Jean Nakhle
@jeannakhle.bsky.social
Associate Editor @natmetabolism.nature.com
He/Him/His. Views are my own.
He/Him/His. Views are my own.
All 3 studies converge on the role of NUDT5-PPAT interaction in regulating nucleotide metabolism. A true testament to collaborative spirit and independent validation in science!
November 13, 2025 at 2:10 PM
All 3 studies converge on the role of NUDT5-PPAT interaction in regulating nucleotide metabolism. A true testament to collaborative spirit and independent validation in science!
and by Stefan Kubicek and @chembiohub.bsky.social:
A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesis
Folate metabolism is intricately linked to purine de novo synthesis through the incorporation of folate-derived one-carbon units into the purine scaffold. By investigating chemical and genetic depende...
www.science.org
November 13, 2025 at 2:10 PM
and by Stefan Kubicek and @chembiohub.bsky.social:
Looks like NUDT5 is having its time in the spotlight!
Check out these two complimentary studies published last week in @science.org.
by @rjdlab.bsky.social:
Check out these two complimentary studies published last week in @science.org.
by @rjdlab.bsky.social:
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 13, 2025 at 2:10 PM
Looks like NUDT5 is having its time in the spotlight!
Check out these two complimentary studies published last week in @science.org.
by @rjdlab.bsky.social:
Check out these two complimentary studies published last week in @science.org.
by @rjdlab.bsky.social:
How interesting! I saw a similar phenotype when treating healthy mesenchymal stem cells with TGF‑β. Within 5 min, mitochondrial network that initially extended to the membrane fragmented and clustered around the nucleus. I still don’t know why! Is TGF‑β implicated in the pathogenesis of psychosis?
October 12, 2025 at 7:25 AM
How interesting! I saw a similar phenotype when treating healthy mesenchymal stem cells with TGF‑β. Within 5 min, mitochondrial network that initially extended to the membrane fragmented and clustered around the nucleus. I still don’t know why! Is TGF‑β implicated in the pathogenesis of psychosis?
This study stands out in a literature dominated by observational studies, short-term trials and a limited selection of sweeteners and sweetness enhancers.
October 7, 2025 at 6:35 PM
This study stands out in a literature dominated by observational studies, short-term trials and a limited selection of sweeteners and sweetness enhancers.
