Andy Chan 🇭🇰🇦🇺
@andysonchan.bsky.social
Fascinated by the mysteries of life, especially how tissue regenerates. Currently as postdoc in the Dominic Grün lab and SFB1425, exploring the decision between cardiac regeneration and fibrosis in mammals using single-cell and spatial transcriptomics.
Reposted by Andy Chan 🇭🇰🇦🇺
Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis.
doi.org/10.1038/s441...
rdcu.be/ePzs6
doi.org/10.1038/s441...
rdcu.be/ePzs6
Spatiotemporal dynamics of the cardioimmune niche during lesion repair - Nature Cardiovascular Research
Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage–fibroblast interactions that control late-stage fibros...
doi.org
November 12, 2025 at 2:22 PM
Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis.
doi.org/10.1038/s441...
rdcu.be/ePzs6
doi.org/10.1038/s441...
rdcu.be/ePzs6
Excited to share our new paper “Spatiotemporal dynamics of the cardioimmune niche during lesion repair” just published in Nature Cardiovascular Research!
Our spatio-temporal map of lesion repair in the heart at single-cell resolution is now published in @natureportfolio.nature.com Cardiovascular Research.
www.nature.com/articles/s44...
We dissected dynamics of multicellular niches that control cardiac repair. See 🧵 for highlights.
www.nature.com/articles/s44...
We dissected dynamics of multicellular niches that control cardiac repair. See 🧵 for highlights.
November 3, 2025 at 11:30 AM
Excited to share our new paper “Spatiotemporal dynamics of the cardioimmune niche during lesion repair” just published in Nature Cardiovascular Research!
Reposted by Andy Chan 🇭🇰🇦🇺
Apple snails can regrow their eyes & @popsci.com is talking about it.
#Research published in @natcomms.nature.com from the @planaria1.bsky.social and @accorsi-alice.bsky.social Labs reveals how these snails rebuild complex, camera-like eyes after injury.
📰 Read the feature: bit.ly/45kXdIn
#Research published in @natcomms.nature.com from the @planaria1.bsky.social and @accorsi-alice.bsky.social Labs reveals how these snails rebuild complex, camera-like eyes after injury.
📰 Read the feature: bit.ly/45kXdIn
Apple snails can regrow their eyeballs
Even without this genetic superpower, human eyes and genes are very similar.
bit.ly
August 6, 2025 at 7:58 PM
Apple snails can regrow their eyes & @popsci.com is talking about it.
#Research published in @natcomms.nature.com from the @planaria1.bsky.social and @accorsi-alice.bsky.social Labs reveals how these snails rebuild complex, camera-like eyes after injury.
📰 Read the feature: bit.ly/45kXdIn
#Research published in @natcomms.nature.com from the @planaria1.bsky.social and @accorsi-alice.bsky.social Labs reveals how these snails rebuild complex, camera-like eyes after injury.
📰 Read the feature: bit.ly/45kXdIn
Reposted by Andy Chan 🇭🇰🇦🇺
New preprint from the lab! Using multiplexed spatial analysis and single-cell multiomics, we resolved the portal liver immune niche and identified crosstalk between cholangiocytes, dendritic cells and gdT cells that controls fibrosis in a mouse cholangitis model.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 16, 2025 at 1:36 PM
New preprint from the lab! Using multiplexed spatial analysis and single-cell multiomics, we resolved the portal liver immune niche and identified crosstalk between cholangiocytes, dendritic cells and gdT cells that controls fibrosis in a mouse cholangitis model.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Andy Chan 🇭🇰🇦🇺
Grateful and excited to launch the Otsuki Regeneration Group at the Hubrecht Institute!
🔗 www.hubrecht.eu/research-gro...
We study how tissues regenerate - and use those principles to build 3D tissues in vitro.
Full announcement: www.linkedin.com/in/leo-otsuk...
@hubrechtinstitute.bsky.social
🔗 www.hubrecht.eu/research-gro...
We study how tissues regenerate - and use those principles to build 3D tissues in vitro.
Full announcement: www.linkedin.com/in/leo-otsuk...
@hubrechtinstitute.bsky.social
July 25, 2025 at 7:30 AM
Grateful and excited to launch the Otsuki Regeneration Group at the Hubrecht Institute!
🔗 www.hubrecht.eu/research-gro...
We study how tissues regenerate - and use those principles to build 3D tissues in vitro.
Full announcement: www.linkedin.com/in/leo-otsuk...
@hubrechtinstitute.bsky.social
🔗 www.hubrecht.eu/research-gro...
We study how tissues regenerate - and use those principles to build 3D tissues in vitro.
Full announcement: www.linkedin.com/in/leo-otsuk...
@hubrechtinstitute.bsky.social
Reposted by Andy Chan 🇭🇰🇦🇺
Out today from the Schwartz lab! A new way to study cell-cell communication from spatial transcriptomics data. Cell Neural Networks on Spatial Transcriptomics (CellNEST) can detect both signals between individual cells and relay networks of communication. www.nature.com/articles/s41...
June 6, 2025 at 5:32 PM
Out today from the Schwartz lab! A new way to study cell-cell communication from spatial transcriptomics data. Cell Neural Networks on Spatial Transcriptomics (CellNEST) can detect both signals between individual cells and relay networks of communication. www.nature.com/articles/s41...
Reposted by Andy Chan 🇭🇰🇦🇺
Nature research paper: Molecular basis of positional memory in limb regeneration
https://go.nature.com/44OtQj3
https://go.nature.com/44OtQj3
Molecular basis of positional memory in limb regeneration - Nature
A molecular analysis of axolotl limb regeneration has identified a positive genetic circuit that maintains posterior cell identity and can be used to reprogramme anterior cells into posterior cells.
go.nature.com
May 22, 2025 at 2:56 PM
Nature research paper: Molecular basis of positional memory in limb regeneration
https://go.nature.com/44OtQj3
https://go.nature.com/44OtQj3
Reposted by Andy Chan 🇭🇰🇦🇺
A paper in Scientific Reports describes a partial skeleton collected from the Middle Jurassic Xinhe Formation of Gansu Province in China that represents a new taxon of non-neosauropod eusauropods and was named Jinchuanloong niedu. go.nature.com/4jmLXQV #Paleosky 🧪
May 30, 2025 at 7:44 PM
A paper in Scientific Reports describes a partial skeleton collected from the Middle Jurassic Xinhe Formation of Gansu Province in China that represents a new taxon of non-neosauropod eusauropods and was named Jinchuanloong niedu. go.nature.com/4jmLXQV #Paleosky 🧪
Reposted by Andy Chan 🇭🇰🇦🇺
A feature in Nature examines the debate among researchers over whether ‘disruptive’ or ‘novel’ science is waning and how to remedy the problem. 🧪
Are groundbreaking science discoveries becoming harder to find?
Researchers are arguing over whether ‘disruptive’ or ‘novel’ science is waning – and how to remedy the problem.
go.nature.com
May 31, 2025 at 1:14 AM
A feature in Nature examines the debate among researchers over whether ‘disruptive’ or ‘novel’ science is waning and how to remedy the problem. 🧪