Asker Brejnrod
@askerbrejnrod.bsky.social
bioinformatics, microbiomes, data scientist
Reposted by Asker Brejnrod
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
November 13, 2025 at 4:00 PM
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Reposted by Asker Brejnrod
@bravo-abad.bsky.social , not recently active on Bluesky, on the use of #Quantum Computing for #Genomics:
journals.aps.org/prxlife/abst...
journals.aps.org/prxlife/abst...
November 3, 2025 at 12:07 PM
@bravo-abad.bsky.social , not recently active on Bluesky, on the use of #Quantum Computing for #Genomics:
journals.aps.org/prxlife/abst...
journals.aps.org/prxlife/abst...
Reposted by Asker Brejnrod
From #drug cabinet → gut #microbiome: screening 312 therapeutic compounds, we mapped 4.6 million microbial protein-level responses to reveal how our drugs don’t just target us, they hit our gut microbes too.
rdcu.be/eMmcT
rdcu.be/eMmcT
October 26, 2025 at 7:09 AM
From #drug cabinet → gut #microbiome: screening 312 therapeutic compounds, we mapped 4.6 million microbial protein-level responses to reveal how our drugs don’t just target us, they hit our gut microbes too.
rdcu.be/eMmcT
rdcu.be/eMmcT
Reposted by Asker Brejnrod
💡 30 scientific recommendations from the #CHINAGUT Conference!
👩🔬 63 experts joined forces to shape the future of:
🦠 #Probiotics
💊 Live biotherapeutic products
💩 #FMT
The goal: standardization, regulation & precision in #microbiome-based therapies.
🔗 doi.org/10.1002/imt2...
👩🔬 63 experts joined forces to shape the future of:
🦠 #Probiotics
💊 Live biotherapeutic products
💩 #FMT
The goal: standardization, regulation & precision in #microbiome-based therapies.
🔗 doi.org/10.1002/imt2...
October 22, 2025 at 3:26 PM
💡 30 scientific recommendations from the #CHINAGUT Conference!
👩🔬 63 experts joined forces to shape the future of:
🦠 #Probiotics
💊 Live biotherapeutic products
💩 #FMT
The goal: standardization, regulation & precision in #microbiome-based therapies.
🔗 doi.org/10.1002/imt2...
👩🔬 63 experts joined forces to shape the future of:
🦠 #Probiotics
💊 Live biotherapeutic products
💩 #FMT
The goal: standardization, regulation & precision in #microbiome-based therapies.
🔗 doi.org/10.1002/imt2...
Reposted by Asker Brejnrod
#Hypertension in middle-aged women may be linked to gut #microbiome changes that boost inflammation. Altered tryptophan metabolism could be a key target for improving heart health. Read more in APS Publications AJP-Heart: https://ow.ly/jCL750Xc0yK #ArticlesInPresS #WomensHealthResearch 🧪
October 21, 2025 at 4:01 PM
#Hypertension in middle-aged women may be linked to gut #microbiome changes that boost inflammation. Altered tryptophan metabolism could be a key target for improving heart health. Read more in APS Publications AJP-Heart: https://ow.ly/jCL750Xc0yK #ArticlesInPresS #WomensHealthResearch 🧪
Reposted by Asker Brejnrod
New preprint out by #RobertKoetsier, the first of his PhD project, on assessing the use of cross-species coexpression analysis to identify primary and secondary metabolic interactions in microbiomes: www.biorxiv.org/content/10.1...
Using cross-species co-expression to predict metabolic interactions in microbiomes
In microbial ecosystems, metabolic interactions are key determinants of species’ relative abundance and activity. Given the immense number of possible interactions in microbial communities, their expe...
www.biorxiv.org
September 22, 2025 at 7:42 AM
New preprint out by #RobertKoetsier, the first of his PhD project, on assessing the use of cross-species coexpression analysis to identify primary and secondary metabolic interactions in microbiomes: www.biorxiv.org/content/10.1...
Reposted by Asker Brejnrod
🧫 Gut microbiome and ageing
Using genetic data, researchers tested 55k links between gut microbes and age-related traits. They found 91 causal relationships, including effects on protein levels tied to inflammation and metabolism.
🔗 doi.org/10.18632/agi...
#SciComm #Microbiome #Ageing 🧪
Using genetic data, researchers tested 55k links between gut microbes and age-related traits. They found 91 causal relationships, including effects on protein levels tied to inflammation and metabolism.
🔗 doi.org/10.18632/agi...
#SciComm #Microbiome #Ageing 🧪
Causal relationships between gut microbiome and hundreds of age-related traits: evidence of a replicable effect on ApoM protein levels | Aging
Aging | doi:10.18632/aging.206293. Federica Grosso, Daniela Zanetti, Serena Sanna
doi.org
September 11, 2025 at 10:24 AM
🧫 Gut microbiome and ageing
Using genetic data, researchers tested 55k links between gut microbes and age-related traits. They found 91 causal relationships, including effects on protein levels tied to inflammation and metabolism.
🔗 doi.org/10.18632/agi...
#SciComm #Microbiome #Ageing 🧪
Using genetic data, researchers tested 55k links between gut microbes and age-related traits. They found 91 causal relationships, including effects on protein levels tied to inflammation and metabolism.
🔗 doi.org/10.18632/agi...
#SciComm #Microbiome #Ageing 🧪
Reposted by Asker Brejnrod
While framed as a critique of Apple’s recent paper, I found this article mostly interesting because it made me think about reasoning in general: mikecaulfield.substack.com/p/the-apple-...
The Apple "Reasoning Collapse" Paper Is Even Dumber Than You Think
We're this far into reasoners and neither hypesters nor skeptics really understand their significance. Also: Read Toulmin.
mikecaulfield.substack.com
June 14, 2025 at 7:01 PM
While framed as a critique of Apple’s recent paper, I found this article mostly interesting because it made me think about reasoning in general: mikecaulfield.substack.com/p/the-apple-...
Reposted by Asker Brejnrod
The unintended consequences of a gut microbiome transplant
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Microbiome mismatches from microbiota transplants lead to persistent off-target metabolic and immunomodulatory effects
Fecal microbiota transplants (FMTs) may not always effectively restore small bowel
microbiota due to regional differences in gut environments, potentially causing unintended
effects on metabolism and ...
www.cell.com
June 6, 2025 at 2:43 PM
The unintended consequences of a gut microbiome transplant
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Asker Brejnrod
Cool study:
Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters www.tandfonline.com/doi/full/10....
Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters www.tandfonline.com/doi/full/10....
Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters
Probiotic supplements containing high β-galactosidase-producing bacteria may aid in the management of lactose intolerance. We previously isolated a strain of Bifidobacterium adolescentis, iVS-1, fr...
www.tandfonline.com
June 5, 2025 at 3:40 PM
Cool study:
Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters www.tandfonline.com/doi/full/10....
Two-week supplementation of Bifidobacterium adolescentis iVS-1 reduces symptoms associated with lactose intolerance in lactose maldigesters www.tandfonline.com/doi/full/10....
Reposted by Asker Brejnrod
The potential risk of age-related macular degeneration with GLP-1 drugs in people with diabetes
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
June 5, 2025 at 3:21 PM
The potential risk of age-related macular degeneration with GLP-1 drugs in people with diabetes
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Asker Brejnrod
📣 Happy to share our review on host-microbiome genomics!
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
June 4, 2025 at 11:02 PM
📣 Happy to share our review on host-microbiome genomics!
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
Reposted by Asker Brejnrod
Our gut microbiome and its metabolites play a critical role for our glucose regulation, as does diet and exercise for improving it, through modulating the gut microbiome
@naturemedicine.bsky.social
www.nature.com/articles/s41...
@naturemedicine.bsky.social
www.nature.com/articles/s41...
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes - Nature Medicine
A map of microbiome–metabolome dynamics in people with type 2 diabetes identifies over 500 blood metabolites associated with impaired glucose control, with approximately one-third linked to an altered...
www.nature.com
April 8, 2025 at 2:19 PM
Our gut microbiome and its metabolites play a critical role for our glucose regulation, as does diet and exercise for improving it, through modulating the gut microbiome
@naturemedicine.bsky.social
www.nature.com/articles/s41...
@naturemedicine.bsky.social
www.nature.com/articles/s41...
Reposted by Asker Brejnrod
Good resource: Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions www.cell.com/molecular-c...
March 26, 2025 at 2:15 PM
Good resource: Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions www.cell.com/molecular-c...
Reposted by Asker Brejnrod
The business of promoting longevity and healthspan through extensive medical testing. A review of 12 companies and why this is a flawed, expensive model without evidence.
erictopol.substack.com/p/the-busine...
erictopol.substack.com/p/the-busine...
March 24, 2025 at 1:48 PM
The business of promoting longevity and healthspan through extensive medical testing. A review of 12 companies and why this is a flawed, expensive model without evidence.
erictopol.substack.com/p/the-busine...
erictopol.substack.com/p/the-busine...
Reposted by Asker Brejnrod
Out now in #NatureMetabolism 📢
Leveraging four large, longitudinal, prospectively-followed mother–child cohorts, this study shows that a western diet in early–mid-pregnancy is associated with neurodevelopmental disorders in the offspring.
Leveraging four large, longitudinal, prospectively-followed mother–child cohorts, this study shows that a western diet in early–mid-pregnancy is associated with neurodevelopmental disorders in the offspring.
March 3, 2025 at 1:27 PM
Out now in #NatureMetabolism 📢
Leveraging four large, longitudinal, prospectively-followed mother–child cohorts, this study shows that a western diet in early–mid-pregnancy is associated with neurodevelopmental disorders in the offspring.
Leveraging four large, longitudinal, prospectively-followed mother–child cohorts, this study shows that a western diet in early–mid-pregnancy is associated with neurodevelopmental disorders in the offspring.
Reposted by Asker Brejnrod
A link between yogurt intake and reduce risk of colon cancer, from cohort of over 130,00 participants, with inverse relationship to Bifidobacterium in gut microbiome
www.tandfonline.com/doi/full/10.... open-access
www.tandfonline.com/doi/full/10.... open-access
February 12, 2025 at 6:18 PM
A link between yogurt intake and reduce risk of colon cancer, from cohort of over 130,00 participants, with inverse relationship to Bifidobacterium in gut microbiome
www.tandfonline.com/doi/full/10.... open-access
www.tandfonline.com/doi/full/10.... open-access
Reposted by Asker Brejnrod
See the numerous positions at Novonesis on bacterial and fungal strain development - in 🇩🇰
www.novonesis.com/en/careers/j...
www.novonesis.com/en/careers/j...
January 27, 2025 at 3:31 PM
See the numerous positions at Novonesis on bacterial and fungal strain development - in 🇩🇰
www.novonesis.com/en/careers/j...
www.novonesis.com/en/careers/j...
Reposted by Asker Brejnrod
Free fatty acid receptor 4 modulates dietary sugar preference via the gut microbiota | @naturemicrobiol.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Free fatty acid receptor 4 modulates dietary sugar preference via the gut microbiota - Nature Microbiology
Bacteroides vulgatus, a gut bacterium, promotes GLP-1 secretion through its metabolite, pantothenate, inhibiting sugar preference in mice.
www.nature.com
January 13, 2025 at 8:48 PM
Free fatty acid receptor 4 modulates dietary sugar preference via the gut microbiota | @naturemicrobiol.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Asker Brejnrod
Ten species comprise half of the bacteriology literature, leaving most species unstudied
@biorxiv-microbiol.bsky.social by Paul A Jensen
www.biorxiv.org/content/10.1...
B. subtilis is #6 😍, anyhow, the literature is biased to models
Would publications on plants or animals be similarly biased?
@biorxiv-microbiol.bsky.social by Paul A Jensen
www.biorxiv.org/content/10.1...
B. subtilis is #6 😍, anyhow, the literature is biased to models
Would publications on plants or animals be similarly biased?
January 5, 2025 at 3:05 PM
Ten species comprise half of the bacteriology literature, leaving most species unstudied
@biorxiv-microbiol.bsky.social by Paul A Jensen
www.biorxiv.org/content/10.1...
B. subtilis is #6 😍, anyhow, the literature is biased to models
Would publications on plants or animals be similarly biased?
@biorxiv-microbiol.bsky.social by Paul A Jensen
www.biorxiv.org/content/10.1...
B. subtilis is #6 😍, anyhow, the literature is biased to models
Would publications on plants or animals be similarly biased?
Reposted by Asker Brejnrod
Interleukin-23 receptor as a biomarker for aging and potential link to senolytic therapy
www.nature.com/articles/s43...
www.nature.com/articles/s43...
IL-23R is a senescence-linked circulating and tissue biomarker of aging - Nature Aging
Using mouse and human plasma, Carver et al. identify factors that are altered with age and test which are reverted by a panel of genetic and pharmacological senolytic interventions in aged mice. They ...
www.nature.com
December 10, 2024 at 3:32 PM
Interleukin-23 receptor as a biomarker for aging and potential link to senolytic therapy
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Asker Brejnrod
A fantastic resource for early life microbiome: over 3K prokaryotes and 130K viral genomes constructed from 20K gut metagenomes.
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
A metagenome-assembled genome inventory for children reveals early-life gut bacteriome and virome dynamics
Existing microbiota databases are biased toward adults, hindering infant gut microbiome profiling. Peng et al. introduce the metagenome-assembled genome inventory for children (MAGIC), featuring 3,299 prokaryotic and 139,624 viral genomes. MAGIC enables characterization of early-life microbiome dynamics, identification of candidate keystone species, and strain-level study of target species.
www.cell.com
December 5, 2024 at 12:09 PM
A fantastic resource for early life microbiome: over 3K prokaryotes and 130K viral genomes constructed from 20K gut metagenomes.
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
Reposted by Asker Brejnrod
Today we publish an (in my opinion) important paper in
@naturemicrobiol.bsky.social 🍾 showing that gut physiology and environment are factors explaining substantial variations in human gut #microbiome composition and #metabolism🦠
Fantastic work Procházková et al. 👏
www.nature.com/articles/s41...
@naturemicrobiol.bsky.social 🍾 showing that gut physiology and environment are factors explaining substantial variations in human gut #microbiome composition and #metabolism🦠
Fantastic work Procházková et al. 👏
www.nature.com/articles/s41...
Gut physiology and environment explain variations in human gut microbiome composition and metabolism - Nature Microbiology
An observational longitudinal clinical trial, incorporating a SmartPill and metabolomics, reveals the role of host factors in shaping the gut microbiome in healthy human adults.
www.nature.com
November 27, 2024 at 10:36 AM
Today we publish an (in my opinion) important paper in
@naturemicrobiol.bsky.social 🍾 showing that gut physiology and environment are factors explaining substantial variations in human gut #microbiome composition and #metabolism🦠
Fantastic work Procházková et al. 👏
www.nature.com/articles/s41...
@naturemicrobiol.bsky.social 🍾 showing that gut physiology and environment are factors explaining substantial variations in human gut #microbiome composition and #metabolism🦠
Fantastic work Procházková et al. 👏
www.nature.com/articles/s41...
Reposted by Asker Brejnrod
Reposted by Asker Brejnrod
This will me my fist blueet! Microbial N-Acyl lipids have been shown to regulate glucose, pain etc among other things. Therefore Helena, Vincent and Martijn asked the question - are there more and if so what types? And boy did they find some www.biorxiv.org/content/10.1...
The microbiome diversifies N-acyl lipid pools - including short-chain fatty acid-derived compounds
N -acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection of N -acyl lipids with untargeted mass spectrometry-based...
www.biorxiv.org
November 19, 2024 at 3:19 AM
This will me my fist blueet! Microbial N-Acyl lipids have been shown to regulate glucose, pain etc among other things. Therefore Helena, Vincent and Martijn asked the question - are there more and if so what types? And boy did they find some www.biorxiv.org/content/10.1...