One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc
The Shutdown of U.S.A.I.D. Has Already Killed Hundreds of Thousands
The short documentary “Rovina’s Choice” tells the story of what goes when aid goes.
newyorkermag.visitlink.me
November 6, 2025 at 9:00 PM
One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc
Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV-Specific CD8+ T Cells
onlinelibrary.wiley.com/doi/10.1002/...
It was a pleasure to contribute to this work by Jochen Hühn and his team (Helmholtz Braunschweig).
onlinelibrary.wiley.com/doi/10.1002/...
It was a pleasure to contribute to this work by Jochen Hühn and his team (Helmholtz Braunschweig).
Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV‐Specific CD8+ T Cells
Differentially methylated regions (DMRs) within the ZEB2 locus progressively demethylate during CD4+ and CD8+ T cell differentiation into cytotoxic CD4+ and CD8+ TEMRA subsets, respectively. This epi...
onlinelibrary.wiley.com
November 6, 2025 at 2:29 PM
Epigenetically Controlled ZEB2 Expression Promotes the Cytotoxic Potential of CMV-Specific CD8+ T Cells
onlinelibrary.wiley.com/doi/10.1002/...
It was a pleasure to contribute to this work by Jochen Hühn and his team (Helmholtz Braunschweig).
onlinelibrary.wiley.com/doi/10.1002/...
It was a pleasure to contribute to this work by Jochen Hühn and his team (Helmholtz Braunschweig).
Reposted by Kilian Schober
#PreprintClub is now on Bluesky!
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
December 10, 2024 at 1:51 PM
#PreprintClub is now on Bluesky!
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
Who are we and what are we doing? We are a group of enthusiastic scientists that gather together once a week to discuss fresh preprints in the field of #immunology. 🦠🧬
Reposted by Kilian Schober
Statistical thinking is a core part of solid biological results. However, many studies still include insufficient sample sizes, have poor experimental design, or select incorrect statistical tests.
Here, the authors present ten statistical tips for cell biology
www.nature.com/articles/s41...
Here, the authors present ten statistical tips for cell biology
www.nature.com/articles/s41...
Ten essential tips for robust statistics in cell biology - Nature Cell Biology
Statistical thinking is a core part of solid, trustworthy biology. However, many studies still include insufficient sample sizes, have poor experimental design or select an incorrect statistical metho...
www.nature.com
November 4, 2025 at 7:52 PM
Statistical thinking is a core part of solid biological results. However, many studies still include insufficient sample sizes, have poor experimental design, or select incorrect statistical tests.
Here, the authors present ten statistical tips for cell biology
www.nature.com/articles/s41...
Here, the authors present ten statistical tips for cell biology
www.nature.com/articles/s41...
www.life-science-alliance.org/content/9/1/...
New paper from the lab of Dirk Mielenz @fau.de. We had the pleasure of contributing a minor part.
New paper from the lab of Dirk Mielenz @fau.de. We had the pleasure of contributing a minor part.
Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation
T helper (Th) cell lineages are linked to metabolism, but precise mechanisms in human Th1 cells remain unclear. We addressed this question by in vitro stimulation and CRISPR/Cas9-mediated gene editing...
www.life-science-alliance.org
November 4, 2025 at 9:35 AM
www.life-science-alliance.org/content/9/1/...
New paper from the lab of Dirk Mielenz @fau.de. We had the pleasure of contributing a minor part.
New paper from the lab of Dirk Mielenz @fau.de. We had the pleasure of contributing a minor part.
Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?
November 3, 2025 at 10:16 AM
Dear single-cell bluesky community: We’re running Cell Ranger (5’ scRNA-seq) on sorted human CD8+ T cells with a custom library. Custom seqs (27–133 bp) appear in FASTQs + BAM but aren’t mapped. They are filtered out by STAR for being too short—any way to lower the length limit or workaround?
Reposted by Kilian Schober
I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
October 30, 2025 at 3:35 PM
I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.
tl;dr it's glam-slop & everyone involved should be embarrassed
Reposted by Kilian Schober
Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
bulletin.ndorms.ox.ac.uk
October 29, 2025 at 8:55 PM
Interested in joining the Powrie Lab? We’re looking for a Postdoctoral Researcher to study the neutralisation capacity of human anti-IL-10 autoantibodies. You’ll be part of our new MRC CoRE in Exposome Immunology!🧫🦠
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Find out more here & apply by 11th Nov: bulletin.ndorms.ox.ac.uk/c/126QDJVBd0...
Reposted by Kilian Schober
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
October 29, 2025 at 3:01 PM
How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Our new study in
@cp-immunity.bsky.social
offers some hints.
cell.com/immunity/ful...
Thanks and congratulations to all contributors
Reposted by Kilian Schober
🚨 The #HIRI invites applications for 2 JUNIOR GROUP LEADER POSITIONS in the areas of:
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
E15 Groups
The Helmholtz Institute for RNA-based Infection Researchopens a call for
www.helmholtz-hiri.de
October 28, 2025 at 4:04 PM
🚨 The #HIRI invites applications for 2 JUNIOR GROUP LEADER POSITIONS in the areas of:
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
🔵 RNA Biology
🔵 RNA Medicine
🔵 RNA Technology
Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Find an overview in this thread. 🧵👇
(1/6)
Reposted by Kilian Schober
Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosis https://www.biorxiv.org/content/10.1101/2025.10.23.682742v1
October 24, 2025 at 1:15 PM
Mapping of CD8 T-cell recognition to latent EBV infection and neuroantigens reveals HLA-specific depletion of T-cell responses in multiple sclerosis https://www.biorxiv.org/content/10.1101/2025.10.23.682742v1
Reposted by Kilian Schober
Together with Ralf Bartenschlager @ciid-heidelberg.bsky.social we are looking for a PhD student!
The project @trr179.bsky.social will revolve around (Hepatitis) viruses and the regulation of pattern recognition receptors in innate antiviral immunity.
Contact us if you're interested!
#PhDPosition
The project @trr179.bsky.social will revolve around (Hepatitis) viruses and the regulation of pattern recognition receptors in innate antiviral immunity.
Contact us if you're interested!
#PhDPosition
October 23, 2025 at 2:18 PM
Together with Ralf Bartenschlager @ciid-heidelberg.bsky.social we are looking for a PhD student!
The project @trr179.bsky.social will revolve around (Hepatitis) viruses and the regulation of pattern recognition receptors in innate antiviral immunity.
Contact us if you're interested!
#PhDPosition
The project @trr179.bsky.social will revolve around (Hepatitis) viruses and the regulation of pattern recognition receptors in innate antiviral immunity.
Contact us if you're interested!
#PhDPosition
Reposted by Kilian Schober
📢 We are announcing the Adaptive Immune Profiling Challenge 2025!
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...
October 22, 2025 at 7:09 PM
📢 We are announcing the Adaptive Immune Profiling Challenge 2025!
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...
Can you predict immune state labels from adaptive immune receptor repertoires?
💰 $10,000 prize pool!
🗓️ Launches Nov 5 on @kaggle.com
More Info: uio-bmi.github.io/adaptive_imm...
Reposted by Kilian Schober
Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 21, 2025 at 3:52 PM
Also tomorrow, Cindy Xintong Li from the University of Oxford will present a preprint about how TCR activation impairs CAR-T cytotoxicity against separate target cells. @kischober.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Eva Brunner joins us as a new PhD student.
Eva studied Applied Biochemistry at the Nuremberg Institute of Technology). During her master thesis, she functionally investigated eosinophils in cutaneous leishmaniasis.
(1/2)
Eva studied Applied Biochemistry at the Nuremberg Institute of Technology). During her master thesis, she functionally investigated eosinophils in cutaneous leishmaniasis.
(1/2)
October 21, 2025 at 11:40 AM
Eva Brunner joins us as a new PhD student.
Eva studied Applied Biochemistry at the Nuremberg Institute of Technology). During her master thesis, she functionally investigated eosinophils in cutaneous leishmaniasis.
(1/2)
Eva studied Applied Biochemistry at the Nuremberg Institute of Technology). During her master thesis, she functionally investigated eosinophils in cutaneous leishmaniasis.
(1/2)
Reposted by Kilian Schober
LJI is recruiting!
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
October 20, 2025 at 3:14 PM
LJI is recruiting!
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
The La Jolla Institute for Immunology (LJI, San Diego, California) invites applications for a tenure-track faculty position.
Reposted by Kilian Schober
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis: Cell www.cell.com/cell/fulltex...
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis
The first-in-human study of anti-BCMA CAR-T therapy for progressive multiple sclerosis
shows a favorable safety profile, depletion of plasma cells in the central nervous
system, and alleviation of mic...
www.cell.com
October 17, 2025 at 7:39 AM
Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis: Cell www.cell.com/cell/fulltex...
In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus | New England Journal of Medicine www.nejm.org/doi/full/10....
In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus | NEJM
In patients with refractory systemic lupus erythematosus, in vivo generation of CD19
CAR T cells by means of lipid nanoparticles led to B-cell depletion, reduced disease
activity, and no major toxi...
www.nejm.org
October 16, 2025 at 6:18 AM
In Vivo CD19 CAR T-Cell Therapy for Refractory Systemic Lupus Erythematosus | New England Journal of Medicine www.nejm.org/doi/full/10....
Nature or nurture? See www.cell.com/immunity/pdf... in response to www.cell.com/immunity/pdf..., with this reply by the original authors: www.cell.com/action/showP.... We need more "letter arguments" in science on platforms with high visibility. Through critical debate we gain critical insight.
Nurture over nature in fate decisions of antigen-specific CD8+ T cell clones from an endogenous repertoire
Abdullah et al.1 recently set out to gauge the influence of T cell receptor (TCR)-intrinsic
vs. -extrinsic factors on memory vs. effector fate decisions of CD8+ T cells. They
concluded that “a majorit...
www.cell.com
October 14, 2025 at 6:40 PM
Nature or nurture? See www.cell.com/immunity/pdf... in response to www.cell.com/immunity/pdf..., with this reply by the original authors: www.cell.com/action/showP.... We need more "letter arguments" in science on platforms with high visibility. Through critical debate we gain critical insight.
Reposted by Kilian Schober
Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
E15 Groups
The Helmholtz Institute for RNA-based Infection Researchopens a call for
www.helmholtz-hiri.de
October 13, 2025 at 1:30 PM
Looking to start your own lab? 🧬🧪 The Helmholtz Institute Würzburg (HIRI) is offering group leader positions in RNA biology, RNA medicine & RNA technology. Apply by October 31 at www.helmholtz-hiri.de/en/jobs-tale...
Reposted by Kilian Schober
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted by Kilian Schober
@biorxivpreprint.bsky.social TCR activation impairs CAR-T cytotoxicity against separate target cells
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 9, 2025 at 12:28 AM
@biorxivpreprint.bsky.social TCR activation impairs CAR-T cytotoxicity against separate target cells
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...