William (Bill) Grey
@billgrey.bsky.social
Group Leader, Leukaemia U.K. John Goldman Fellow, MRC CDA Fellow. We study proteostasis in healthy and malignant blood stem cells. www.proteostem.co.uk
Reposted by William (Bill) Grey
Correct link: www.findaphd.com/phds/?Keywor...
dave boucher PhD Projects, Programmes & Scholarships - 3 PhDs Listed
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucher. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
November 10, 2025 at 7:47 PM
Correct link: www.findaphd.com/phds/?Keywor...
Reposted by William (Bill) Grey
3 PhD positions in the lab for British Students. Inflammasome, cell death and skin immunity, with fantastic colleagues. Check them out or share it with curious and motivated PhD students: www.findaphd.com/phds/?Keywor... @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social @biologyatyork.bsky.social
dave boucherare PhD Projects, Programmes & Scholarships
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucherare. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
November 10, 2025 at 5:27 PM
3 PhD positions in the lab for British Students. Inflammasome, cell death and skin immunity, with fantastic colleagues. Check them out or share it with curious and motivated PhD students: www.findaphd.com/phds/?Keywor... @yorkshirebiodtp.bsky.social @ybri-uoy.bsky.social @biologyatyork.bsky.social
All #PhD adverts are now live with some deadlines upcoming: www.findaphd.com/phds/?Keywor...
November 9, 2025 at 2:35 PM
All #PhD adverts are now live with some deadlines upcoming: www.findaphd.com/phds/?Keywor...
🚨 We have 3 fully funded PhD studentships open!
Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology
📍Start Oct 2026 | 💡Apply via MRC & BBSRC
👇Details in thread 👇
Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology
📍Start Oct 2026 | 💡Apply via MRC & BBSRC
👇Details in thread 👇
October 31, 2025 at 1:20 PM
🚨 We have 3 fully funded PhD studentships open!
Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology
📍Start Oct 2026 | 💡Apply via MRC & BBSRC
👇Details in thread 👇
Join the Grey Lab & collaborators at @biologyatyork.bsky.social, @universityofleeds.bky.social & @ybri-uoy.bsky.social to explore stem cells, proteomics & leukaemia biology
📍Start Oct 2026 | 💡Apply via MRC & BBSRC
👇Details in thread 👇
Reposted by William (Bill) Grey
A decade of bold ideas, brilliant minds & real impact. 💡
Our John Goldman Fellowships are driving progress in leukaemia research, from identifying new drug targets to repurposing existing medicines.
Read more: www.leukaemiauk.org.uk/stories/a-de...
Our John Goldman Fellowships are driving progress in leukaemia research, from identifying new drug targets to repurposing existing medicines.
Read more: www.leukaemiauk.org.uk/stories/a-de...
A decade of progress and impact - Leukaemia UK
This October marks ten years since Leukaemia UK launched its John Goldman Fellowship (JGF) programme. In this blog, and the next, we’ll explore its impact and successes.
www.leukaemiauk.org.uk
October 30, 2025 at 5:35 PM
A decade of bold ideas, brilliant minds & real impact. 💡
Our John Goldman Fellowships are driving progress in leukaemia research, from identifying new drug targets to repurposing existing medicines.
Read more: www.leukaemiauk.org.uk/stories/a-de...
Our John Goldman Fellowships are driving progress in leukaemia research, from identifying new drug targets to repurposing existing medicines.
Read more: www.leukaemiauk.org.uk/stories/a-de...
Reposted by William (Bill) Grey
Explore the October Issue of #ExpHem including the article Mer receptor expression promotes multiple myeloma disease development via a cell-extrinsic mechanism ➡️ www.exphem.org/current
October 24, 2025 at 4:31 PM
Explore the October Issue of #ExpHem including the article Mer receptor expression promotes multiple myeloma disease development via a cell-extrinsic mechanism ➡️ www.exphem.org/current
Reposted by William (Bill) Grey
Surprising finding that standard chemo renders AML resistant to subsequent treatment with menin inhibitors. Published in @isehsociety.bsky.social journal Exp. Hem.: www.exphem.org/article/S030...
Upfront Menin-inhibitor resistance in multiply pretreated leukemias
10% of acute leukemias carry rearrangements of the KMT2A gene (Mixed-Lineage Leukemia-1,
MLL-1). More than 80 fusion partners have been identified, and differences in fusion
partner have been linked t...
www.exphem.org
September 30, 2025 at 5:51 PM
Surprising finding that standard chemo renders AML resistant to subsequent treatment with menin inhibitors. Published in @isehsociety.bsky.social journal Exp. Hem.: www.exphem.org/article/S030...
Reposted by William (Bill) Grey
We all must take the responsibility and don’t just complaint about these problems. Take action and don’t be a spectator!
Breaking the cycle of institutional betrayal and the culture of silence requires decisive actions to promote transparency, accountability and supportive environments in both academia and industry go.nature.com/482BUOY
rdcu.be/eIcEI
rdcu.be/eIcEI
Chronic silencing is a critical barrier to breaking the cycle of bullying in academia and industry - Nature Biotechnology
Breaking the cycle of institutional betrayal and the culture of silence requires decisive actions to promote transparency, accountability and supportive environments in both academia and industry.
go.nature.com
September 29, 2025 at 3:02 PM
We all must take the responsibility and don’t just complaint about these problems. Take action and don’t be a spectator!
Reposted by William (Bill) Grey
Our latest work is available on BioRxiv!
WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.
www.biorxiv.org/content/10.1...
WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.
www.biorxiv.org/content/10.1...
WS6 enables scalable ex vivo expansion and gene editing of epithelial basal stem cells
Modeling human epithelial diseases and developing cell-based therapies require robust methods to expand and manipulate epithelial stem and progenitor cells in vitro. Basal stem/progenitor cells from s...
www.biorxiv.org
September 16, 2025 at 7:24 PM
Our latest work is available on BioRxiv!
WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.
www.biorxiv.org/content/10.1...
WS6 allows extended culture of basal epithelial cells and allows clonal expansion of primary airway epithelial cells after CRISPR editing, with clonal populations retaining their differentiation capacity.
www.biorxiv.org/content/10.1...
Reposted by William (Bill) Grey
Humanized MPN xenograft model that offers valuable insights into how human BM MSCs interact with JAK2V617F mutant clone.
onlinelibrary.wiley.com/doi/10.1002/... @hemasphere-journal.bsky.social
onlinelibrary.wiley.com/doi/10.1002/... @hemasphere-journal.bsky.social
Mesenchymal stromal cells from JAK2V617F myeloproliferative neoplasms support healthy and malignant hematopoiesis in a humanized scaffold model in vivo
Myeloproliferative Neoplasms (MPN) are malignancies of hematopoietic stem and progenitor cells (HSPCs) that lead to the overproduction of mature blood cells. These disorders include Essential Thrombo....
onlinelibrary.wiley.com
August 23, 2025 at 11:53 AM
Humanized MPN xenograft model that offers valuable insights into how human BM MSCs interact with JAK2V617F mutant clone.
onlinelibrary.wiley.com/doi/10.1002/... @hemasphere-journal.bsky.social
onlinelibrary.wiley.com/doi/10.1002/... @hemasphere-journal.bsky.social
Reposted by William (Bill) Grey
New Preprint 🚨. Our latest work is now available in biorXiv: A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche. www.biorxiv.org/content/10.1...
July 21, 2025 at 9:25 PM
New Preprint 🚨. Our latest work is now available in biorXiv: A new double reporter strategy reveals a subset of non-migratory hematopoietic stem cells localized in a dynamic bone marrow niche. www.biorxiv.org/content/10.1...
Reposted by William (Bill) Grey
Congratulations to everyone!
It’s incredibly exciting to see our lab getting recognition with the postdoc grant to Keiki.
www.stemcellcenter.lu.se/article/thre...
It’s incredibly exciting to see our lab getting recognition with the postdoc grant to Keiki.
www.stemcellcenter.lu.se/article/thre...
Three researchers receive Barncancerfonden funding to investigate the causes of childhood leukemia
Lund University. This spring Barncancerfonden, the Swedish Childhood Cancer Foundation, awarded SEK 64 million to 29 researchers across the country. The funding includes positions of up to six years f...
www.stemcellcenter.lu.se
July 19, 2025 at 12:28 PM
Congratulations to everyone!
It’s incredibly exciting to see our lab getting recognition with the postdoc grant to Keiki.
www.stemcellcenter.lu.se/article/thre...
It’s incredibly exciting to see our lab getting recognition with the postdoc grant to Keiki.
www.stemcellcenter.lu.se/article/thre...
Reposted by William (Bill) Grey
Thrilled to share our latest research just published in Leukemia. www.nature.com/articles/s41...
Grateful to all co-authors for their dedicated effort and collaboration. @lundstem.bsky.social @lunduniversity.bsky.social
Grateful to all co-authors for their dedicated effort and collaboration. @lundstem.bsky.social @lunduniversity.bsky.social
Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state - Leukemia
Leukemia - Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state
www.nature.com
July 14, 2025 at 2:40 PM
Thrilled to share our latest research just published in Leukemia. www.nature.com/articles/s41...
Grateful to all co-authors for their dedicated effort and collaboration. @lundstem.bsky.social @lunduniversity.bsky.social
Grateful to all co-authors for their dedicated effort and collaboration. @lundstem.bsky.social @lunduniversity.bsky.social
Reposted by William (Bill) Grey
Excited to share our collaborative work with Sheila Singh's lab: we performed an in vivo genome-wide CRISPRa screen using a lung TRACERx PDX model to uncover drivers of brain metastasis. BACE1 - already investigated as target in Alzheimer's - was as a key hit.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A genome-wide in vivo CRISPR activation screen identifies BACE1 as a therapeutic vulnerability of lung cancer brain metastasis
Beta-secretase 1 promotes the spread of lung cancers to the brain through epidermal growth factor receptor signaling.
www.science.org
July 3, 2025 at 9:09 AM
Excited to share our collaborative work with Sheila Singh's lab: we performed an in vivo genome-wide CRISPRa screen using a lung TRACERx PDX model to uncover drivers of brain metastasis. BACE1 - already investigated as target in Alzheimer's - was as a key hit.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by William (Bill) Grey
Following on from our recent paper showing novel post-transcriptional roles for B-catenin in leukaemia cells, a very well done to Drs Sevim & Park for writing a superb review in @natureportfolio.nature.com Oncogene summarising our current understanding of this field.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Post-transcriptional control of gene expression by β-catenin: expanding the non-canonical ARMoury - Oncogene
Oncogene - Post-transcriptional control of gene expression by β-catenin: expanding the non-canonical ARMoury
www.nature.com
June 25, 2025 at 11:21 AM
Following on from our recent paper showing novel post-transcriptional roles for B-catenin in leukaemia cells, a very well done to Drs Sevim & Park for writing a superb review in @natureportfolio.nature.com Oncogene summarising our current understanding of this field.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by William (Bill) Grey
Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!
Dive into cutting-edge innate immunity & inflammation science at our event on September 11!
From immune cell roles to inflammasome signalling, discover advances shaping clinical care.
📆Abstract deadline: 15 July
🐦Early bird registration ends: 27 August
🔗 bit.ly/43q9x9r
From immune cell roles to inflammasome signalling, discover advances shaping clinical care.
📆Abstract deadline: 15 July
🐦Early bird registration ends: 27 August
🔗 bit.ly/43q9x9r
May 28, 2025 at 5:43 PM
Interested in innate immunity and inflammation? Join us in September for a great meeting! Superb lineup of speaker and lots of opportunities for Ecrs to present!
Reposted by William (Bill) Grey
Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde @lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI
Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis
Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the
frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations
confer a fitness advantag...
bit.ly
May 23, 2025 at 3:04 PM
Excited to see the first commentary in Experimental Hematology (@isehsociety.bsky.social)! Kudos to Aishwarya, Linde @lindemileslab.bsky.social, and Grant @challenlab.bsky.social for highlighting recent papers in Exp Hem on cell-extrinsic factors in Tet2-mutant clonal hematopoiesis!! bit.ly/4k3pEAI
Reposted by William (Bill) Grey
Excited to share our perspective just out in @leukemia journal! What is bone marrow niche doing in shaping clonal dynamics in MDS and Leukemias.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Is the bone marrow microenvironment the hidden catalyst in malignant haematopoiesis? - Leukemia
Leukemia - Is the bone marrow microenvironment the hidden catalyst in malignant haematopoiesis?
www.nature.com
May 1, 2025 at 5:59 AM
Excited to share our perspective just out in @leukemia journal! What is bone marrow niche doing in shaping clonal dynamics in MDS and Leukemias.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by William (Bill) Grey
We're excited to see the launch of the TARGET study, co-led by @billgrey.bsky.social, to tackle AML relapse by targeting chemo-resistant stem cells.
This could mean oral treatments at home, fewer side effects, and safer options for all. 🧡
This could mean oral treatments at home, fewer side effects, and safer options for all. 🧡
A new research study @leedsth.nhs.uk and @york.ac.uk is set to transform treatments for one of the most aggressive and hard-to-treat blood cancers.
Read ▶️ www.leedsth.nhs.uk/news/new-res...
@leukaemiauk.bsky.social @bloodcanceruk.bsky.social @cbr-uoy.bsky.social
Read ▶️ www.leedsth.nhs.uk/news/new-res...
@leukaemiauk.bsky.social @bloodcanceruk.bsky.social @cbr-uoy.bsky.social
April 25, 2025 at 10:07 AM
We're excited to see the launch of the TARGET study, co-led by @billgrey.bsky.social, to tackle AML relapse by targeting chemo-resistant stem cells.
This could mean oral treatments at home, fewer side effects, and safer options for all. 🧡
This could mean oral treatments at home, fewer side effects, and safer options for all. 🧡
Reposted by William (Bill) Grey
A new research study @leedsth.nhs.uk and @york.ac.uk is set to transform treatments for one of the most aggressive and hard-to-treat blood cancers.
Read ▶️ www.leedsth.nhs.uk/news/new-res...
@leukaemiauk.bsky.social @bloodcanceruk.bsky.social @cbr-uoy.bsky.social
Read ▶️ www.leedsth.nhs.uk/news/new-res...
@leukaemiauk.bsky.social @bloodcanceruk.bsky.social @cbr-uoy.bsky.social
April 24, 2025 at 8:57 AM
A new research study @leedsth.nhs.uk and @york.ac.uk is set to transform treatments for one of the most aggressive and hard-to-treat blood cancers.
Read ▶️ www.leedsth.nhs.uk/news/new-res...
@leukaemiauk.bsky.social @bloodcanceruk.bsky.social @cbr-uoy.bsky.social
Read ▶️ www.leedsth.nhs.uk/news/new-res...
@leukaemiauk.bsky.social @bloodcanceruk.bsky.social @cbr-uoy.bsky.social
Reposted by William (Bill) Grey
📢 New PhD Opportunity
🧬🧪 Excited to share a fully funded PhD studentship is available in my lab @gdsc-sussex.bsky.social
📅 Deadline: 2nd May 2025
👉 www.sussex.ac.uk/study/fees-f...
Please share with anyone who might be interested.
🧬🧪 Excited to share a fully funded PhD studentship is available in my lab @gdsc-sussex.bsky.social
📅 Deadline: 2nd May 2025
👉 www.sussex.ac.uk/study/fees-f...
Please share with anyone who might be interested.
PhD Studentship: Structure and function of tyrosine fusion kinases in leukaemia and their regulation by the HSP90 molecular chaperone at University of Sussex
Discover a PhD Studentship: Structure and function of tyrosine fusion kinases in leukaemia and their regulation by the HSP90 molecular chaperone on jobs.ac.uk. Apply now and explore other PhD opportun...
www.jobs.ac.uk
April 16, 2025 at 9:16 AM
📢 New PhD Opportunity
🧬🧪 Excited to share a fully funded PhD studentship is available in my lab @gdsc-sussex.bsky.social
📅 Deadline: 2nd May 2025
👉 www.sussex.ac.uk/study/fees-f...
Please share with anyone who might be interested.
🧬🧪 Excited to share a fully funded PhD studentship is available in my lab @gdsc-sussex.bsky.social
📅 Deadline: 2nd May 2025
👉 www.sussex.ac.uk/study/fees-f...
Please share with anyone who might be interested.
Reposted by William (Bill) Grey
🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social!
We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.
doi.org/10.1242/jcs....
We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.
doi.org/10.1242/jcs....
Compound screening in human airway basal cells identifies Wnt pathway activators as potential pro-regenerative therapies
Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.
doi.org
April 14, 2025 at 10:28 AM
🚨Today our phenotypic screening work with primary human airway basal cells is published @jcellsci.bsky.social!
We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.
doi.org/10.1242/jcs....
We found that multiple Wnt activating compounds promote basal cell proliferation and validated 1-azakenpaullone in vivo.
doi.org/10.1242/jcs....
Reposted by William (Bill) Grey
Excited to share our work - online today as a preprint. Here, we characterize precocious aging in HSCs of mice and people with sickle cell disease. Excitingly, we demonstrate the potential of senolytics to restore HSC function to the bone marrow of mice with SCD.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Senolytics Restore Hematopoietic Stem Cells Function in Sickle Cell Disease
Sickle Cell Disease (SCD) is a blood disorder affecting millions worldwide. Emerging evidence reveals that SCD pathophysiology increases risk of myeloid malignancies and hematopoietic stem cell (HSC) ...
www.biorxiv.org
February 10, 2025 at 2:51 AM
Excited to share our work - online today as a preprint. Here, we characterize precocious aging in HSCs of mice and people with sickle cell disease. Excitingly, we demonstrate the potential of senolytics to restore HSC function to the bone marrow of mice with SCD.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by William (Bill) Grey
New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC
A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...
doi.org
February 5, 2025 at 10:55 AM
New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC
Reposted by William (Bill) Grey
ICYMI... #ExpHem featured incredible research in 2024. Our journal has a variety of different content available, including Special Issues. Check out our collections, including guest editors @krikirschner.bsky.social @keisukeito-lab.bsky.social and more on www.exphem.org/content/spec....
January 30, 2025 at 4:05 PM
ICYMI... #ExpHem featured incredible research in 2024. Our journal has a variety of different content available, including Special Issues. Check out our collections, including guest editors @krikirschner.bsky.social @keisukeito-lab.bsky.social and more on www.exphem.org/content/spec....