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My name's Kate and I'm community lead for Medical.watch, a free newsletter for oncology/hematology professionals.
Our story is here: www.resources.medical.watch/post/why-we-...
I love to post SUPER COOL videos...like this one!
Thrilled to see the timely piece
👉 “Precision Oncology and Modernizing Evidence Standards”
🔑 Key takeaways:
🔵 RCT-only frameworks miss the reality of #PrecisionMedicine
🟢 Basket, umbrella & N-of-1 trials are cornerstones of #PrecisionOncology
Thrilled to see the timely piece
👉 “Precision Oncology and Modernizing Evidence Standards”
🔑 Key takeaways:
🔵 RCT-only frameworks miss the reality of #PrecisionMedicine
🟢 Basket, umbrella & N-of-1 trials are cornerstones of #PrecisionOncology
Low-dose aspirin in PI3K-altered localized #ColorectalCancer (ALASCCA)
“Low-dose aspirin cut 3-yr recurrence by ~50% in PI3K-altered localized colorectal cancer.”
www.nejm.org/doi/full/10....
Low-dose aspirin in PI3K-altered localized #ColorectalCancer (ALASCCA)
“Low-dose aspirin cut 3-yr recurrence by ~50% in PI3K-altered localized colorectal cancer.”
www.nejm.org/doi/full/10....
New study (JHU + Genentech)
✅ 58.5% of pts on ICIs reported fatigue
✅ Fatigue linked to ↑ Th1 cytokines (IFN-γ, IL-2, IL-12)
✅ Expansion of CD8+ effector T cells
✅ Fatigue = surrogate of immune activation
New study (JHU + Genentech)
✅ 58.5% of pts on ICIs reported fatigue
✅ Fatigue linked to ↑ Th1 cytokines (IFN-γ, IL-2, IL-12)
✅ Expansion of CD8+ effector T cells
✅ Fatigue = surrogate of immune activation
J Geriatr Oncol (Sept 2025, Raddoux et al.)
👏 Congrats to the authors & to the #GeriOnc community advancing care for older #MM patients.
📊 Prospective study in 200 older adults w/ newly diagnosed #MultipleMyeloma
J Geriatr Oncol (Sept 2025, Raddoux et al.)
👏 Congrats to the authors & to the #GeriOnc community advancing care for older #MM patients.
📊 Prospective study in 200 older adults w/ newly diagnosed #MultipleMyeloma
Melissa Troester, Kornelia Polyak, and Sherene Loi will address this question in an educational session at #SABCS25 (December 9-12). Learn more:
buff.ly/OB6T5Xs
@loisher.bsky.social
Melissa Troester, Kornelia Polyak, and Sherene Loi will address this question in an educational session at #SABCS25 (December 9-12). Learn more:
buff.ly/OB6T5Xs
@loisher.bsky.social
New review (Nat Rev Clin Oncol)
✅ Pathophysiology of chemo-, RT- & IO-induced neurotoxicity
✅ Clinical recognition & biomarkers
✅ Prevention & management strategies
🔍 Key messages – Cavaletti, Cámara, DeAngelis et al. Nat Rev Clin Oncol 2025
New review (Nat Rev Clin Oncol)
✅ Pathophysiology of chemo-, RT- & IO-induced neurotoxicity
✅ Clinical recognition & biomarkers
✅ Prevention & management strategies
🔍 Key messages – Cavaletti, Cámara, DeAngelis et al. Nat Rev Clin Oncol 2025
✅ Updated dx & staging recs
✅ 1L & r/r treatment algorithms
✅ Integration of CAR-T, bispecifics & BTKis
www.annalsofoncology.org/article/S092...
✅ Updated dx & staging recs
✅ 1L & r/r treatment algorithms
✅ Integration of CAR-T, bispecifics & BTKis
www.annalsofoncology.org/article/S092...
In the SunRISe-1 trial: complete responses reported in 82%
ascopost.com/news/septemb...
In the SunRISe-1 trial: complete responses reported in 82%
ascopost.com/news/septemb...
May we continue to carry forward the lessons of unity, resilience, and compassion.
May we continue to carry forward the lessons of unity, resilience, and compassion.
New pooled analysis in JCO
(8 RCTs, n=1,604)🌟
✅ HER2+ = worse PFS & OS
❌ Not predictive for Bev vs anti-EGFR
➡️ Prognostic, not predictive
#GIOnc #ColorectalCancer #mCRC #HER2 #Oncology #JCO #Medicalwatch
ascopubs.org/doi/10.1200/...
New pooled analysis in JCO
(8 RCTs, n=1,604)🌟
✅ HER2+ = worse PFS & OS
❌ Not predictive for Bev vs anti-EGFR
➡️ Prognostic, not predictive
#GIOnc #ColorectalCancer #mCRC #HER2 #Oncology #JCO #Medicalwatch
ascopubs.org/doi/10.1200/...
New open-access review (Mauro, de Castro, Zeitlhoefler, Villanueva, Mazzaferro, Llovet et al.)
🔑 Highlights:
✅ 3rd leading cause of cancer death
✅ Etiology shift → viral ↓ | ALD & MASLD ↑
✅ Prevention: HBV vax + antivirals effective
New open-access review (Mauro, de Castro, Zeitlhoefler, Villanueva, Mazzaferro, Llovet et al.)
🔑 Highlights:
✅ 3rd leading cause of cancer death
✅ Etiology shift → viral ↓ | ALD & MASLD ↑
✅ Prevention: HBV vax + antivirals effective
Cost-effectiveness of perioperative Durvalumab + Gem/Cis in MIBC (Germany)
📊 Results:
➡️ Cost: €113,224 (SoC) → €126,386 (+€13,162)
➡️ QALYs: 3.16 → 3.37 (+0.21)
➡️ ICER: €61,006/QALY
➡️ WTP €100,000 → 76.5% probability of cost-effectiveness
Cost-effectiveness of perioperative Durvalumab + Gem/Cis in MIBC (Germany)
📊 Results:
➡️ Cost: €113,224 (SoC) → €126,386 (+€13,162)
➡️ QALYs: 3.16 → 3.37 (+0.21)
➡️ ICER: €61,006/QALY
➡️ WTP €100,000 → 76.5% probability of cost-effectiveness
Ulrika Årehed Kågström tells The ASCO Post about successes and remaining challenges
ascopost.com/news/septemb...
Ulrika Årehed Kågström tells The ASCO Post about successes and remaining challenges
ascopost.com/news/septemb...
SITC’s #virtual Advances in Cancer Immunotherapy: A Focus on Lung Cancers program Sept. 12. Learn more: ow.ly/I7HJ50WT8wW 🧪
@drjnaidoo.bsky.social
SITC’s #virtual Advances in Cancer Immunotherapy: A Focus on Lung Cancers program Sept. 12. Learn more: ow.ly/I7HJ50WT8wW 🧪
@drjnaidoo.bsky.social
Prognosis & biology of ER-low metastatic breast cancer – TONIC & multicenter cohort
🔑 Key Messages:
✅ ER-low (1–9%) behaves biologically closer to TNBC than ER+/HER2−
✅ Worse OS vs ER+/HER2−; prognosis similar to TNBC
✅ Phenotypic switch from ER+ → ER-low at relapse = poor outcomes
Prognosis & biology of ER-low metastatic breast cancer – TONIC & multicenter cohort
🔑 Key Messages:
✅ ER-low (1–9%) behaves biologically closer to TNBC than ER+/HER2−
✅ Worse OS vs ER+/HER2−; prognosis similar to TNBC
✅ Phenotypic switch from ER+ → ER-low at relapse = poor outcomes
Geriatric Assessment: ASCO Global Guideline
🔑 Key Messages:
✅ GA identifies vulnerabilities missed by standard oncology evals
✅ Guides treatment tailoring, ↓ toxicity & ↑ QOL in older adults
✅ Universal GA recommended in all ≥65y pts w/ cancer
Geriatric Assessment: ASCO Global Guideline
🔑 Key Messages:
✅ GA identifies vulnerabilities missed by standard oncology evals
✅ Guides treatment tailoring, ↓ toxicity & ↑ QOL in older adults
✅ Universal GA recommended in all ≥65y pts w/ cancer
View session details: www.sitcancer.org/2025/schedul...
View session details: www.sitcancer.org/2025/schedul...
Honored to have worked alongside #EnriqueSoto & cols in developing this guideline
Check out the latest recommendations on GA, designed to improve care worldwide
📄Full guideline ascopubs.org/doi/pdf/10.1...
🎙️Don’t miss the accompanying podcast!
How this can help gain understanding on why some breast cancers are more aggressive than others: spr.ly/6012A8cXg #OncSky #EndCancer
How this can help gain understanding on why some breast cancers are more aggressive than others: spr.ly/6012A8cXg #OncSky #EndCancer
#JITC #ImmunoSky #MedSky
#JITC #ImmunoSky #MedSky