Alex Tonks
@alextonks.bsky.social
Head of Haematology/ Professor / Cancer and Leukaemia researcher / Cardiff University, School of Medicine / Supervisor / Educator / Collaborator
Reposted by Alex Tonks
Very grateful to have been awarded our first @bloodcanceruk.bsky.social research grant over the summer for our work targeting aberrant Wnt/β-catenin signalling in acute myeloid leukaemia (AML).
Our new project headed by Dr Wagstaff begins Oct 1st developing new ways to target oncogenic β-catenin 👊
Our new project headed by Dr Wagstaff begins Oct 1st developing new ways to target oncogenic β-catenin 👊
September 30, 2025 at 3:06 PM
Very grateful to have been awarded our first @bloodcanceruk.bsky.social research grant over the summer for our work targeting aberrant Wnt/β-catenin signalling in acute myeloid leukaemia (AML).
Our new project headed by Dr Wagstaff begins Oct 1st developing new ways to target oncogenic β-catenin 👊
Our new project headed by Dr Wagstaff begins Oct 1st developing new ways to target oncogenic β-catenin 👊
Reposted by Alex Tonks
Couldn't recommend this PhD highly enough! Go join an exciting new young PI doing some super interesting/translational leukaemia research.
📢 New PhD Opportunity
🧬🧪 Excited to share a fully funded PhD studentship is available in my lab @gdsc-sussex.bsky.social
📅 Deadline: 2nd May 2025
👉 www.sussex.ac.uk/study/fees-f...
Please share with anyone who might be interested.
🧬🧪 Excited to share a fully funded PhD studentship is available in my lab @gdsc-sussex.bsky.social
📅 Deadline: 2nd May 2025
👉 www.sussex.ac.uk/study/fees-f...
Please share with anyone who might be interested.
PhD Studentship: Structure and function of tyrosine fusion kinases in leukaemia and their regulation by the HSP90 molecular chaperone at University of Sussex
Discover a PhD Studentship: Structure and function of tyrosine fusion kinases in leukaemia and their regulation by the HSP90 molecular chaperone on jobs.ac.uk. Apply now and explore other PhD opportun...
www.jobs.ac.uk
April 16, 2025 at 5:44 PM
Couldn't recommend this PhD highly enough! Go join an exciting new young PI doing some super interesting/translational leukaemia research.
Reposted by Alex Tonks
Fantastic to see significant investment in health and social care research in Wales. Excited & proud to co-lead a new £3M Wales Applied Virology Unit with @richstanton.bsky.social and David Gillespie
- impactful research ahead #Virology #Unit #Research
healthandcareresearchwales.org/about/news/m...
- impactful research ahead #Virology #Unit #Research
healthandcareresearchwales.org/about/news/m...
Health and Care Research Wales announces major £49m investment in research infrastructure
Health and Care Research Wales announces major £49m investment in research infrastructure
healthandcareresearchwales.org
January 27, 2025 at 2:12 PM
Fantastic to see significant investment in health and social care research in Wales. Excited & proud to co-lead a new £3M Wales Applied Virology Unit with @richstanton.bsky.social and David Gillespie
- impactful research ahead #Virology #Unit #Research
healthandcareresearchwales.org/about/news/m...
- impactful research ahead #Virology #Unit #Research
healthandcareresearchwales.org/about/news/m...
Reposted by Alex Tonks
Early-career researchers describe how they juggled workloads, emotions and finances after having children. Todays issue of Nature 🧪
January 15, 2025 at 6:28 PM
Early-career researchers describe how they juggled workloads, emotions and finances after having children. Todays issue of Nature 🧪
Reposted by Alex Tonks
Please share our new PhD position:
We are looking for a data scientists to work on leukaemia models of #AML and cancer stem cells or #LSCs.
This mixes wet and dry lab and aims to replace animals in research by developing new in vitro tools.
tinyurl.com/6rfan796
tinyurl.com/fmys7cay
We are looking for a data scientists to work on leukaemia models of #AML and cancer stem cells or #LSCs.
This mixes wet and dry lab and aims to replace animals in research by developing new in vitro tools.
tinyurl.com/6rfan796
tinyurl.com/fmys7cay
Multi-omic analysis of human blood cancer stem cells to develop new predictive tools, and develop novel culture systems at University of York on FindAPhD.com
PhD Project - Multi-omic analysis of human blood cancer stem cells to develop new predictive tools, and develop novel culture systems at University of York, listed on FindAPhD.com
tinyurl.com
January 14, 2025 at 1:32 PM
Please share our new PhD position:
We are looking for a data scientists to work on leukaemia models of #AML and cancer stem cells or #LSCs.
This mixes wet and dry lab and aims to replace animals in research by developing new in vitro tools.
tinyurl.com/6rfan796
tinyurl.com/fmys7cay
We are looking for a data scientists to work on leukaemia models of #AML and cancer stem cells or #LSCs.
This mixes wet and dry lab and aims to replace animals in research by developing new in vitro tools.
tinyurl.com/6rfan796
tinyurl.com/fmys7cay
Reposted by Alex Tonks
Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports
imageimageA reduction in oxidation phosphorylation is considered to be a hallmark of pro-inflammatory
macrophage polarization. This study shows that respiratory inhibition is not required
for macropha...
www.embopress.org
January 6, 2025 at 3:58 PM
Pro-inflammatory macrophage activation does not require inhibition of oxidative phosphorylation | EMBO reports
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Alex Tonks
We are hiring a post-doc to study SUMOylation in leukemias @igmm-montpel.bsky.social
Apply here: emploi.cnrs.fr/Offres/CDD/U...
Apply here: emploi.cnrs.fr/Offres/CDD/U...
Portail Emploi CNRS - Offre d'emploi - Post-doctorant chimioresistance des leucémies aigues et SUMOylation (H/F)
emploi.cnrs.fr
January 7, 2025 at 11:23 AM
We are hiring a post-doc to study SUMOylation in leukemias @igmm-montpel.bsky.social
Apply here: emploi.cnrs.fr/Offres/CDD/U...
Apply here: emploi.cnrs.fr/Offres/CDD/U...
Reposted by Alex Tonks
This is the most accessible explanation I have ever read on FDR. 👏👏 👏
Chatomics! Testing 10,000 genes at once? 🧬 If you’re relying on p-values alone, you’re probably drowning in false positives. Let’s talk about FDR and q-values—the smarter way to analyze your results.
January 3, 2025 at 11:54 AM
This is the most accessible explanation I have ever read on FDR. 👏👏 👏
Reposted by Alex Tonks
Chatomics! Testing 10,000 genes at once? 🧬 If you’re relying on p-values alone, you’re probably drowning in false positives. Let’s talk about FDR and q-values—the smarter way to analyze your results.
January 2, 2025 at 2:45 PM
Chatomics! Testing 10,000 genes at once? 🧬 If you’re relying on p-values alone, you’re probably drowning in false positives. Let’s talk about FDR and q-values—the smarter way to analyze your results.
Reposted by Alex Tonks
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics
Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...
doi.org
January 3, 2025 at 7:18 PM
How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by Alex Tonks
Announcement 📣 REGISTRATION IS LIVE!! If you plan to join us in Cardiff for #IAMXVI then do register ASAP as places are limited! Do note the early bird deadline is 1 Feb! See you in #Cardiff in July #virology #adenovirus #meeting
www.eventsforce.net/cbs/frontend...
www.eventsforce.net/cbs/frontend...
www.eventsforce.net
January 2, 2025 at 5:58 PM
Announcement 📣 REGISTRATION IS LIVE!! If you plan to join us in Cardiff for #IAMXVI then do register ASAP as places are limited! Do note the early bird deadline is 1 Feb! See you in #Cardiff in July #virology #adenovirus #meeting
www.eventsforce.net/cbs/frontend...
www.eventsforce.net/cbs/frontend...
Reposted by Alex Tonks
Check out our new review in @isehsociety.bsky.social journal Experimental Hematology, asking the question: to what degree is HSC dysfunction responsible for hematologic aging www.exphem.org/article/S030...
DEFINE_ME
www.exphem.org
December 30, 2024 at 11:55 AM
Check out our new review in @isehsociety.bsky.social journal Experimental Hematology, asking the question: to what degree is HSC dysfunction responsible for hematologic aging www.exphem.org/article/S030...
Reposted by Alex Tonks
The strategy of the European Cancer Stem Cell Research Institute is to translate our cutting-edge research into novel therapies. We welcome the opportunity to host academic and clinical researchers whose interests align with the focus of ECSCRI.
December 20, 2024 at 1:46 PM
The strategy of the European Cancer Stem Cell Research Institute is to translate our cutting-edge research into novel therapies. We welcome the opportunity to host academic and clinical researchers whose interests align with the focus of ECSCRI.
Reposted by Alex Tonks
We are hiring!!
We are looking for a research assistant/ associate to get involved in an EPSRC Programme Grant that aims to engineer an in vitro bone marrow niche to control stem cell regulation, metastatic evolution and cancer dormancy
eur03.safelinks.protection.outlook.com?url=https%3A...
We are looking for a research assistant/ associate to get involved in an EPSRC Programme Grant that aims to engineer an in vitro bone marrow niche to control stem cell regulation, metastatic evolution and cancer dormancy
eur03.safelinks.protection.outlook.com?url=https%3A...
'
eur03.safelinks.protection.outlook.com
December 11, 2024 at 6:20 PM
We are hiring!!
We are looking for a research assistant/ associate to get involved in an EPSRC Programme Grant that aims to engineer an in vitro bone marrow niche to control stem cell regulation, metastatic evolution and cancer dormancy
eur03.safelinks.protection.outlook.com?url=https%3A...
We are looking for a research assistant/ associate to get involved in an EPSRC Programme Grant that aims to engineer an in vitro bone marrow niche to control stem cell regulation, metastatic evolution and cancer dormancy
eur03.safelinks.protection.outlook.com?url=https%3A...
Reposted by Alex Tonks
Two upcoming meetings for your 2025 diaries:
EHA Research Conference (ReCon) - Malaga 17-20 March
ehaweb.org/meetings/eha...
@isehsociety.bsky.social ISEH Annual Meeting - Kumamoto 24-27 Sept www.iseh.org/page/iseh2025
and for HSC biologists in Europe...hold November 13-15th 2025 too.... !
EHA Research Conference (ReCon) - Malaga 17-20 March
ehaweb.org/meetings/eha...
@isehsociety.bsky.social ISEH Annual Meeting - Kumamoto 24-27 Sept www.iseh.org/page/iseh2025
and for HSC biologists in Europe...hold November 13-15th 2025 too.... !
EHA Research Conference 2025
Dates: March 17-20, 2025Location: Málaga, SpainChairs: Alba Maiques Diaz, Ruud Delwel, Panagiotis Ntziachristos, Marcus Buschbeck, Mark Dawson, Özgen Deniz, Kimberly Stegmaier, and Nina Cabezas Wallsc...
ehaweb.org
December 20, 2024 at 1:34 PM
Two upcoming meetings for your 2025 diaries:
EHA Research Conference (ReCon) - Malaga 17-20 March
ehaweb.org/meetings/eha...
@isehsociety.bsky.social ISEH Annual Meeting - Kumamoto 24-27 Sept www.iseh.org/page/iseh2025
and for HSC biologists in Europe...hold November 13-15th 2025 too.... !
EHA Research Conference (ReCon) - Malaga 17-20 March
ehaweb.org/meetings/eha...
@isehsociety.bsky.social ISEH Annual Meeting - Kumamoto 24-27 Sept www.iseh.org/page/iseh2025
and for HSC biologists in Europe...hold November 13-15th 2025 too.... !
Great opportunity here 👇 if looking for a PhD project in great lab
Good news. #fullyfunded #phdstudentship to be announced early Jan. DM or email now if you want to know more.
December 16, 2024 at 11:05 PM
Great opportunity here 👇 if looking for a PhD project in great lab
Reposted by Alex Tonks
We are one of just 7 UK cancer centres that are contributing to the CRUK Black Leaders in Cancer PhD Scholarship Programme. We have 10 exciting projects on offer to eligible candidates of Black heritage backgrounds. Read more about the scheme and what we have on offer www.ncl.ac.uk/cancer/train...
CRUK Black Leaders PhD Scholarship | Centre for Cancer | Newcastle University
www.ncl.ac.uk
November 20, 2024 at 3:39 PM
We are one of just 7 UK cancer centres that are contributing to the CRUK Black Leaders in Cancer PhD Scholarship Programme. We have 10 exciting projects on offer to eligible candidates of Black heritage backgrounds. Read more about the scheme and what we have on offer www.ncl.ac.uk/cancer/train...
Introducing my Generation Z students to the save button in reality! You don’t want to know what they thought the 5.25 disk was
December 16, 2024 at 4:05 PM
Introducing my Generation Z students to the save button in reality! You don’t want to know what they thought the 5.25 disk was
Reposted by Alex Tonks
A student of mine was very concerned by a news report saying the relative risk of a particular type of brain cancer had gone up by 50% When I looked at the absolute risk it went from 4 to 6 per 100,000. Told him not to worry. People have trouble dealing with absolute v relative risk!🧪
December 14, 2024 at 1:28 PM
A student of mine was very concerned by a news report saying the relative risk of a particular type of brain cancer had gone up by 50% When I looked at the absolute risk it went from 4 to 6 per 100,000. Told him not to worry. People have trouble dealing with absolute v relative risk!🧪
Reposted by Alex Tonks
Registration and abstract submission is now open for this EMBO Childhood Leukaemia workshop that I am excited to help organise. See you in Kolkata!!
Molecular Basis and Mechanisms of Therapy Personalisation in Paediatric Leukaemia
Only in the last decade have clinicians in India, with support from colleagues from the west, organized to develop multi-centre modern protocols for children with acute leukaemia. These protocols inc…
meetings.embo.org
December 15, 2024 at 12:22 PM
Registration and abstract submission is now open for this EMBO Childhood Leukaemia workshop that I am excited to help organise. See you in Kolkata!!
Reposted by Alex Tonks
At #ASH24, sharing this terrific article on social media at medical conferences from @mtmdphd.bsky.social @rubenmesamd.bsky.social @bldcancerdoc.bsky.social #NaveenPemmaraju👇👇👇
pubmed.ncbi.nlm.nih.gov/29153078/
pubmed.ncbi.nlm.nih.gov/29153078/
The use and impact of Twitter at medical conferences: Best practices and Twitter etiquette - PubMed
The use of social media, and in particular, Twitter, for professional use among healthcare providers is rapidly increasing across the world. One medical subspecialty that is leading the integration of...
pubmed.ncbi.nlm.nih.gov
December 6, 2024 at 6:25 PM
At #ASH24, sharing this terrific article on social media at medical conferences from @mtmdphd.bsky.social @rubenmesamd.bsky.social @bldcancerdoc.bsky.social #NaveenPemmaraju👇👇👇
pubmed.ncbi.nlm.nih.gov/29153078/
pubmed.ncbi.nlm.nih.gov/29153078/
Tonks lab Christmas party! Shuffle board and ice free curling. Well done Rosie squared and for slaying the boys. Thanks to Owen Hughes for organising
December 3, 2024 at 11:33 PM
Tonks lab Christmas party! Shuffle board and ice free curling. Well done Rosie squared and for slaying the boys. Thanks to Owen Hughes for organising
Glorious sunny morning discussing leukaemia and new therapies for AML for students at Bath University. Thanks to Zoe Burke for the invite. #AML #inspiringnextgen
December 2, 2024 at 10:21 AM
Glorious sunny morning discussing leukaemia and new therapies for AML for students at Bath University. Thanks to Zoe Burke for the invite. #AML #inspiringnextgen
Reposted by Alex Tonks
First post on BSky and I'm going to use it to promote the outstanding line up of faculty that we've managed to put together for #ISEH2025 in Kumamoto, Japan (with more to come). Save the date: lots of space reserved in the program for you to present your exciting science! Link below.
🚨 Save the Date!🚨 ISEH is heading to Kumamoto, Japan for #ISEH2025. Check out our confirmed speakers so far and mark your calendars for a great program you won't want to miss ➡️ iseh.org/iseh2025
November 27, 2024 at 7:45 AM
First post on BSky and I'm going to use it to promote the outstanding line up of faculty that we've managed to put together for #ISEH2025 in Kumamoto, Japan (with more to come). Save the date: lots of space reserved in the program for you to present your exciting science! Link below.
Reposted by Alex Tonks
Unraveling lipid metabolism for acute myeloid leukemia... : Current Opinion in Hematology 🧪
journals.lww.com/co-hematolog...
journals.lww.com/co-hematolog...
Unraveling lipid metabolism for acute myeloid leukemia... : Current Opinion in Hematology
man leukemia, particularly highlighting work in leukemic stem cells (LSCs), where lipids were assessed directly as a metabolite.
Recent findings
Lipid metabolism is essential to support LSC functio...
journals.lww.com
November 26, 2024 at 9:16 AM
Unraveling lipid metabolism for acute myeloid leukemia... : Current Opinion in Hematology 🧪
journals.lww.com/co-hematolog...
journals.lww.com/co-hematolog...