Santiago Zelenay
@santiagozelenay.bsky.social
Immunologist, Senior Group Leader at Cancer Research UK Manchester Institute
https://www.cruk.manchester.ac.uk/Our-Research/Cancer-Inflammation-and-Immunity
https://www.cruk.manchester.ac.uk/Our-Research/Cancer-Inflammation-and-Immunity
Reposted by Santiago Zelenay
You've got just a few days left to submit your proposal to join us as a new Group Leader
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
October 30, 2025 at 11:47 AM
You've got just a few days left to submit your proposal to join us as a new Group Leader
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
📅 Applications close 2nd November
Package includes:
🪙Multi-year funding
🧪Core Facility Access
🥼 #Postdoc & #PhD positions
🤝Mentorship
Visit our website to apply:
www.cruk.manchester.ac.uk/career/new-g...
Reposted by Santiago Zelenay
Exciting #postdoc opportunity to join @turajliclab.bsky.social here in #Manchester (with visiting scientist status @crick.ac.uk) to use novel tools to investigate #aneuploidy in #KidneyCancer
For full details of the position, including how to apply, visit:
www.cruk.manchester.ac.uk/career/mi-25...
For full details of the position, including how to apply, visit:
www.cruk.manchester.ac.uk/career/mi-25...
October 24, 2025 at 11:33 AM
Exciting #postdoc opportunity to join @turajliclab.bsky.social here in #Manchester (with visiting scientist status @crick.ac.uk) to use novel tools to investigate #aneuploidy in #KidneyCancer
For full details of the position, including how to apply, visit:
www.cruk.manchester.ac.uk/career/mi-25...
For full details of the position, including how to apply, visit:
www.cruk.manchester.ac.uk/career/mi-25...
Reposted by Santiago Zelenay
Just 3 days left to apply for a #postdoc position with @clausjorgensen.bsky.social and the Systems Oncology group
🥼Study a novel therapeutic target in #PancreaticCancer relating to the #TumourMicroenvironment
For full details & to apply please visit: www.cruk.manchester.ac.uk/career/mi-25...
🥼Study a novel therapeutic target in #PancreaticCancer relating to the #TumourMicroenvironment
For full details & to apply please visit: www.cruk.manchester.ac.uk/career/mi-25...
October 23, 2025 at 3:49 PM
Just 3 days left to apply for a #postdoc position with @clausjorgensen.bsky.social and the Systems Oncology group
🥼Study a novel therapeutic target in #PancreaticCancer relating to the #TumourMicroenvironment
For full details & to apply please visit: www.cruk.manchester.ac.uk/career/mi-25...
🥼Study a novel therapeutic target in #PancreaticCancer relating to the #TumourMicroenvironment
For full details & to apply please visit: www.cruk.manchester.ac.uk/career/mi-25...
Reposted by Santiago Zelenay
Now online in Cancer Discovery @aacrjournals.bsky.social: Glucocorticoids Unleash Immune-dependent Melanoma Control through Inhibition of the GARP/TGF β Axis - by Charles Earnshaw, @santiagozelenay.bsky.social, and colleagues doi.org/10.1158/2159... @cruk-mi.bsky.social
October 22, 2025 at 7:08 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Glucocorticoids Unleash Immune-dependent Melanoma Control through Inhibition of the GARP/TGF β Axis - by Charles Earnshaw, @santiagozelenay.bsky.social, and colleagues doi.org/10.1158/2159... @cruk-mi.bsky.social
Reposted by Santiago Zelenay
We have exciting research projects led by group leaders including @jloke1.bsky.social, @giampazolias.bsky.social, @turajliclab.bsky.social, @sylvaindelaunay.bsky.social and @santiagozelenay.bsky.social
See full details of all #PhD opportunities here:
www.cruk.manchester.ac.uk/phd-student-...
See full details of all #PhD opportunities here:
www.cruk.manchester.ac.uk/phd-student-...
PhD Student Recruitment 2026 - OPEN | CRUK Manchester Institute
We are pleased to announce seven exciting postgraduate opportunities within the Cancer Research UK Manchester Institute for new PhD Students to start in 2026
www.cruk.manchester.ac.uk
October 17, 2025 at 10:41 AM
We have exciting research projects led by group leaders including @jloke1.bsky.social, @giampazolias.bsky.social, @turajliclab.bsky.social, @sylvaindelaunay.bsky.social and @santiagozelenay.bsky.social
See full details of all #PhD opportunities here:
www.cruk.manchester.ac.uk/phd-student-...
See full details of all #PhD opportunities here:
www.cruk.manchester.ac.uk/phd-student-...
Reposted by Santiago Zelenay
Exciting new research from our Cancer Inflammation and Immunity Group led by @santiagozelenay.bsky.social on the counterintuitive effects of steroids to enhance responses to immunotherapy in #melanoma
Visit our website for more on this paper published today in Cancer Discovery
Visit our website for more on this paper published today in Cancer Discovery
Glucocorticoids Unleash Immune-dependent Melanoma Control Through Inhibition Of The GARP/TGF β Axis | Cancer Research UK Manchester Institute
This study uncovers a surprising role for GCs in triggering CD8+ T cell–dependent tumour control through downregulation of GARP and thus TGF β signalling.
www.cruk.manchester.ac.uk
October 15, 2025 at 3:45 PM
Exciting new research from our Cancer Inflammation and Immunity Group led by @santiagozelenay.bsky.social on the counterintuitive effects of steroids to enhance responses to immunotherapy in #melanoma
Visit our website for more on this paper published today in Cancer Discovery
Visit our website for more on this paper published today in Cancer Discovery
Reposted by Santiago Zelenay
We are recruiting!
🥼 Scientific Officer to work with @drwilliamhill.bsky.social
💻 Computational Immunologist in the lab of @santiagozelenay.bsky.social
📝 Executive Assistant to our new Institute Director Prof Samra Turajlić @turajliclab.bsky.social
Details at:
www.cruk.manchester.ac.uk/careers/
🥼 Scientific Officer to work with @drwilliamhill.bsky.social
💻 Computational Immunologist in the lab of @santiagozelenay.bsky.social
📝 Executive Assistant to our new Institute Director Prof Samra Turajlić @turajliclab.bsky.social
Details at:
www.cruk.manchester.ac.uk/careers/
August 8, 2025 at 12:36 PM
We are recruiting!
🥼 Scientific Officer to work with @drwilliamhill.bsky.social
💻 Computational Immunologist in the lab of @santiagozelenay.bsky.social
📝 Executive Assistant to our new Institute Director Prof Samra Turajlić @turajliclab.bsky.social
Details at:
www.cruk.manchester.ac.uk/careers/
🥼 Scientific Officer to work with @drwilliamhill.bsky.social
💻 Computational Immunologist in the lab of @santiagozelenay.bsky.social
📝 Executive Assistant to our new Institute Director Prof Samra Turajlić @turajliclab.bsky.social
Details at:
www.cruk.manchester.ac.uk/careers/
Reposted by Santiago Zelenay
We are delighted to announce, along with Cancer Research UK (@cancerresearchuk.org), The University of Manchester (@manchester.ac.uk) and The Christie NHS Foundation Trust, the appointment of Professor Samra Turajlić as our new Director! ⭐
Full story here: www.cruk.manchester.ac.uk/news/profess...
Full story here: www.cruk.manchester.ac.uk/news/profess...
June 18, 2025 at 9:21 AM
We are delighted to announce, along with Cancer Research UK (@cancerresearchuk.org), The University of Manchester (@manchester.ac.uk) and The Christie NHS Foundation Trust, the appointment of Professor Samra Turajlić as our new Director! ⭐
Full story here: www.cruk.manchester.ac.uk/news/profess...
Full story here: www.cruk.manchester.ac.uk/news/profess...
Reposted by Santiago Zelenay
We are recruiting a #postdoctoral researcher for our Cancer Inflammation and Immunity group headed by @santiagozelenay.bsky.social
For all the project details, research background, information about the position and the Institute, please visit:
www.cruk.manchester.ac.uk/career/mi-25...
For all the project details, research background, information about the position and the Institute, please visit:
www.cruk.manchester.ac.uk/career/mi-25...
February 28, 2025 at 4:08 PM
We are recruiting a #postdoctoral researcher for our Cancer Inflammation and Immunity group headed by @santiagozelenay.bsky.social
For all the project details, research background, information about the position and the Institute, please visit:
www.cruk.manchester.ac.uk/career/mi-25...
For all the project details, research background, information about the position and the Institute, please visit:
www.cruk.manchester.ac.uk/career/mi-25...
And learn more about the role and how to apply here:
www.cruk.manchester.ac.uk/career/mi-25...
Please share with anyone who might be interested!
www.cruk.manchester.ac.uk/career/mi-25...
Please share with anyone who might be interested!
February 14, 2025 at 4:00 PM
And learn more about the role and how to apply here:
www.cruk.manchester.ac.uk/career/mi-25...
Please share with anyone who might be interested!
www.cruk.manchester.ac.uk/career/mi-25...
Please share with anyone who might be interested!
Interested in investigating the principles that regulate the establishment of tumour environments that promote or inhibit the anti-tumour function of the immune system? Our group is currently recruiting a postdoctoral fellow.
Learn more about our research 👇
www.cruk.manchester.ac.uk/research-gro...
Learn more about our research 👇
www.cruk.manchester.ac.uk/research-gro...
MI/25/01 – Postdoctoral Scientist – Cancer Inflammation And Immunity Group | Cancer Research UK Manchester Institute
www.cruk.manchester.ac.uk
February 14, 2025 at 3:56 PM
Interested in investigating the principles that regulate the establishment of tumour environments that promote or inhibit the anti-tumour function of the immune system? Our group is currently recruiting a postdoctoral fellow.
Learn more about our research 👇
www.cruk.manchester.ac.uk/research-gro...
Learn more about our research 👇
www.cruk.manchester.ac.uk/research-gro...
Reposted by Santiago Zelenay
I am excited to share our study showing how the immune system strikes a delicate balance between tolerating food and defending against helminth infections.
www.science.org/doi/10.1126/....
www.science.org/doi/10.1126/....
Identification of antigen-presenting cell–T cell interactions driving immune responses to food
The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal ant...
www.science.org
December 21, 2024 at 2:09 AM
I am excited to share our study showing how the immune system strikes a delicate balance between tolerating food and defending against helminth infections.
www.science.org/doi/10.1126/....
www.science.org/doi/10.1126/....
Reposted by Santiago Zelenay
Interesting work, it's becoming clear that @santiagozelenay.bsky.social's 2015 work on the COX-PGE axis' role in tumor immune evasion is robust (and also that we really need to focus on type I IFN in anti-tumor immunity).
#Immunology #Immunotherapy #Immunosky
#Immunology #Immunotherapy #Immunosky
December 15, 2024 at 10:20 AM
Interesting work, it's becoming clear that @santiagozelenay.bsky.social's 2015 work on the COX-PGE axis' role in tumor immune evasion is robust (and also that we really need to focus on type I IFN in anti-tumor immunity).
#Immunology #Immunotherapy #Immunosky
#Immunology #Immunotherapy #Immunosky
Reposted by Santiago Zelenay
But because, as many people like to complain, nothing in immunology is simple, Ifn gamma also has an important role to play
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade
Inflammation can fuel or suppress cancer. Bonavita et al. identify NK cells as primary orchestrators of T cell inflammation in murine models and devise an inflammatory signature that predicts patient survival and response to immunotherapy in multiple malignancies.
www.cell.com
December 15, 2024 at 10:22 AM
But because, as many people like to complain, nothing in immunology is simple, Ifn gamma also has an important role to play
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Santiago Zelenay
⏰ Final call!
🧑🔬 Last week to apply for this fantastic opportunity to work with the exceptional @giampazolias.bsky.social at @cruk-mi.bsky.social. #TeamManchester
To apply (deadline 1 Dec 2024):
www.cruk.manchester.ac.uk/recruitment/...
🧑🔬 Last week to apply for this fantastic opportunity to work with the exceptional @giampazolias.bsky.social at @cruk-mi.bsky.social. #TeamManchester
To apply (deadline 1 Dec 2024):
www.cruk.manchester.ac.uk/recruitment/...
November 26, 2024 at 8:56 AM
⏰ Final call!
🧑🔬 Last week to apply for this fantastic opportunity to work with the exceptional @giampazolias.bsky.social at @cruk-mi.bsky.social. #TeamManchester
To apply (deadline 1 Dec 2024):
www.cruk.manchester.ac.uk/recruitment/...
🧑🔬 Last week to apply for this fantastic opportunity to work with the exceptional @giampazolias.bsky.social at @cruk-mi.bsky.social. #TeamManchester
To apply (deadline 1 Dec 2024):
www.cruk.manchester.ac.uk/recruitment/...
Reposted by Santiago Zelenay
Are so-called 'M2-like' CD206+ macrophages immunosuppressive? On the contrary, we find that they are critical for T cell mediated anti-tumor immunity. Arja Ray drove this study with help from Ken Hu, Kelly Kersten, Alexis Combes and others
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Critical role of CD206+ macrophages in organizing anti-tumor immunity
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
November 6, 2023 at 10:45 PM
Are so-called 'M2-like' CD206+ macrophages immunosuppressive? On the contrary, we find that they are critical for T cell mediated anti-tumor immunity. Arja Ray drove this study with help from Ken Hu, Kelly Kersten, Alexis Combes and others
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Santiago Zelenay
We’ve renewed funding for our Lung Cancer Centre of Excellence for the next 5 years!
With up to £4m support from our partner ScottishPower, researchers will continue to find new ways to beat
#LungCancer 👇
@cruk-mi.bsky.social @thecrick.bsky.social news.cancerresearchuk.org/2024/11/20/4...
With up to £4m support from our partner ScottishPower, researchers will continue to find new ways to beat
#LungCancer 👇
@cruk-mi.bsky.social @thecrick.bsky.social news.cancerresearchuk.org/2024/11/20/4...
£4m funding renewal for lung cancer research in Manchester and London - Cancer Research UK - Cancer News
The Lung Cancer Centre of Excellence will continue its groundbreaking research with up to £4m of funding support from ScottishPower.
news.cancerresearchuk.org
November 20, 2024 at 10:23 AM
We’ve renewed funding for our Lung Cancer Centre of Excellence for the next 5 years!
With up to £4m support from our partner ScottishPower, researchers will continue to find new ways to beat
#LungCancer 👇
@cruk-mi.bsky.social @thecrick.bsky.social news.cancerresearchuk.org/2024/11/20/4...
With up to £4m support from our partner ScottishPower, researchers will continue to find new ways to beat
#LungCancer 👇
@cruk-mi.bsky.social @thecrick.bsky.social news.cancerresearchuk.org/2024/11/20/4...
Reposted by Santiago Zelenay
Enjoying an izakaya with Santiago Zelenay in Kyoto, a Demengeot lab reunion.
November 11, 2024 at 11:58 PM
Enjoying an izakaya with Santiago Zelenay in Kyoto, a Demengeot lab reunion.
Reposted by Santiago Zelenay
The final event of the CCII-Kyoto inaugural symposium: a workshop for students/postdocs on #immunity #Metabolism #inflammation & #ageing with Hongbo Chi, Santiago Zelenay & Osamu Takeuchi
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
November 19, 2024 at 12:10 AM
The final event of the CCII-Kyoto inaugural symposium: a workshop for students/postdocs on #immunity #Metabolism #inflammation & #ageing with Hongbo Chi, Santiago Zelenay & Osamu Takeuchi
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
Reposted by Santiago Zelenay
💥Exciting #ERCResearch funded postdoc opportunities in my lab at @cruk-mi.bsky.social to study #NutrientHostMicrobiome interactions in #CancerImmunity in mice and humans. #CancerImmunology#MucosalImmunology#Microbiome
⏰Deadline: 1 December 2024
Apply👇
www.cruk.manchester.ac.uk/recruitment/...
⏩RT
⏰Deadline: 1 December 2024
Apply👇
www.cruk.manchester.ac.uk/recruitment/...
⏩RT
November 19, 2024 at 12:57 AM
💥Exciting #ERCResearch funded postdoc opportunities in my lab at @cruk-mi.bsky.social to study #NutrientHostMicrobiome interactions in #CancerImmunity in mice and humans. #CancerImmunology#MucosalImmunology#Microbiome
⏰Deadline: 1 December 2024
Apply👇
www.cruk.manchester.ac.uk/recruitment/...
⏩RT
⏰Deadline: 1 December 2024
Apply👇
www.cruk.manchester.ac.uk/recruitment/...
⏩RT