Dominic Grün
@dominicgrun.bsky.social
Quantitative Single-Cell Biology
Prof at Würzburg Institute of Systems Immunology (WüSI)
Prof at Würzburg Institute of Systems Immunology (WüSI)
Reposted by Dominic Grün
Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis.
doi.org/10.1038/s441...
rdcu.be/ePzs6
doi.org/10.1038/s441...
rdcu.be/ePzs6
Spatiotemporal dynamics of the cardioimmune niche during lesion repair - Nature Cardiovascular Research
Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage–fibroblast interactions that control late-stage fibros...
doi.org
November 12, 2025 at 2:22 PM
Research | Chan et al. generate a high-resolution spatiotemporal atlas of healing hearts and reveal cellular networks of lesion repair, including macrophage-fibroblast interactions that control late-stage fibrosis.
doi.org/10.1038/s441...
rdcu.be/ePzs6
doi.org/10.1038/s441...
rdcu.be/ePzs6
Reposted by Dominic Grün
We are delighted to announce our #HighlyCited2025 researchers: Ronny Thomale, @angelifriedmann.bsky.social , Georg Gasteiger, @dominicgrun.bsky.social, and Christoph Wanner. Congratulations!
➡️ www.uni-wuerzburg.de/en/news-and-...
➡️ www.uni-wuerzburg.de/en/news-and-...
November 12, 2025 at 9:19 AM
We are delighted to announce our #HighlyCited2025 researchers: Ronny Thomale, @angelifriedmann.bsky.social , Georg Gasteiger, @dominicgrun.bsky.social, and Christoph Wanner. Congratulations!
➡️ www.uni-wuerzburg.de/en/news-and-...
➡️ www.uni-wuerzburg.de/en/news-and-...
Our spatio-temporal map of lesion repair in the heart at single-cell resolution is now published in @natureportfolio.nature.com Cardiovascular Research.
www.nature.com/articles/s44...
We dissected dynamics of multicellular niches that control cardiac repair. See 🧵 for highlights.
www.nature.com/articles/s44...
We dissected dynamics of multicellular niches that control cardiac repair. See 🧵 for highlights.
November 3, 2025 at 10:51 AM
Our spatio-temporal map of lesion repair in the heart at single-cell resolution is now published in @natureportfolio.nature.com Cardiovascular Research.
www.nature.com/articles/s44...
We dissected dynamics of multicellular niches that control cardiac repair. See 🧵 for highlights.
www.nature.com/articles/s44...
We dissected dynamics of multicellular niches that control cardiac repair. See 🧵 for highlights.
The Roadmap of the Human Liver Cell Atlas is out in @natrevgastrohep.nature.com laying out the scope and goals of our Human Liver Cell Atlas emerging from the @cziscience.bsky.social funded Liver Seed Network.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 14, 2025 at 7:13 AM
The Roadmap of the Human Liver Cell Atlas is out in @natrevgastrohep.nature.com laying out the scope and goals of our Human Liver Cell Atlas emerging from the @cziscience.bsky.social funded Liver Seed Network.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dominic Grün
** Now seeking postdocs **
Join our interdisciplinary and transnational team in Würzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery.
Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.
Join our interdisciplinary and transnational team in Würzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery.
Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.
October 5, 2025 at 9:48 PM
** Now seeking postdocs **
Join our interdisciplinary and transnational team in Würzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery.
Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.
Join our interdisciplinary and transnational team in Würzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery.
Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.
Registration for our "Advances in Single-Cell Technologies" meeting is still open and we invite abstract submissions until October 30th. Join us in beautiful Freiburg together with an excellent line-up of single-cell technology experts!
www.uniklinik-freiburg.de/single-cell-...
www.uniklinik-freiburg.de/single-cell-...
October 1, 2025 at 2:37 PM
Registration for our "Advances in Single-Cell Technologies" meeting is still open and we invite abstract submissions until October 30th. Join us in beautiful Freiburg together with an excellent line-up of single-cell technology experts!
www.uniklinik-freiburg.de/single-cell-...
www.uniklinik-freiburg.de/single-cell-...
Join our "Advances in Single-Cell Technologies" meeting in December in Freiburg, co-organised with Marco Prinz and @katrinkierdorf.bsky.social. Excellent line-up of speakers covering spatial technologies, lineage tracing, computational methods, and more.
www.uniklinik-freiburg.de/single-cell-...
www.uniklinik-freiburg.de/single-cell-...
July 21, 2025 at 6:15 AM
Join our "Advances in Single-Cell Technologies" meeting in December in Freiburg, co-organised with Marco Prinz and @katrinkierdorf.bsky.social. Excellent line-up of speakers covering spatial technologies, lineage tracing, computational methods, and more.
www.uniklinik-freiburg.de/single-cell-...
www.uniklinik-freiburg.de/single-cell-...
New preprint from the lab! Using multiplexed spatial analysis and single-cell multiomics, we resolved the portal liver immune niche and identified crosstalk between cholangiocytes, dendritic cells and gdT cells that controls fibrosis in a mouse cholangitis model.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 16, 2025 at 1:36 PM
New preprint from the lab! Using multiplexed spatial analysis and single-cell multiomics, we resolved the portal liver immune niche and identified crosstalk between cholangiocytes, dendritic cells and gdT cells that controls fibrosis in a mouse cholangitis model.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dominic Grün
Join us for a series of presentations from leading data science experts, including @francescafinotello.bsky.social, @dominicgrun.bsky.social, Johanna Klughammer, Malte Lücken, @fabiantheis.bsky.social and @jwrth.genomic.social.ap.brid.gy.
July 4, 2025 at 7:20 PM
Join us for a series of presentations from leading data science experts, including @francescafinotello.bsky.social, @dominicgrun.bsky.social, Johanna Klughammer, Malte Lücken, @fabiantheis.bsky.social and @jwrth.genomic.social.ap.brid.gy.
Few dates left to apply for this tenure-track professorship on Single-Cell Systems Biology in my department at @uni-wuerzburg.de. Competitive package and highly attractive research environment at the Institute of Systems Immunology.
We have an attractive opening for a tenure-track professorship in Single-Cell Systems Biology. Excellent package and infrastructure at @uni-wuerzburg.de Institute of Systems Immunology. Great place to live and work in the heart of the franconian wine region!
jobs.sciencecareers.org/job/673667/j...
jobs.sciencecareers.org/job/673667/j...
junior professorship position (f/m/d) in Single-Cell Systems Biology - Würzburg (Stadt), Bayern (DE) job with Julius-Maximilians-University Würzburg - Faculty of Medicine | 673667
The Julius-Maximilians-University Würzburg, Faculty of Medicine is offering one junior professorship position (f/m/d) in Single-Cell Systems Biology.
jobs.sciencecareers.org
July 2, 2025 at 7:00 AM
Few dates left to apply for this tenure-track professorship on Single-Cell Systems Biology in my department at @uni-wuerzburg.de. Competitive package and highly attractive research environment at the Institute of Systems Immunology.
Consider attending the MOPITAS autumn school on Spatial Transcriptomics in Munich with expert lectures and hands-on sessions for all steps of spatial transcriptomics data analysis.
event.sdu.dk/mopitas-scho...
event.sdu.dk/mopitas-scho...
June 11, 2025 at 3:46 PM
Consider attending the MOPITAS autumn school on Spatial Transcriptomics in Munich with expert lectures and hands-on sessions for all steps of spatial transcriptomics data analysis.
event.sdu.dk/mopitas-scho...
event.sdu.dk/mopitas-scho...
We have an attractive opening for a tenure-track professorship in Single-Cell Systems Biology. Excellent package and infrastructure at @uni-wuerzburg.de Institute of Systems Immunology. Great place to live and work in the heart of the franconian wine region!
jobs.sciencecareers.org/job/673667/j...
jobs.sciencecareers.org/job/673667/j...
junior professorship position (f/m/d) in Single-Cell Systems Biology - Würzburg (Stadt), Bayern (DE) job with Julius-Maximilians-University Würzburg - Faculty of Medicine | 673667
The Julius-Maximilians-University Würzburg, Faculty of Medicine is offering one junior professorship position (f/m/d) in Single-Cell Systems Biology.
jobs.sciencecareers.org
June 2, 2025 at 9:29 AM
We have an attractive opening for a tenure-track professorship in Single-Cell Systems Biology. Excellent package and infrastructure at @uni-wuerzburg.de Institute of Systems Immunology. Great place to live and work in the heart of the franconian wine region!
jobs.sciencecareers.org/job/673667/j...
jobs.sciencecareers.org/job/673667/j...
Reposted by Dominic Grün
A triumph of perseverance from twitterless Tom Weber, Christine Biben and the team, our in vivo barcoding "LoxCode mouse" used to resolve epiblast fate to fetal organs is finally published in @cellpress.bsky.social and available through @jacksonlab.bsky.social www.sciencedirect.com/science/arti...
LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs
Much remains to be learned about the clonal fate of mammalian epiblast cells. Here, we develop high-diversity Cre recombinase-driven LoxCode barcoding…
www.sciencedirect.com
May 16, 2025 at 4:32 AM
A triumph of perseverance from twitterless Tom Weber, Christine Biben and the team, our in vivo barcoding "LoxCode mouse" used to resolve epiblast fate to fetal organs is finally published in @cellpress.bsky.social and available through @jacksonlab.bsky.social www.sciencedirect.com/science/arti...
Registration for the upcoming symposium "Imaging the Immune System VI" in Würzburg is still open. Fantastic speaker line-up at a beautiful historic venue in the centre of Würzburg.
imaging-immune-system.wuesi.com
imaging-immune-system.wuesi.com
May 14, 2025 at 9:17 AM
Registration for the upcoming symposium "Imaging the Immune System VI" in Würzburg is still open. Fantastic speaker line-up at a beautiful historic venue in the centre of Würzburg.
imaging-immune-system.wuesi.com
imaging-immune-system.wuesi.com
Reposted by Dominic Grün
Barry Blitt’s cover for this week’s issue, “The First Hundred Days.” #NewYorkerCovers nyer.cm/ysrCZ47
April 28, 2025 at 4:20 PM
Barry Blitt’s cover for this week’s issue, “The First Hundred Days.” #NewYorkerCovers nyer.cm/ysrCZ47
Reposted by Dominic Grün
Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction published in Nature Cell Biology! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks also to all our collaborators 👏🏻👏🏻
New research by the @ninacabezas.bsky.social lab & collaborators from @uniklinik-fr.bsky.social.
A vitamin A metabolite may offer a targeted therapeutic strategy for heart attack patients by regulating HSCs to minimize excessive inflammation and preserve long-term heart function.
A vitamin A metabolite may offer a targeted therapeutic strategy for heart attack patients by regulating HSCs to minimize excessive inflammation and preserve long-term heart function.
Healing a broken heart
A vitamin A metabolite, 4-oxo-retinoic acid, can regulate the activity of hematopoietic stem cells and thereby reduce inflammation after a heart attack, ultimately improving heart function in the long...
www.ie-freiburg.mpg.de
April 2, 2025 at 2:32 PM
Extremely happy to share our study on the regulation of HSCs in the context of myocardial infarction published in Nature Cell Biology! Driven by two amazing scientists in my lab - Jasmin and Maricarmen and co-led with the awesome cardiologist Timo! Huge thanks also to all our collaborators 👏🏻👏🏻
Reposted by Dominic Grün
1/ New preprint! 🍳
@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!
doi.org/10.1101/2025...
@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!
doi.org/10.1101/2025...
March 18, 2025 at 2:48 PM
1/ New preprint! 🍳
@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!
doi.org/10.1101/2025...
@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!
doi.org/10.1101/2025...
Reposted by Dominic Grün
We're looking to hire a research assistant for flow cytometry of brain tumor immune cells! Apply here -> ki.varbi.com/en/what:job/...
Research Assistant in the field of glioblastoma immunology
Do you want to contribute to top quality medical research? The Sten Linnarsson lab is a part of Unit of Molecular Neurobiology at the Department of Medical Biochemistry and Biophysics (MBB) . Linnarss
ki.varbi.com
March 17, 2025 at 9:47 PM
We're looking to hire a research assistant for flow cytometry of brain tumor immune cells! Apply here -> ki.varbi.com/en/what:job/...
Reposted by Dominic Grün
6 days left to apply to the Post-doc opening in our lab
@ebi.embl.org to develop&apply #bioinformatics & #machine-learning methods to study intra-/extra cellular networks to extract disease mechanisms from #single-cell and #spatial multiomic data: embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
@ebi.embl.org to develop&apply #bioinformatics & #machine-learning methods to study intra-/extra cellular networks to extract disease mechanisms from #single-cell and #spatial multiomic data: embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
Postdoctoral fellow - Saez-Rodriguez Group
Your group Saez-Rodriguez Research Group Your supervisor Julio Saez-Rodriguez Your role As a postdoctoral fellow in the Saez Rodriguez group, you will develop and apply computational methods and tools...
embl.wd103.myworkdayjobs.com
March 17, 2025 at 6:01 PM
6 days left to apply to the Post-doc opening in our lab
@ebi.embl.org to develop&apply #bioinformatics & #machine-learning methods to study intra-/extra cellular networks to extract disease mechanisms from #single-cell and #spatial multiomic data: embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
@ebi.embl.org to develop&apply #bioinformatics & #machine-learning methods to study intra-/extra cellular networks to extract disease mechanisms from #single-cell and #spatial multiomic data: embl.wd103.myworkdayjobs.com/EMBL/job/Hin...
Reposted by Dominic Grün
This is my institution. These are the people I work with making these decisions. The situation is heartbreaking. Public medical schools have no other choice; there is no other source of funding, and everyone in academia is at extreme risk right now.
March 12, 2025 at 8:49 PM
This is my institution. These are the people I work with making these decisions. The situation is heartbreaking. Public medical schools have no other choice; there is no other source of funding, and everyone in academia is at extreme risk right now.
Reposted by Dominic Grün
Currently, there's a lot of interest in quantitative models that would help us understand and predict features of the complex cellular systems that underlie human health and disease - think about virtual cells, for example. On can trace some of these ideas back to the early days of systems biology.
Adapting systems biology to address the complexity of human disease in the single-cell era go.nature.com/3XBo6Vh #Review by @davidsebfischer.bsky.social, Martin A. Villanueva, Peter S. Winter & Alex K. Shalek @broadinstitute.org @mitofficial.bsky.social @ragoninstitute.bsky.social
Adapting systems biology to address the complexity of human disease in the single-cell era - Nature Reviews Genetics
Differences between humans and experimental models create a translational gap that makes it difficult to extrapolate research findings. The authors review systems-focused approaches to identify and co...
go.nature.com
March 13, 2025 at 3:53 AM
Currently, there's a lot of interest in quantitative models that would help us understand and predict features of the complex cellular systems that underlie human health and disease - think about virtual cells, for example. On can trace some of these ideas back to the early days of systems biology.
Reposted by Dominic Grün
Today, along with 2,000 other NIH employees, I had to clear out my office 😭
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
February 14, 2025 at 11:31 PM
Today, along with 2,000 other NIH employees, I had to clear out my office 😭
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
It was truly the honor of my life to work with such incredibly passionate people focused on improving human health. I’ve never experienced a more positive culture where *everyone* cared about their job and serving others.
Reposted by Dominic Grün
New online! Decoding cell–cell communication using spatial transcriptomics
Decoding cell–cell communication using spatial transcriptomics
Nature Reviews Genetics, Published online: 21 February 2025; doi:10.1038/s41576-025-00824-3In this Tools of the Trade article, Ankit Agrawal introduces the computational framework NiCo (Niche Covariation), which integrates spatial transcriptomics with…
www.nature.com
February 21, 2025 at 4:00 PM
New online! Decoding cell–cell communication using spatial transcriptomics
Check out this nice "Tools of the Trade" piece in Nature Reviews Genetics written by Ankit Agrawal on our NiCo algorithm for the analysis of single-cell spatial transcriptomics data from platforms like Xenium, MERSCOPE, seqFISH etc.
Feel free to reach out for advice.
www.nature.com/articles/s41...
Feel free to reach out for advice.
www.nature.com/articles/s41...
Decoding cell–cell communication using spatial transcriptomics - Nature Reviews Genetics
In this Tools of the Trade article, Ankit Agrawal introduces the computational framework NiCo (Niche Covariation), which integrates spatial transcriptomics with single-cell RNA-sequencing data to stud...
www.nature.com
February 21, 2025 at 3:35 PM
Check out this nice "Tools of the Trade" piece in Nature Reviews Genetics written by Ankit Agrawal on our NiCo algorithm for the analysis of single-cell spatial transcriptomics data from platforms like Xenium, MERSCOPE, seqFISH etc.
Feel free to reach out for advice.
www.nature.com/articles/s41...
Feel free to reach out for advice.
www.nature.com/articles/s41...
Reposted by Dominic Grün
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.