Anders Sejr Hansen
@andersshansen.bsky.social
Associate Professor at MIT BE : http://ashansenlab.com
Interested in understanding the relationship between 3D genome structure and function
Interested in understanding the relationship between 3D genome structure and function
Wonderful to see the beautiful preprint from Sabate et al now published - TADs are also dynamic structures in human cells, with remarkably similar parameters between mESCs and HCT116 cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 15, 2025 at 5:24 PM
Wonderful to see the beautiful preprint from Sabate et al now published - TADs are also dynamic structures in human cells, with remarkably similar parameters between mESCs and HCT116 cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Anders Sejr Hansen
In this episode we talked with @andersshansen.bsky.social from MIT about his work on the impact of 3D genome structures on gene expression and advanced techniques like Region Capture Micro-C for mapping genome organisation. #podcast #epigenetics
Listen here: activemotif.com/podcasts-and...
Listen here: activemotif.com/podcasts-and...
November 14, 2025 at 8:01 AM
In this episode we talked with @andersshansen.bsky.social from MIT about his work on the impact of 3D genome structures on gene expression and advanced techniques like Region Capture Micro-C for mapping genome organisation. #podcast #epigenetics
Listen here: activemotif.com/podcasts-and...
Listen here: activemotif.com/podcasts-and...
Reposted by Anders Sejr Hansen
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Alternate proteins from the same gene contribute differently to health and rare disease | Whitehead Institute
Iain Cheeseman and colleagues reveal the underappreciated role of single genes producing multiple proteins in atypical presentations of rare disease, and present case studies of affected patients thro...
wi.mit.edu
November 7, 2025 at 4:14 PM
From an accidental discovery of hidden biology to a new framework to understanding and diagnosing rare disease. Thrilled to share the most recent work from our lab and the amazing Jimmy Ly.
wi.mit.edu/news/alterna...
wi.mit.edu/news/alterna...
Reposted by Anders Sejr Hansen
🧬🔬🦠🧫🧪@science.org Escherichia coli with a 57-codon genetic code | Science www.science.org/doi/10.1126/...
October 23, 2025 at 9:51 PM
🧬🔬🦠🧫🧪@science.org Escherichia coli with a 57-codon genetic code | Science www.science.org/doi/10.1126/...
Thanks also very much to Anne Trafton from MIT News for writing a nice article about the findings:
news.mit.edu/2025/surpris...
news.mit.edu/2025/surpris...
October 20, 2025 at 7:05 PM
Thanks also very much to Anne Trafton from MIT News for writing a nice article about the findings:
news.mit.edu/2025/surpris...
news.mit.edu/2025/surpris...
Our collab w. V Goel, @nicholas-aboreden.bsky.social , J Jusuf, G Blobel, L Mirny, @irate-physicist.bsky.social out in @natsmb.nature.com www.nature.com/articles/s41...
Was co-submitted with @allanaschooley.bsky.social @jobdekker.bsky.social whose paper should also come out soon
Brief thread 👇
Was co-submitted with @allanaschooley.bsky.social @jobdekker.bsky.social whose paper should also come out soon
Brief thread 👇
October 20, 2025 at 6:36 PM
Our collab w. V Goel, @nicholas-aboreden.bsky.social , J Jusuf, G Blobel, L Mirny, @irate-physicist.bsky.social out in @natsmb.nature.com www.nature.com/articles/s41...
Was co-submitted with @allanaschooley.bsky.social @jobdekker.bsky.social whose paper should also come out soon
Brief thread 👇
Was co-submitted with @allanaschooley.bsky.social @jobdekker.bsky.social whose paper should also come out soon
Brief thread 👇
Reposted by Anders Sejr Hansen
Very happy that this insightful story by @andersshansen.bsky.social is out @natsmb.nature.com, www.nature.com/articles/s41.... A nice press release explaining the progress also from the home institute @mitdeptofbe.bsky.social here: news.mit.edu/2025/surpris...
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
www.nature.com
October 20, 2025 at 9:30 AM
Very happy that this insightful story by @andersshansen.bsky.social is out @natsmb.nature.com, www.nature.com/articles/s41.... A nice press release explaining the progress also from the home institute @mitdeptofbe.bsky.social here: news.mit.edu/2025/surpris...
Reposted by Anders Sejr Hansen
Excited to share our paper on dynamics of microcompartments during M-to-G1 is now published in @natsmb.nature.com www.nature.com/articles/s41...
Compared to biorxiv, published includes new analysis from James Jusuf and Viraat Goel (from @andersshansen.bsky.social lab) on transcriptional spiking
Compared to biorxiv, published includes new analysis from James Jusuf and Viraat Goel (from @andersshansen.bsky.social lab) on transcriptional spiking
October 17, 2025 at 2:58 PM
Excited to share our paper on dynamics of microcompartments during M-to-G1 is now published in @natsmb.nature.com www.nature.com/articles/s41...
Compared to biorxiv, published includes new analysis from James Jusuf and Viraat Goel (from @andersshansen.bsky.social lab) on transcriptional spiking
Compared to biorxiv, published includes new analysis from James Jusuf and Viraat Goel (from @andersshansen.bsky.social lab) on transcriptional spiking
Check out Shdema's preprint that uses high-res Micro-C to delineate 3D genome structure in three tomato species highlighting both activating and repressive loops and the independence of looping and insulation in tomato:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 17, 2025 at 12:50 AM
Check out Shdema's preprint that uses high-res Micro-C to delineate 3D genome structure in three tomato species highlighting both activating and repressive loops and the independence of looping and insulation in tomato:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Anders Sejr Hansen
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 3:06 PM
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Reposted by Anders Sejr Hansen
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
October 2, 2025 at 5:11 PM
Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky
Reposted by Anders Sejr Hansen
Happy #FluorescenceFriday! Our #CellLineOfTheWeek is SMC (structural maintenance of chromosomes) protein 1A! 🧬🛠️
Our cell lines & plasmids are available for just the cost of shipping to reduce the barriers to scientific discovery.
📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social
Our cell lines & plasmids are available for just the cost of shipping to reduce the barriers to scientific discovery.
📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social
October 3, 2025 at 8:45 PM
Happy #FluorescenceFriday! Our #CellLineOfTheWeek is SMC (structural maintenance of chromosomes) protein 1A! 🧬🛠️
Our cell lines & plasmids are available for just the cost of shipping to reduce the barriers to scientific discovery.
📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social
Our cell lines & plasmids are available for just the cost of shipping to reduce the barriers to scientific discovery.
📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social
Reposted by Anders Sejr Hansen
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
A human-specific regulatory mechanism revealed in a pre-implantation model
Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.
rdcu.be
October 1, 2025 at 6:08 PM
Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
Reposted by Anders Sejr Hansen
Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance.
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
September 22, 2025 at 10:54 AM
Some proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance.
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
The regulation of most proteins is dominated by different regulatory mechanisms across cell types.
Gratifyingly, this complex regulation defines simple rules ⬇️
www.biorxiv.org/content/10.1...
Reposted by Anders Sejr Hansen
New cures feel sudden, but the seeds were planted decades ago by basic scientists.
Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵
Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵
Huntington's disease successfully treated for first time
One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.
www.bbc.com
September 25, 2025 at 1:39 AM
New cures feel sudden, but the seeds were planted decades ago by basic scientists.
Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵
Which seeds will turn into cures? Unpredictable looking forward, a straight line looking back. 🧪🧬 🧵
It's also nice to see a very rigorous and careful approach to analyzing interactions in live-cell imaging data subject to noise. Direct simple thresholding of such data will inevitably give artefactual numbers.
September 24, 2025 at 7:13 PM
It's also nice to see a very rigorous and careful approach to analyzing interactions in live-cell imaging data subject to noise. Direct simple thresholding of such data will inevitably give artefactual numbers.
Really enjoyed reading the new @lucagiorgetti.bsky.social lab preprint that makes the case that not all E-P interactions are created equal - it is the subset of long-lived extrusion-mediated E-P interactions that are most transcriptionally important:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 24, 2025 at 7:08 PM
Really enjoyed reading the new @lucagiorgetti.bsky.social lab preprint that makes the case that not all E-P interactions are created equal - it is the subset of long-lived extrusion-mediated E-P interactions that are most transcriptionally important:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Anders Sejr Hansen
That was >40 years ago!
So many of John's papers still read incredibly prescient to this day.
Fun fact, John is still around and scheduled to give his faculty talk to my department this Wednesday.
So many of John's papers still read incredibly prescient to this day.
Fun fact, John is still around and scheduled to give his faculty talk to my department this Wednesday.
September 21, 2025 at 10:59 PM
That was >40 years ago!
So many of John's papers still read incredibly prescient to this day.
Fun fact, John is still around and scheduled to give his faculty talk to my department this Wednesday.
So many of John's papers still read incredibly prescient to this day.
Fun fact, John is still around and scheduled to give his faculty talk to my department this Wednesday.
Asking BlueSky for help: For a review, I am trying to accurately credit the first paper that measured pairwise 3D distances between 2 pieces of DNA on the same chromosome (or cosmid). Is Trask 1989 the first?
I know of earlier single-locus papers (1982).
www.sciencedirect.com/science/arti...
I know of earlier single-locus papers (1982).
www.sciencedirect.com/science/arti...
September 21, 2025 at 6:54 PM
Asking BlueSky for help: For a review, I am trying to accurately credit the first paper that measured pairwise 3D distances between 2 pieces of DNA on the same chromosome (or cosmid). Is Trask 1989 the first?
I know of earlier single-locus papers (1982).
www.sciencedirect.com/science/arti...
I know of earlier single-locus papers (1982).
www.sciencedirect.com/science/arti...
Jamie Drayton and I were fortunate to contribute some RCMC analyses to this beautiful paper from Eder, Moene...van Steensel that systematically maps the relationship between enhancer location and gene expression (and nice to see RCMC predict expression in Fig 2H-I):
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
September 19, 2025 at 7:41 PM
Jamie Drayton and I were fortunate to contribute some RCMC analyses to this beautiful paper from Eder, Moene...van Steensel that systematically maps the relationship between enhancer location and gene expression (and nice to see RCMC predict expression in Fig 2H-I):
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Anders Sejr Hansen
Excited to share another new preprint from our lab in which we developed a cluster-based phasing strategy using long read nano-NOMe-seq data to link distinct CTCF binding states—captured at the single molecule level—to the transcriptional status of genes: biorxiv.org/content/10.1...
September 9, 2025 at 5:44 PM
Excited to share another new preprint from our lab in which we developed a cluster-based phasing strategy using long read nano-NOMe-seq data to link distinct CTCF binding states—captured at the single molecule level—to the transcriptional status of genes: biorxiv.org/content/10.1...
Reposted by Anders Sejr Hansen
Speaker Spotlight: Don’t miss @Anders_S_Hansen from MIT as he unpacks the secrets of distal gene regulation in space and time! Learn how enhancers find and activate their target genes—revealing new insights into the selectivity and dynamics of gene control. Reserve your seat:
September 17, 2025 at 10:59 PM
Speaker Spotlight: Don’t miss @Anders_S_Hansen from MIT as he unpacks the secrets of distal gene regulation in space and time! Learn how enhancers find and activate their target genes—revealing new insights into the selectivity and dynamics of gene control. Reserve your seat:
Very interesting new @wbickmor.bsky.social commentary on the mechanistic mystery that is very distal enhancer-promoter interactions www.nature.com/articles/s41...
Is enhancer-driven gene regulation all wrapped up? - Nature Reviews Genetics
In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.
www.nature.com
September 17, 2025 at 12:41 PM
Very interesting new @wbickmor.bsky.social commentary on the mechanistic mystery that is very distal enhancer-promoter interactions www.nature.com/articles/s41...
Reposted by Anders Sejr Hansen
New preprint! Graduate student Océane Marescal leverages quiescence - proliferative hibernation - to reveal unexpected dynamics for “constitutively”-localized centromere proteins. To understand the logic of cell division, you need to consider non-dividing cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The dynamics of centromere assembly and disassembly during quiescence
Quiescence is a state in which cells undergo a prolonged proliferative arrest while maintaining their capacity to reenter the cell cycle. Here, we analyze entry and exit from quiescence, focusing on h...
www.biorxiv.org
September 9, 2025 at 11:14 AM
New preprint! Graduate student Océane Marescal leverages quiescence - proliferative hibernation - to reveal unexpected dynamics for “constitutively”-localized centromere proteins. To understand the logic of cell division, you need to consider non-dividing cells.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
This is a fantastic review
REVIEW: Timing is everything: transcription bursting in development
By Jee Min Kim and Daniel Larson
➡️ https://tinyurl.com/gd352465
#transcription #molecularbiology #transcriptionbursting #embryonicdevelopment #stemcell #differentiation #mRNA #development #molecularmechanism
By Jee Min Kim and Daniel Larson
➡️ https://tinyurl.com/gd352465
#transcription #molecularbiology #transcriptionbursting #embryonicdevelopment #stemcell #differentiation #mRNA #development #molecularmechanism
September 8, 2025 at 3:17 PM
This is a fantastic review