Sander Wuyts, PhD 🧬
@swuyts.bsky.social
Helping scientists find the epitope specificity of their T-cell receptors at @immunewatch.bsky.social (www.immunewatch.com)
Scientist on an entrepreneurial journey
PhD in bioinformatics and microbiology
Ex-Bork (EMBL) and Lebeer lab
Scientist on an entrepreneurial journey
PhD in bioinformatics and microbiology
Ex-Bork (EMBL) and Lebeer lab
Pinned
Why did I trade academia for a startup environment?
Because several scientist I worked with during my PhD convinced me of their mission:
They want to fully decode the T-cell repertoire.
I recently found an old slide that visualises this goal beautifully.
#ImmunoSky
1/5
Because several scientist I worked with during my PhD convinced me of their mission:
They want to fully decode the T-cell repertoire.
I recently found an old slide that visualises this goal beautifully.
#ImmunoSky
1/5
Well thank you for doing all the work.
Going from potential computational matches to real in-depth validation, nice to see that in one paper!
Going from potential computational matches to real in-depth validation, nice to see that in one paper!
February 12, 2026 at 4:11 PM
Well thank you for doing all the work.
Going from potential computational matches to real in-depth validation, nice to see that in one paper!
Going from potential computational matches to real in-depth validation, nice to see that in one paper!
Taking our score-cutoff of 0.23 it does confidently says 86333_1456 is a match, while for the other two not.
Especially if you narrow down to the separate chain level, then it has its doubt about the specificity of the alpha chains...
In any case, thanks for sharing!
Especially if you narrow down to the separate chain level, then it has its doubt about the specificity of the alpha chains...
In any case, thanks for sharing!
February 12, 2026 at 3:49 PM
Taking our score-cutoff of 0.23 it does confidently says 86333_1456 is a match, while for the other two not.
Especially if you narrow down to the separate chain level, then it has its doubt about the specificity of the alpha chains...
In any case, thanks for sharing!
Especially if you narrow down to the separate chain level, then it has its doubt about the specificity of the alpha chains...
In any case, thanks for sharing!
Hi Joe, Good stuff.
Thanks for clearly pointing out these edge cases!
But of course, I wondered if ImmuneWatch DETECT would have a clear separation between your reactive EBNA3A TCRs and non-reactive ones.
It's always easy in hindsight so take it for what it's worth 😉
Thanks for clearly pointing out these edge cases!
But of course, I wondered if ImmuneWatch DETECT would have a clear separation between your reactive EBNA3A TCRs and non-reactive ones.
It's always easy in hindsight so take it for what it's worth 😉
February 12, 2026 at 3:49 PM
Hi Joe, Good stuff.
Thanks for clearly pointing out these edge cases!
But of course, I wondered if ImmuneWatch DETECT would have a clear separation between your reactive EBNA3A TCRs and non-reactive ones.
It's always easy in hindsight so take it for what it's worth 😉
Thanks for clearly pointing out these edge cases!
But of course, I wondered if ImmuneWatch DETECT would have a clear separation between your reactive EBNA3A TCRs and non-reactive ones.
It's always easy in hindsight so take it for what it's worth 😉
I'll be in London at the festival of Genomics later this week.
Hit me up if you want to connect!
Hit me up if you want to connect!
January 25, 2026 at 7:36 AM
I'll be in London at the festival of Genomics later this week.
Hit me up if you want to connect!
Hit me up if you want to connect!
I can imagine that this must also have been a rough week for you. All the best during these hard times.
Thanks for the write-up
Thanks for the write-up
January 25, 2026 at 7:36 AM
I can imagine that this must also have been a rough week for you. All the best during these hard times.
Thanks for the write-up
Thanks for the write-up
One of my favourite pics of Peer.
Took this one on a summer day in 2021 during a lab get-to-together at his place.
Cheer to you too Peer.
#PeerBork
Took this one on a summer day in 2021 during a lab get-to-together at his place.
Cheer to you too Peer.
#PeerBork
January 19, 2026 at 9:09 AM
One of my favourite pics of Peer.
Took this one on a summer day in 2021 during a lab get-to-together at his place.
Cheer to you too Peer.
#PeerBork
Took this one on a summer day in 2021 during a lab get-to-together at his place.
Cheer to you too Peer.
#PeerBork
Reposted by Sander Wuyts, PhD 🧬
For many years, Peer Bork organised Bio-IT retreats to bring together the bioinformaticians across EMBL, in Garmisch-Partenkirchen and later Feldberg. Days out on the mountain followed by forward-looking and meta-science oriented sessions in the hut that fueled many projects and careers.
January 17, 2026 at 10:22 AM
For many years, Peer Bork organised Bio-IT retreats to bring together the bioinformaticians across EMBL, in Garmisch-Partenkirchen and later Feldberg. Days out on the mountain followed by forward-looking and meta-science oriented sessions in the hut that fueled many projects and careers.
I can not believe this news.
The EMBL community, microbiome field and bioinformatics in general loses a legend 😢
www.embl.org/news/embl-an...
The EMBL community, microbiome field and bioinformatics in general loses a legend 😢
www.embl.org/news/embl-an...
In remembrance of Peer Bork | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.
www.embl.org
January 16, 2026 at 5:10 PM
I can not believe this news.
The EMBL community, microbiome field and bioinformatics in general loses a legend 😢
www.embl.org/news/embl-an...
The EMBL community, microbiome field and bioinformatics in general loses a legend 😢
www.embl.org/news/embl-an...
I'll bee in London at the end of the month for the Festival of Genomics.
Who can I run into?
Who can I run into?
January 12, 2026 at 2:27 PM
I'll bee in London at the end of the month for the Festival of Genomics.
Who can I run into?
Who can I run into?
Enjoy this festive season on LinkedIn!
December 17, 2025 at 8:05 AM
Enjoy this festive season on LinkedIn!
December 4, 2025 at 10:03 AM
Was thinking of attending as well. Unfortunately I am in the other 10% now 😂
December 4, 2025 at 10:03 AM
Was thinking of attending as well. Unfortunately I am in the other 10% now 😂
Ja mijn broers zijn altijd onder de indruk dat we alles van ons gezin in die auto krijgen :)
November 26, 2025 at 11:54 AM
Ja mijn broers zijn altijd onder de indruk dat we alles van ons gezin in die auto krijgen :)
Fair enough! Prijs is ook wel effectief gestegen tegenover wanneer ik hem heb aangeschaft
November 26, 2025 at 11:53 AM
Fair enough! Prijs is ook wel effectief gestegen tegenover wanneer ik hem heb aangeschaft
Ik heb deze oefening 3 jaar geleden gedaan. Ionis en Enyaq stonden ook op shortlist. Ben uiteindelijk bij Polestar 2 uitgekomen wegens leverbaarheid en betere prijs.
Enorm tevreden van! Wil uw lijstje niet terug openbreken maar is er een reden waarom die er niet tussen staat?
Enorm tevreden van! Wil uw lijstje niet terug openbreken maar is er een reden waarom die er niet tussen staat?
November 26, 2025 at 10:13 AM
Ik heb deze oefening 3 jaar geleden gedaan. Ionis en Enyaq stonden ook op shortlist. Ben uiteindelijk bij Polestar 2 uitgekomen wegens leverbaarheid en betere prijs.
Enorm tevreden van! Wil uw lijstje niet terug openbreken maar is er een reden waarom die er niet tussen staat?
Enorm tevreden van! Wil uw lijstje niet terug openbreken maar is er een reden waarom die er niet tussen staat?
Cool! Congrats on getting those papers out!
November 25, 2025 at 9:19 PM
Cool! Congrats on getting those papers out!
Zou dat in Galatasaray zijn gebeurd die stuntzege?
November 25, 2025 at 8:55 PM
Zou dat in Galatasaray zijn gebeurd die stuntzege?
Finding the putative target of a TCR is hard!
But I am really excited to see that innovative cancer therapy companies like Obsidian Therapeutics are getting some real value out of using our database + machine learning algorithm.
But I am really excited to see that innovative cancer therapy companies like Obsidian Therapeutics are getting some real value out of using our database + machine learning algorithm.
November 24, 2025 at 9:26 AM
Finding the putative target of a TCR is hard!
But I am really excited to see that innovative cancer therapy companies like Obsidian Therapeutics are getting some real value out of using our database + machine learning algorithm.
But I am really excited to see that innovative cancer therapy companies like Obsidian Therapeutics are getting some real value out of using our database + machine learning algorithm.
That's a very nice way of putting it :)
November 11, 2025 at 7:19 PM
That's a very nice way of putting it :)
Crazy excited about Jack White being on tour again! He was just announced headlining Best Kept Secret festival in the NL 🥳
October 28, 2025 at 1:47 PM
Crazy excited about Jack White being on tour again! He was just announced headlining Best Kept Secret festival in the NL 🥳
Or on Spotify:
open.spotify.com/episode/00h1...
open.spotify.com/episode/00h1...
The Repertoire Room: Episode 3 - Arman Aksoy (Obsidian Therapeutics)
Spotify video
open.spotify.com
October 28, 2025 at 12:52 PM
Or on Spotify:
open.spotify.com/episode/00h1...
open.spotify.com/episode/00h1...
Among many things, in this episode we discuss:
- Obsidian's lead program, OBX-115, a modified TIL cell therapy
- The critical role of TCR sequencing in profiling infusion products, tracking clonotypes, and identifying biomarkers for therapy response.
Listen/View here:
youtu.be/J41q0fUqeVo?...
- Obsidian's lead program, OBX-115, a modified TIL cell therapy
- The critical role of TCR sequencing in profiling infusion products, tracking clonotypes, and identifying biomarkers for therapy response.
Listen/View here:
youtu.be/J41q0fUqeVo?...
The Repertoire Room: Episode 3 - Arman Aksoy (Obsidian Therapeutics)
YouTube video by ImmuneWatch
youtu.be
October 28, 2025 at 12:52 PM
Among many things, in this episode we discuss:
- Obsidian's lead program, OBX-115, a modified TIL cell therapy
- The critical role of TCR sequencing in profiling infusion products, tracking clonotypes, and identifying biomarkers for therapy response.
Listen/View here:
youtu.be/J41q0fUqeVo?...
- Obsidian's lead program, OBX-115, a modified TIL cell therapy
- The critical role of TCR sequencing in profiling infusion products, tracking clonotypes, and identifying biomarkers for therapy response.
Listen/View here:
youtu.be/J41q0fUqeVo?...
Episode 3 of “The Repertoire Room” has just been released!
After 2 episodes with technology providers in the TCR sequencing space, I now wanted to have a conversation with someone that was really using these technologies to push innovative therapies to patients.
Enter: @armanaksoy.bsky.social
After 2 episodes with technology providers in the TCR sequencing space, I now wanted to have a conversation with someone that was really using these technologies to push innovative therapies to patients.
Enter: @armanaksoy.bsky.social
October 28, 2025 at 12:52 PM
Episode 3 of “The Repertoire Room” has just been released!
After 2 episodes with technology providers in the TCR sequencing space, I now wanted to have a conversation with someone that was really using these technologies to push innovative therapies to patients.
Enter: @armanaksoy.bsky.social
After 2 episodes with technology providers in the TCR sequencing space, I now wanted to have a conversation with someone that was really using these technologies to push innovative therapies to patients.
Enter: @armanaksoy.bsky.social