Q-Immuno lab at UCL
@qimmuno.bsky.social
Quantitative immunology lab (PI: Andreas Tiffeau-Mayer)
https://qimmuno.com/
We use ideas from the physics of living systems and machine learning to understand human adaptive immunity in health and disease.
https://qimmuno.com/
We use ideas from the physics of living systems and machine learning to understand human adaptive immunity in health and disease.
Looking forward to connecting with many of you!
December 2, 2025 at 10:23 AM
Looking forward to connecting with many of you!
Later on I will give an invited talk in the session "AI driven insights into immune responses: vaccines, infections, and disease" laying out a vision for combining AI with TCRseq to study human immunity.
December 2, 2025 at 10:22 AM
Later on I will give an invited talk in the session "AI driven insights into immune responses: vaccines, infections, and disease" laying out a vision for combining AI with TCRseq to study human immunity.
Carolin Turner and Peter Thomas will talk in the Decoding and harnessing diversity in adaptive immune receptor repertoires session on T cell immunity to TB and SARS-CoV-2, respectively
December 2, 2025 at 10:22 AM
Carolin Turner and Peter Thomas will talk in the Decoding and harnessing diversity in adaptive immune receptor repertoires session on T cell immunity to TB and SARS-CoV-2, respectively
If you're at @britsocimm.bsky.social Congress, come catch three talks today with updates about our research!
December 2, 2025 at 10:21 AM
If you're at @britsocimm.bsky.social Congress, come catch three talks today with updates about our research!
Reposted by Q-Immuno lab at UCL
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils
Human T cell responses are often studied using blood, yet most T cells reside in tissues.
By comparing T cell receptor repertoires from millions of T cells from autologous
tonsils and blood, Sureshcha...
www.cell.com
November 26, 2025 at 3:47 PM
We are #absolutely #thrilled to #present @cp-immunity.bsky.social - Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils: Immunity www.cell.com/immunity/ful...
Reposted by Q-Immuno lab at UCL
Guidelines for T cell nomenclature www.nature.com/articles/s41...
Guidelines for T cell nomenclature - Nature Reviews Immunology
This Consensus Statement clarifies the existing subset-based nomenclature for T cells. Furthermore, it proposes an alternative modular nomenclature that is designed to be brief and flexible and to avo...
www.nature.com
November 19, 2025 at 11:27 AM
Guidelines for T cell nomenclature www.nature.com/articles/s41...
Excited for the line-up of speakers at the London Quantitative Immunology Network meeting Nov 19th -- check out the programme here 👉 evilab.ai/quantitative...
Come join us at ICR Chelsea :)
Come join us at ICR Chelsea :)
November 13, 2025 at 10:50 AM
Excited for the line-up of speakers at the London Quantitative Immunology Network meeting Nov 19th -- check out the programme here 👉 evilab.ai/quantitative...
Come join us at ICR Chelsea :)
Come join us at ICR Chelsea :)
Reposted by Q-Immuno lab at UCL
A really nice overview of key Treg discoveries relevant for today's exciting Nobel announcement
www.nobelprize.org/uploads/2025...
www.nobelprize.org/uploads/2025...
www.nobelprize.org
October 6, 2025 at 3:19 PM
A really nice overview of key Treg discoveries relevant for today's exciting Nobel announcement
www.nobelprize.org/uploads/2025...
www.nobelprize.org/uploads/2025...
To keep up-to-date with future events, also consider signing up for the LDN Q-Immuno mailing list. Instructions here: qimmuno.com/ldnqimmuno/
LDN-Q-Immuno · The Q-Immuno Lab
qimmuno.com
September 27, 2025 at 2:59 PM
To keep up-to-date with future events, also consider signing up for the LDN Q-Immuno mailing list. Instructions here: qimmuno.com/ldnqimmuno/
Join us for the next London Quantitative Immunology meet-up at the ICR in Chelsea on 19th November 2-5pm!
Free sign-up and short talk submission here: forms.gle/YZT1y2Sp6YVj...
Free sign-up and short talk submission here: forms.gle/YZT1y2Sp6YVj...
Quantitative Immunology Nov 25'
Quantitative Immunology Meet up - November
forms.gle
September 27, 2025 at 2:58 PM
Join us for the next London Quantitative Immunology meet-up at the ICR in Chelsea on 19th November 2-5pm!
Free sign-up and short talk submission here: forms.gle/YZT1y2Sp6YVj...
Free sign-up and short talk submission here: forms.gle/YZT1y2Sp6YVj...
Reposted by Q-Immuno lab at UCL
Driven to understand why transplants fail, Dr Andreas Tiffeau-Mayer (@qimmuno.bsky.social) used a UCL – University of Sydney Strategic Ignition Grant to combine computational and clinical expertise with collaborators in Australia ⬇️
Find out more about the Grants and apply by 13 Oct: bit.ly/4pFUd2S
Find out more about the Grants and apply by 13 Oct: bit.ly/4pFUd2S
Using machine learning to combat rejection in medical transplants
Dr Andreas Tiffeau-Mayer (UCL Division of Infection and Immunity) used the UCL – University of Sydney Strategic Ignition Grant to further knowledge about why some medical transplants fail.
www.ucl.ac.uk
September 22, 2025 at 4:09 PM
Driven to understand why transplants fail, Dr Andreas Tiffeau-Mayer (@qimmuno.bsky.social) used a UCL – University of Sydney Strategic Ignition Grant to combine computational and clinical expertise with collaborators in Australia ⬇️
Find out more about the Grants and apply by 13 Oct: bit.ly/4pFUd2S
Find out more about the Grants and apply by 13 Oct: bit.ly/4pFUd2S
How can repertoire analysis inform the selection of TCRs for cancer immunotherapy? We've summarised emerging experimental and computational approaches in a review led by @UDemael doi.org/10.3390/cell...
doi.org
August 19, 2025 at 2:01 PM
How can repertoire analysis inform the selection of TCRs for cancer immunotherapy? We've summarised emerging experimental and computational approaches in a review led by @UDemael doi.org/10.3390/cell...
Reposted by Q-Immuno lab at UCL
🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals.
✅ Wet & dry lab
✅ September 2025 enrolment
✅ UK tuition fees only
www.ucl.ac.uk/medical-scie...
✅ Wet & dry lab
✅ September 2025 enrolment
✅ UK tuition fees only
www.ucl.ac.uk/medical-scie...
Pre-Cancer Immunology
The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.
www.ucl.ac.uk
August 5, 2025 at 5:57 PM
🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals.
✅ Wet & dry lab
✅ September 2025 enrolment
✅ UK tuition fees only
www.ucl.ac.uk/medical-scie...
✅ Wet & dry lab
✅ September 2025 enrolment
✅ UK tuition fees only
www.ucl.ac.uk/medical-scie...
Reposted by Q-Immuno lab at UCL
Calling data scientists: we have opening in our Data Science core @icr.ac.uk to lead work around cancer spatial biology and single cell analysis. These are staff scientist type positions, ideal for someone who wants to help drive computational research. Apply here: jobs.icr.ac.uk/vacancies/12...
Data Scientist in Sutton | The Institute of Cancer Research
View details and apply for this Data Scientist vacancy in Sutton.
Salary : Salary range £39,805 to £49,023 (depending on the experience)
Reporting to: Professor Trevor Graham
...
jobs.icr.ac.uk
May 22, 2025 at 10:25 AM
Calling data scientists: we have opening in our Data Science core @icr.ac.uk to lead work around cancer spatial biology and single cell analysis. These are staff scientist type positions, ideal for someone who wants to help drive computational research. Apply here: jobs.icr.ac.uk/vacancies/12...
Very important work! We've been waiting for someone to do this. It has been clear for some time that a proportion of aggregated TCR-pMHC data might not be reliable. It will be interesting to reassess performance in light of this more robustly validated data.
A functionally validated TCR-pMHC database for TCR specificity model development https://www.biorxiv.org/content/10.1101/2025.04.28.651095v1
May 2, 2025 at 9:33 AM
Very important work! We've been waiting for someone to do this. It has been clear for some time that a proportion of aggregated TCR-pMHC data might not be reliable. It will be interesting to reassess performance in light of this more robustly validated data.
In our updated preprint, we show that mlTCRdist weights are predictive for pMHCs highly dissimilar (≥ 6 edits) to any seen during training! We are excited about these findings as such wide extrapolation has so far remained out of reach for sequence-based machine learning approaches. 🎉
May 1, 2025 at 10:06 AM
In our updated preprint, we show that mlTCRdist weights are predictive for pMHCs highly dissimilar (≥ 6 edits) to any seen during training! We are excited about these findings as such wide extrapolation has so far remained out of reach for sequence-based machine learning approaches. 🎉
How to learn rules of TCR-pMHC binding that generalize? We propose that co-specificity rules are likely more universal and can thus be learned from less data.
arxiv.org/abs/2412.13722
arxiv.org/abs/2412.13722
Data-driven Discovery of Biophysical T Cell Receptor Co-specificity Rules
The biophysical interactions between the T cell receptor (TCR) and its ligands determine the specificity of the cellular immune response. However, the immense diversity of receptors and ligands has ma...
arxiv.org
May 1, 2025 at 10:03 AM
How to learn rules of TCR-pMHC binding that generalize? We propose that co-specificity rules are likely more universal and can thus be learned from less data.
arxiv.org/abs/2412.13722
arxiv.org/abs/2412.13722
Reposted by Q-Immuno lab at UCL
Interested in T cell immunity in TB? Check out our new pre-print on antigen-agnostic identification of generalisable human in vivo Mtb-reactive T cell responses: www.biorxiv.org/content/10.1...
with @qimmuno.bsky.social & @innate2adaptive.bsky.social
with @qimmuno.bsky.social & @innate2adaptive.bsky.social
Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones.
T cells contribute to immune protection and pathogenesis in tuberculosis, but measurements of polyclonal responses have failed to resolve correlates of outcome. We report the first temporal…
www.biorxiv.org
April 21, 2025 at 5:28 PM
Interested in T cell immunity in TB? Check out our new pre-print on antigen-agnostic identification of generalisable human in vivo Mtb-reactive T cell responses: www.biorxiv.org/content/10.1...
with @qimmuno.bsky.social & @innate2adaptive.bsky.social
with @qimmuno.bsky.social & @innate2adaptive.bsky.social
Reposted by Q-Immuno lab at UCL
Hi, I’m Peter the Postdoc and today I’ll be taking over the feed from the 3rd London Quantitative Immunology Day! I’ll be sharing updates and insights as the day progresses, so stay tuned!
April 10, 2025 at 8:33 AM
Hi, I’m Peter the Postdoc and today I’ll be taking over the feed from the 3rd London Quantitative Immunology Day! I’ll be sharing updates and insights as the day progresses, so stay tuned!
Reposted by Q-Immuno lab at UCL
(1/2)
Another successful #qimmuno day has drawn to a close, but discussions continue in the pub around the corner! Congrats to the organising committee @qimmuno.bsky.social for an excellent day and to all the speakers for engaging talks.
Another successful #qimmuno day has drawn to a close, but discussions continue in the pub around the corner! Congrats to the organising committee @qimmuno.bsky.social for an excellent day and to all the speakers for engaging talks.
April 10, 2025 at 5:05 PM
(1/2)
Another successful #qimmuno day has drawn to a close, but discussions continue in the pub around the corner! Congrats to the organising committee @qimmuno.bsky.social for an excellent day and to all the speakers for engaging talks.
Another successful #qimmuno day has drawn to a close, but discussions continue in the pub around the corner! Congrats to the organising committee @qimmuno.bsky.social for an excellent day and to all the speakers for engaging talks.
Two days to go until the 3rd LDN Q-Immuno Day at UCL! We are looking forward to welcome you on Thursday for an incredible line-up of speakers. Full schedule now available here: qimmuno.com/ldnday/
LDNQImmuno · April 10th
qimmuno.com
April 8, 2025 at 8:13 AM
Two days to go until the 3rd LDN Q-Immuno Day at UCL! We are looking forward to welcome you on Thursday for an incredible line-up of speakers. Full schedule now available here: qimmuno.com/ldnday/
Two weeks to go for our London Quantitative Immunology day on April 10th! Last chance to submit abstracts for contributed talks is today 👉 qimmuno.com/ldnday/
LDNQImmuno · April 10th
qimmuno.com
March 27, 2025 at 10:06 AM
Two weeks to go for our London Quantitative Immunology day on April 10th! Last chance to submit abstracts for contributed talks is today 👉 qimmuno.com/ldnday/
Reposted by Q-Immuno lab at UCL
The recent "Mal-ID" paper in Science diagnoses diseases from immune repertoires. But a powerful model like Mal-ID can learn differences between groups of immune repertoires that are unrelated to the diseases of interest. We explore these pitfalls in our eLetter response.
Disease diagnostics using machine learning of B cell and T cell receptor sequences
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen ...
www.science.org
March 19, 2025 at 10:35 PM
The recent "Mal-ID" paper in Science diagnoses diseases from immune repertoires. But a powerful model like Mal-ID can learn differences between groups of immune repertoires that are unrelated to the diseases of interest. We explore these pitfalls in our eLetter response.
Come join us for the 3rd LDN Quantitative Immunology Day on 10th of April @ucl.ac.uk ! All info and free registration 👉 qimmuno.com/ldnday/
LDNQImmuno · April 10th
A community day for researchers in the quantitative life sciences from across London.
qimmuno.com
March 4, 2025 at 9:14 AM
Come join us for the 3rd LDN Quantitative Immunology Day on 10th of April @ucl.ac.uk ! All info and free registration 👉 qimmuno.com/ldnday/
4. Finally, we used our information theory framework to explain why predictions for some epitopes are easier regardless of model and we introduce a simple technique to provide error bars for comparing model performance which removes the variance resulting from this effect.
January 17, 2025 at 9:51 PM
4. Finally, we used our information theory framework to explain why predictions for some epitopes are easier regardless of model and we introduce a simple technique to provide error bars for comparing model performance which removes the variance resulting from this effect.