That would explain it - thanks!

What I did find interesting is Fig. S4U-V and Fig. S5. It's a pretty striking phenotype how much TCRs are enriched in fetuses with publicly known antigen specificity. And I would have wished for a more prominent declaration that the study is based on aborted fetuses (not just in the methods).

I agree with you that there's a lot of "atlasing" going on here. To cite Faust (English translation for you):

Ah! Now I’ve done Philosophy,
I’ve finished Law and Medicine,
And sadly even Theology:
Taken fierce pains, from end to end.
Now here I am, a fool for sure!
No wiser than I was before.

I didn't see them really assigning a subset from adults as naive with high certainty in the first place (using CITEseq or ribosomal genes among others). Without that context, it's very hard to distinguish ET from mature naive from mature early TSCM/TCM in scRNAseq.

All the best for this new chapter, Paul!

Congrats, Dominic!

Thanks a lot! Unfortunately our barcodes and UMIs are not on the same read, therefore this possibility probably won't work, but we'll look into it.

In her free time Eva enjoys hiking, horse riding, listening to audiobooks and spending time with family and friends.

Welcome, Eva!

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