Jean Nakhle
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jeannakhle.bsky.social
Jean Nakhle
@jeannakhle.bsky.social
Associate Editor @natmetabolism.nature.com‬

He/Him/His. Views are my own.
Reposted by Jean Nakhle
On #WorldDiabetesDay, we highlight key findings from our latest primary research and review articles 🧵 (1/8)
November 14, 2025 at 12:05 PM
Out now in @natmetabolism.nature.com by @jourdainlab.bsky.social 📢

A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interaction with PPAT.
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
doi.org
November 13, 2025 at 2:10 PM
Reposted by Jean Nakhle
Thrilled to publish our new study on #mitochondrial ROS coming from complex III, revealing this key site in #astrocytes 🎯as a crucial immunometabolic signal transducer🤯 and potential therapeutic target for #dementia #FTD 💊 rdcu.be/eOc0m 👈💪 Great commentary by H. Pan and F. Yin🤩! tinyurl.com/4hdytw4c
November 4, 2025 at 6:30 PM
Read this Research Highlight of the SWEET trial by @natrevendo.nature.com :

www.nature.com/articles/s42...
October 31, 2025 at 11:11 AM
Reposted by Jean Nakhle
@commsaicomp.bsky.social has launched and seeks your submissions for publications!

You can follow them and all our journals with our starter pack.
October 30, 2025 at 4:16 PM
Last chance to apply 🚨
🚨Job Alert🚨
If you are interested in being an editor at Nature Metabolism and Nature Communications, apply below by Oct 26🧪
Associate or Senior Editor (Nature Metabolism and Nature Communications)
Job Title: Associate or Senior Editor (Nature Metabolism and Nature Communications) Location(s): New York, Jersey City, Philadelphia, Beijing or Shanghai Application Deadline: October 26th, 2025 About Springer Nature Springer Nature is one of the leading publishers of research in the world. We publish the largest number of journals and books and are a pioneer in open research. Through our leading brands, trusted for more than 180 years, we provide technology-enabled products, platforms and services that help researchers to uncover new ideas and share their discoveries, health professionals to stay at the forefront of medical science, and educators to advance learning. We are proud to be part of progress, working together with the communities we serve to share knowledge and bring greater understanding to the world. For more information, please visit about.springernature.com and @SpringerNature. About the Brand Nature Portfolio is a flagship portfolio of journals, products and services including Nature and the Nature-branded journals, dedicated to serving the scientific community. Visit nature.com and follow @Nature / @NaturePortfolio Nature Portfolio is a world leader in publishing high-quality research. The Nature Portfolio journals include Nature, the Nature Research journals, the Nature Reviews journals, Nature Communications as well as the Communications journals and NPJ series. Nature Communications is the leading Nature Portfolio fully open Open Access journal publishing high-quality scientific research across natural, clinical, social and applied sciences. About the Role Do you love science but feel that a career at the bench isn’t enough to satisfy your desire to learn more about scientific research? Do you enjoy reading papers outside your chosen area of research? If the answer is ‘yes’ to any or all these questions, you could be the person we’re looking for to join the Nature Portfolio editorial team! To help us build on the success of the portfolio, we’re seeking an editor with experience in metabolic disease research who has a critical eye, a deep understanding of their subject and interests beyond, and who can think on their feet. Knowledge of liver disease (MAFLD/MASH), lipid biology or immunometabolism is desirable, although we are open to applications from scientists working in any discipline covered by the journal. This is a permanent position within the Nature Portfolio. The successful candidate will primarily support Nature Metabolism but collaborate closely with the translational and clinical research team, and other teams, at Nature Communications. Please note that responsibilities and journal assignments may evolve over time in response to portfolio needs Nature Metabolism publishes high-quality papers in all areas of metabolic research and metabolic health - from fundamental cell biology to basic biomedical and translational research - providing a highly visible forum for communicating important advances to a broad readership. Role Responsibilities: Handling original research papers and working closely with editor teams on all aspects of the editorial process, including manuscript selection and overseeing peer review. Making well-reasoned editorial decisions on submitted manuscripts in the light of expert advice. Contributing to content and strategy in this area at Nature Metabolism and Nature Communications. Commissioning, editing content such as Reviews, or writing editorials. Liaising extensively with editors at other journals in the Nature Portfolio and with experts in the international scientific community. Attending conferences and visiting research institutions. Experience, Skills & Qualifications: A PhD (or equivalent) in a relevant research field covered by the journal Additional research experience is preferred but not required. A thorough understanding of recent trends and developments in the field is essential. A passion for science and a thirst to learn more. You must be able to demonstrate the breadth of your interest in scientific research, both within and beyond your speciality. The ability to read and assess the novelty, context and implications of research submitted to the journal from different areas of this discipline. Excellent communication and interpersonal skills, including fluent English (written and spoken). Be eager to travel and meet scientists worldwide, learn more about them and their research, and help them learn more about us and what we are looking for in the papers we seek to publish. Editorial experience is not required, although applicants with editorial experience are encouraged to apply and may be considered for Senior Editor positions. The successful candidates will report to the Chief Editor of Nature Metabolism. This demanding and intellectually stimulating role is in either of our offices in New York, New Jersey, Philadelphia, Shanghai or Beijing. We are open to applications from internal candidates from any of our offices. The position is offered on a permanent basis, and its starting date is envisaged as soon as possible. To Apply: Applicants should include a CV, a cover letter explaining their interest in the position, preferred office of employment, and a concise (300-400 words) discussion of recent developments or trends in the wider metabolism field, which you have found particularly exciting (and explaining why). Application Deadline: October 26th, 2025. Candidates will be considered as they apply. Springer Nature US provides a comprehensive and competitive benefits package which includes the benefit offerings listed below: Medical, Dental and Vision 401(k) with company match and contribution Hybrid office working policy, Summer Hours, and paid time off Flexible Spending and Commuter programs Multiple Life insurance options Disability coverage Tuition Assistance Voluntary benefits: Identity Theft Protection, Pet Insurance, and Legal Assistance Insurance Employee Assistance Program Family friendly benefits and a variety of employee discounts An array of Employee Social Networks US Annualized Base Salary Range: Associate Editor: $80,000 / Senior Editor: $95,000. The salary offer may vary based on work experience, education, skill level and equity. The US salary range does not align with the salary ranges in other countries when converted to the currency of that country. Springer Nature is an Equal Opportunity Employer that complies with the laws and regulations set forth in the following https://www.eeoc.gov/sites/default/files/2023-06/22-088_EEOC_KnowYourRights6.12ScreenRdr.pdf poster. At Springer Nature, we value the diversity of our teams and work to build an inclusive culture, where people are treated fairly and can bring their differences to work and thrive. We empower our colleagues and value their diverse perspectives as we strive to attract, nurture and develop the very best talent. Springer Nature was awarded Diversity Team of the Year at the 2022 British Diversity Awards. Find out more about our DEI work here: https://group.springernature.com/gp/group/taking-responsibility/diversity-equity-inclusion. If you have any access needs related to disability, neurodivergence or a chronic condition, please contact us so we can make all necessary accommodation. For more information about career opportunities in Springer Nature please visit https://springernature.wd3.myworkdayjobs.com/SpringerNatureCareers/ #LI-MD1 Job Posting End Date: 27-10-2025 Wir sind ein ehrgeiziges und dynamisches Unternehmen, das einige der bekanntesten Namen in den Bereichen Forschung, Bildung und professionelles Verlagswesen beheimatet. Wir sind im Mittelpunkt einer sich wandelnden Branche und sind immer auf der Suche nach großartigen Mitarbeitern, denen es wichtig ist, unseren Kunden und den Gemeinschaften, mit denen wir zusammenarbeiten, Qualität zu liefern. Im Gegenzug werden Sie feststellen, dass wir allen unseren Mitarbeitern die Türen zur Entdeckung öffnen - wir bieten die Möglichkeit, von einigen der Besten der Branche zu lernen, mit einer Kultur, die Neugierde fördert und Menschen dazu befähigt, bestmögliche Lösungen zu finden. Ganz gleich, ob Sie am Anfang Ihrer Karriere stehen oder ein erfahrener Profi sind, wir laden Sie ein, mehr über die von uns angebotenen Aufgaben zu erfahren und unsere aktuellen Stellenangebote zu erkunden. We are a global and progressive business, founded on a heritage of trusted and respected brands – including Springer, founded in 1842, Macmillan, founded in 1843 and Nature, first published in 1869. Nearly two centuries of progress and advancement in science and education have helped shape the business we are today. Research and learning continues to be the cornerstone of progress, and we will continue to open doors to discovery through trusted brands and innovative products and services. Springer Nature Group was created in May 2015 through the combination of Nature Publishing Group, Macmillan Education and Springer Science+Business Media.
bit.ly
October 25, 2025 at 9:10 AM
Reposted by Jean Nakhle
✨New issue✨

Check out the latest in #Metabolism research from across all disciplines 🧪

Read about #DietarySugars, #Drosophila development, #Exenatide, #Ketone metabolism, #Neurolipids, #NAD+, #RedoxPathways, and many more topics!

www.nature.com/natmetab/vol...
October 24, 2025 at 7:50 PM
Reposted by Jean Nakhle
Register for this exciting Nature Conference on 'Healthy Brain Aging' and meet eminent researchers in the field as well as editors from @natmetabolism.nature.com & other @natureportfolio.nature.com journals! 🧪

🚨Abstract submission deadline Oct 17th!

Registration and other details: t.co/iiCzYAv9mH
October 15, 2025 at 1:54 PM
Out now in @natmetabolism.nature.com 🧪

FGF21 levels increase in response to acute mental stress in individuals with impaired OxPhos capacity, and correlate with stress-related hormones and psychosocial factors.

Read the full study by @martinpicardenergy.bsky.social here:

doi.org/10.1038/s422...
October 14, 2025 at 11:15 AM
Reposted by Jean Nakhle
Less than 70% of science Nobel prize winners awarded this century hail from the country in which they were awarded their prize.
“Mobility benefits everyone. Each newcomer brings fresh ideas, new techniques & different ways of looking at old problems”
🧪 #academicSky
www.nature.com/articles/d41...
More than 30% of this century’s science Nobel prizewinners immigrated: see their journeys
The most common destination for eventual Nobel laureates in physics, chemistry and medicine since 2000 is the United States, Nature has found.
www.nature.com
October 9, 2025 at 10:58 PM
Come work with us! 🧪
October 8, 2025 at 3:08 PM
Out now in @natmetabolism.nature.com 🧪

In a multicenter, randomized, controlled trial, long-term consumption of sweeteners and sweetness enhancers improved body weight control and elicited beneficial gut microbiota changes in adults with overweight or obesity.

www.nature.com/articles/s42...
Effect of sweeteners and sweetness enhancers on weight management and gut microbiota composition in individuals with overweight or obesity: the SWEET study - Nature Metabolism
The SWEET project is a multicenter, randomized, controlled trial that shows that long-term consumption of sweeteners and sweetness enhancers improves body weight control and elicits beneficial gut microbiota changes in adults with overweight or obesity.
www.nature.com
October 7, 2025 at 6:35 PM
Reposted by Jean Nakhle
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize
October 6, 2025 at 9:34 AM
I’ll be attending the Metabolism & Cancer congress in La Grande-Motte next week. If you’re there, let’s chat 😊
October 3, 2025 at 11:43 AM
I’ll be in Daegu 🇰🇷 for the Nature Conference on Healthy Brain Aging.

Come say hi if you’re around and want to chat about Nature Metabolism (or metabolism stuff in general!) 🧠🧪
Register for this exciting Nature Conference on 'Healthy Brain Aging' and meet eminent researchers in the field as well as editors from @natmetabolism.nature.com & other @natureportfolio.nature.com journals! 🧪

Abstract submission deadline Oct 17th!

Registration and other details: t.co/iiCzYAv9mH
🚨Conference Alert🚨

@natmetabolism.nature.com @nataging.nature.com @natneuro.nature.com and @commsbio.nature.com come together for this exciting conference on 'Healthy Brain Aging' in Daegu, South Korea (Dec 9-11, 2025)

Registration and other details: t.co/iiCzYAv9mH
October 2, 2025 at 7:39 PM
Reposted by Jean Nakhle
#Editorial

If you have ever been surprised by seeing an editor at a conference and wondered what they are doing there, this month's editorial has all the answers you need.

#MicroSky #AcademicChatter

www.nature.com/articles/s41...
Why editors go to conferences - Nature Microbiology
You may have spotted us at different conferences and wondered what we’re doing amid active researchers. Here, we demystify the editorial aims of conference attendance.
www.nature.com
October 1, 2025 at 5:59 PM
Reposted by Jean Nakhle
🌟 Thrilled to share that my lab’s first publication is now out in @natmetabolism.nature.com. Congrats to the team 🎉

🧠 We discovered that neurons use endogenous fatty acids as an energy fuel, challenging long-standing models of sugars being the exclusive energy source for neurons. 1/3
October 1, 2025 at 4:11 AM
Reposted by Jean Nakhle
One of our top-rated articles on altmetric.com this past week was published open access in @natmetabolism.nature.com. You can read 'Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD' here: www.nature.com/articles/s42...

#CanSky #OncoSky
Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD - Nature Metabolism
Feng, Luo and colleagues show that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD).
www.nature.com
September 26, 2025 at 6:45 PM
Reposted by Jean Nakhle
✨New issue!✨

Check out the latest in #metabolism research from across all disciplines.

Read about #Ferroptosis, #MASLD, #DietaryBiomarkers, #CoA metabolism, #Immune signaling, #Tumor biology and many more topics! 🧪

www.nature.com/natmetab/vol...
September 24, 2025 at 8:58 PM
Reposted by Jean Nakhle
Genotype-phenotype data from over 450,000 people was analyzed to discover 205 genomic loci where an allele associated with increase adiposity was associated with a lower cardiometabolic disease risk to an individual, according to a paper in Nature Medicine. go.nature.com/4pDuTKP #medsky 🧬 🧪
September 22, 2025 at 7:25 PM
Reposted by Jean Nakhle
A study in Nature Metabolism shows that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrogenase (SORD). go.nature.com/3IaPoO9 #medsky 🧪
September 23, 2025 at 1:09 PM