Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.   

The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) w...

Under hyperproliferative conditions, escalation of genomic activity provokes high levels of DNA mechanical stress. Cancer cells cope with this stress through topoisomerase activity. Topoisomerases sup...

Merigliano et al. identified a non-canonical, “off-pore” role for nucleoporins in genome stability and in the spatial regulation of homologous recombination in multicellular eukaryotes. Nup98 condensates form at DNA breaks within pericentromeric heterochromatin to prevent aberrant recombination by excluding Rad51, while promoting the mobilization of repair sites through immiscibility with heterochromatin protein 1 (HP1) condensates.

A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Nature - Ku limits RNA-induced innate immunity to allow Alu-expansion in primates

The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of genome architecture and spatial genome regulation emerged early in animal evolution.

Research Assistant (Jackson Group) (Fixed Term) in the Cancer Research UK Cambridge Institute at the University of Cambridge.