James Reading
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jamesreading.bsky.social
James Reading
@jamesreading.bsky.social
Immunologist | Assoc. Prof at UCL | Using T Cells to Track & Target Tumourigenesis | Cancer Interception | Immune Prevention |
https://www.ucl.ac.uk/medical-sciences/divisions/cancer/our-research/pre-cancer-immunology
🚨 PhD Position available in our lab 🚨 exploring the power of blood immune multi-omics to detect lung cancer years prior to clinical diagnosis in a unique cohort of >10,000 CT screened individuals.
✅ Wet & dry lab
✅ September 2025 enrolment
✅ UK tuition fees only

www.ucl.ac.uk/medical-scie...
Pre-Cancer Immunology
The Pre-Cancer Immunology Lab (James Reading Lab) is mapping pre-invasive T cell dynamics during carcinogenesis to detect and intercept cancer development.
www.ucl.ac.uk
August 5, 2025 at 5:57 PM
Reposted by James Reading
🚨 Final day to send in your application to join @giampazolias.bsky.social & the Cancer Immunosurveillance group @cruk-mi.bsky.social.

Don’t miss this great opportunity!
@mcrcnews.bsky.social
We are recruiting #postdoctoral scientists to join @giampazolias.bsky.social and our Cancer Immunosurveillance group 🧪🥼🧫🦠

For full details of the position, please visit our website:

www.cruk.manchester.ac.uk/career/mi-24...

Closing date: 4th April

#OncoSky #CanSky #CancerResearch #microbiome
April 4, 2025 at 6:37 AM
Reposted by James Reading
Nature research paper: Clonal driver neoantigen loss under EGFR TKI and immune selection pressures

https://go.nature.com/4k6SCQD
Clonal driver neoantigen loss under EGFR TKI and immune selection pressures - Nature
We show the evolution of a case of EGFR mutant lung cancer treated with a combination of erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine targeting somatic mutations, including EGFR exon 19 deletion.
go.nature.com
February 20, 2025 at 2:49 PM
Reposted by James Reading
Interested in investigating the principles that regulate the establishment of tumour environments that promote or inhibit the anti-tumour function of the immune system? Our group is currently recruiting a postdoctoral fellow.
Learn more about our research 👇
www.cruk.manchester.ac.uk/research-gro...
MI/25/01 – Postdoctoral Scientist – Cancer Inflammation And Immunity Group | Cancer Research UK Manchester Institute
www.cruk.manchester.ac.uk
February 14, 2025 at 3:56 PM
Reposted by James Reading
#hiring #postdoc
We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here:
www.gla.ac.uk/explore/jobs...
University of Glasgow - Explore - Jobs at Glasgow - Appointments - Research Associate (Breast Cancer Now) [164192]Search iconClose menu iconMenu icon bar 1Menu icon bar 2Menu icon bar 3
www.gla.ac.uk
February 7, 2025 at 10:23 AM
Reposted by James Reading
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
doi.org
January 3, 2025 at 7:18 PM
Reposted by James Reading
Interesting work, it's becoming clear that @santiagozelenay.bsky.social's 2015 work on the COX-PGE axis' role in tumor immune evasion is robust (and also that we really need to focus on type I IFN in anti-tumor immunity).
#Immunology #Immunotherapy #Immunosky
December 15, 2024 at 10:20 AM
Reposted by James Reading
A very rare position for an immunology professorship at Cambridge. Something to think about!

www.jobs.cam.ac.uk/job/49381/
Associate Professor/Professor of Infection and/or Immunity - Job Opportunities - University of Cambridge
Associate Professor/Professor of Infection and/or Immunity in the Department of Pathology at the University of Cambridge.
www.jobs.cam.ac.uk
December 13, 2024 at 9:53 AM
Reposted by James Reading
This week in #Science #Immunology: Jan Petersen, Jamie Rossjohn, & colleagues have solved the #CrystalStructure of human #LAG3#HLADR1#peptide complex, a major target of #ImmuneCheckpoint #therapy!
Crystal structure of the human LAG-3–HLA-DR1–peptide complex
The structural basis of how the immune checkpoint molecule LAG-3 binds peptide HLA-II is resolved.
www.science.org
December 13, 2024 at 10:45 PM
What a sensational line up!
We have a great line up and we are super excited by all the abstracts we have recieved!

Register by Dec. 12 (11:59pm MST) to save $200 USD & access 2 meetings for the price of one! Join us in Vancouver in Feb. for the T Cell Differentiation in Tissue Microenvironments Keystone. hubs.la/Q02ZKxQV0
https://hubs.la/Q02ZKxQV0
t.co
November 30, 2024 at 10:59 PM
Reposted by James Reading
🚀 Advancing T-cell receptor (TCR) research! We developed tcrBLOSUM, a specialized substitution matrix for sensitive alignment of distant epitope-specific TCRs. Find out how our findings expand TCR analysis: doi.org/10.1093/bib/... #Bioinformatics #Immunology #AIRR with @pmeysman.bsky.social
tcrBLOSUM: an amino acid substitution matrix for sensitive alignment of distant epitope-specific TCRs
Abstract. Deciphering the specificity of T-cell receptor (TCR) repertoires is crucial for monitoring adaptive immune responses and developing targeted immu
doi.org
November 26, 2024 at 6:50 PM
Every exemplar, case and occurrence needn't be a vignette
November 26, 2024 at 1:56 PM
Wonderful work @barralab.bsky.social on the role of NKT cells in gut epithelial cell homeostasis. Huge congrats to Patricia, the team and @martalebrusant.bsky.social a rising unconventional T cell superstar that we are lucky to have slaying it in our lab!
November 24, 2024 at 5:16 PM
Reposted by James Reading
Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out!
@vivianlilab.bsky.social @kingscollegelondon.bsky.social

www.cell.com/cell-reports...
IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells
The crosstalk between immune and epithelial cells is vital to maintain intestinal homeostasis. Lebrusant-Fernandez et al. identify NKT cells in the small intestine as key regulators of epithelial biol...
www.cell.com
November 24, 2024 at 11:00 AM
Reposted by James Reading
Totally agree. The immune system is an excellent biosensor and recorder of past experiences. UPenn Immune Health www.med.upenn.edu/immunehealth/ together with our Colton Autoimmunity Consortium www.coltonconsortium.org is profiling Immune Health of 1000's of subjects. Many ways to work towards a GIO
November 24, 2024 at 12:57 PM