Guillaume Bossis
@guillaumebo6.bsky.social
Biologist, PI @igmm-montpel.bsky.social @cnrs.bsky.social, Montpellier, France. Acute Myeloid Leukemia and SUMOylation
https://www.igmm.cnrs.fr/en/team/sumoaml/
https://www.igmm.cnrs.fr/en/team/sumoaml/
Reposted by Guillaume Bossis
New online: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer
Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer
Nature Structural & Molecular Biology, Published online: 25 September 2025; doi:10.1038/s41594-025-01681-8This study reveals how human small ubiquitin-like modifier (SUMO) E1 recruits its E2 partner UBC9 and transfers SUMO1 through large structural changes, uncovering key mechanisms that ensure specificity and fidelity in SUMOylation, an essential protein modification pathway.
go.nature.com
September 25, 2025 at 11:59 AM
New online: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer
🔥 The #EMBOSUMO workshop kicks off TODAY! 🎉 Thanks @embo.org @biologists.bsky.social @proteocure.bsky.social @sebiology.bsky.social @newphyt.bsky.social @umontpellier.bsky.social @occitanie.bsky.social for their support. More info: meetings.embo.org/event/25-sum...
September 22, 2025 at 7:46 AM
🔥 The #EMBOSUMO workshop kicks off TODAY! 🎉 Thanks @embo.org @biologists.bsky.social @proteocure.bsky.social @sebiology.bsky.social @newphyt.bsky.social @umontpellier.bsky.social @occitanie.bsky.social for their support. More info: meetings.embo.org/event/25-sum...
Reposted by Guillaume Bossis
Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant
hematopoiesis. www.cell.com/trends/cance...
hematopoiesis. www.cell.com/trends/cance...
Reawakening retrotransposons: immune modulation in normal and malignant hematopoiesis
Retrotransposons are mobile repetitive elements that constitute around 43% of the
human genome. Normally silenced through epigenetic mechanisms, retrotransposons can
become reactivated in response to ...
www.cell.com
September 3, 2025 at 5:02 AM
Our new review is out in Trends in Cancer. We had fund writing this :) We discuss the roles of retrotransposons in immune modulation in normal and malignant
hematopoiesis. www.cell.com/trends/cance...
hematopoiesis. www.cell.com/trends/cance...
Reposted by Guillaume Bossis
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation www.biorxiv.org/content/10.1... @embl.org
August 18, 2025 at 12:39 PM
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation www.biorxiv.org/content/10.1... @embl.org
📣 Happy to share our last publication on SUMOylation and Natural Killers in AML. aacrjournals.org/mct/article-...
Targeting SUMOylation triggers interferon-ß-dependent activation of patient and allogenic Natural Killer cells in preclinical models of Acute Myeloid Leukemia
Abstract. Natural Killer (NK) cells can play a significant role in the anti-tumoral immune response. In patients with Acute Myeloid Leukemia (AML), NK cells are however often found in low numbers and ...
aacrjournals.org
July 16, 2025 at 8:15 AM
📣 Happy to share our last publication on SUMOylation and Natural Killers in AML. aacrjournals.org/mct/article-...
Reposted by Guillaume Bossis
📢 The 21st Annual Meeting of Cancéropôle GSO is back!
🗓️ November 26–28, 2025 in Agen
Join us around cancer research !
Abstract submissions:
Oral: until September 19
Posters: until October 3
👉Registration: until October 31
More info: kgso.fr/events/21st-...
🗓️ November 26–28, 2025 in Agen
Join us around cancer research !
Abstract submissions:
Oral: until September 19
Posters: until October 3
👉Registration: until October 31
More info: kgso.fr/events/21st-...
June 30, 2025 at 10:05 PM
📢 The 21st Annual Meeting of Cancéropôle GSO is back!
🗓️ November 26–28, 2025 in Agen
Join us around cancer research !
Abstract submissions:
Oral: until September 19
Posters: until October 3
👉Registration: until October 31
More info: kgso.fr/events/21st-...
🗓️ November 26–28, 2025 in Agen
Join us around cancer research !
Abstract submissions:
Oral: until September 19
Posters: until October 3
👉Registration: until October 31
More info: kgso.fr/events/21st-...
Reposted by Guillaume Bossis
📣 We are recruiting new group leaders in Innovative Biology!
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
May 28, 2025 at 12:12 PM
📣 We are recruiting new group leaders in Innovative Biology!
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
RNA biology
Epigenetic regulation
Cell cycle regulation
Cancer, immunology
Virology
Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
Reposted by Guillaume Bossis
Learn more about SUMOylation at EMBO Workshop "SUMOylation: From discovery to translation" in La Grande Motte, France, 22–25 September 2025
Early Bird Registration/Abstract Submission by 1 May
Late Bird Registration by 1 June
meetings.embo.org/event/25-sum...
#EMBOsumoylation #EMBOevents 🧪
Early Bird Registration/Abstract Submission by 1 May
Late Bird Registration by 1 June
meetings.embo.org/event/25-sum...
#EMBOsumoylation #EMBOevents 🧪
SUMOylation: From discovery to translation
Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins …
meetings.embo.org
April 25, 2025 at 7:02 AM
Learn more about SUMOylation at EMBO Workshop "SUMOylation: From discovery to translation" in La Grande Motte, France, 22–25 September 2025
Early Bird Registration/Abstract Submission by 1 May
Late Bird Registration by 1 June
meetings.embo.org/event/25-sum...
#EMBOsumoylation #EMBOevents 🧪
Early Bird Registration/Abstract Submission by 1 May
Late Bird Registration by 1 June
meetings.embo.org/event/25-sum...
#EMBOsumoylation #EMBOevents 🧪
Reposted by Guillaume Bossis
New preprint from the Lab at @cabimer.bsky.social. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single experimental workflow.
Chromatin Immunoprecipitation (ChIP) and Co-Immunoprecipitation (CoIP) assays are the most common approaches to characterize the genomic localization and protein interactors, respectively, for a prote...
www.biorxiv.org
April 28, 2025 at 7:55 AM
New preprint from the Lab at @cabimer.bsky.social. We present PLAMseq, using TurboID to do like ChIPseq and proximity proteomics in the same protocol with extra powers like mapping protein interactions in the genome.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Guillaume Bossis
Hello Ubiquitin-like fans, check this 👇👇👇
Early Bird Registration Deadline
🗓️ 1 May 2025
Abstract Submission Deadline
🗓️ 1 May 2025
Don't miss the date!
@proteocure.bsky.social, @biologists.bsky.social @umontpellier.bsky.social
#ubiquitin #SUMO #EMBO Workshop
meetings.embo.org/event/25-sum...
Early Bird Registration Deadline
🗓️ 1 May 2025
Abstract Submission Deadline
🗓️ 1 May 2025
Don't miss the date!
@proteocure.bsky.social, @biologists.bsky.social @umontpellier.bsky.social
#ubiquitin #SUMO #EMBO Workshop
meetings.embo.org/event/25-sum...
April 14, 2025 at 10:10 AM
Hello Ubiquitin-like fans, check this 👇👇👇
Early Bird Registration Deadline
🗓️ 1 May 2025
Abstract Submission Deadline
🗓️ 1 May 2025
Don't miss the date!
@proteocure.bsky.social, @biologists.bsky.social @umontpellier.bsky.social
#ubiquitin #SUMO #EMBO Workshop
meetings.embo.org/event/25-sum...
Early Bird Registration Deadline
🗓️ 1 May 2025
Abstract Submission Deadline
🗓️ 1 May 2025
Don't miss the date!
@proteocure.bsky.social, @biologists.bsky.social @umontpellier.bsky.social
#ubiquitin #SUMO #EMBO Workshop
meetings.embo.org/event/25-sum...
April 3, 2025 at 1:28 PM
Reposted by Guillaume Bossis
🚀 Excited to share our latest article in #singlecell proteomics published in Cell!
We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution!
www.cell.com/cell/fulltex...
We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution!
www.cell.com/cell/fulltex...
Global analysis of protein turnover dynamics in single cells
The SC-pSILAC method enables single-cell measurement of both protein abundance and
turnover, providing notable advances in the depth and versatility of proteomic technologies.
eur02.safelinks.protection.outlook.com
March 31, 2025 at 3:12 PM
🚀 Excited to share our latest article in #singlecell proteomics published in Cell!
We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution!
www.cell.com/cell/fulltex...
We've developed SC-pSILAC to simultaneously measure protein turnover and abundance in single cells, unlocking the first large-scale, 2D proteomic insights at single-cell resolution!
www.cell.com/cell/fulltex...
Reposted by Guillaume Bossis
🚨🚨 This is a very clear signal to all us researcher to stay off the US for the next three years: A French academic, who was on assignment from the CNRS, was detained by officers & later deported after landing at George Bush International Airport ahead of conference.🧵
www.lbc.co.uk/world-news/d...
www.lbc.co.uk/world-news/d...
Diplomatic row erupts after French researcher expelled from US for expressing 'a personal opinion' on Trump
A diplomatic row has erupted between France and the US after a French researcher was expelled from the country for expressing "a personal opinion" on Trump.
www.lbc.co.uk
March 20, 2025 at 6:20 AM
🚨🚨 This is a very clear signal to all us researcher to stay off the US for the next three years: A French academic, who was on assignment from the CNRS, was detained by officers & later deported after landing at George Bush International Airport ahead of conference.🧵
www.lbc.co.uk/world-news/d...
www.lbc.co.uk/world-news/d...
Reminder: join us for the @embo.org Workshop SUMOylation: from discovery to translation, Sept 22-25 in La Grande Motte. With the support of @proteocure.bsky.social, @biologists.bsky.social @umontpellier.bsky.social. Don't wait to register
meetings.embo.org/event/25-sum...
meetings.embo.org/event/25-sum...
SUMOylation: From discovery to translation
Sumoylation is an essential post-translational modification that regulates thousands of target proteins in a dynamic manner. Small ubiquitin-like modifiers (SUMOs) can be attached to target proteins …
meetings.embo.org
March 14, 2025 at 11:19 AM
Reminder: join us for the @embo.org Workshop SUMOylation: from discovery to translation, Sept 22-25 in La Grande Motte. With the support of @proteocure.bsky.social, @biologists.bsky.social @umontpellier.bsky.social. Don't wait to register
meetings.embo.org/event/25-sum...
meetings.embo.org/event/25-sum...
Reposted by Guillaume Bossis
We are delighted to announce our first-ever BlueSky post – and the latest paper from our lab. with the Leney Lab @leneyms.bsky.social
dlvr.it/TJN3yl
@cp-molcell.bsky.social
@unibirmingham.bsky.social
dlvr.it/TJN3yl
@cp-molcell.bsky.social
@unibirmingham.bsky.social
SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair
Garvin et al. find that the poorly explored SUMO isoform, SUMO4, enhances the deSUMOylation
activity of the SUMO protease SENP1. Consequently, SUMO4 acts to restrain excessive
cellular SUMOylation. In...
dlvr.it
March 11, 2025 at 1:53 PM
We are delighted to announce our first-ever BlueSky post – and the latest paper from our lab. with the Leney Lab @leneyms.bsky.social
dlvr.it/TJN3yl
@cp-molcell.bsky.social
@unibirmingham.bsky.social
dlvr.it/TJN3yl
@cp-molcell.bsky.social
@unibirmingham.bsky.social
Reposted by Guillaume Bossis
Today, more than 10,000 people across the United States and beyond Stood Up for Science. I feel deeply humbled, inspired, and energized—our work is far from over, but witnessing so many people unite to champion science and the hope it brings is truly incredible.
March 8, 2025 at 4:13 AM
Today, more than 10,000 people across the United States and beyond Stood Up for Science. I feel deeply humbled, inspired, and energized—our work is far from over, but witnessing so many people unite to champion science and the hope it brings is truly incredible.
Reposted by Guillaume Bossis
Will our leaders be able to react and ensure that France once again becomes the land of enlightenment? That would mean 3% of GDP for research, not for guns and pain
March 8, 2025 at 6:56 AM
Will our leaders be able to react and ensure that France once again becomes the land of enlightenment? That would mean 3% of GDP for research, not for guns and pain
We keep standing up for Sciences in Montpellier @standupforscifr.bsky.social
March 7, 2025 at 6:36 PM
We keep standing up for Sciences in Montpellier @standupforscifr.bsky.social
#StandUpForScience Montpellier @standupforscifr.bsky.social
March 7, 2025 at 3:51 PM
#StandUpForScience Montpellier @standupforscifr.bsky.social
Reposted by Guillaume Bossis
Université de Montpellier, Campus Triolet
March 7, 2025 at 3:12 PM
Université de Montpellier, Campus Triolet
Reposted by Guillaume Bossis
Stand up for Science in Montpellier!
@standupforscifr.bsky.social @standupforscience.bsky.social @cnrsbiologie.bsky.social
@biolum-montpellier.bsky.social
@cnrsoccitanieest.bsky.social
@standupforscifr.bsky.social @standupforscience.bsky.social @cnrsbiologie.bsky.social
@biolum-montpellier.bsky.social
@cnrsoccitanieest.bsky.social
March 7, 2025 at 2:38 PM
Stand up for Science in Montpellier!
@standupforscifr.bsky.social @standupforscience.bsky.social @cnrsbiologie.bsky.social
@biolum-montpellier.bsky.social
@cnrsoccitanieest.bsky.social
@standupforscifr.bsky.social @standupforscience.bsky.social @cnrsbiologie.bsky.social
@biolum-montpellier.bsky.social
@cnrsoccitanieest.bsky.social
#StandUpForScience Montpellier, France @standupforscifr.bsky.social @standupforscience.bsky.social
March 7, 2025 at 1:22 PM
#StandUpForScience Montpellier, France @standupforscifr.bsky.social @standupforscience.bsky.social
Reposted by Guillaume Bossis
My favorite thing about the @standupforscience.bsky.social map is that the French people obviously maintain their solidarity and know the history of our joint venture in revolution. Those in power in the U.S. would have us forget this, but I ’ll be Santa Fe tomorrow, how’s about you?
March 6, 2025 at 3:19 PM
My favorite thing about the @standupforscience.bsky.social map is that the French people obviously maintain their solidarity and know the history of our joint venture in revolution. Those in power in the U.S. would have us forget this, but I ’ll be Santa Fe tomorrow, how’s about you?
Reposted by Guillaume Bossis
Les rassemblements, débats, discussions ouvertes et marches s'organisent vite :
- Retrouvez toutes les informations des initiatives existantes
- Inscrivez les nouvelles en moins de 2 min
standupforscience.fr/tous-les-eve...
- Retrouvez toutes les informations des initiatives existantes
- Inscrivez les nouvelles en moins de 2 min
standupforscience.fr/tous-les-eve...
Tous les évènements | Stand Up For Science France
standupforscience.fr
March 6, 2025 at 8:02 AM
Les rassemblements, débats, discussions ouvertes et marches s'organisent vite :
- Retrouvez toutes les informations des initiatives existantes
- Inscrivez les nouvelles en moins de 2 min
standupforscience.fr/tous-les-eve...
- Retrouvez toutes les informations des initiatives existantes
- Inscrivez les nouvelles en moins de 2 min
standupforscience.fr/tous-les-eve...
Reposted by Guillaume Bossis
"The universities control the knowledge in our society (...) We have to agressivly attack the universities (...). Fundamental lies that feminism is liberating (...) There is wisdom in what Nixon said, the professors are the enemy "
bryanalexander.org/politics/the...
www.youtube.com/watch?v=0FR6...
bryanalexander.org/politics/the...
www.youtube.com/watch?v=0FR6...
J.D. Vance | The Universities are the Enemy | National Conservatism Conference II
YouTube video by National Conservatism
www.youtube.com
March 3, 2025 at 10:22 AM
"The universities control the knowledge in our society (...) We have to agressivly attack the universities (...). Fundamental lies that feminism is liberating (...) There is wisdom in what Nixon said, the professors are the enemy "
bryanalexander.org/politics/the...
www.youtube.com/watch?v=0FR6...
bryanalexander.org/politics/the...
www.youtube.com/watch?v=0FR6...